Journal Highlight: A proteomic approach to obesity and type 2 diabetes

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  • Published: Aug 24, 2015
  • Author: spectroscopyNOW
  • Channels: Proteomics
thumbnail image: Journal Highlight: A proteomic approach to obesity and type 2 diabetes
Some of the advances in understanding type 2 diabetes that have occurred through the application of proteomics have been reviewed along with current improvements in proteomic methodologies and new strategies that could be employed to further advance our understanding of this pathology.

A proteomic approach to obesity and type 2 diabetes

Journal of Cellular and Molecular Medicine, 2015, 19, 1455-1470
Elena López-Villar, Gabriel Á. Martos-Moreno, Julie A. Chowen, Shigeru Okada, John J. Kopchick and Jesús Argente

Abstract: The incidence of obesity and type diabetes 2 has increased dramatically resulting in an increased interest in its biomedical relevance. However, the mechanisms that trigger the development of diabetes type 2 in obese patients remain largely unknown. Scientific, clinical and pharmaceutical communities are dedicating vast resources to unravel this issue by applying different omics tools. During the last decade, the advances in proteomic approaches and the Human Proteome Organization have opened and are opening a new door that may be helpful in the identification of patients at risk and to improve current therapies. Here, we briefly review some of the advances in our understanding of type 2 diabetes that have occurred through the application of proteomics. We also review, in detail, the current improvements in proteomic methodologies and new strategies that could be employed to further advance our understanding of this pathology. By applying these new proteomic advances, novel therapeutic and/or diagnostic protein targets will be discovered in the obesity/Type 2 diabetes area.

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