Proteomics & Genomics / Ezine
Proteomics of the photoneuroendocrine circadian system of the brain
Date: Mar 22, 2010
Author:
The anatomy and function of the circadian-generating system in mammals is described, and recent proteomic studies that investigate day/night changes in the retina, suprachiasmatic nucleus and pineal gland are reviewed.
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Intact protein sizing
Date: Mar 15, 2010
Author: Steve Down
A new protocol for the high-throughput proteomics analysis of intact proteins has been demonstrated by scientists in the USA, who combined pre-fractionation and mass spectrometry with high resolution tandem mass spectrometry to allow the identification of proteins up to 80 kDa.
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Biomarkers of brain damage in HIV infection
Date: Mar 1, 2010
Author: Steve Down
A long-term study combining proteomic and brain imaging technologies has identified one particular protein as a marker of brain injury in people in the advanced stages of HIV infection, a condition which is difficult to track as it is normally clinically silent.
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Proteomics of brain extracellular fluid (ECF) and cerebrospinal fluid (CSF)
Date: Feb 22, 2010
Author:
The available literature on proteomic experiments that analyze human cerebrospinal fluid (CSF) and brain extracellular fluid (ECF), mostly obtained by cerebral microdialysis, has been reviewed.
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Riding shotgun for small numbers of cancer cells
Date: Feb 15, 2010
Author: Steve Down
A strategy has been described for the analysis of 500-5000 cancer cells by shotgun proteomics, which will be useful for profiling cells in the blood or tissue of cancer patients for diagnosis and prognosis.
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Predicting pancreatic cancer survival
Date: Feb 1, 2010
Author: Steve Down
New biomarkers in pancreatic cancer have been identified that can predict the likelihood of short-term survival of patients receiving gemcitabine therapy, earmarking those who will gain no benefit from the treatment.
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Proteomics enhances evolutionary and functional analysis of reproductive proteins
Date: Jan 25, 2010
Author:
Advances in genomic and proteomic technologies and the molecular and genomic tools for functional analysis are reviewed in the context of using evolutionary data to make predictions about interactions among reproductive proteins.
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Recognising kidney transplant rejection
Date: Jan 15, 2010
Author: Steve Down
A series of biomarkers for acute kidney transplant rejection has been identified in urine by mass spectrometry and cross-validated by ELISA, establishing the basis for the serial, rapid, non-invasive monitoring of graft rejection.
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New biomarker for CJD
Date: Jan 4, 2010
Author: Steve Down
A new biomarker for CJD has been identified in cerebrospinal fluid by European scientists. Elevated levels of ubiquitin can lead to the correct diagnosis of cases where other established protein markers fail.
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Soil metaproteomics: a review of an emerging environmental science. Significance, methodology and perspectives
Date: Dec 21, 2009
Author:
A review of soil proteomics is provided by looking at the methodologies used in order to illustrate the challenges and gaps in this field, and to provide a broad perspective about the use and meaning of soil metaproteomics.
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