Proteomics @ spectroscopyNOW

The application of spectroscopy in proteomics

Techniques include LC-MS, LC-MS/MS, GC-MS, MALDI-TOF-MS and metabolomics.

Monthly Highlight

Webinar
Beyond Basic DIA - New Workflows using Orbitrap Mass Spectrometry for Large Scale Quantitation

In this webinar, we will cover building high performance methods, generating a high quality spectral library and using it to reveal important expression changes in your pathway of interest, and even how to go back in time and use a DIA file’s record observable proteome to retrospectively interrogate data for new target peptides and proteins.

Read More thumbnail image: <font color=red>Webinar</font><br/>Beyond Basic DIA - New Workflows using Orbitrap Mass Spectrometry for Large Scale Quantitation

Metabolomics: What You See is What You Extract

In recent years, life sciences have shifted towards a more holistic approach to the study of organisms, considering them as a whole rather than as a sum of individual parts. This approach, known as systems biology, is necessarily interdisciplinary, requiring the use of physiological, physical, molecular, biochemical and chemical methods to observe and measure the response of an organism to diverse conditions. The omics technologies, such as genomics, transcriptomics, proteomics and metabolomics, are...

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Advertorial Feature

Compound Search

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Two seconds here could save you months in the lab by using Wiley's Compound Search tool. Check the database coverage now... it's free!         We understand that you don't have time to wade through thousands of results. Compound Search's sole purpose is to tell you whether a compound appears in a specific database so that you'll know whether that database meets your needs. To speed this up, we provide exact structure matches only. Compound Search enables users to perform...

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Ezines

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The amount of trypsin used in typical in-gel digestion procedures can be reduced ten-fold at least, without any loss of performance. In fact, some aspects are improved, such as a reduction in the number of trypsin autolysis products and a notable increase in the number of proteins identified in complex samples.

Korean scientists have found a number of proteins that have altered abundances in human plasma from people infected with the H1N1 influenza virus, with the potential to become biomarkers of infection.

This review aims to summarize and analyze the different proteomic approaches used to study granzymes and discusses both the convincing and controversial outcomes.

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Education

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This article on the history and impact of mass spectrometry in the pharmaceutical industry is the first in a new series for Pharmaceutical Formulation & Quality, the premier source of news and information for pharmaceutical and biopharmaceutical industry professionals.

Proteomics Glossary

Sep 28, 2005

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A glossary of common terms in proteomics, reproduced with the permission of Cambridge Healthtech Institute

This special feature paper, published in the Journal of Mass Spectrometry, highlights the benefits of using LC/MS/MS methods in proteome analysis in favour of the traditional 2DE/MS technique.

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Journals

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Radiation and Health is a specialty section of Frontiers in Public Health.

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Webinars

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Effective use of novel data independent analysis methods to obtain comprehensive and reproducible characterization of a biological pathway

Date: Sep 16, 2014 - 15:00

Data Independent Analysis (DIA) bridges protein identification and targeted quantitation by acting as a screening technique to rapidly and thoroughly survey a sample and direct future targeted analysis. DIA creates a comprehensive record of a sample by sequentially scanning all ions across a wide mass-to-charge range ensuring that all detectable parent ions and fragments are examined. In this webinar, we will cover building high performance methods, generating a high quality spectral library and using it...

thumbnail image: Effective use of novel data independent analysis methods to obtain comprehensive and reproducible characterization of a biological pathway
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Blog

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Trypsin under the microscope

Steve Down

Aug 20, 2014

Conventional digestion of proteins with trypsin does not give the best results, as two recent studies have illustrated.

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Videos

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Thermo Scientific launches 'game-changing' Vanquish UHPLC system

Date: Jul 15, 2014

Fraser McLeod, Vice President & General Manager for HPLC at Thermo Fisher Scientific talks exclusively to separationsNOW.com about the game-changing Vanquish UHPLC system.

thumbnail image: Thermo Scientific launches 'game-changing' Vanquish UHPLC system
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