Proteomics & Genomics / Ezine
Telling porkies: Dietary studies on cloned pigs show poor metabolome consistency
Date: Jun 15, 2012
Author: Steve Down
A metabolomics comparison of cloned and normal pigs fed controlled or ad libitum diets has revealed differences between the two animal types and confirmed earlier NMR observations that cloned pigs do not have a reduced level of inter-individual variations.
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Food for thought: Protein indicators of appetite in saliva
Date: Jun 1, 2012
Author: Steve Down
A preliminary study on the response of the saliva proteome to food has identified two proteins which might be biomarkers for appetite, say researchers in the UK, with the potential to replace invasive blood tests and subjective measures.
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Journal Highlight: The role of targeted chemical proteomics in pharmacology
Date: May 21, 2012
Author:
The role of chemical proteomics in determining the specificity of drugs and their analogues for anticipated known targets, which leads to the discovery of unexpected targets and potential side effects, is discussed with examples. The process leads to the refinement of second- and third-generation drug design for treatment of many diseases.
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Radical problems: Cigarette smoke attacks proteins in oral tissue
Date: May 15, 2012
Author: Steve Down
The reactive aldehydes present in cigarette smoke have a rapid and toxic effect on human oral fibroblasts, oxidising key proteins and reducing their cellular levels, according to a transatlantic study.
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Storm in a teacup: Iron levels unchanged but saliva proteome modified after drinking green tea
Date: May 1, 2012
Author: Steve Down
The salivary proteome of rats is modified when green tea is added to their diet, according to researchers in the USA, but the levels of iron in their blood remain unaffected, clarifying this controversial issue.
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Journal Highlight: Proteomics: present and future in fish, shellfish and seafood
Date: Apr 23, 2012
Author:
A brief overview of current classical proteomics methodology (electrophoresis and mass spectrometry) is presented and focused in the context of applications beneficial to the field of fish, shellfish and seafood/seafood products.
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Seafood spoilers: Streptococcal bacteria in vacuum-packed seafood product isolated and characterised
Date: Apr 15, 2012
Author: Steve Down
A pathogen that causes streptococcosis in fish has been isolated from a spoiled sample of refrigerated, vacuum-packed seafood and characterised by genotyping and proteomic analysis. The mass spectrum of its soluble proteins displays several peaks that are unique to this species and will allow its rapid identification in food products.
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Cancer classification: MALDI imaging distinguishes different types of cancer
Date: Apr 1, 2012
Author: Steve Down
Six common types of tumour have been differentiated by mass spectrometry in a proof-of-principle proteomics study by European scientists, which could lead to a personalised treatment regime for cancer sufferers.
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Journal Highlight: Platelet proteomics
Date: Mar 26, 2012
Author:
The aim of this review is to describe recent improvements in platelet proteome studies in normal and pathological conditions, and to depict the main pitfalls associated with platelet proteomics.
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Climate change consequences: Excess ozone causes major changes in the redox proteome of soybean plants
Date: Mar 15, 2012
Author: Steve Down
Long-term exposure to elevated levels of ozone in the field changes the proteome of soybean plants, specifically modifying many redox proteins. The results may help to understand why the yields of soybean crops are strongly decreased under high ozone atmospheric conditions and lead to new ozone-resistant bioengineered varieties.
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