Proteomics & Genomics / Ezine
Counting calories: changes in the white adipose tissue proteome induced by caloric restriction
Date: Oct 15, 2010
Author: Steve Down
The proteome of rat white adipose tissue is affected by caloric restriction, say Spanish scientists, in different ways to the effects of aging. The positive changes include an improvement in oxidative stress and energy metabolism, which could lead to the identification of biomarkers of aging.
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Towards the male contraceptive
Date: Oct 1, 2010
Author: Steve Down
Proteins involved in regulating the heat-induced suppression of human spermatogenesis, which were identified in a proteomics study, can be considered potential targets for the development of male contraceptives.
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Using HPLC-mass spectrometry to teach proteomics concepts with problem-based techniques
Date: Sep 27, 2010
Author:
Practical instruction of proteomics concepts was provided using HPLC coupled with a mass selective detection system for the analysis of simulated protein digests, illustrating that complex concepts can be taught in the undergraduate biochemistry laboratory using a problem-based approach.
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Chernobyl flax takes the flak
Date: Sep 15, 2010
Author: Steve Down
Flax plants grown in soil that is still contaminated following the Chernobyl incident displayed remarkably limited adaptive changes in the proteome in response to ionising radiation.
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Not so cold storage
Date: Sep 1, 2010
Author: Steve Down
Storing human plasma at -30°C, rather than the -80°C recommended in current standard operating procedures, has no adverse effects on the abundances of high-molecular-weight proteins, say Spanish scientists. This will allow the analysis of far more samples by 2D-DIGE in the study of human disease.
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Comparative physiological and proteomic responses to drought stress in two poplar species originating from different altitudes
Date: Aug 23, 2010
Author:
Cuttings of Populus kangdingensis C. Wang et Tung and Populus cathayana Rehder were examined during a single growing season in a greenhouse for comparative analysis of their physiological and proteomic responses to drought stress.
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Modelling experience not required
Date: Aug 15, 2010
Author: Steve Down
A combined transcriptomic and proteomic approach has been used for the first time to construct a gene and protein data reference set for a marine fouling invertebrate, as a rapid alternative to whole genome sequencing.
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Allergenic prawn proteins
Date: Aug 1, 2010
Author: Steve Down
The key major allergenic proteins in black tiger prawns were identified using immunoblotting and proteomics techniques, and a signature peptide for tropomyosin, the major allergen, was identified for future quantitative studies in the seafood industry.
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Glioma pathophysiology: Insights emerging from proteomics
Date: Jul 26, 2010
Author:
A systematic review of multiple independent proteomic analyses of glioma combined with a network analysis of differentially expressed proteins has revealed a robust and cohesive network for glioblastoma.
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Cue antigens for Q fever
Date: Jul 15, 2010
Author: Steve Down
A protein microarray containing almost 2000 open reading frames has been used to detect seroactive antigens for the bacterium Coxiella burnetti, the agent of Q fever. Some of the antigens were used in an immunostrip for disease diagnosis and are candidates for vaccines.
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