The application of spectroscopy in proteomics
Techniques include LC-MS, LC-MS/MS, GC-MS, MALDI-TOF-MS and metabolomics.
In this webinar, we will cover building high performance methods, generating a high quality spectral library and using it to reveal important expression changes in your pathway of interest, and even how to go back in time and use a DIA file’s record observable proteome to retrospectively interrogate data for new target peptides and proteins.Read More
In recent years, life sciences have shifted towards a more holistic approach to the study of organisms, considering them as a whole rather than as a sum of individual parts. This approach, known as systems biology, is necessarily interdisciplinary, requiring the use of physiological, physical, molecular, biochemical and chemical methods to observe and measure the response of an organism to diverse conditions. The omics technologies, such as genomics, transcriptomics, proteomics and metabolomics, are...Read More
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Aug 15, 2014
The amount of trypsin used in typical in-gel digestion procedures can be reduced ten-fold at least, without any loss of performance. In fact, some aspects are improved, such as a reduction in the number of trypsin autolysis products and a notable increase in the number of proteins identified in complex samples.
Aug 4, 2014
Korean scientists have found a number of proteins that have altered abundances in human plasma from people infected with the H1N1 influenza virus, with the potential to become biomarkers of infection.
Jul 21, 2014
This review aims to summarize and analyze the different proteomic approaches used to study granzymes and discusses both the convincing and controversial outcomes.View All Ezines
May 22, 2010
This article on the history and impact of mass spectrometry in the pharmaceutical industry is the first in a new series for Pharmaceutical Formulation & Quality, the premier source of news and information for pharmaceutical and biopharmaceutical industry professionals.
Sep 28, 2005
A glossary of common terms in proteomics, reproduced with the permission of Cambridge Healthtech Institute
Sep 28, 2005
This special feature paper, published in the Journal of Mass Spectrometry, highlights the benefits of using LC/MS/MS methods in proteome analysis in favour of the traditional 2DE/MS technique.View All Education Articles
Date: Sep 16, 2014 - 15:00
Data Independent Analysis (DIA) bridges protein identification and targeted quantitation by acting as a screening technique to rapidly and thoroughly survey a sample and direct future targeted analysis. DIA creates a comprehensive record of a sample by sequentially scanning all ions across a wide mass-to-charge range ensuring that all detectable parent ions and fragments are examined. In this webinar, we will cover building high performance methods, generating a high quality spectral library and using it...
Timothy D. Veenstra
Jul 19, 2013
May 1, 2013
Walter A. Korfmacher
Mar 12, 2013
Aug 17, 2014
Aug 1, 2014
Jul 23, 2014
Aug 20, 2014
Conventional digestion of proteins with trypsin does not give the best results, as two recent studies have illustrated.
Date: Jul 15, 2014
Fraser McLeod, Vice President & General Manager for HPLC at Thermo Fisher Scientific talks exclusively to separationsNOW.com about the game-changing Vanquish UHPLC system.