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Journal Highlight: The time course of the adaptations of human muscle proteome to bed rest and the underlying mechanisms

Date: Nov 26, 2012

Author: spectroscopyNOW

Two bed rest campaigns followed by proteomics analysis have been undertaken to help understand the underlying molecular mechanisms behind the complex adaptations of human skeletal muscle to disuse.

Read More thumbnail image: Journal Highlight The time course of the adaptations of human muscle proteome to bed rest and the underlying mechanisms

Hidden treasure: Extended workflow yields thousand of proteins from archived FFPE tissue

Date: Nov 15, 2012

Author: Steve Down

Formalin-fixed paraffin-embedded clinical tissue samples can yield data on about 10,000 proteins using a specially designed preparation protocol, say European scientists, while a second study demonstrates that FFPE tissues stored for up to 10 years are still viable for biomarker studies.

Read More thumbnail image: Hidden treasure Extended workflow yields thousand of proteins from archived FFPE tissue

Space travel syndrome: Bodily changes reflected in urine proteome following long-term flights

Date: Nov 1, 2012

Author: Steve Down

The urinary protein compositions of Russian cosmonauts are changed during extended space flight in the International Space Station, say scientists in the first study of its type on urine.

Read More thumbnail image: Space travel syndrome Bodily changes reflected in urine proteome following long-term flights

Journal Highlight: A bovine PeptideAtlas of milk and mammary gland proteomes

Date: Oct 22, 2012

Author: spectroscopyNOW

A bovine PeptideAtlas, representing a first collection of Bos taurus proteome data sets within the PeptideAtlas framework, has been was built primarily as a source of information for designing SRM assays for studying milk production and mammary gland health.

Read More thumbnail image: Journal Highlight A bovine PeptideAtlas of milk and mammary gland proteomes

Clinical protein assays: Enrichment effects on interlab reproducibility in SRM studies

Date: Oct 15, 2012

Author: Steve Down

The suitability of selected reaction monitoring for measuring proteins in clinical samples has been confirmed by good interlab reproducibilities even when different enrichment protocols are used.

Read More thumbnail image: Clinical protein assays Enrichment effects on interlab reproducibility in SRM studies

A binding agreement: Folding changes reveal protein-drug interactions

Date: Oct 5, 2012

Author: Steve Down

Proteins targeted by particular drugs and metabolites can be identified by a simple process in which the effects on protein unfolding are measured by SDS-PAGE following proteolytic digestion.

Read More thumbnail image: A binding agreement Folding changes reveal protein-drug interactions

Journal Highlight: Five years later: The current status of the use of proteomics and transcriptomics in EMF research

Date: Sep 24, 2012

Author: spectroscopyNOW

This review examines the status of research into the effects of electromagnetic fields using proteomics and transcriptomics methods, as part of the European Cooperation in the Field of Scientific and Technical Research (COST) Action.

Read More thumbnail image: Journal Highlight Five years later The current status of the use of proteomics and transcriptomics in EMF research

Money in the biobank: Standard protocols required to make best use of stored biosamples

Date: Sep 15, 2012

Author: Steve Down

The preparation, collection, storage and quality of biological samples for biobanks need to be standardised so that they can be fully utilised for the study of human disease, say an international team of scientists.

Read More thumbnail image: Money in the biobank Standard protocols required to make best use of stored biosamples

Shared biomarker development: Common protein sequences across different invertebrates

Date: Sep 1, 2012

Author: Steve Down

The evolutionary conservation of vitellogenin-like proteins, which are precursors of the major egg yolk protein, allows them to be identified and quantified in unsequenced species that are absent from public databases, say French researchers.

Read More thumbnail image: Shared biomarker development Common protein sequences across different invertebrates

Journal Highlight: Cancer and viruses: A double-edged sword

Date: Aug 27, 2012

Author: spectroscopyNOW

The neoplastic potential of human tumour-associated viruses and associated vaccine successes are reviewed, including the use of oncolytic viruses for therapeutic intervention and the potential of proteomics technology in the field of oncovirology.

Read More thumbnail image: Journal Highlight Cancer and viruses A double-edged sword
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