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Pain on the brain: NMR tracks analgesics

Date: Apr 1, 2016

Author: David Bradley

Nuclear magnetic resonance spectroscopy (NMR) can be used to measure brain metabolites following administration of painkillers and so provide a useful way to evaluate objectively the analgesic effect as well as to study the mode of action of old and new types of painkiller.

Read More thumbnail image: Pain on the brain NMR tracks analgesics

Zinc control: NMR untangles Alzheimer's

Date: Mar 15, 2016

Author: David Bradley

An important clue as to the underlying mechanism of Alzheimer's disease has been identified using nuclear magnetic resonance (NMR) spectroscopy by researchers from the Lomonosov Moscow State University scientists and their colleagues from the Institute of Molecular Biology, Russian Academy of Sciences and the King's College London. They report details in the journal Scientific Reports.

Read More thumbnail image: Zinc control NMR untangles Alzheimers

Journal Highlight: Rapid NMR assignments of proteins by using optimized combinatorial selective unlabeling

Date: Mar 8, 2016

Author: spectroscopyNOW

A new approach for rapid resonance assignments in proteins based on amino acid selective unlabeling can augment existing approaches and will be useful for identifying active-site residues involved in ligand binding, phosphorylation, or protein–protein interactions.

Read More thumbnail image: Journal Highlight Rapid NMR assignments of proteins by using optimized combinatorial selective unlabeling

Imaging Parkinson's protein: NMR and EPR

Date: Mar 1, 2016

Author: David Bradley

A combined approach using nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) spectroscopy reveals details of the changes that occur in the protein α-synuclein in Parkinson's disease.

Read More thumbnail image: Imaging Parkinsons protein NMR and EPR

NMR spots biosimilars: Filgrastim found

Date: Feb 15, 2016

Author: David Bradley

Protein NMR spectroscopy can be used to demonstrate the high similarity of the three dimensional structure between various product sources according to research published in the journal Nature Biotechnology.

Read More thumbnail image: NMR spots biosimilars Filgrastim found

Journal Highlight: A community resource of experimental data for NMR / X-ray crystal structure pairs

Date: Feb 8, 2016

Author: spectroscopyNOW

An online NMR / X-ray Structure Pair Data Repository has been developed to provide experimental structures for at least one representative of each of hundreds of targeted protein domain families.

Read More thumbnail image: Journal Highlight A community resource of experimental data for NMR  X-ray crystal structure pairs

Journal Highlight: NMR logging to estimate hydraulic conductivity in unconsolidated aquifers

Date: Feb 1, 2016

Author: spectroscopyNOW

The application of NMR logging in unconsolidated aquifers suggests that a new set of constants can be defined to give high-resolution, cost-effective estimates of the estimate hydraulic conductivity.

Read More thumbnail image: Journal Highlight NMR logging to estimate hydraulic conductivity in unconsolidated aquifers

Metabolic tracking: NMR and radiolabels

Date: Feb 1, 2016

Author: David Bradley

Unexpected systematic signals in the proton NMR spectra of an iron catalyst have serendipitously led to a new way to radiolabel compounds and track how drugs are metabolized in the body.

Read More thumbnail image: Metabolic tracking NMR and radiolabels

Carbon dioxide: NMR reveals photosynthetic shift

Date: Jan 15, 2016

Author: David Bradley

Rising levels of the greenhouse gas carbon dioxide in the Earth's atmosphere are the focus of great concern, as we well know. Now, scientists in Sweden have demonstrated that the anthropogenic increase since the end of the Industrial Revolution may have changed photosynthetic metababolism in green plants.

Read More thumbnail image: Carbon dioxide NMR reveals photosynthetic shift

Diamonds: The NMR spectroscopist's best friend?

Date: Jan 7, 2016

Author: David Bradley

The shiniest of carbon allotropes, diamond, could turn out to be the NMR spectroscopist's and the MRI radiologist's best friend, thanks to work undertaken by scientists at the the Lawrence Berkeley National Laboratory and the University of California, Berkeley.

Read More thumbnail image: Diamonds The NMR spectroscopists best friend
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