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Journal Highlight: Reconstructing the pipeline by introducing multiplexed MRM-MS for cancer biomarker verification: An NCI-CPTC initiative perspective

Date: Jan 24, 2011

Author:

The use of multiple reaction monitoring in mass spectrometry, with or without affinity enrichment, is reviewed as a sensitive, reproducible and quantitative platform for cancer biomarker verification.

Read More thumbnail image: Journal Highlight Reconstructing the pipeline by introducing multiplexed MRM-MS for cancer biomarker verification An NCI-CPTC initiative perspective

Brain death predictors: proteomics reveals molecular safeguards against death

Date: Jan 15, 2011

Author: Steve Down

The proteome of an area of the brain that has been associated with brain death is distinctively different from that of another part of the brain, say Chinese scientists, with raised levels of antioxidant proteins in particular. These findings will help to establish the origins of brain death.

Read More thumbnail image: Brain death predictors proteomics reveals molecular safeguards against death

Discolouration of cooked potatoes: proteomics points to a solution

Date: Jan 1, 2011

Author: Steve Down

The wound response proteins associated with the black discolouration of potatoes following cooking have been identified by quantitative proteomics and cluster analysis, which should help to produce varieties with a reduced darkening tendency.

Read More thumbnail image: Discolouration of cooked potatoes proteomics points to a solution

Journal Highlight: Transcriptomic and proteomic insights of the wine yeast biomass propagation process

Date: Dec 20, 2010

Author:

Transcriptome and proteome profiles have been established for the commercial wine yeast strain T73 during an important yeast biomass propagation, revealing that the metabolic transition from fermentation to respiration is the most critical step in biomass propagation.

Read More thumbnail image: Journal Highlight Transcriptomic and proteomic insights of the wine yeast biomass propagation process

Population proteomics of hake: proteins can pinpoint the location of the fish

Date: Dec 15, 2010

Author: Steve Down

Three distinct populations of European hake have been distinguished by the levels of their liver and brain proteins, allowing fish classification according to origin. This should help in the monitoring and surveillance of fish stocks and prevent overfishing.

Read More thumbnail image: Population proteomics of hake proteins can pinpoint the location of the fish

Safety assessment of nanomaterials: proteomics predicts biomarkers of exposure to silica nanoparticles

Date: Dec 1, 2010

Author: Steve Down

Silica nanoparticles of different sizes induce increased levels of acute-phase proteins in the plasma of mice in a size-dependent manner following iv treatment. These proteins will be valuable indicators of exposure and could help to develop safer nanomaterials.

Read More thumbnail image: Safety assessment of nanomaterials proteomics predicts biomarkers of exposure to silica nanoparticles

Journal Highlight: Achievements and perspectives of top-down proteomics

Date: Nov 22, 2010

Author:

In this review article, the state-of-the-art of top-down approach is described along with its major advantages and drawbacks and the most recent trends are discussed, with references for all the covered topics reported in the text.

Read More thumbnail image: Journal Highlight Achievements and perspectives of top-down proteomics

Cockroach allergens identified: Personalised profiling of allergic people on the horizon

Date: Nov 15, 2010

Author: Steve Down

A comprehensive screening procedure has identified ten new allergenic proteins from the German cockroach and opens up the possibility of personalised profiling of individuals who suffer from cockroach allergies.

Read More thumbnail image: Cockroach allergens identified Personalised profiling of allergic people on the horizon

The proteome of your pint: novel ligand capture technique uncovers more proteins

Date: Nov 1, 2010

Author: Steve Down

The proteome of beer has been examined using two peptide libraries to capture the proteins for subsequent identification, a technique which uncovered many trace proteins and could be used to help brewers alter the characteristics of the final product.

Read More thumbnail image: The proteome of your pint novel ligand capture technique uncovers more proteins

Journal Highlight: Proteomic profiling reveals a catalogue of new candidate proteins for human skin aging

Date: Oct 25, 2010

Author:

A proteomic analysis of intrinsic human skin aging was carried out by quantifying proteins extracted and fluorescently labeled from sun-protected human foreskin samples pooled from 'young' and 'old' men.

Read More thumbnail image: Journal Highlight Proteomic profiling reveals a catalogue of new candidate proteins for human skin aging
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