Journal Highlight: Mechanism of cellular uptake of graphene oxide studied by surface-enhanced Raman Spectroscopy

Skip to Navigation

Ezine

  • Published: Oct 1, 2012
  • Author: spectroscopyNOW
  • Channels: Raman
thumbnail image: Journal Highlight: Mechanism of cellular uptake of graphene oxide studied by surface-enhanced Raman Spectroscopy

Mechanism of cellular uptake of graphene oxide studied by Surface-Enhanced Raman Spectroscopy

Small, 2012, 8, 2577-2584
Jie Huang, Cheng Zong, He Shen, Min Liu, Biao Chen, Bin Ren, Zhijun Zhang

Surface-enhanced Raman scattering spectroscopy is employed to investigate the cellular internalization of graphene oxide loaded with Au nanoparticles by Ca Ski cells. Abstract: The last few years have witnessed rapid development of biological and medical applications of graphene oxide (GO), such as drug/gene delivery, biosensing, and bioimaging. However, little is known about the cellular uptake mechanism and pathway of GO. In this work, surface-enhanced Raman scattering (SERS) spectroscopy is employed to investigate the cellular internalization of GO loaded with Au nanoparticles (NPs) by Ca Ski cells. The presence of Au NPs on the surface of GO enables detection of enhanced intrinsic Raman signals of GO inside the cell. The SERS results reveal that GO is distributed inhomogeneously inside the cell. Furthermore, internalization of Au-GO into Ca Ski cells is mainly via clathrin-mediated endocytosis, and is an energy-dependent process.

  • This paper is free to view for all users registered on separationsNOW.com until the end of November 2012.
    After this time, you can purchase it using Pay-Per-View on Wiley Online Library.

Social Links

Share This Links

Bookmark and Share

Microsites

Suppliers Selection
Societies Selection

Banner Ad

Click here to see
all job opportunities

Copyright Information

Interested in separation science? Visit our sister site separationsNOW.com

Copyright © 2017 John Wiley & Sons, Inc. All Rights Reserved