Journal Highlight: Polymorphic transformation of anhydrous caffeine upon grinding and hydrostatic pressurizing analyzed by low-frequency Raman spectroscopy

Polymorphic transformation of anhydrous caffeine upon grinding and hydrostatic pressurizing analyzed by low-frequency Raman spectroscopy

Journal of Pharmaceutical Sciences, 2013, 102, 162-170
Alain Hédoux, Yannick Guinet, Laurent Paccou, Florence Danède, Patrick Derollez

Abstract: Low-frequency Raman investigations were carried out upon pressurizing and grinding both crystalline forms of anhydrous caffeine at room temperature. These investigations have led to the detection of metastable states under stress. Upon moderated hydrostatic compression, only form I transform into a metastable state characterized by a Raman band-shape resembling that of form II. Above 2 GPa, both pressurized forms convert into an identical disordered state, suggesting a pressure-induced amorphization. In contrast to hydrostatic compression, grinding induces transformation of each phase into the other, leading to an intermediate state only stabilized under long enough grinding. The origin of these metastable states induced by stress was related to the disordered nature of both crystalline forms of caffeine and the stability conditions at room temperature of form I.

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