Proteomics & Genomics / Ezine
Doped veal biomarkers
Date: Nov 13, 2009
Author: Steve Down
A preliminary proteomics study on the serum of veal calves by MALDI TOFMS has revealed that one particular protein fragment is indicative of treatment with illegal drugs, although more biomarkers are necessary for absolute confirmation.
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Snakebite effects from wound fluid
Date: Nov 1, 2009
Author: Steve Down
The wound exudates produced by the injection of two snake venom toxins into mice display contrasting proteomic profiles, illustrating the different mechanisms of tissue damage at play, say American researchers.
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Approaching clinical proteomics: Current state and future fields of application in cellular proteomics
Date: Oct 26, 2009
Author:
Recent advances are reviewed that fulfil the criteria for clinical proteomics with the focus on cellular proteomics (cytoproteomics) as related to preanalytical and analytical standardization and to quality control measures required for their effective implementation into routine laboratory testing to generate novel actionable health information.
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Not a dry eye in the house
Date: Oct 15, 2009
Author: Steve Down
A panel of 4 proteins that can predict dry eye syndrome with an accuracy of 96% has been identified in human tears, with a subset that are associated with inflammation successfully classifying the clinical severity of the condition.
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Sulphur mustard changes BAL fluid proteome
Date: Oct 1, 2009
Author: Steve Down
Inhalation of mustard gas changes the proteomic profile of bronchoalveolar lavage fluid, say Iranian researchers, who examined long-term casualties exposed during the Iran-Iraq war. The altered profile will aid attempts to identify therapeutic targets for mustard gas-induced lung disease.
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Assessing the impact of transcriptomics, proteomics and metabolomics on fungal phytopathology
Date: Sep 28, 2009
Author:
This review assesses the impact of transcriptomics, proteomics and metabolomics on fungal plant pathology over the last decade and discusses their futures. Key examples highlighting the application of these technologies to fungal plant pathogens are also reviewed.
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Dyeing for proteins
Date: Sep 15, 2009
Author: Steve Down
A set of novel protein labelling dyes, evaluated for 1D and 2D gel electrophoresis on human skin proteins, performed better than standard post-electrophoresis staining, increasing the number of spots detected and providing better sensitivity.
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Growth hormone detection
Date: Sep 1, 2009
Author: Steve Down
The administration of recombinant human growth hormone to humans can be accomplished using a panel of six protein ions identified by MALDI MS or six peptide ions identified by LC/MS, say researchers in the UK. Their study combined proteomics with artificial neural networks in the first study of its type in biomarker discovery.
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Proteomic characterisation of subclover seed storage proteins during germination
Date: Aug 24, 2009
Author:
The seed storage proteome of the non-model species (Trifolium subterraneum), was characterised in mature dry seeds and during imbibition using two-dimensional electrophoresis coupled with tandem mass spectrometry.
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Oxidised Alzheimer's proteins identified
Date: Aug 15, 2009
Author: Steve Down
Specific brain proteins modified by lipid peroxidation products in a region-specific manner have been identified in Alzheimer's disease patients. The two regions examined are highly susceptible, linking oxidative damage to neurodegeneration.
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