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Saliva for disease biomarkers: Gender and acid stimulation effects

Date: Mar 1, 2017

Author: Steve Down

A more complete understanding of the effects of gender and acid simulation on the saliva proteome has been provided by scientists in China to help support the search for disease-specific biomarkers.

Read More thumbnail image: Saliva for disease biomarkers Gender and acid stimulation effects

Journal Highlight: Extracellular proteasomes are deficient in 19S subunits as revealed by iTRAQ quantitative proteomics

Date: Feb 20, 2017

Author: spectroscopyNOW

To gain insight into the molecular and functional differences between extracellular and cellular proteasomes, the subunit compositions have been compared using iTRAQ-based quantitative proteomics.

Read More thumbnail image: Journal Highlight Extracellular proteasomes are deficient in 19S subunits as revealed by iTRAQ quantitative proteomics

Neutrophils and surgical trauma: Protein alterations

Date: Feb 15, 2017

Author: Steve Down

The activation of neutrophils following surgery has been studied by proteomic techniques to reveal some of the biochemical processes that are affected by trauma, offering therapeutic targets to treat post-operative complications.

Read More thumbnail image: Neutrophils and surgical trauma Protein alterations

Induced pluripotent stem cells: Proteomics test

Date: Feb 2, 2017

Author: Steve Down

Induced pluripotent human stem cells can be distinguished from non-pluripotent cells within minutes using a novel proteomics assay that targets 15 biomarker peptides originating from 4 particular transcription factors.

Read More thumbnail image: Induced pluripotent stem cells Proteomics test

Journal Highlight: The effects of acute and chronic exercise on skeletal muscle proteome

Date: Jan 23, 2017

Author: spectroscopyNOW

This review aims to update the fast-growing exercise-proteomic scenario, leading to some new perspectives about the molecular events under skeletal muscle plasticity in response to physical activity.

Read More thumbnail image: Journal Highlight The effects of acute and chronic exercise on skeletal muscle proteome

Acute kidney injury: Biomarker protocol with labelled proteins

Date: Jan 15, 2017

Author: Steve Down

A novel method for accurately measuring multiple biomarkers of acute kidney injury that was developed in France uses isotope-labelled protein standards and can be rolled out to other diseases in different clinical scenarios.

Read More thumbnail image: Acute kidney injury Biomarker protocol with labelled proteins

Nasal cancer prognosis: 14-3-3 epsilon predictor for asparaginase treatment

Date: Jan 4, 2017

Author: Steve Down

The response of patients with extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) to treatment with asparaginase can be predicted by levels of the protein 14-3-3 epsilon, say Chinese scientists.

Read More thumbnail image: Nasal cancer prognosis 14-3-3 epsilon predictor for asparaginase treatment

Journal Highlight: Acute phase proteins as promising biomarkers: Perspectives and limitations for human and veterinary medicine

Date: Dec 19, 2016

Author: spectroscopyNOW

Current reviews on acute phase proteins and their use as biomarkers are discussed with examples of their general, extended and differential extrahepatic expression, leading to the conclusion that their diagnostic value should be reassessed.

Read More thumbnail image: Journal Highlight Acute phase proteins as promising biomarkers Perspectives and limitations for human and veterinary medicine

Large proteins: FTICR to the rescue

Date: Dec 16, 2016

Author: Steve Down

A powerful FTICR mass spectrometer installed recently in the National High Magnetic Field Laboratory in the USA has successfully observed thousands of protein isoforms in a top-down analysis, many of them with molecular masses above 30 kDa.

Read More thumbnail image: Large proteins FTICR to the rescue

Biowarfare agents: Toxin testing

Date: Dec 2, 2016

Author: Steve Down

Toxins that have been added to foods as chemical and biological warfare agents can be detected using a novel proteomics approach which bypasses the need for antibody-based isolation by employing isotope-labelled versions of the toxins.

Read More thumbnail image: Biowarfare agents Toxin testing
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