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Journal Highlight: Biomarkers of systemic lupus erythematosus identified using mass spectrometry-based proteomics: a systematic review

Date: May 22, 2017

Author: spectroscopyNOW

A systematic review of published reports on proteomic biomarkers identified in systemic lupus erythematosus patients using mass spectrometry-based proteomics has been conducted, highlighting their potential disease association and clinical utility.

Read More thumbnail image: Journal Highlight Biomarkers of systemic lupus erythematosus identified using mass spectrometry-based proteomics a systematic review

Morphine addiction: Enzyme activity

Date: May 16, 2017

Author: Steve Down

Polish scientists have measured the activities of four enzymes in the brain implicated in the mechanism of morphine addiction in the search for therapeutic targets which do not produce the serious side effects during pain treatment.

Read More thumbnail image: Morphine addiction Enzyme activity

Osteoporosis biomarkers: Serum proteomics

Date: May 1, 2017

Author: Steve Down

A large-scale study of older men in the US has identified a number of proteins in serum that are good candidates for biomarkers of future hip bone loss and fracture by correlation with the bone mineral density measurements.

Read More thumbnail image: Osteoporosis biomarkers Serum proteomics

Journal Highlight: The oxidized thiol proteome in aging and cataractous mouse and human lens revealed by ICAT labeling

Date: Apr 24, 2017

Author: spectroscopyNOW

All of the disulfide-forming noncrystallin proteins associated with age-related cataractogenesis in mice and humans have been identified using ICAT labelling techniques.

Read More thumbnail image: Journal Highlight The oxidized thiol proteome in aging and cataractous mouse and human lens revealed by ICAT labeling

Milk whey glycoproteins: Interspecies comparison

Date: Apr 15, 2017

Author: Steve Down

A comprehensive examination of the glycoproteins in the milk whey from several mammals by Chinese researchers has identified more than 200 N-glycosylation sites, the majority of which have not been reported previously.

Read More thumbnail image: Milk whey glycoproteins Interspecies comparison

Forensic body fluids: Protein biomarkers

Date: Apr 2, 2017

Author: Steve Down

Biological stains such as urine, saliva and seminal fluid can be distinguished from each other using panels of unique protein biomarkers, offering a reliable way to assign the origin of a DNA profile in forensic cases, say researchers in the USA.

Read More thumbnail image: Forensic body fluids Protein biomarkers

Journal Highlight: Detergents: Friends not foes for high-performance membrane proteomics toward precision medicine

Date: Mar 27, 2017

Author: spectroscopyNOW

This review analyzes detergent properties behind recent proteomic advances and proposes that rational use of detergents may reconcile outstanding membrane proteomics dilemmas, enabling ultradeep coverage and minimal artifacts.

Read More thumbnail image: Journal Highlight Detergents Friends not foes for high-performance membrane proteomics toward precision medicine

Ant venom: Protein and peptide profiles

Date: Mar 16, 2017

Author: Steve Down

Peptides and proteins in the venom of the South American bullet ant have been compared following two extraction methods, with the ultimate aim of finding new drug and biopesticide candidates.

Read More thumbnail image: Ant venom Protein and peptide profiles

Saliva for disease biomarkers: Gender and acid stimulation effects

Date: Mar 1, 2017

Author: Steve Down

A more complete understanding of the effects of gender and acid simulation on the saliva proteome has been provided by scientists in China to help support the search for disease-specific biomarkers.

Read More thumbnail image: Saliva for disease biomarkers Gender and acid stimulation effects

Journal Highlight: Extracellular proteasomes are deficient in 19S subunits as revealed by iTRAQ quantitative proteomics

Date: Feb 20, 2017

Author: spectroscopyNOW

To gain insight into the molecular and functional differences between extracellular and cellular proteasomes, the subunit compositions have been compared using iTRAQ-based quantitative proteomics.

Read More thumbnail image: Journal Highlight Extracellular proteasomes are deficient in 19S subunits as revealed by iTRAQ quantitative proteomics
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