Proteomics & Genomics / Ezine
Journal Highlight: Cancer and viruses: A double-edged sword
Date: Aug 27, 2012
Author: spectroscopyNOW
The neoplastic potential of human tumour-associated viruses and associated vaccine successes are reviewed, including the use of oncolytic viruses for therapeutic intervention and the potential of proteomics technology in the field of oncovirology.
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Staph test: Profiling bacterial infection in wounds
Date: Aug 16, 2012
Author: Steve Down
The response of a wound to infection by Staphylococcus aureus has been followed by mass spectrometry to show the changes that occur at the site as the infection takes hold and spreads.
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Seeing through the smokescreen: Proteins implicated in bone loss induced by smoking
Date: Aug 1, 2012
Author: Steve Down
Cigarette smoke induces increased amounts of two proteins that accelerate the production of cells which break down bone and induce bone resorption, leading to lower bone density.
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Journal Highlight: Strategies for membrane interaction proteomics: No mass spectrometry required
Date: Jul 23, 2012
Author: spectroscopyNOW
This review describes some of the major non-mass spectrometry-based methods and technologies used for the investigation of intracellular membrane protein complexes and highlights their advantages and drawbacks.
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A vein attempt: Debris from angioplasty good for proteomics
Date: Jul 16, 2012
Author: Steve Down
Scraps of biological material that are trapped in embolic protection devices during a balloon angioplasty procedure can provide clues to the protein changes caused by inflammation during atherosclerosis.
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Classifying MRSA: Biomarker peptides of different strains by rapid mass spectrometric profiling
Date: Jul 1, 2012
Author: Steve Down
Three strains of antibiotic-resistant Staphylococcus aureus can be distinguished by the mass spectrometric detection of specific peptides, providing the opportunity for developing a diagnostic test.
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Journal Highlight: Insights on neoplastic stem cells from gel-based proteomics of childhood germ cell tumors
Date: Jun 25, 2012
Author: spectroscopyNOW
The first proteomics study of childhood germ cell tumours suggests that glucocorticoid receptor signalling is an area of interest for these and neoplastic stem cells.
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Telling porkies: Dietary studies on cloned pigs show poor metabolome consistency
Date: Jun 15, 2012
Author: Steve Down
A metabolomics comparison of cloned and normal pigs fed controlled or ad libitum diets has revealed differences between the two animal types and confirmed earlier NMR observations that cloned pigs do not have a reduced level of inter-individual variations.
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Food for thought: Protein indicators of appetite in saliva
Date: Jun 1, 2012
Author: Steve Down
A preliminary study on the response of the saliva proteome to food has identified two proteins which might be biomarkers for appetite, say researchers in the UK, with the potential to replace invasive blood tests and subjective measures.
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Journal Highlight: The role of targeted chemical proteomics in pharmacology
Date: May 21, 2012
Author:
The role of chemical proteomics in determining the specificity of drugs and their analogues for anticipated known targets, which leads to the discovery of unexpected targets and potential side effects, is discussed with examples. The process leads to the refinement of second- and third-generation drug design for treatment of many diseases.
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