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Spot the difference: NMR technique for drug design

Date: Oct 15, 2017

Author: David Bradley

A powerful new NMR technique DiffErential EPitope mapping by STD NMR spectroscopy (DEEP-STD NMR) is being used by researchers in the UK to reveal the nature of the contact between ligand and protein target with a view to developing new pharmaceuticals with fewer side-effects.

Read More thumbnail image: Spot the difference NMR technique for drug design

New 1.2 GHz NMR Spectrometers - New Horizons?

Date: Oct 3, 2017

Author: Prof. Dr. Harald Schwalbe

The latest ultrahigh-field NMR spectrometers are a huge technological challenge that require large financial investments. In his Guest Editorial written in the July issue of Angewandte Chemie, Harald Schwalbe justifies the need for spectrometers with higher magnetic field strengths. The important results from previous generations of high-field NMR spectrometers are discussed, and research areas are identified that will benefit from the latest spectrometers.

Read More thumbnail image: New 1_2 GHz NMR Spectrometers - New Horizons

Journal Highlight: Lipoprotein particle concentration measured by nuclear magnetic resonance spectroscopy is associated with gestational age at delivery: a prospective cohort study

Date: Oct 2, 2017

Author: spectroscopyNOW

The complex relationship between maternal lipoproteins and preterm birth has been studied using NMR to measure lipoprotein particle levels in the blood of women at 24-29 weeks gestation.

Read More thumbnail image: Journal Highlight Lipoprotein particle concentration measured by nuclear magnetic resonance spectroscopy is associated with gestational age at delivery a prospective cohort study

Cryo-electron microscopy: Alzheimer's fibrils

Date: Oct 1, 2017

Author: David Bradley

A technique that can augment X-ray crystallographic and spectroscopic studies has been demonstrated to provide an atomic resolution in imaging of the amyloid fibrils present in Alzheimer's disease, thanks to European research.

Read More thumbnail image: Cryo-electron microscopy Alzheimers fibrils

Journal Highlight: T1 Nuclear magnetic relaxation dispersion of hyperpolarized sodium and cesium hydrogencarbonate-13C

Date: Sep 4, 2017

Author: spectroscopyNOW

The T1 dispersion from low to clinical magnetic fields of different hyperpolarized hydrogencarbonate formulations previously proposed in the literature for in vivo pH measurements has been measured to aid pH mapping in tissue.

Read More thumbnail image: Journal Highlight T1 Nuclear magnetic relaxation dispersion of hyperpolarized sodium and cesium hydrogencarbonate-13C

Date rape drug metabolite: NMR reveals evidence next day

Date: Aug 15, 2017

Author: David Bradley

Nuclear magnetic resonance (NMR) spectroscopy can be used to quickly identify a biomarker for the presence of gamma-hydroxybutyric acid (GHB, the so-called "date rape" drug) in a biological sample from a putative victim of crime. Details are reported in the American Chemical Society's journal Analytical Chemistry.

Read More thumbnail image: Date rape drug metabolite NMR reveals evidence next day

Social rank: Stressed out by NMR

Date: Aug 1, 2017

Author: David Bradley

Social ranking is a major determining factor for vulnerability to chronic stress, according to a new study that uses nuclear magnetic resonance (NMR) spectroscopy to look at energy metabolism in the brain as a predictive biomarker.

Read More thumbnail image: Social rank Stressed out by NMR

Journal Highlight: Interpretation of seemingly contradictory data: Low NMR S2 order parameters observed in helices and high NMR S2 order parameters in disordered loops of the protein hGH at low pH

Date: Jul 31, 2017

Author: spectroscopyNOW

S2 order parameter-restraining MD simulations have been used to explain the contradictory S2 order parameters for backbone N−H vectors derived from NMR relaxation measurements on hGH at low pH.

Read More thumbnail image: Journal Highlight Interpretation of seemingly contradictory data Low NMR S2 order parameters observed in helices and high NMR S2 order parameters in disordered loops of the protein hGH at low pH

Phosphorus rubber: Multinuclear NMR

Date: Jul 15, 2017

Author: David Bradley

Poly-(1-phospha-isoprene) is a phosphorus-containing analogue of natural rubber that might find applications in creating macromolecular gold complexes for use in nanotechnology. 31P{1H} nuclear magnetic resonance (NMR) spectroscopy was used to provide a preliminary structure of the compound.

Read More thumbnail image: Phosphorus rubber Multinuclear NMR

Journal Highlight: Territorial origin of olive oil: representing georeferenced maps of olive oils by NMR profiling

Date: Jul 3, 2017

Author: spectroscopyNOW

1H NMR spectra have been used to build a geographic information system map permitting the identification of territorial regions of Italian olive oils having strong similarities in chemical content.

Read More thumbnail image: Journal Highlight Territorial origin of olive oil representing georeferenced maps of olive oils by NMR profiling
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