Proteomics & Genomics / Ezine
Proteomics of brain extracellular fluid (ECF) and cerebrospinal fluid (CSF)
Date: Feb 22, 2010
Author:
The available literature on proteomic experiments that analyze human cerebrospinal fluid (CSF) and brain extracellular fluid (ECF), mostly obtained by cerebral microdialysis, has been reviewed.
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Riding shotgun for small numbers of cancer cells
Date: Feb 15, 2010
Author: Steve Down
A strategy has been described for the analysis of 500-5000 cancer cells by shotgun proteomics, which will be useful for profiling cells in the blood or tissue of cancer patients for diagnosis and prognosis.
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Predicting pancreatic cancer survival
Date: Feb 1, 2010
Author: Steve Down
New biomarkers in pancreatic cancer have been identified that can predict the likelihood of short-term survival of patients receiving gemcitabine therapy, earmarking those who will gain no benefit from the treatment.
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Proteomics enhances evolutionary and functional analysis of reproductive proteins
Date: Jan 25, 2010
Author:
Advances in genomic and proteomic technologies and the molecular and genomic tools for functional analysis are reviewed in the context of using evolutionary data to make predictions about interactions among reproductive proteins.
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Recognising kidney transplant rejection
Date: Jan 15, 2010
Author: Steve Down
A series of biomarkers for acute kidney transplant rejection has been identified in urine by mass spectrometry and cross-validated by ELISA, establishing the basis for the serial, rapid, non-invasive monitoring of graft rejection.
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New biomarker for CJD
Date: Jan 4, 2010
Author: Steve Down
A new biomarker for CJD has been identified in cerebrospinal fluid by European scientists. Elevated levels of ubiquitin can lead to the correct diagnosis of cases where other established protein markers fail.
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Soil metaproteomics: a review of an emerging environmental science. Significance, methodology and perspectives
Date: Dec 21, 2009
Author:
A review of soil proteomics is provided by looking at the methodologies used in order to illustrate the challenges and gaps in this field, and to provide a broad perspective about the use and meaning of soil metaproteomics.
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Cascading to separation success
Date: Dec 15, 2009
Author: Steve Down
Cascade affinity separation using a series of affinity ligands has been used to fractionate the proteins in mouse testis for mass spectrometric analysis. It led to the largest proteome database to date for this type of tissue.
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Tracking new malaria drug targets
Date: Dec 1, 2009
Author: Steve Down
The proteomic analysis of blood from patients infected with two common malaria parasites has identified about 100 proteins, including known drug targets and potential new ones that have not been detected in reported studies using lab cultures.
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Biomarkers of lung-related diseases: Current knowledge by proteomic approaches
Date: Nov 23, 2009
Author:
The potential applications of the proteomics approach in studying lung-related diseases and biomarker discovery have been reviewed.
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