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Journal Highlight: A bovine PeptideAtlas of milk and mammary gland proteomes

Date: Oct 22, 2012

Author: spectroscopyNOW

A bovine PeptideAtlas, representing a first collection of Bos taurus proteome data sets within the PeptideAtlas framework, has been was built primarily as a source of information for designing SRM assays for studying milk production and mammary gland health.

Read More thumbnail image: Journal Highlight A bovine PeptideAtlas of milk and mammary gland proteomes

Clinical protein assays: Enrichment effects on interlab reproducibility in SRM studies

Date: Oct 15, 2012

Author: Steve Down

The suitability of selected reaction monitoring for measuring proteins in clinical samples has been confirmed by good interlab reproducibilities even when different enrichment protocols are used.

Read More thumbnail image: Clinical protein assays Enrichment effects on interlab reproducibility in SRM studies

A binding agreement: Folding changes reveal protein-drug interactions

Date: Oct 5, 2012

Author: Steve Down

Proteins targeted by particular drugs and metabolites can be identified by a simple process in which the effects on protein unfolding are measured by SDS-PAGE following proteolytic digestion.

Read More thumbnail image: A binding agreement Folding changes reveal protein-drug interactions

Journal Highlight: Five years later: The current status of the use of proteomics and transcriptomics in EMF research

Date: Sep 24, 2012

Author: spectroscopyNOW

This review examines the status of research into the effects of electromagnetic fields using proteomics and transcriptomics methods, as part of the European Cooperation in the Field of Scientific and Technical Research (COST) Action.

Read More thumbnail image: Journal Highlight Five years later The current status of the use of proteomics and transcriptomics in EMF research

Money in the biobank: Standard protocols required to make best use of stored biosamples

Date: Sep 15, 2012

Author: Steve Down

The preparation, collection, storage and quality of biological samples for biobanks need to be standardised so that they can be fully utilised for the study of human disease, say an international team of scientists.

Read More thumbnail image: Money in the biobank Standard protocols required to make best use of stored biosamples

Shared biomarker development: Common protein sequences across different invertebrates

Date: Sep 1, 2012

Author: Steve Down

The evolutionary conservation of vitellogenin-like proteins, which are precursors of the major egg yolk protein, allows them to be identified and quantified in unsequenced species that are absent from public databases, say French researchers.

Read More thumbnail image: Shared biomarker development Common protein sequences across different invertebrates

Journal Highlight: Cancer and viruses: A double-edged sword

Date: Aug 27, 2012

Author: spectroscopyNOW

The neoplastic potential of human tumour-associated viruses and associated vaccine successes are reviewed, including the use of oncolytic viruses for therapeutic intervention and the potential of proteomics technology in the field of oncovirology.

Read More thumbnail image: Journal Highlight Cancer and viruses A double-edged sword

Staph test: Profiling bacterial infection in wounds

Date: Aug 16, 2012

Author: Steve Down

The response of a wound to infection by Staphylococcus aureus has been followed by mass spectrometry to show the changes that occur at the site as the infection takes hold and spreads.

Read More thumbnail image: Staph test Profiling bacterial infection in wounds

Seeing through the smokescreen: Proteins implicated in bone loss induced by smoking

Date: Aug 1, 2012

Author: Steve Down

Cigarette smoke induces increased amounts of two proteins that accelerate the production of cells which break down bone and induce bone resorption, leading to lower bone density.

Read More thumbnail image: Seeing through the smokescreen Proteins implicated in bone loss induced by smoking

Journal Highlight: Strategies for membrane interaction proteomics: No mass spectrometry required

Date: Jul 23, 2012

Author: spectroscopyNOW

This review describes some of the major non-mass spectrometry-based methods and technologies used for the investigation of intracellular membrane protein complexes and highlights their advantages and drawbacks.

Read More thumbnail image: Journal Highlight Strategies for membrane interaction proteomics No mass spectrometry required
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