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Hepatitis C treatment: Antiviral response prediction

Date: Sep 17, 2018

Author: Steve Down

A combined proteomics and pharmacogenomics approach to the treatment of hepatitis C with direct acting antiviral therapies has identified three peptides derived from human corticosteroid binding globulin that can predict the response to treatment.

Read More thumbnail image: Hepatitis C treatment Antiviral response prediction

Journal Highlight: Rapid determination of soil classes in soil profiles using vis–NIR spectroscopy and multiple objectives mixed support vector classification

Date: Sep 17, 2018

Author: spectroscopyNOW

The multiple objectives mixed support vector classification method provides a fast objective diagnostic of soil classes for use in soil surveys and can help to update soil databases.

Read More thumbnail image: Journal Highlight Rapid determination of soil classes in soil profiles using visNIR spectroscopy and multiple objectives mixed support vector classification

Hypertension prediction: Metabolomics model

Date: Sep 15, 2018

Author: Steve Down

Essential hypertension can be predicted by a mass spectrometric test that measures the amounts of six metabolites in dried blood spots, which will help clinicians to diagnose the condition when the recognised symptoms have not appeared.

Read More thumbnail image: Hypertension prediction Metabolomics model

X-rays closing in: Single amyloid structures

Date: Sep 15, 2018

Author: David Bradley

X-ray scattering from amyloid fibrils could offer new clues as to the role these aberrant protein fragments play in Alzheimer's and Parkinson's diseases, according to an international team. The team used graphene to overcome interference from other substances that contaminated their small samples of amyloid taking them another step towards the possibility of single-molecule X-ray laser analysis.

Read More thumbnail image: X-rays closing in Single amyloid structures

Bactericidal polymers: Phosphorus NMR links up activity

Date: Sep 15, 2018

Author: David Bradley

Researchers in Canada have used phosphorus-31 nuclear magnetic resonance (NMR) spectroscopy to study hydrophilic phosphonium polymers that have surprising antibacterial activity and selectivity.

Read More thumbnail image: Bactericidal polymers Phosphorus NMR links up activity

Curcumin against cancer: AAS tests metal

Date: Sep 15, 2018

Author: David Bradley

Atomic absorption spectrometry (AAS) has been used to determine platinum levels in A549 cancer cells and tumour tissues in experiments to test the efficacy of combining the natural product curcumin with the well-known anticancer drug cisplatin.

Read More thumbnail image: Curcumin against cancer AAS tests metal

Coffee time: PARAFAC analysis of HPLC-DAD

Date: Sep 15, 2018

Author: David Bradley

Researchers in Brazil have used various volatile organic solvents to extract components of different types of coffee and used the PARAFAC method with high-performance liquid chromatography (HPLC) diode array data to create metabolomic fingerprints of reference and crossed coffees.

Read More thumbnail image: Coffee time PARAFAC analysis of HPLC-DAD

Journal Highlight: Wide‐range tuning and enhancement of organic long‐persistent luminescence using emitter dopants

Date: Sep 10, 2018

Author: spectroscopyNOW

The characteristics of emissions from organic long‐persistent luminescent systems have been improved by the addition of doping emitter molecules, enabling the development of a wide range of organic glow‐in‐the‐dark paints.

Read More thumbnail image: Journal Highlight Widerange tuning and enhancement of organic longpersistent luminescence using emitter dopants

Journal Highlight: Estimation of visceral fat in 9 to 13‐year‐old girls using dual‐energy x‐ray absorptiometry (DXA) and anthropometry

Date: Sep 10, 2018

Author: spectroscopyNOW

Dual x-ray absorptiometry with and without anthropometry were used to estimate visceral fat in young girls, the combination proving to give more accurate results.

Read More thumbnail image: Journal Highlight Estimation of visceral fat in 9 to 13yearold girls using dualenergy xray absorptiometry DXA and anthropometry

Journal Highlight: Optimization of extraction and analytical protocol for mass spectrometry‐based metabolomics analysis of hepatotoxicity

Date: Sep 10, 2018

Author: spectroscopyNOW

An optimised LC/MS‐based metabolomics protocol for extraction and analysis of endogenous metabolites from liver tissue during hepatotoxicity provides high reliability and reproducibility for polar and nonpolar metabolites.

Read More thumbnail image: Journal Highlight Optimization of extraction and analytical protocol for mass spectrometrybased metabolomics analysis of hepatotoxicity
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