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Psoriasis severity and treatment: Metabolomics uncovers amino acid biomarkers

Date: Dec 3, 2014

Author: Steve Down

A metabolomics study of the plasma from psoriasis sufferers has highlighted numerous circulating amino acids that increase in abundance with the severity of the disease but return towards normal levels following treatment with a protein drug that targets tumour necrosis factor alpha.

Read More thumbnail image: Psoriasis severity and treatment Metabolomics uncovers amino acid biomarkers

Liver damage by lead acetate: Oxidised proteins and cell damage

Date: Nov 24, 2014

Author: Steve Down

Exposure to lead acetate on the skin results in oxidation of protein in the liver that could ultimately cause liver damage, say Taiwanese researchers.

Read More thumbnail image: Liver damage by lead acetate Oxidised proteins and cell damage

Journal Highlight: Proteomics in farm animals models of human diseases

Date: Nov 24, 2014

Author: spectroscopyNOW

This review offers a snapshot of how proteomic techniques have been applied to farm animals to improve their use as biomedical models.

Read More thumbnail image: Journal Highlight Proteomics in farm animals models of human diseases

Viper venoms: Variations affect antivenom efficacy

Date: Nov 14, 2014

Author: Steve Down

The venoms of three closely related Middle Eastern vipers have widely different protein compositions, say an international team of scientists, who suggest that the single antivenom currently used for them all will offer limited success.

Read More thumbnail image: Viper venoms Variations affect antivenom efficacy

Journal Highlight: Proteomic identification of responsive proteins of Vibrio parahaemolyticus under high hydrostatic pressure

Date: Oct 27, 2014

Author: spectroscopyNOW

Proteome profiles were performed to determine the effects of high hydrostatic pressure on the food pathogen Vibrio parahaemolyticus ATCC 17802 in order to understand how it responds to mechanical stress injury.

Read More thumbnail image: Journal Highlight Proteomic identification of responsive proteins of Vibrio parahaemolyticus under high hydrostatic pressure

Ozone liver stress: Inhalation alters hepatic proteome

Date: Oct 15, 2014

Author: Steve Down

Exposure to ozone modifies the proteome of the rat liver, according to scientists in the USA, compounding the adverse health effects that are already recognised in other organs like the lungs and heart.

Read More thumbnail image: Ozone liver stress Inhalation alters hepatic proteome

Biomarker background for joint diseases: Synovial fluid proteome of healthy knees

Date: Oct 1, 2014

Author: Steve Down

The proteome of synovial fluid from healthy porcine knee joints has been characterised as a model for human joints to create a reference point for the identification of biomarkers in joint diseases like arthritis.

Read More thumbnail image: Biomarker background for joint diseases Synovial fluid proteome of healthy knees

Journal Highlight: Response to cold acclimation in diapause pupae of Hyles euphorbiae (Lepidoptera: Sphingidae): candidate biomarker identification using proteomics

Date: Sep 22, 2014

Author: spectroscopyNOW

Candidate protein biomarkers and biological processes that are associated with cold acclimation of overwintering Hyles euphorbiae diapause pupae have been identified to help explore intraspecific patterns of local adaptation to different climates.

Read More thumbnail image: Journal Highlight Response to cold acclimation in diapause pupae of Hyles euphorbiae Lepidoptera Sphingidae candidate biomarker identification using proteomics

Proteome dynamics: Deuterium oxide doping

Date: Sep 15, 2014

Author: Steve Down

Human subjects have been drinking deuterated water to investigate protein turnover in the body, in a protocol which has been proven to be safe and effective and could lead to a greater understanding of cardiovascular protein dynamics.

Read More thumbnail image: Proteome dynamics Deuterium oxide doping

Cell phone effects: Testicular proteome modified

Date: Sep 1, 2014

Author: Steve Down

The testicular proteome of the rat is modified by exposure to electromagnetic fields of similar strengths to those emitted by cell phones, with some new proteins being induced.

Read More thumbnail image: Cell phone effects Testicular proteome modified
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