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Shared biomarker development: Common protein sequences across different invertebrates

Date: Sep 1, 2012

Author: Steve Down

The evolutionary conservation of vitellogenin-like proteins, which are precursors of the major egg yolk protein, allows them to be identified and quantified in unsequenced species that are absent from public databases, say French researchers.

Read More thumbnail image: Shared biomarker development Common protein sequences across different invertebrates

Journal Highlight: Cancer and viruses: A double-edged sword

Date: Aug 27, 2012

Author: spectroscopyNOW

The neoplastic potential of human tumour-associated viruses and associated vaccine successes are reviewed, including the use of oncolytic viruses for therapeutic intervention and the potential of proteomics technology in the field of oncovirology.

Read More thumbnail image: Journal Highlight Cancer and viruses A double-edged sword

Staph test: Profiling bacterial infection in wounds

Date: Aug 16, 2012

Author: Steve Down

The response of a wound to infection by Staphylococcus aureus has been followed by mass spectrometry to show the changes that occur at the site as the infection takes hold and spreads.

Read More thumbnail image: Staph test Profiling bacterial infection in wounds

Seeing through the smokescreen: Proteins implicated in bone loss induced by smoking

Date: Aug 1, 2012

Author: Steve Down

Cigarette smoke induces increased amounts of two proteins that accelerate the production of cells which break down bone and induce bone resorption, leading to lower bone density.

Read More thumbnail image: Seeing through the smokescreen Proteins implicated in bone loss induced by smoking

Journal Highlight: Strategies for membrane interaction proteomics: No mass spectrometry required

Date: Jul 23, 2012

Author: spectroscopyNOW

This review describes some of the major non-mass spectrometry-based methods and technologies used for the investigation of intracellular membrane protein complexes and highlights their advantages and drawbacks.

Read More thumbnail image: Journal Highlight Strategies for membrane interaction proteomics No mass spectrometry required

A vein attempt: Debris from angioplasty good for proteomics

Date: Jul 16, 2012

Author: Steve Down

Scraps of biological material that are trapped in embolic protection devices during a balloon angioplasty procedure can provide clues to the protein changes caused by inflammation during atherosclerosis.

Read More thumbnail image: A vein attempt Debris from angioplasty good for proteomics

Classifying MRSA: Biomarker peptides of different strains by rapid mass spectrometric profiling

Date: Jul 1, 2012

Author: Steve Down

Three strains of antibiotic-resistant Staphylococcus aureus can be distinguished by the mass spectrometric detection of specific peptides, providing the opportunity for developing a diagnostic test.

Read More thumbnail image: Classifying MRSA Biomarker peptides of different strains by rapid mass spectrometric profiling

Journal Highlight: Insights on neoplastic stem cells from gel-based proteomics of childhood germ cell tumors

Date: Jun 25, 2012

Author: spectroscopyNOW

The first proteomics study of childhood germ cell tumours suggests that glucocorticoid receptor signalling is an area of interest for these and neoplastic stem cells.

Read More thumbnail image: Journal Highlight Insights on neoplastic stem cells from gel-based proteomics of childhood germ cell tumors

Telling porkies: Dietary studies on cloned pigs show poor metabolome consistency

Date: Jun 15, 2012

Author: Steve Down

A metabolomics comparison of cloned and normal pigs fed controlled or ad libitum diets has revealed differences between the two animal types and confirmed earlier NMR observations that cloned pigs do not have a reduced level of inter-individual variations.

Read More thumbnail image: Telling porkies Dietary studies on cloned pigs show poor metabolome consistency

Food for thought: Protein indicators of appetite in saliva

Date: Jun 1, 2012

Author: Steve Down

A preliminary study on the response of the saliva proteome to food has identified two proteins which might be biomarkers for appetite, say researchers in the UK, with the potential to replace invasive blood tests and subjective measures.

Read More thumbnail image: Food for thought Protein indicators of appetite in saliva
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