NMR Knowledge Base / Ezine
Fold it: Solid-state NMR unravels proteins
Date: Apr 1, 2012
Author: David Bradley
Researchers have developed a novel solid-state NMR spectroscopic method that uses paramagnetic tags to help them visualize the shape of protein molecules. The technique could be used to help scientists understand the properties of various biological molecules under normal, healthy conditions and also in those that are involved in a range of diseases.
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Interacting chaperones: NMR and X-ray combine to unravel combined relationship
Date: Mar 15, 2012
Author: David Bradley
Researchers in the US have combined nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography to gain new insights into the way in which a member of the histone chaperone family of specialized proteins functions.
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Journal Highlight: NMR analysis of metabolic responses to extreme conditions of the temperature-dependent coral pathogen Vibrio coralliilyticus
Date: Mar 5, 2012
Author:
The NMR analysis of polar metabolites of Vibrio coralliilyticus grown under normal and stressed conditions revealed a novel bioplastic-type compound in the stressed metabolome, consistent with acute nutrient limitation.
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Shroom doom: NMR reveals fatal attraction
Date: Feb 13, 2012
Author: David Bradley
Nuclear magnetic resonance spectroscopy, mass spectrometry and other techniques have been used to demonstrate that the consumption of toxic mushrooms may have been responsible for a series of unexplained deaths in China during the last three decades.
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Brain cancer metabolite: NMR homes in on prognosis
Date: Feb 1, 2012
Author: David Bradley
NMR spectroscopy has the potential to predict the prognosis and response to treatment of patients with low-grade infiltrating brain cancer, gliomas, that have mutations in the isocitrate dehydrogenase 1 gene, according to new imaging studies based on the technique.
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Root of tooth decay: NMR chews over liquorice
Date: Jan 15, 2012
Author: David Bradley
Dried liquorice root contains substances that apparently stop tooth decay. Research published in the Journal of the American Chemical Society describes the isolation and NMR spectroscopic analysis of key components.
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Delocalized silicon: Spectroscopy reveals more
Date: Jan 5, 2012
Author: David Bradley
The sigma electrons in polycyclic oligosilanes are delocalised across the Si-Si bonds of a three-dimensional silicon framework. Such frameworks are often present in crystalline and amorphous silicon and related silicon clusters, such as the persilastaffanes now investigated using NMR spectroscopy.
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Macrocyclic fishing: Combinatorial approach to metal selectors
Date: Dec 15, 2011
Author: David Bradley
Chemists in Europe have used dynamic combinatorial libraries (DCLs) to fish out macrocycles that are selective for different heavy metal ions. This classic supramolecular work extends an approach used widely in pharmaceutical drug discovery to good effect in an unrelated field. The team used NMR spectroscopy, X-ray diffraction and other techniques to study the optimal four macrocycles.
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Psoriasis on your CV: NMR helps spot heart disease link
Date: Dec 1, 2011
Author: David Bradley
NMR spectroscopy has been used to determine lipid levels in patients with the skin disorder psoriasis. The results point to a possible explanation for a link with cardiovascular disease.
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Useful carbon dioxide: NMR plots its redemption
Date: Nov 15, 2011
Author: David Bradley
Researchers at the Institut Rayonnement Matière de Saclay in Gif-sur-Yvette, France, have developed a novel method for converting the greenhouse gas, carbon dioxide, into either useable building blocks for chemical syntheses or new fuels. The team used nuclear magnetic resonance spectroscopy to track progress of their reactions.
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