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Hepatitis C treatment: Antiviral response prediction

Date: Sep 17, 2018

Author: Steve Down

A combined proteomics and pharmacogenomics approach to the treatment of hepatitis C with direct acting antiviral therapies has identified three peptides derived from human corticosteroid binding globulin that can predict the response to treatment.

Read More thumbnail image: Hepatitis C treatment Antiviral response prediction

Music therapy: Proteome implications

Date: Sep 1, 2018

Author: Steve Down

A proteomics study of the effects of musical stimulation on spatial learning and memory in rats has implicated a pair of proteins that could provide a basis for studying clinical applications of music therapy in humans.

Read More thumbnail image: Music therapy Proteome implications

Journal Highlight: Triggering of cancer cell cycle arrest by a novel scorpion venom‐derived peptide — Gonearrestide

Date: Aug 20, 2018

Author: spectroscopyNOW

A novel scorpion venom‐derived peptide that has been identified in an in‐house constructed scorpion venom library through a combination of high‐throughput NGS transcriptomics and MS/MS proteomics inhibited the growth of primary colon cancer cells and solid tumours by triggering cell cycle arrest.

Read More thumbnail image: Journal Highlight Triggering of cancer cell cycle arrest by a novel scorpion venomderived peptide  Gonearrestide

Ageing proteins: Plasma biomarkers in healthy people

Date: Aug 15, 2018

Author: Steve Down

Around 220 proteins have been linked to age in a proteomics study of healthy people of all ages, which could be used to predict morbidity and death as well as offer ways to slow the progression of aging.

Read More thumbnail image: Ageing proteins Plasma biomarkers in healthy people

Fatigue in multiple sclerosis: Protein biomarkers

Date: Aug 1, 2018

Author: Steve Down

Several biomarkers of fatigue in patients with multiple sclerosis have been identified in a proteomics study, pointing to a disturbance of central nervous system plasticity as a key factor.

Read More thumbnail image: Fatigue in multiple sclerosis Protein biomarkers

Journal Highlight: Prediction of skin anti‐aging clinical benefits of an association of ingredients from marine and maritime origins: Ex vivo evaluation using a label‐free quantitative proteomic and customized data processing approach

Date: Jul 23, 2018

Author: spectroscopyNOW

A comprehensive evaluation of the activity on the skin of an association of ingredients from marine and maritime origins has been carried out using label‐free quantitative proteomic analysis, in order to predict the clinical benefits if used in a skin care product.

Read More thumbnail image: Journal Highlight Prediction of skin antiaging clinical benefits of an association of ingredients from marine and maritime origins Ex vivo evaluation using a labelfree quantitative proteomic and customized data processing approach

Sputum proteome: Optimising label-free mapping

Date: Jul 15, 2018

Author: Steve Down

The healthy human sputum proteome has been derived in an international project, assessing the sources of variability and revealing a core set of 284 proteins that will be useful for studying patients with inflammatory respiratory diseases.

Read More thumbnail image: Sputum proteome Optimising label-free mapping

Graphene oxide nanomaterials: Toxicity mechanisms

Date: Jul 1, 2018

Author: Steve Down

Typical environmental levels of graphene oxide nanoparticles modify the abundances of nearly 250 proteins in zebrafish larvae, tested as a model aquatic species, and bring about malformations and increased mortality, a new proteomics study has revealed.

Read More thumbnail image: Graphene oxide nanomaterials Toxicity mechanisms

Journal Highlight: Revealing the inhibitory effect of ginseng on mitochondrial respiration through synaptosomal proteomics

Date: Jun 25, 2018

Author: spectroscopyNOW

A proteomics study of the synaptosomes of rats treated with ginseng has shown that it can regulate the function of mitochondria and alter the energy metabolism of cells, which may be useful for the treatment of central nervous disorders.

Read More thumbnail image: Journal Highlight Revealing the inhibitory effect of ginseng on mitochondrial respiration through synaptosomal proteomics

Asthma control: Protein biomarkers

Date: Jun 15, 2018

Author: Steve Down

A proteomics study has identified a link between the levels of proteins in the serum and sputum of asthmatics for whom the disease is poorly controlled, providing early indications when further clinical intervention is needed to give a better outcome.

Read More thumbnail image: Asthma control Protein biomarkers
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