Journal Highlight: Identification of unique proteomic signatures in allergic and non-allergic skin disease

Skip to Navigation

Ezine

  • Published: Aug 21, 2017
  • Author: spectroscopyNOW
  • Channels: Proteomics
thumbnail image: Journal Highlight: Identification of unique proteomic signatures in allergic and non-allergic skin disease

Unique proteomic signatures have been identified to distinguish between inflammatory diseases with similar epidermal disruption and overlapping epithelial inflammation.

Identification of unique proteomic signatures in allergic and non-allergic skin disease

Clinical & Experimental Allergy, 2017, online
J. Wang, M. Suárez-Fariñas, Y. Estrada, M. L. Parker, L. Greenlees, G. Stephens, J. Krueger, E. Guttman-Yassky and M. D. Howell

Abstract: Atopic dermatitis (AD), psoriasis (PS), and contact dermatitis (CD) are common skin diseases, characterized by barrier disruption and systemic inflammation, with unique epidermal signatures and common inflammatory pathways identified by transcriptomic profiling. This study profiled proteomic signatures in serum from subjects with AD, PS, and CD compared with healthy controls (HC). Sera from 20 subjects with moderate to severe AD, 10 subjects with CD, 12 subjects with moderate to severe PS, 10 subjects with both AD and CD, and 10 HC with no history of skin disease was analysed using high-throughput proteomic analysis that detects expression of 1129 protein targets. Protein expression was compared between disease and HC, and across diseases for statistical significance (fold change ≥ 1.5 and false discovery rate ≤ 0.05), to identify unique proteomic signatures for each disease. Complement C5A anaphylatoxin (C5A), lipopolysaccharide binding protein (LBP), C-reactive protein (CRP), ILT-4, C-C motif ligand 18 (PARC), and sialic acid-binding Ig-like lectin 14 (SIG14) were significantly modulated in all three diseases compared with HC. We identified unique signatures for AD (Immunoglobulin E (IgE), thymus- and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC)), CD (10 proteins), and PS (kynureninase (KYNU)). Proteomic profiling in subjects with both AD and CD identified additional dysregulated proteins compared with subjects with either condition alone, indicating an exacerbated inflammation reaction. Unique sera proteomic signatures may distinguish between inflammatory skin diseases despite similar epidermal barrier disruption and epithelial inflammation. This may provide insight into disease pathogenesis, diagnosis, and therapeutic intervention in difficult-to-treat subjects.

  • This paper is free to view for all users registered on spectroscopyNOW.com until the end of October 2017.
    After this time, you can purchase it using Pay-Per-View on Wiley Online Library.

Follow us on Twitter!

Social Links

Share This Links

Bookmark and Share

Microsites

Suppliers Selection
Societies Selection

Banner Ad

Click here to see
all job opportunities

Copyright Information

Interested in separation science? Visit our sister site separationsNOW.com

Copyright © 2017 John Wiley & Sons, Inc. All Rights Reserved