Proteomics & Genomics / Ezine
The impact of atmospheric composition on plants: A case study of ozone and poplar
Date: May 25, 2009
Author:
This review shows that the contribution of genomic tools (transcriptomics, proteomics, and metabolomics) for a better understanding of the mechanistic cellular responses to ozone largely relies on spectrometric measurements.
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Juvenile arthritis markers
Date: May 15, 2009
Author: Steve Down
A comparison of the proteome of matched synovial fluid and plasma samples from patients with juvenile idiopathic arthritis has revealed a set of proteins that differentiate the fluid from the plasma. They also segregate patient subgroups, allowing for clinical discrimination and flagging up patients for different treatment strategies.
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Possums for snake venoms
Date: May 1, 2009
Author: Steve Down
The venoms of four pit vipers have been characterised following preliminary fractionation by affinity binding to an anti-haemorrhagic protein derived from an opossum that is resistant to snake venom. The method separated metalloproteinases from the other protein classes, permitting more detailed study.
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Applications of proteomics in the study of inflammatory bowel diseases: Current status and future directions with available technologies
Date: Apr 27, 2009
Author:
This review aims to highlight the current status of proteomic studies of inflammatory bowel diseases and introduce the available and emerging proteomic technologies that have potential applications in their study.
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Exhaled proteome
Date: Apr 15, 2009
Author: Steve Down
The exhaled breath proteome has been determined by scientists in Belgium after optimisation of the extraction and concentration procedures to maximise protein content. The techniques will be useful for biomarker screening of respiratory diseases.
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Cocaine abstinence alters brain proteome
Date: Apr 1, 2009
Author: Steve Down
The levels of a number of proteins in the brain that are altered during cocaine administration do not return to normal even after 100 days of abstinence, say US researchers, and might be responsible for the persistent relapse urge experienced by recovering addicts.
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Generation and validation of affinity reagents on a proteome-wide level
Date: Mar 23, 2009
Author:
The advantages and disadvantages of several systematic efforts to generate validated affinity reagents on a whole human proteome level are discussed and the problems related to quality assessment of antibodies to be used in multi-platform applications are addressed.
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Genome mining for Leishmania vaccines
Date: Mar 15, 2009
Author: Steve Down
A genome mining approach has been used to identify potential antigens for vaccine development against leishmaniasis, a common disease which affects millions of people worldwide.
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Caffeine and coral bleaching
Date: Mar 1, 2009
Author: Steve Down
Caffeine that is discharged into the sea in treated wastewater probably plays a part in coral bleaching, say researchers from the USA. A proteomics study revealed that it affects heat shock proteins in the algal species that give the corals their colour.
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Identification of the proteome composition occurring during embryonic development of bees (Apis mellifera)
Date: Feb 23, 2009
Author:
An initial molecular picture of honeybee embryos has been derived by the proteomic analysis of 24, 48 and 72 h embryos and quantitative proteomics was used to measure the levels of the main proteins at the different stages.
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