Proteomics & Genomics / Ezine
Bolts from nuts
Date: Aug 1, 2009
Author: Steve Down
The allergen contents of different varieties of peanut have been compared by proteomics techniques, revealing the existence of hitherto unreported fragments of major allergens. Indonesian nuts were found to contain lower amounts of major allergens, which has implications for food production.
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Evolution of nacre: Biochemistry and proteomics of the shell organic matrix of the cephalopod Nautilus macromphalus
Date: Jul 27, 2009
Author:
The nacre matrix of the cephalopod Nautilus macromphalus has been biochemically characterized, in part by a proteomic approach applied to the acetic acid-soluble and -insoluble shell matrices and the spots obtained after 2D gel electrophoresis. Most of the obtained partial sequences are entirely new.
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Making horse sense
Date: Jul 15, 2009
Author: Steve Down
The effects of equine drugs of abuse on the levels of proteins in horse plasma have been studied by scientists in the UK, leading to the discovery of candidate protein biomarkers for doping. These candidates were detected and measured using targeted analysis of their tryptic peptides.
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Obesity and LDL proteins
Date: Jul 1, 2009
Author: Steve Down
Obesity is associated with changes in the protein composition of low-density lipoprotein (LDL), as well as high levels of LDL cholesterol, according to scientists in Sweden. The transport protein transthyretin was found to be enriched in LDL from obese subjects and may be linked to an increased risk of cardiovascular disease.
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Proteomics in globe artichoke: Protein extraction and sample complexity reduction by PEG fractionation
Date: Jun 22, 2009
Author:
The first leaf proteome analysis for globe artichoke is reported, removing the highly abundant leaf protein RuBisCO to improve spot resolution of the less abundant proteins. In all, 841 distinct protein spots were detected.
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Prospective biomarkers are too common
Date: Jun 15, 2009
Author: Steve Down
A review of proteomics studies in the literature covering five species has revealed a common set of differentially expressed proteins, representing a set of regularly detected protein families. Many are linked to stress response, and their use as biomarkers of any other condition should be considered with caution.
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Stressed out
Date: Jun 1, 2009
Author: Steve Down
The metabolic pathways of rats subjected to acute and chronic stress varied in the same way but the changes were reversible once the stress was withdrawn. Chronic stress also induced behavioural and physiological signs of depression which were supported by changes in the levels of metabolites associated with depression.
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The impact of atmospheric composition on plants: A case study of ozone and poplar
Date: May 25, 2009
Author:
This review shows that the contribution of genomic tools (transcriptomics, proteomics, and metabolomics) for a better understanding of the mechanistic cellular responses to ozone largely relies on spectrometric measurements.
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Juvenile arthritis markers
Date: May 15, 2009
Author: Steve Down
A comparison of the proteome of matched synovial fluid and plasma samples from patients with juvenile idiopathic arthritis has revealed a set of proteins that differentiate the fluid from the plasma. They also segregate patient subgroups, allowing for clinical discrimination and flagging up patients for different treatment strategies.
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Possums for snake venoms
Date: May 1, 2009
Author: Steve Down
The venoms of four pit vipers have been characterised following preliminary fractionation by affinity binding to an anti-haemorrhagic protein derived from an opossum that is resistant to snake venom. The method separated metalloproteinases from the other protein classes, permitting more detailed study.
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