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NMR spots biosimilars: Filgrastim found

Date: Feb 15, 2016

Author: David Bradley

Protein NMR spectroscopy can be used to demonstrate the high similarity of the three dimensional structure between various product sources according to research published in the journal Nature Biotechnology.

Read More thumbnail image: NMR spots biosimilars Filgrastim found

Journal Highlight: A community resource of experimental data for NMR / X-ray crystal structure pairs

Date: Feb 8, 2016

Author: spectroscopyNOW

An online NMR / X-ray Structure Pair Data Repository has been developed to provide experimental structures for at least one representative of each of hundreds of targeted protein domain families.

Read More thumbnail image: Journal Highlight A community resource of experimental data for NMR  X-ray crystal structure pairs

Journal Highlight: NMR logging to estimate hydraulic conductivity in unconsolidated aquifers

Date: Feb 1, 2016

Author: spectroscopyNOW

The application of NMR logging in unconsolidated aquifers suggests that a new set of constants can be defined to give high-resolution, cost-effective estimates of the estimate hydraulic conductivity.

Read More thumbnail image: Journal Highlight NMR logging to estimate hydraulic conductivity in unconsolidated aquifers

Metabolic tracking: NMR and radiolabels

Date: Feb 1, 2016

Author: David Bradley

Unexpected systematic signals in the proton NMR spectra of an iron catalyst have serendipitously led to a new way to radiolabel compounds and track how drugs are metabolized in the body.

Read More thumbnail image: Metabolic tracking NMR and radiolabels

Carbon dioxide: NMR reveals photosynthetic shift

Date: Jan 15, 2016

Author: David Bradley

Rising levels of the greenhouse gas carbon dioxide in the Earth's atmosphere are the focus of great concern, as we well know. Now, scientists in Sweden have demonstrated that the anthropogenic increase since the end of the Industrial Revolution may have changed photosynthetic metababolism in green plants.

Read More thumbnail image: Carbon dioxide NMR reveals photosynthetic shift

Diamonds: The NMR spectroscopist's best friend?

Date: Jan 7, 2016

Author: David Bradley

The shiniest of carbon allotropes, diamond, could turn out to be the NMR spectroscopist's and the MRI radiologist's best friend, thanks to work undertaken by scientists at the the Lawrence Berkeley National Laboratory and the University of California, Berkeley.

Read More thumbnail image: Diamonds The NMR spectroscopists best friend

Journal Highlight: Water proton NMR for in situ detection of insulin aggregates

Date: Jan 4, 2016

Author: spectroscopyNOW

Human insulin preparations were used to demonstrate that the transverse relaxation rate of water protons can serve as a sensitive and reliable indicator to detect and quantify both visible and sub-visible protein aggregates.

Read More thumbnail image: Journal Highlight Water proton NMR for in situ detection of insulin aggregates

Unravelling Helicobacter: Bactofilin insights from NMR

Date: Dec 15, 2015

Author: David Bradley

A novel approach to solid-state NMR spectroscopy has allowed researchers to unravel structural details of bactofilin from the ulcer-causing corkscrew bacterium, Helicobacter pylori.

Read More thumbnail image: Unravelling Helicobacter Bactofilin insights from NMR

Ionic liquids: Enzymatic cellulose processing

Date: Dec 1, 2015

Author: David Bradley

The promise of room temperature ionic liquids (RTILs) as alternatives to toxic and inflammable volatile organic solvents for green chemistry has been on the boil for at least a couple of decades. Now, team has found that enzymatic activity can be sustained in processing cellulose, from wood, for conversion of this raw material into other useful compounds.

Read More thumbnail image: Ionic liquids Enzymatic cellulose processing

Journal Highlight: Single-scan multidimensional NMR analysis of mixtures at sub-millimolar concentrations by using SABRE hyperpolarization

Date: Nov 30, 2015

Author: spectroscopyNOW

An approach to obtain clean, SABRE-hyperpolarized 2D 1H NMR spectra of mixtures of small molecules at sub-mM concentrations in a single scan uses para-hydrogen and a deuterated co-substrate for hyperpolarization and ultrafast 2D NMR for acquisition.

Read More thumbnail image: Journal Highlight Single-scan multidimensional NMR analysis of mixtures at sub-millimolar concentrations by using SABRE hyperpolarization
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