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Meat adulteration: Substitute meats and allergens

Date: Nov 2, 2018

Author: Steve Down

The adulteration of meat and meat products by other types of meat or allergenic foods such as egg white, soy and milk has been accomplished using a stable-isotope-labelled quantification strategy by scientists in Poland.

Read More thumbnail image: Meat adulteration Substitute meats and allergens

Journal Highlight: Taxonomic landscape of the dark proteomes: Whole‐proteome scale interplay between structural darkness, intrinsic disorder, and crystallization propensity

Date: Oct 22, 2018

Author: spectroscopyNOW

A whole‐proteome scale analysis has been carried out for 5.4 million proteins from 987 proteomes in the three domains of life and viruses to uncover relationships between structural coverage, degree of putative intrinsic disorder, and predicted propensity for structure determination.

Read More thumbnail image: Journal Highlight Taxonomic landscape of the dark proteomes Wholeproteome scale interplay between structural darkness intrinsic disorder and crystallization propensity

Forensic biofluids under fingernails: Combined genomic and proteomic approach

Date: Oct 15, 2018

Author: Steve Down

A combined approach involving DNA profiling and proteome analysis has been applied to the analysis of traces of biofluids trapped under fingernails to provide forensic evidence, using a single microswab for both procedures.

Read More thumbnail image: Forensic biofluids under fingernails Combined genomic and proteomic approach

Rapid enzyme digestion: Greater proteome coverage

Date: Oct 2, 2018

Author: Steve Down

Rapid enzymatic processing of proteins over a few minutes in proteomic studies to give only partial digestion is at least as good as complete digestion, say US researchers, providing a valid alternative that streamlines and speeds up proteome characterisation.

Read More thumbnail image: Rapid enzyme digestion Greater proteome coverage

Journal Highlight: Corneocyte proteomics: Applications to skin biology and dermatology

Date: Sep 24, 2018

Author: spectroscopyNOW

The application of mass spectrometry‐based proteomics to the analysis of complex cellular structures in the epidermis and its appendages (nail plate, hair shaft) has been reviewed and is predicted to find use in disease risk stratification, detection, diagnosis and prognosis after the discovery phase and clinical validation.

Read More thumbnail image: Journal Highlight Corneocyte proteomics Applications to skin biology and dermatology

Hepatitis C treatment: Antiviral response prediction

Date: Sep 17, 2018

Author: Steve Down

A combined proteomics and pharmacogenomics approach to the treatment of hepatitis C with direct acting antiviral therapies has identified three peptides derived from human corticosteroid binding globulin that can predict the response to treatment.

Read More thumbnail image: Hepatitis C treatment Antiviral response prediction

Music therapy: Proteome implications

Date: Sep 1, 2018

Author: Steve Down

A proteomics study of the effects of musical stimulation on spatial learning and memory in rats has implicated a pair of proteins that could provide a basis for studying clinical applications of music therapy in humans.

Read More thumbnail image: Music therapy Proteome implications

Journal Highlight: Triggering of cancer cell cycle arrest by a novel scorpion venom‐derived peptide — Gonearrestide

Date: Aug 20, 2018

Author: spectroscopyNOW

A novel scorpion venom‐derived peptide that has been identified in an in‐house constructed scorpion venom library through a combination of high‐throughput NGS transcriptomics and MS/MS proteomics inhibited the growth of primary colon cancer cells and solid tumours by triggering cell cycle arrest.

Read More thumbnail image: Journal Highlight Triggering of cancer cell cycle arrest by a novel scorpion venomderived peptide  Gonearrestide

Ageing proteins: Plasma biomarkers in healthy people

Date: Aug 15, 2018

Author: Steve Down

Around 220 proteins have been linked to age in a proteomics study of healthy people of all ages, which could be used to predict morbidity and death as well as offer ways to slow the progression of aging.

Read More thumbnail image: Ageing proteins Plasma biomarkers in healthy people

Fatigue in multiple sclerosis: Protein biomarkers

Date: Aug 1, 2018

Author: Steve Down

Several biomarkers of fatigue in patients with multiple sclerosis have been identified in a proteomics study, pointing to a disturbance of central nervous system plasticity as a key factor.

Read More thumbnail image: Fatigue in multiple sclerosis Protein biomarkers
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