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Journal Highlight: Acute phase proteins as promising biomarkers: Perspectives and limitations for human and veterinary medicine

Date: Dec 19, 2016

Author: spectroscopyNOW

Current reviews on acute phase proteins and their use as biomarkers are discussed with examples of their general, extended and differential extrahepatic expression, leading to the conclusion that their diagnostic value should be reassessed.

Read More thumbnail image: Journal Highlight Acute phase proteins as promising biomarkers Perspectives and limitations for human and veterinary medicine

Large proteins: FTICR to the rescue

Date: Dec 16, 2016

Author: Steve Down

A powerful FTICR mass spectrometer installed recently in the National High Magnetic Field Laboratory in the USA has successfully observed thousands of protein isoforms in a top-down analysis, many of them with molecular masses above 30 kDa.

Read More thumbnail image: Large proteins FTICR to the rescue

Biowarfare agents: Toxin testing

Date: Dec 2, 2016

Author: Steve Down

Toxins that have been added to foods as chemical and biological warfare agents can be detected using a novel proteomics approach which bypasses the need for antibody-based isolation by employing isotope-labelled versions of the toxins.

Read More thumbnail image: Biowarfare agents Toxin testing

Journal Highlight: Skin aging caused by intrinsic or extrinsic processes characterized with functional proteomics

Date: Nov 21, 2016

Author: spectroscopyNOW

An immunohistological investigation and proteome profiling has been carried out on nude mice skin to verify the specific responses during aging caused by intrinsic and extrinsic factors.

Read More thumbnail image: Journal Highlight Skin aging caused by intrinsic or extrinsic processes characterized with functional proteomics

Drug-protein binding: New design route

Date: Nov 16, 2016

Author: Steve Down

The active plasma proteins that bind with the antibiotic ertapenem have been identified in a study that will improve drug design operations and allow tailoring of dosages for individual patients.

Read More thumbnail image: Drug-protein binding New design route

Alcoholic and non-alcoholic liver disease: Discriminating protein biomarkers

Date: Nov 1, 2016

Author: Steve Down

A set of proteins has been identified by Korean researchers that distinguish between alcoholic and non-alcoholic liver disease and could prove to be useful biomarkers for the harmful build up of triglycerides and fatty acids.

Read More thumbnail image: Alcoholic and non-alcoholic liver disease Discriminating protein biomarkers

Journal Highlight: Omics-based approaches to understand mechanosensitive endothelial biology and atherosclerosis

Date: Oct 24, 2016

Author: spectroscopyNOW

Omics approaches to the study of atherosclerosis are reviewed to show how they can reveal the pathophysiology and identify novel molecular diagnostics and therapeutic targets to prevent or treat the disease.

Read More thumbnail image: Journal Highlight Omics-based approaches to understand mechanosensitive endothelial biology and atherosclerosis

Atmospheric aerosol proteins: Metaproteomics revelations

Date: Oct 15, 2016

Author: Steve Down

Proteins lurking in the particulates of atmospheric aerosols have been analysed by proteomics techniques, providing a way to assess risks to human health from bacteria and allergens that are present.

Read More thumbnail image: Atmospheric aerosol proteins Metaproteomics revelations

Stress-induced immunosuppression: Proteomics clues

Date: Oct 1, 2016

Author: Steve Down

A proteomics study carried out in China has uncovered proteins that are affected by the onset of immunosuppression brought on by chronic stress, as a first step for elucidating the molecular processes behind the effect.

Read More thumbnail image: Stress-induced immunosuppression Proteomics clues

Journal Highlight: Clinically-oriented proteomic investigation of sickle cell disease: Opportunities and challenges

Date: Sep 19, 2016

Author: spectroscopyNOW

The opportunities lying ahead for proteomic discovery in sickle cell disease are reviewed while establishing a tentative conceptual framework for clinically oriented investigations for actionable improvements at the bedside.

Read More thumbnail image: Journal Highlight Clinically-oriented proteomic investigation of sickle cell disease Opportunities and challenges
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