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Biomarker background for joint diseases: Synovial fluid proteome of healthy knees

Date: Oct 1, 2014

Author: Steve Down

The proteome of synovial fluid from healthy porcine knee joints has been characterised as a model for human joints to create a reference point for the identification of biomarkers in joint diseases like arthritis.

Read More thumbnail image: Biomarker background for joint diseases Synovial fluid proteome of healthy knees

Journal Highlight: Response to cold acclimation in diapause pupae of Hyles euphorbiae (Lepidoptera: Sphingidae): candidate biomarker identification using proteomics

Date: Sep 22, 2014

Author: spectroscopyNOW

Candidate protein biomarkers and biological processes that are associated with cold acclimation of overwintering Hyles euphorbiae diapause pupae have been identified to help explore intraspecific patterns of local adaptation to different climates.

Read More thumbnail image: Journal Highlight Response to cold acclimation in diapause pupae of Hyles euphorbiae Lepidoptera Sphingidae candidate biomarker identification using proteomics

Proteome dynamics: Deuterium oxide doping

Date: Sep 15, 2014

Author: Steve Down

Human subjects have been drinking deuterated water to investigate protein turnover in the body, in a protocol which has been proven to be safe and effective and could lead to a greater understanding of cardiovascular protein dynamics.

Read More thumbnail image: Proteome dynamics Deuterium oxide doping

Cell phone effects: Testicular proteome modified

Date: Sep 1, 2014

Author: Steve Down

The testicular proteome of the rat is modified by exposure to electromagnetic fields of similar strengths to those emitted by cell phones, with some new proteins being induced.

Read More thumbnail image: Cell phone effects Testicular proteome modified

Journal Highlight: Proteomic strategies for the discovery of novel diagnostic and therapeutic targets for infectious diseases

Date: Aug 25, 2014

Author: spectroscopyNOW

In this review, proteomic information on host–viral protein interactions obtained through differing technologies is compared and ways to determine the functional aspect of the host response to infection are described.

Read More thumbnail image: Journal Highlight Proteomic strategies for the discovery of novel diagnostic and therapeutic targets for infectious diseases

Trypsin autolysis reduced: In-gel digestion improved

Date: Aug 15, 2014

Author: Steve Down

The amount of trypsin used in typical in-gel digestion procedures can be reduced ten-fold at least, without any loss of performance. In fact, some aspects are improved, such as a reduction in the number of trypsin autolysis products and a notable increase in the number of proteins identified in complex samples.

Read More thumbnail image: Trypsin autolysis reduced In-gel digestion improved

Swine flu biomarkers: Plasma proteins mark H1N1 infection

Date: Aug 4, 2014

Author: Steve Down

Korean scientists have found a number of proteins that have altered abundances in human plasma from people infected with the H1N1 influenza virus, with the potential to become biomarkers of infection.

Read More thumbnail image: Swine flu biomarkers Plasma proteins mark H1N1 infection

Journal Highlight: Blessing or curse? Proteomics in granzyme research

Date: Jul 21, 2014

Author: spectroscopyNOW

This review aims to summarize and analyze the different proteomic approaches used to study granzymes and discusses both the convincing and controversial outcomes.

Read More thumbnail image: Journal Highlight Blessing or curse Proteomics in granzyme research

Insulin undone: Endogenous and synthetic forms measured in plasma

Date: Jul 20, 2014

Author: Steve Down

Natural insulin and its synthetic variants present in the human body can be distinguished by mass spectrometry following global immunoaffinity extraction, a technique that will be useful in clinical, forensic and sports doping settings.

Read More thumbnail image: Insulin undone Endogenous and synthetic forms measured in plasma

Canine proteome: Human disease model

Date: Jul 3, 2014

Author: Steve Down

The canine urinary proteome has been characterised in the US and compared to that of human urine, to see if it can act as a model for the study of human diseases.

Read More thumbnail image: Canine proteome Human disease model
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