Proteomics & Genomics / Ezine
Enduring effects of exercise
Date: Jun 1, 2010
Author: Steve Down
A detailed study of the urinary proteome following a period of endurance exercise revealed several proteins at increased levels, which were linked to physiological changes. The results form the basis of a plan to establish individual 2D PAGE protein maps which could lead to a personal monitoring system for athletes.
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Comprehensive human urine standards for comparability and standardization in clinical proteome analysis
Date: May 24, 2010
Author:
Real-life male and female urine samples with well-characterized proteomes and peptidomes have been generated for use as reference standards in urine clinical proteomics studies.
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Who's afraid of the GM crops?
Date: May 15, 2010
Author: Steve Down
A study of transgenic maize plants using several -omic techniques revealed that the local growing environment had a far greater effect on gene expression, protein and metabolite levels than variations in genotypes.
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Extending tumour margins
Date: May 1, 2010
Author: Steve Down
MALDI mass spectrometry has revealed that cells in the apparently normal tissue left behind following the surgical removal of a tumour bear a close resemblance to tumour cells at the molecular level. This might explain why so many cancers recur and suggests that tumour margins should be extended for maximum patient safety.
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Complexity and coordination of root growth at low water potentials: recent advances from transcriptomic and proteomic analyses
Date: Apr 26, 2010
Author:
Progress in understanding root growth regulation and adaptation under water-stressed conditions is reviewed, with emphasis on recent advances from transcriptomic and proteomic analyses of maize and soybean primary roots.
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Clues to multidrug resistance in ovarian cancer
Date: Apr 15, 2010
Author: Steve Down
A proteomics study of ovarian cancer has identified a series of proteins that might be implicated in multidrug resistance to cisplatin, a drug commonly used for treatment. The involvement of two proteins in particular was shown to be highly probable.
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Scar tissue probed
Date: Apr 1, 2010
Author: Steve Down
Keloid scar tissue formed on human skin contains altered levels of proteins related to inflammation, fibrosis, antifibrosis and tumour suppression, say researchers in Singapore, some of which might be useful targets for controlling scar formation.
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Proteomics of the photoneuroendocrine circadian system of the brain
Date: Mar 22, 2010
Author:
The anatomy and function of the circadian-generating system in mammals is described, and recent proteomic studies that investigate day/night changes in the retina, suprachiasmatic nucleus and pineal gland are reviewed.
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Intact protein sizing
Date: Mar 15, 2010
Author: Steve Down
A new protocol for the high-throughput proteomics analysis of intact proteins has been demonstrated by scientists in the USA, who combined pre-fractionation and mass spectrometry with high resolution tandem mass spectrometry to allow the identification of proteins up to 80 kDa.
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Biomarkers of brain damage in HIV infection
Date: Mar 1, 2010
Author: Steve Down
A long-term study combining proteomic and brain imaging technologies has identified one particular protein as a marker of brain injury in people in the advanced stages of HIV infection, a condition which is difficult to track as it is normally clinically silent.
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