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Journal Highlight: A simplified framework to optimize MRI contrast preparation

Date: Nov 19, 2018

Author: spectroscopyNOW

A rigorous optimal control framework has been designed for the design of preparation schemes that optimize MRI contrast based on relaxation time differences.

Read More thumbnail image: Journal Highlight A simplified framework to optimize MRI contrast preparation

Journal Highlight: Proteomic analysis of extracellular vesicles for cancer diagnostics

Date: Nov 19, 2018

Author: spectroscopyNOW

This review summarizes current advancements in extracellular vesicle (EV) subtype characterization, cancer EV capturing and proteomic analysis technologies, as well as possible EV‐based multiomics for cancer diagnostics.

Read More thumbnail image: Journal Highlight Proteomic analysis of extracellular vesicles for cancer diagnostics

Acupuncture for vascular dementia: Proteins implicated

Date: Nov 15, 2018

Author: Steve Down

The molecular mechanisms behind the improvement of vascular dementia initiated by acupuncture have been investigated by Chinese scientists who used proteomics to indicate that proteins involved in oxidative stress, apoptosis and synaptic function were affected.

Read More thumbnail image: Acupuncture for vascular dementia Proteins implicated

Metabolic tissue imaging: Ambient mass spectrometry for global coverage

Date: Nov 15, 2018

Author: Steve Down

A wide range of metabolites have been mapped in tissue using ambient mass spectrometry, which could help to divulge molecular processes and pathological mechanisms and lead to the discovery of new biomarkers.

Read More thumbnail image: Metabolic tissue imaging Ambient mass spectrometry for global coverage

Chemometrics of cannabinoids: THC under strain

Date: Nov 15, 2018

Author: David Bradley

 A chemometric approach has demonstrated that many strains of marijuana (Cannabis sativa) have almost identical levels of the psychoactive components tetrahydrocannabinol (THC) and cannabidiol (CBD), despite the urban folklore and street names associated with different "products".

Read More thumbnail image: Chemometrics of cannabinoids THC under strain

Nitrogen under pressure: Polymorph X-rayed

Date: Nov 15, 2018

Author: David Bradley

An unusually complex form of one of the most abundant chemical elements on Earth has been observed in the laboratory for the first time and its structure determined by X-ray crystallography.

Read More thumbnail image: Nitrogen under pressure Polymorph X-rayed

Wild red wine: Microwave plasma-AES

Date: Nov 15, 2018

Author: David Bradley

The low-cost of microwave plasma-atomic emission spectrometry (MP-AES) outweighs its limitations and offers a simpler alternative technique for the quantitation of transition metals in food and drink samples.

Read More thumbnail image: Wild red wine Microwave plasma-AES

CryoEM to usurp NMR? Small molecules succumb

Date: Nov 15, 2018

Author: David Bradley

Nuclear magnetic resonance (NMR) spectroscopy has been an invaluable tool for fifty years allowing chemists and others to figure out the structures of a vast range of molecules based on inferring connectivity between the atoms particular in small organic molecules. Now, that relative upstart technique electron cryo-microscopy (cryoEM) has been used to provide routine and unambiguous structural determination of small organic molecules that one might see as augmenting NMR studies and perhaps even going one...

Read More thumbnail image: CryoEM to usurp NMR Small molecules succumb

Journal Highlight: Moving window partial least squares after orthogonal signal correction as a coupling method for determination of uranium and thorium by ultrasound‐assisted emulsification microextraction

Date: Nov 12, 2018

Author: spectroscopyNOW

A fast, simple, and efficient ultrasound‐assisted emulsification microextraction coupled with orthogonal signal correction‐moving window PLS has been used for the preconcentration and simultaneous spectrophotometric determination of uranium and thorium in water.

Read More thumbnail image: Journal Highlight Moving window partial least squares after orthogonal signal correction as a coupling method for determination of uranium and thorium by ultrasoundassisted emulsification microextraction

Journal Highlight: In vivo diffusion MRI detects early spinal cord axonal pathology in a mouse model of ALS

Date: Nov 8, 2018

Author:

Diffusion magnetic resonance imaging (MRI) exhibits contrast that identifies macro‐ and microstructural changes in neurodegenerative diseases. Previous studies have shown that MR diffusion tensor imaging (DTI) can observe changes in spinal cord white matter in animals and humans affected with symptomatic amyotrophic lateral sclerosis (ALS).

Read More thumbnail image: Journal Highlight In vivo diffusion MRI detects early spinal cord axonal pathology in a mouse model of ALS
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