Journal Highlight: Thousand-fold enhancement of single-molecule fluorescence near a single gold nanorod

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  • Published: Feb 11, 2013
  • Author: spectroscopyNOW
  • Channels: UV/Vis Spectroscopy
thumbnail image: Journal Highlight: Thousand-fold enhancement of single-molecule fluorescence near a single gold nanorod

Thousand-fold Enhancement of Single-Molecule Fluorescence Near a Single Gold Nanorod

Angewandte Chemie International Edition, 2013, 52, 1217-1221
Haifeng Yuan, Saumyakanti Khatua, Peter Zijlstra, Mustafa Yorulmaz, Michel Orrit

Large enhancements of single-molecule fluorescence up to 1100 times have been achieved using synthesised gold nanorods by selecting a dye with its absorption and emission very close to the surface plasmon resonance of the nanorods.

Abstract: Large enhancements of single-molecule fluorescence up to 1100 times by using synthesized gold nanorods are reported. This high enhancement is achieved by selecting a dye with its absorption and emission very close to the surface plasmon resonance of the nanorods and by measuring the maximum enhancement corresponding to the optimum position of the fluorophore with respect to the nanorod. This promises a wider application of fluorescence correlation spectroscopy to many systems, notably in biology, where the analyte concentrations can be very high and cannot be arbitrarily reduced. We note that the enhancement factors reported here are still well below the theoretically predicted values. Further improvements including the use of dyes with a better spectral overlap with the nanorods and a still lower intrinsic quantum yield will be explored in the near future.

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