Proteomics & Genomics / Ezine
Journal Highlight: Reconstructing the pipeline by introducing multiplexed MRM-MS for cancer biomarker verification: An NCI-CPTC initiative perspective
Date: Jan 24, 2011
Author:
The use of multiple reaction monitoring in mass spectrometry, with or without affinity enrichment, is reviewed as a sensitive, reproducible and quantitative platform for cancer biomarker verification.
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Brain death predictors: proteomics reveals molecular safeguards against death
Date: Jan 15, 2011
Author: Steve Down
The proteome of an area of the brain that has been associated with brain death is distinctively different from that of another part of the brain, say Chinese scientists, with raised levels of antioxidant proteins in particular. These findings will help to establish the origins of brain death.
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Discolouration of cooked potatoes: proteomics points to a solution
Date: Jan 1, 2011
Author: Steve Down
The wound response proteins associated with the black discolouration of potatoes following cooking have been identified by quantitative proteomics and cluster analysis, which should help to produce varieties with a reduced darkening tendency.
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Journal Highlight: Transcriptomic and proteomic insights of the wine yeast biomass propagation process
Date: Dec 20, 2010
Author:
Transcriptome and proteome profiles have been established for the commercial wine yeast strain T73 during an important yeast biomass propagation, revealing that the metabolic transition from fermentation to respiration is the most critical step in biomass propagation.
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Population proteomics of hake: proteins can pinpoint the location of the fish
Date: Dec 15, 2010
Author: Steve Down
Three distinct populations of European hake have been distinguished by the levels of their liver and brain proteins, allowing fish classification according to origin. This should help in the monitoring and surveillance of fish stocks and prevent overfishing.
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Safety assessment of nanomaterials: proteomics predicts biomarkers of exposure to silica nanoparticles
Date: Dec 1, 2010
Author: Steve Down
Silica nanoparticles of different sizes induce increased levels of acute-phase proteins in the plasma of mice in a size-dependent manner following iv treatment. These proteins will be valuable indicators of exposure and could help to develop safer nanomaterials.
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Journal Highlight: Achievements and perspectives of top-down proteomics
Date: Nov 22, 2010
Author:
In this review article, the state-of-the-art of top-down approach is described along with its major advantages and drawbacks and the most recent trends are discussed, with references for all the covered topics reported in the text.
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Cockroach allergens identified: Personalised profiling of allergic people on the horizon
Date: Nov 15, 2010
Author: Steve Down
A comprehensive screening procedure has identified ten new allergenic proteins from the German cockroach and opens up the possibility of personalised profiling of individuals who suffer from cockroach allergies.
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The proteome of your pint: novel ligand capture technique uncovers more proteins
Date: Nov 1, 2010
Author: Steve Down
The proteome of beer has been examined using two peptide libraries to capture the proteins for subsequent identification, a technique which uncovered many trace proteins and could be used to help brewers alter the characteristics of the final product.
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Journal Highlight: Proteomic profiling reveals a catalogue of new candidate proteins for human skin aging
Date: Oct 25, 2010
Author:
A proteomic analysis of intrinsic human skin aging was carried out by quantifying proteins extracted and fluorescently labeled from sun-protected human foreskin samples pooled from 'young' and 'old' men.
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