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Polymorphic formulation: Chemometric tablet assessment

Date: Dec 15, 2017

Author: David Bradley

Chemometrics coupled to mid (MIR) and near (NIR) infrared spectroscopy, digital optical microscopy, differential scanning calorimetry, melting point, and dissolution properties have been used to predict the dissolution performance of different polymorphs in tablets of the widely used non-steroidal anti-inflammatory drug mefenamic acid.

Read More thumbnail image: Polymorphic formulation Chemometric tablet assessment

Chemometrics shown to fix complexity of herbal mix

Date: Dec 14, 2017

Author: Ryan De Vooght-Johnson

Lianqiao Baidu pills are a popular traditional Chinese medicine made from a mixture of herbal ingredients, but up to now there has been no accurate way to analyse their quality. Researchers from Shenyang Pharmaceutical University in China categorised the quality of this material using extraction, HPLC, measurements of its antioxidant power and chemometric methods.

Read More thumbnail image: Chemometrics shown to fix complexity of herbal mix

Journal Highlight: Understanding the molecular interaction in solutions by chemometric resolution of near−infrared spectra

Date: Dec 11, 2017

Author: spectroscopyNOW

A chemometric method for resolving overlapping analytical signals from components in solution based on the rotation of the loadings in PCA has been used to calculate the spectra of ethanol and water from the NIR spectra of ethanol−water mixtures.

Read More thumbnail image: Journal Highlight Understanding the molecular interaction in solutions by chemometric resolution of nearinfrared spectra

Journal Highlight: Nerve detection using optical spectroscopy, an evaluation in four different models: In human and swine, in-vivo, and post mortem

Date: Dec 4, 2017

Author: spectroscopyNOW

Nerve and surrounding tissues in human (in vivo and post mortem) and swine (in vivo and post mortem) have been structurally compared macroscopically, histologically, and spectroscopically using diffuse reflective spectra.

Read More thumbnail image: Journal Highlight Nerve detection using optical spectroscopy an evaluation in four different models In human and swine in-vivo and post mortem

Journal Highlight: Metabolomics toward personalized medicine

Date: Dec 4, 2017

Author: spectroscopyNOW

Metabolomics strategies and studies that focus on the discovery of biomarkers that have "personalized" diagnostic, prognostic, and therapeutic value, validated for monitoring disease progression and responses to various management regimens, have been compared and evaluated.

Read More thumbnail image: Journal Highlight Metabolomics toward personalized medicine

Journal Highlight: Scanning X-ray diffraction on cardiac tissue: automatized data analysis and processing

Date: Dec 4, 2017

Author: spectroscopyNOW

A scanning X-ray diffraction study of cardiac tissue has been performed covering the entire cross section of a mouse heart slice using a technique that could be easily extended to characterize tissue from a diseased heart.

Read More thumbnail image: Journal Highlight Scanning X-ray diffraction on cardiac tissue automatized data analysis and processing

Monitoring bone fracture healing: Protein signals

Date: Dec 1, 2017

Author: Steve Down

Scientists in the USA have uncovered a suite of proteins in serum that might be able to follow the progression of fracture healing and lead to the development of treatments to accelerate the process.

Read More thumbnail image: Monitoring bone fracture healing Protein signals

Topological motions: Ultra-violet probe

Date: Dec 1, 2017

Author: David Bradley

European scientists have finally resolved a seeming paradox in the conflicting data from ultraviolet studies and magnetotransport examination of topological insulators. The explanation could open up this intriguing group of compounds to new electronics applications and quantum devices.

Read More thumbnail image: Topological motions Ultra-violet probe

In utero cannabis exposure: Umbilical cord assessment

Date: Dec 1, 2017

Author: Steve Down

An international team of scientists has developed a way to measure cannabis in the umbilical cord, allowing clinicians to assess the risks to newborns without relying on the word of their mothers.

Read More thumbnail image: In utero cannabis exposure Umbilical cord assessment

Box–Behnken design makes rhubarb extracts fine

Date: Dec 1, 2017

Author: Ryan De Vooght-Johnson

Medicinal rhubarb has long being used in traditional Chinese medicine, but accurate assays of its many active compounds are hampered by the expense of analytical standards. Scientists from Tianjin University and Tianjin University of Traditional Chinese Medicine have developed a new methods of assaying multiple rhubarb compounds by quantitative analysis of multi-components with a single marker (QAMS), while also optimising their extraction with a Box–Behnken design.

Read More thumbnail image: BoxBehnken design makes rhubarb extracts fine
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