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Protein imaging: The power of MALDI

Date: Jun 2, 2016

Author: Steve Down

The power of two different MALDI mass spectrometric techniques for visualising proteins in tissue segments has been demonstrated by US scientists who exploited high-speed scanning and improved spatial resolution capabilities.

Read More thumbnail image: Protein imaging The power of MALDI

Journal Highlight: Defining the proteome of human iris, ciliary body, retinal pigment epithelium, and choroid

Date: May 23, 2016

Author: spectroscopyNOW

The mass spectrometric proteome of the human iris, ciliary body, and retinal pigment epithelium/choroid has been determined and the data deposited in the ProteomeXchange Consortium

Read More thumbnail image: Journal Highlight Defining the proteome of human iris ciliary body retinal pigment epithelium and choroid

Decompression sickness: Protein biomarkers

Date: May 15, 2016

Author: Steve Down

The onset of decompression sickness in rats leads to a change in the proteome, highlighting proteins which could act as biomarkers of the condition as well as shedding light on the physiological mechanism at play.

Read More thumbnail image: Decompression sickness Protein biomarkers

Dioxin exposure: Human protein biomarkers of TCDD

Date: May 1, 2016

Author: Steve Down

Scientists in the Republic of Korea have identified a number of proteins in human hepatocyte cells that are affected by low doses of 2,3,7,8-tetrachloro-p-dioxin and could act as toxicological biomarkers. Some of them were subsequently found in the blood of exposed incineration workers.

Read More thumbnail image: Dioxin exposure Human protein biomarkers of TCDD

Journal Highlight: Functional proteomics within the genus Lactobacillus

Date: Apr 25, 2016

Author: spectroscopyNOW

This review focuses on the novel and comprehensive knowledge of functional proteomics and metaproteomics of Lactobacillus species, providing a large list of proteomic case studies to illustrate the adaptability of the main metabolic pathways to various life conditions.

Read More thumbnail image: Journal Highlight Functional proteomics within the genus Lactobacillus

Meat management: Tandem MS for species identification

Date: Apr 15, 2016

Author: Steve Down

A wide number of animal species that are raised for human consumption have been identified in an untargeted way by matching peptide tandem mass spectra from shotgun processing to a reference library, which will help to prevent food fraud.

Read More thumbnail image: Meat management Tandem MS for species identification

Breast cancer biomarkers: Nipple discharge analysis

Date: Apr 2, 2016

Author: Steve Down

Promising biomarkers of invasive breast cancer have been uncovered by scientists in Japan who tapped into nipple discharge, an often ignored biofluid, as a source of locally secreted proteins.

Read More thumbnail image: Breast cancer biomarkers Nipple discharge analysis

Journal Highlight: Single-cell mass spectrometry for discovery proteomics: Quantifying translational cell heterogeneity in the 16-cell frog (Xenopus) embryo

Date: Mar 21, 2016

Author: spectroscopyNOW

Mass spectrometry has been used to quantify the expression of diverse proteins in single embryonic cells to enable untargeted (discovery) proteomics with a lower limit of detection of 25 amol.

Read More thumbnail image: Journal Highlight Single-cell mass spectrometry for discovery proteomics Quantifying translational cell heterogeneity in the 16-cell frog Xenopus embryo

Cell and lung transplantation: Protein biomarker for subsequent lung disease

Date: Mar 16, 2016

Author: Steve Down

A plasma protein has been earmarked as a potential marker for the onset of bronchiolitis obliterans syndrome, a life-threatening complication that can follow hematopoietic cell transplantation or lung transplantation.

Read More thumbnail image: Cell and lung transplantation Protein biomarker for subsequent lung disease

Dust mite allergens: Proteomics expands range

Date: Mar 1, 2016

Author: Steve Down

Novel protein allergens from a house dust mite have been revealed by a proteomics study which lends support to the allergen-specific immunotherapeutic approach to treatment.

Read More thumbnail image: Dust mite allergens Proteomics expands range
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