NMR Knowledge Base / Ezine
Sweet complexity: Sugars and diabetes
Date: Jan 7, 2013
Author: David Bradley
NMR spectroscopy has been used to investigate dicarbonyl sugars formed inside the human body from the natural breakdown of the simple sugar, glucose. The implications for understanding the link with diabetes are discussed.
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Tight fit: Loose fit
Date: Dec 15, 2012
Author:
Advanced NMR techniques have allowed a US team to map the molecular chaperone Hsp70 in different states looking at individual amino acids within the protein as they respond to different sample conditions.
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Journal Highlight: Combined use of filtered and edited 1H NMR spectroscopy to detect 13C-enriched compounds in complex mixtures
Date: Dec 3, 2012
Author: spectroscopyNOW
The 13C background signal can be distinguished from resonances of 13C-enriched xenobiotics by the absence of a 12C component, detected by combined analysis of 13C-filtered and -edited proton NMR spectra.
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Particulate matter: NMR checks on brain cancer
Date: Dec 1, 2012
Author:
NMR relaxometry can be used to detect the minuscule cell particles (microvesicles) that are shed by cancer cells and enter the blood stream. The approach offers the potential for a simple, inexpensive and relatively non-invasive way to diagnose and monitor brain cancer researchers say.
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Alzheimer's analysed: New clues in brain disease
Date: Nov 15, 2012
Author:
Recent studies have added weight to the idea that amyloid-beta is a causative agent in Alzheimer's disease rather than the plaques formed from these chunks of misfolded peptide that deposit in the diseased brain. Now, European researchers have used REAPDOR solid-state NMR spectroscopy to analyse the hydrogen bonds in the tiny fibrils of amyloid-beta peptide, offering another perspective on this neurodegenerative disorder.
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Journal Highlight: Quantitative NMR: An applicable method for quantitative analysis of medicinal plant extracts and herbal products
Date: Nov 5, 2012
Author: spectroscopyNOW
A quantitative NMR method has been reported for quantitative analysis of three medicinal plant extracts and their herbal products without the need of authentic standards.
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3D target: Membrane protein structure
Date: Nov 1, 2012
Author: David Bradley
X-ray crystallography has been used to identify two new small chaperone molecules. The targets may prove useful in developing the first pharmaceutical treatment for the rare but debilitating inherited metabolic disorder Schindler/Kanzaki disease.
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Fast switch: RNA vs NMR
Date: Oct 15, 2012
Author: David Bradley
Researchers have used NMR spectroscopy to tease out details of the smallest and fastest-known molecular switches composed of ribonucleic acid, RNA. These structures exist only fleetingly and yet look set to be become important targets for the development of new antiviral and antibiotic drugs.
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Nobel chemistry: pharma directions
Date: Oct 10, 2012
Author: David Bradley
The Royal Swedish Academy of Sciences has awarded the 2012 Nobel Prize in Chemistry jointly to Robert Lefkowitz of the Howard Hughes Medical Institute and Duke University Medical Center and Brian Kobilka Stanford of the University School of Medicine, Stanford "for studies of G-protein–coupled receptors".
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Journal Highlight: 1H-Nuclear magnetic resonance-based metabonomic analysis of brain in rhesus monkeys with morphine treatment and withdrawal intervention
Date: Oct 1, 2012
Author: spectroscopyNOW
Metabolic changes in brain hippocampus and prefrontal cortex of rhesus monkeys were measured by 1H-NMR, coupled with partial least squares and orthogonal signal correction analysis, to study morphine dependence and withdrawal therapy in a model highly related to humans.
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