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Amyloidosis classification: MALDI mass spectrometric imaging

Date: Dec 15, 2017

Author: Steve Down

Scientists in Germany have used mass spectrometry imaging coupled with ion mobility separation to identify amyloid peptides in a proof-of-concept study that will allow different types of amyloidosis to be classified.

Read More thumbnail image: Amyloidosis classification MALDI mass spectrometric imaging

Big cat diets: Whisker isotopes track prey

Date: Dec 15, 2017

Author: Steve Down

The growth rate and stable isotope distribution of lion and leopard whiskers have been measured as a basis for mapping the diets of animals in the wild.

Read More thumbnail image: Big cat diets Whisker isotopes track prey

Methane mystery: Marine microbes X-rayed

Date: Dec 15, 2017

Author: David Bradley

Industry and agriculture generate vast quantities of methane, a potent greenhouse gas. However, marine microbes also represent an important source although exactly how is entangled in the "ocean methane paradox." Now, US researchers have used X-ray crystallography to explain it.

Read More thumbnail image: Methane mystery Marine microbes X-rayed

Hot attraction: Atomic interferometry

Date: Dec 15, 2017

Author: David Bradley

 Hot bodies attract atoms, contrary to what physicists had assumed. The proof is in the atom interferometry data from researchers in the USA. Steven Chu of Stanford University and formerly the University of California Berkeley, Claude Cohen-Tannoudji, and William Phillips used optical tweezers to observe the minute effect.

Read More thumbnail image: Hot attraction Atomic interferometry

One flu over: NMR insights

Date: Dec 15, 2017

Author: David Bradley

When you catch influenza, the virus hijacks the inner workings of your cells to make copies of itself. The copies accumulate in viral buds that then break free from the host cell to infect another host. Researchers at Massachusetts Institute of Technology have now used solid-state nuclear magnetic resonance (NMR) spectroscopy to obtain a clear picture of how these buds pinch off from the host cell membrane.

Read More thumbnail image: One flu over NMR insights

Polymorphic formulation: Chemometric tablet assessment

Date: Dec 15, 2017

Author: David Bradley

Chemometrics coupled to mid (MIR) and near (NIR) infrared spectroscopy, digital optical microscopy, differential scanning calorimetry, melting point, and dissolution properties have been used to predict the dissolution performance of different polymorphs in tablets of the widely used non-steroidal anti-inflammatory drug mefenamic acid.

Read More thumbnail image: Polymorphic formulation Chemometric tablet assessment

Chemometrics shown to fix complexity of herbal mix

Date: Dec 14, 2017

Author: Ryan De Vooght-Johnson

Lianqiao Baidu pills are a popular traditional Chinese medicine made from a mixture of herbal ingredients, but up to now there has been no accurate way to analyse their quality. Researchers from Shenyang Pharmaceutical University in China categorised the quality of this material using extraction, HPLC, measurements of its antioxidant power and chemometric methods.

Read More thumbnail image: Chemometrics shown to fix complexity of herbal mix

Journal Highlight: Understanding the molecular interaction in solutions by chemometric resolution of near−infrared spectra

Date: Dec 11, 2017

Author: spectroscopyNOW

A chemometric method for resolving overlapping analytical signals from components in solution based on the rotation of the loadings in PCA has been used to calculate the spectra of ethanol and water from the NIR spectra of ethanol−water mixtures.

Read More thumbnail image: Journal Highlight Understanding the molecular interaction in solutions by chemometric resolution of nearinfrared spectra

Journal Highlight: Nerve detection using optical spectroscopy, an evaluation in four different models: In human and swine, in-vivo, and post mortem

Date: Dec 4, 2017

Author: spectroscopyNOW

Nerve and surrounding tissues in human (in vivo and post mortem) and swine (in vivo and post mortem) have been structurally compared macroscopically, histologically, and spectroscopically using diffuse reflective spectra.

Read More thumbnail image: Journal Highlight Nerve detection using optical spectroscopy an evaluation in four different models In human and swine in-vivo and post mortem

Journal Highlight: Metabolomics toward personalized medicine

Date: Dec 4, 2017

Author: spectroscopyNOW

Metabolomics strategies and studies that focus on the discovery of biomarkers that have "personalized" diagnostic, prognostic, and therapeutic value, validated for monitoring disease progression and responses to various management regimens, have been compared and evaluated.

Read More thumbnail image: Journal Highlight Metabolomics toward personalized medicine
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