Proteomics & Genomics / Ezine
Better than snail's pace
Date: Jul 1, 2010
Author: Steve Down
The changes in protein expression in an embryonic snail as it develops from a shell-less to a shelled form have been tracked by Taiwanese scientists, using de novo peptide sequencing to counter the lack of gastropod genomic and proteomic data.
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Investigation of the binding of Cr(III) complexes to bovine and human serum proteins: A proteomic approach
Date: Jun 28, 2010
Author:
The interactions of Cr(III) complexes with serum proteins and their internalization by U937 macrophage-like cells was studied by a proteomic approach, in the context of Co-Cr alloy-based implants.
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A route to personalised therapy selection
Date: Jun 15, 2010
Author: Steve Down
The plasma proteomes of patients with glioblastoma multiforme brain tumours were used to classify the type of tumour and indicate which patients would respond best to immunotherapy, heralding a new approach to personal medicine.
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Enduring effects of exercise
Date: Jun 1, 2010
Author: Steve Down
A detailed study of the urinary proteome following a period of endurance exercise revealed several proteins at increased levels, which were linked to physiological changes. The results form the basis of a plan to establish individual 2D PAGE protein maps which could lead to a personal monitoring system for athletes.
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Comprehensive human urine standards for comparability and standardization in clinical proteome analysis
Date: May 24, 2010
Author:
Real-life male and female urine samples with well-characterized proteomes and peptidomes have been generated for use as reference standards in urine clinical proteomics studies.
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Who's afraid of the GM crops?
Date: May 15, 2010
Author: Steve Down
A study of transgenic maize plants using several -omic techniques revealed that the local growing environment had a far greater effect on gene expression, protein and metabolite levels than variations in genotypes.
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Extending tumour margins
Date: May 1, 2010
Author: Steve Down
MALDI mass spectrometry has revealed that cells in the apparently normal tissue left behind following the surgical removal of a tumour bear a close resemblance to tumour cells at the molecular level. This might explain why so many cancers recur and suggests that tumour margins should be extended for maximum patient safety.
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Complexity and coordination of root growth at low water potentials: recent advances from transcriptomic and proteomic analyses
Date: Apr 26, 2010
Author:
Progress in understanding root growth regulation and adaptation under water-stressed conditions is reviewed, with emphasis on recent advances from transcriptomic and proteomic analyses of maize and soybean primary roots.
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Clues to multidrug resistance in ovarian cancer
Date: Apr 15, 2010
Author: Steve Down
A proteomics study of ovarian cancer has identified a series of proteins that might be implicated in multidrug resistance to cisplatin, a drug commonly used for treatment. The involvement of two proteins in particular was shown to be highly probable.
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Scar tissue probed
Date: Apr 1, 2010
Author: Steve Down
Keloid scar tissue formed on human skin contains altered levels of proteins related to inflammation, fibrosis, antifibrosis and tumour suppression, say researchers in Singapore, some of which might be useful targets for controlling scar formation.
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