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Viper venoms: Variations affect antivenom efficacy

Date: Nov 14, 2014

Author: Steve Down

The venoms of three closely related Middle Eastern vipers have widely different protein compositions, say an international team of scientists, who suggest that the single antivenom currently used for them all will offer limited success.

Read More thumbnail image: Viper venoms Variations affect antivenom efficacy

Journal Highlight: Proteomic identification of responsive proteins of Vibrio parahaemolyticus under high hydrostatic pressure

Date: Oct 27, 2014

Author: spectroscopyNOW

Proteome profiles were performed to determine the effects of high hydrostatic pressure on the food pathogen Vibrio parahaemolyticus ATCC 17802 in order to understand how it responds to mechanical stress injury.

Read More thumbnail image: Journal Highlight Proteomic identification of responsive proteins of Vibrio parahaemolyticus under high hydrostatic pressure

Ozone liver stress: Inhalation alters hepatic proteome

Date: Oct 15, 2014

Author: Steve Down

Exposure to ozone modifies the proteome of the rat liver, according to scientists in the USA, compounding the adverse health effects that are already recognised in other organs like the lungs and heart.

Read More thumbnail image: Ozone liver stress Inhalation alters hepatic proteome

Biomarker background for joint diseases: Synovial fluid proteome of healthy knees

Date: Oct 1, 2014

Author: Steve Down

The proteome of synovial fluid from healthy porcine knee joints has been characterised as a model for human joints to create a reference point for the identification of biomarkers in joint diseases like arthritis.

Read More thumbnail image: Biomarker background for joint diseases Synovial fluid proteome of healthy knees

Journal Highlight: Response to cold acclimation in diapause pupae of Hyles euphorbiae (Lepidoptera: Sphingidae): candidate biomarker identification using proteomics

Date: Sep 22, 2014

Author: spectroscopyNOW

Candidate protein biomarkers and biological processes that are associated with cold acclimation of overwintering Hyles euphorbiae diapause pupae have been identified to help explore intraspecific patterns of local adaptation to different climates.

Read More thumbnail image: Journal Highlight Response to cold acclimation in diapause pupae of Hyles euphorbiae Lepidoptera Sphingidae candidate biomarker identification using proteomics

Proteome dynamics: Deuterium oxide doping

Date: Sep 15, 2014

Author: Steve Down

Human subjects have been drinking deuterated water to investigate protein turnover in the body, in a protocol which has been proven to be safe and effective and could lead to a greater understanding of cardiovascular protein dynamics.

Read More thumbnail image: Proteome dynamics Deuterium oxide doping

Cell phone effects: Testicular proteome modified

Date: Sep 1, 2014

Author: Steve Down

The testicular proteome of the rat is modified by exposure to electromagnetic fields of similar strengths to those emitted by cell phones, with some new proteins being induced.

Read More thumbnail image: Cell phone effects Testicular proteome modified

Journal Highlight: Proteomic strategies for the discovery of novel diagnostic and therapeutic targets for infectious diseases

Date: Aug 25, 2014

Author: spectroscopyNOW

In this review, proteomic information on host–viral protein interactions obtained through differing technologies is compared and ways to determine the functional aspect of the host response to infection are described.

Read More thumbnail image: Journal Highlight Proteomic strategies for the discovery of novel diagnostic and therapeutic targets for infectious diseases

Trypsin autolysis reduced: In-gel digestion improved

Date: Aug 15, 2014

Author: Steve Down

The amount of trypsin used in typical in-gel digestion procedures can be reduced ten-fold at least, without any loss of performance. In fact, some aspects are improved, such as a reduction in the number of trypsin autolysis products and a notable increase in the number of proteins identified in complex samples.

Read More thumbnail image: Trypsin autolysis reduced In-gel digestion improved

Swine flu biomarkers: Plasma proteins mark H1N1 infection

Date: Aug 4, 2014

Author: Steve Down

Korean scientists have found a number of proteins that have altered abundances in human plasma from people infected with the H1N1 influenza virus, with the potential to become biomarkers of infection.

Read More thumbnail image: Swine flu biomarkers Plasma proteins mark H1N1 infection
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