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Alzheimer's biomarkers: Novel metabolites and protein candidates

Date: Jun 15, 2017

Author: Steve Down

Scientists in China have identified a range of potential biomarkers of Alzheimer's disease from a metabolomics and proteomics study of the rat model, providing insight into diagnosis of the condition and candidates for therapeutic targets.

Read More thumbnail image: Alzheimers biomarkers Novel metabolites and protein candidates

Gulf War Illness: Proteomics clues to affected biological pathways

Date: Jun 1, 2017

Author: Steve Down

Two complementary proteomics experiments have been carried out on the mouse model of Gulf War Illness to identify modified biological pathways in the central nervous system that might lead to targets for novel therapeutic agents.

Read More thumbnail image: Gulf War Illness Proteomics clues to affected biological pathways

Journal Highlight: Biomarkers of systemic lupus erythematosus identified using mass spectrometry-based proteomics: a systematic review

Date: May 22, 2017

Author: spectroscopyNOW

A systematic review of published reports on proteomic biomarkers identified in systemic lupus erythematosus patients using mass spectrometry-based proteomics has been conducted, highlighting their potential disease association and clinical utility.

Read More thumbnail image: Journal Highlight Biomarkers of systemic lupus erythematosus identified using mass spectrometry-based proteomics a systematic review

Morphine addiction: Enzyme activity

Date: May 16, 2017

Author: Steve Down

Polish scientists have measured the activities of four enzymes in the brain implicated in the mechanism of morphine addiction in the search for therapeutic targets which do not produce the serious side effects during pain treatment.

Read More thumbnail image: Morphine addiction Enzyme activity

Osteoporosis biomarkers: Serum proteomics

Date: May 1, 2017

Author: Steve Down

A large-scale study of older men in the US has identified a number of proteins in serum that are good candidates for biomarkers of future hip bone loss and fracture by correlation with the bone mineral density measurements.

Read More thumbnail image: Osteoporosis biomarkers Serum proteomics

Journal Highlight: The oxidized thiol proteome in aging and cataractous mouse and human lens revealed by ICAT labeling

Date: Apr 24, 2017

Author: spectroscopyNOW

All of the disulfide-forming noncrystallin proteins associated with age-related cataractogenesis in mice and humans have been identified using ICAT labelling techniques.

Read More thumbnail image: Journal Highlight The oxidized thiol proteome in aging and cataractous mouse and human lens revealed by ICAT labeling

Milk whey glycoproteins: Interspecies comparison

Date: Apr 15, 2017

Author: Steve Down

A comprehensive examination of the glycoproteins in the milk whey from several mammals by Chinese researchers has identified more than 200 N-glycosylation sites, the majority of which have not been reported previously.

Read More thumbnail image: Milk whey glycoproteins Interspecies comparison

Forensic body fluids: Protein biomarkers

Date: Apr 2, 2017

Author: Steve Down

Biological stains such as urine, saliva and seminal fluid can be distinguished from each other using panels of unique protein biomarkers, offering a reliable way to assign the origin of a DNA profile in forensic cases, say researchers in the USA.

Read More thumbnail image: Forensic body fluids Protein biomarkers

Journal Highlight: Detergents: Friends not foes for high-performance membrane proteomics toward precision medicine

Date: Mar 27, 2017

Author: spectroscopyNOW

This review analyzes detergent properties behind recent proteomic advances and proposes that rational use of detergents may reconcile outstanding membrane proteomics dilemmas, enabling ultradeep coverage and minimal artifacts.

Read More thumbnail image: Journal Highlight Detergents Friends not foes for high-performance membrane proteomics toward precision medicine

Ant venom: Protein and peptide profiles

Date: Mar 16, 2017

Author: Steve Down

Peptides and proteins in the venom of the South American bullet ant have been compared following two extraction methods, with the ultimate aim of finding new drug and biopesticide candidates.

Read More thumbnail image: Ant venom Protein and peptide profiles
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