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Kawasaki disease: Protein biomarker candidates

Date: Jan 17, 2019

Author: Steve Down

The rare but serious condition known as Kawasaki disease, which mainly affects children under the age of five, produces a modified urinary protein profile that could lead to the development of a diagnostic panel of proteins.

Read More thumbnail image: Kawasaki disease Protein biomarker candidates

Preeclampsia proteins: Placental biomarkers

Date: Jan 3, 2019

Author: Steve Down

A proteomics analysis of the placental proteins of pregnant women with preeclampsia has revealed 37 proteins with altered abundances which could be used to develop diagnostic tests or treatments for this disease.

Read More thumbnail image: Preeclampsia proteins Placental biomarkers

Mining the human proteome: Deeper coverage to find missing proteins

Date: Dec 17, 2018

Author: Steve Down

The depth of coverage of the human proteome can be markedly extended by introducing a preliminary alkaline 2D-LC step before analysis by LC/MS with selected reaction monitoring using isotope-labelled standards or shotgun LC/MS/MS analysis.

Read More thumbnail image: Mining the human proteome Deeper coverage to find missing proteins

Journal Highlight: A proteomics and other omics approach in the context of farmed fish welfare and biomarker discovery

Date: Dec 17, 2018

Author: spectroscopyNOW

Current methods and assays used to measure animal and farmed fish welfare have been discussed and the introduction of a new type of welfare biomarkers using cutting‐edge technologies like proteomics and other omics technologies have been reviewed.

Read More thumbnail image: Journal Highlight A proteomics and other omics approach in the context of farmed fish welfare and biomarker discovery

Paediatric kidney transplant rejection: Peptide biomarkers

Date: Dec 1, 2018

Author: Steve Down

Kidney transplant rejection in children, specifically chronic active antibody-mediated rejection (cAMBR), can be predicted by a panel of urinary peptides, many derived from collagen species, a development that could indicate those patients who would benefit from increased immunosuppressive treatment.

Read More thumbnail image: Paediatric kidney transplant rejection Peptide biomarkers

Journal Highlight: Proteomic analysis of extracellular vesicles for cancer diagnostics

Date: Nov 19, 2018

Author: spectroscopyNOW

This review summarizes current advancements in extracellular vesicle (EV) subtype characterization, cancer EV capturing and proteomic analysis technologies, as well as possible EV‐based multiomics for cancer diagnostics.

Read More thumbnail image: Journal Highlight Proteomic analysis of extracellular vesicles for cancer diagnostics

Acupuncture for vascular dementia: Proteins implicated

Date: Nov 15, 2018

Author: Steve Down

The molecular mechanisms behind the improvement of vascular dementia initiated by acupuncture have been investigated by Chinese scientists who used proteomics to indicate that proteins involved in oxidative stress, apoptosis and synaptic function were affected.

Read More thumbnail image: Acupuncture for vascular dementia Proteins implicated

Meat adulteration: Substitute meats and allergens

Date: Nov 2, 2018

Author: Steve Down

The adulteration of meat and meat products by other types of meat or allergenic foods such as egg white, soy and milk has been accomplished using a stable-isotope-labelled quantification strategy by scientists in Poland.

Read More thumbnail image: Meat adulteration Substitute meats and allergens

Journal Highlight: Taxonomic landscape of the dark proteomes: Whole‐proteome scale interplay between structural darkness, intrinsic disorder, and crystallization propensity

Date: Oct 22, 2018

Author: spectroscopyNOW

A whole‐proteome scale analysis has been carried out for 5.4 million proteins from 987 proteomes in the three domains of life and viruses to uncover relationships between structural coverage, degree of putative intrinsic disorder, and predicted propensity for structure determination.

Read More thumbnail image: Journal Highlight Taxonomic landscape of the dark proteomes Wholeproteome scale interplay between structural darkness intrinsic disorder and crystallization propensity

Forensic biofluids under fingernails: Combined genomic and proteomic approach

Date: Oct 15, 2018

Author: Steve Down

A combined approach involving DNA profiling and proteome analysis has been applied to the analysis of traces of biofluids trapped under fingernails to provide forensic evidence, using a single microswab for both procedures.

Read More thumbnail image: Forensic biofluids under fingernails Combined genomic and proteomic approach
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