Proteomics & Genomics / Ezine
Autistic alterations: Metabolic shifts in children with autism spectrum disorders
Date: Dec 3, 2012
Author: Steve Down
A metabolomics study of children with autism spectrum disorders has identified lower levels of several amino acids and antioxidants as well as an altered gut metabolism, providing a deeper knowledge of these changes.
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Journal Highlight: The time course of the adaptations of human muscle proteome to bed rest and the underlying mechanisms
Date: Nov 26, 2012
Author: spectroscopyNOW
Two bed rest campaigns followed by proteomics analysis have been undertaken to help understand the underlying molecular mechanisms behind the complex adaptations of human skeletal muscle to disuse.
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Hidden treasure: Extended workflow yields thousand of proteins from archived FFPE tissue
Date: Nov 15, 2012
Author: Steve Down
Formalin-fixed paraffin-embedded clinical tissue samples can yield data on about 10,000 proteins using a specially designed preparation protocol, say European scientists, while a second study demonstrates that FFPE tissues stored for up to 10 years are still viable for biomarker studies.
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Space travel syndrome: Bodily changes reflected in urine proteome following long-term flights
Date: Nov 1, 2012
Author: Steve Down
The urinary protein compositions of Russian cosmonauts are changed during extended space flight in the International Space Station, say scientists in the first study of its type on urine.
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Journal Highlight: A bovine PeptideAtlas of milk and mammary gland proteomes
Date: Oct 22, 2012
Author: spectroscopyNOW
A bovine PeptideAtlas, representing a first collection of Bos taurus proteome data sets within the PeptideAtlas framework, has been was built primarily as a source of information for designing SRM assays for studying milk production and mammary gland health.
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Clinical protein assays: Enrichment effects on interlab reproducibility in SRM studies
Date: Oct 15, 2012
Author: Steve Down
The suitability of selected reaction monitoring for measuring proteins in clinical samples has been confirmed by good interlab reproducibilities even when different enrichment protocols are used.
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A binding agreement: Folding changes reveal protein-drug interactions
Date: Oct 5, 2012
Author: Steve Down
Proteins targeted by particular drugs and metabolites can be identified by a simple process in which the effects on protein unfolding are measured by SDS-PAGE following proteolytic digestion.
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Journal Highlight: Five years later: The current status of the use of proteomics and transcriptomics in EMF research
Date: Sep 24, 2012
Author: spectroscopyNOW
This review examines the status of research into the effects of electromagnetic fields using proteomics and transcriptomics methods, as part of the European Cooperation in the Field of Scientific and Technical Research (COST) Action.
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Money in the biobank: Standard protocols required to make best use of stored biosamples
Date: Sep 15, 2012
Author: Steve Down
The preparation, collection, storage and quality of biological samples for biobanks need to be standardised so that they can be fully utilised for the study of human disease, say an international team of scientists.
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Shared biomarker development: Common protein sequences across different invertebrates
Date: Sep 1, 2012
Author: Steve Down
The evolutionary conservation of vitellogenin-like proteins, which are precursors of the major egg yolk protein, allows them to be identified and quantified in unsequenced species that are absent from public databases, say French researchers.
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