Journal Highlight: Proteomic analysis of mouse soleus muscles affected by hindlimb unloading and reloading

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  • Published: Dec 21, 2015
  • Author: spectroscopyNOW
  • Channels: Proteomics
thumbnail image: Journal Highlight: Proteomic analysis of mouse soleus muscles affected by hindlimb unloading and reloading
Proteomic analysis was performed on mouse soleus subjected to hindlimb unloading and reloading to identify new dysregulated proteins involved in disuse muscle atrophy, which can be induced by prolonged space flight, bed rest or denervation.

Proteomic analysis of mouse soleus muscles affected by hindlimb unloading and reloading

Muscle & Nerve, 2015, 52, 803-811
Fei Wang, Peng Zhang, Hongju Liu, Ming Fan and Xiaoping Chen

Abstract: Disuse muscle atrophy, induced by prolonged space flight, bed rest, or denervation, is a common process with obvious changes in slow-twitch soleus muscles. Proteomic analysis was performed on mouse soleus subjected to hindlimb unloading (HU) and hindlimb reloading (HR) to identify new dysregulated proteins. Following HU, the mass and cross-sectional area of muscle fibers decreased, but they recovered after HR. Proteomic analyses revealed 9 down-regulated and 7 up-regulated proteins in HU, and 2 down-regulated and 5 up-regulated proteins in HR. The dysregulated proteins were mainly involved in energy metabolism, protein degradation, and cytoskeleton stability. Among the dysregulated proteins were fatty acid binding protein 3, α-B crystalline, and transthyretin. These results indicate that muscle atrophy induced by unloading is related to activation of proteolysis, metabolic alterations toward glycolysis, destruction of myofibrillar integrity, and dysregulation of heat shock proteins (HSPs). The dysregulated proteins may play a role in muscle atrophy and the recovery process.

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