Proteomics & Genomics / Ezine
Journal Highlight: The Human Protein Atlas as a proteomic resource for biomarker discovery
Date: Nov 21, 2011
Author:
The current status of the Human Protein Atlas project, which provides an important source of information for numerous biomedical research projects, including biomarker discovery efforts, is reviewed.
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Immunity protein pointers: Truncated protein is risk factor for respiratory viral infection in boys
Date: Nov 15, 2011
Author: Steve Down
Several innate immunity proteins have been identified in the nasal lavage fluid of small children suffering from a respiratory virus infection, including full-length and truncated versions of an antibacterial protein which were implicated in higher risk factors for infant boys.
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Memorable proteins: Spatial learning instigates short-term changes in protein abundances in the brain
Date: Nov 1, 2011
Author: Steve Down
The protein changes occurring in the part of the brain that deals with new memories have been charted during a spatial learning activity by rats in an international study which revealed two discrete change phases within 12 hours of training.
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Journal Highlight: Changes in the bovine whey proteome during the early lactation period
Date: Oct 24, 2011
Author:
A two-dimensional gel-based approach was used in this study to investigate time-dependent changes in the bovine whey proteome during the early lactation period.
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Beer haze clearing up: Barley proteins implicated in sediment formation
Date: Oct 15, 2011
Author: Steve Down
A proteomics study following proteins through the brewing process has suggested that the haze found in beers originates predominantly from barley proteins, rather than the hordein proteins in malt that had previously been implicated.
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Sleep apnoea diagnosis: serum proteins linked to disease severity
Date: Oct 1, 2011
Author: Steve Down
Diagnosis of obstructive sleep apnoea based on serum protein levels took a step closer following a preliminary proteomic study on affected men in which the expression of some proteins was related to the severity of the condition.
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Journal Highlight: Proteomic analysis of peach endocarp and mesocarp during early fruit development
Date: Sep 26, 2011
Author:
The development of the stone and formation of peach fruit were explored using a proteomic approach, revealing 68 proteins with different expression patterns in both the endocarp and mesocarp during early fruit development, the majority being involved in primary or secondary metabolism.
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Archived cancer biomarkers: Phosphoprotein panel identified from preserved prostate cancer tissue
Date: Sep 15, 2011
Author: Steve Down
The phosphoprotein signatures of archived prostate cancer tissues have been successfully characterised by a gel-free proteomics approach in a pilot study that can form the basis of a biomarker discovery campaign.
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Sickle cell testing: High throughput mass spectrometry method could lead to cheap, universal neonate screening
Date: Sep 1, 2011
Author: Steve Down
Universal screening of newborn children for sickle cell disease is possible due to the development of a rapid mass spectrometric method designed to detect all types of haemoglobin variant and which can process up to 1000 samples a day.
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Journal Highlight: Proteomic signatures in antibiotic research
Date: Aug 22, 2011
Author:
This review recapitulates how antibiotic proteomic signatures are established and highlights areas of antibiotic research benefiting most from proteomic signatures.
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