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Journal Highlight: Multiplex quantitative SILAC for analysis of archaeal proteomes: a case study of oxidative stress responses

Date: Jan 22, 2018

Author: spectroscopyNOW

SILAC has been used for the quantitative comparison of archaeal proteomes using Haloferax volcanii as a model to demonstrate its value as a method that holds promise for unravelling gene function.

Read More thumbnail image: Journal Highlight Multiplex quantitative SILAC for analysis of archaeal proteomes a case study of oxidative stress responses

Journal Highlight: Real world MRI experience with nonconditional and conditional cardiac rhythm devices after MagnaSafe

Date: Jan 22, 2018

Author: spectroscopyNOW

The recent MagnaSafe Registry of nonthoracic MRI with nonconditional cardiac implantable electronic devices has been independently validated and extended to thoracic MRIs, arguing against replacing nonconditional with conditional devices when MRI is performed in a carefully controlled environment.

Read More thumbnail image: Journal Highlight Real world MRI experience with nonconditional and conditional cardiac rhythm devices after MagnaSafe

Network premiere for fumarase-insufficient cells

Date: Jan 16, 2018

Author: Ryan De Vooght-Johnson

Fumarase is an important enzyme, and work with rats suggested that low levels may affect amino acid levels and possibly be associated with hypertension. Scientists in China have examined the metabolites of human cells that had been genetically altered to be deficient in fumarase, comparing them to the metabolites from control cells using GC-MS and chemometric methods, such as pathway analysis.

Read More thumbnail image: Network premiere for fumarase-insufficient cells

Oral squamous cell carcinoma: Dual protein biomarkers

Date: Jan 15, 2018

Author: Steve Down

A combination of two proteins found in saliva can predict oral squamous cell carcinoma and are unaffected by the risk factors human papillomavirus and Epstein-Barr virus, leading to the possibility of a clinical test for the cancer.

Read More thumbnail image: Oral squamous cell carcinoma Dual protein biomarkers

Journal Highlight: Feasibility of desorption electrospray ionization mass spectrometry for diagnosis of oral tongue squamous cell carcinoma

Date: Jan 15, 2018

Author: spectroscopyNOW

DESI-MS has been used to differentiate oral tongue squamous cell carcinoma from adjacent normal epithelium using PCA-LDA of the spectra, the m/z 700–900 prediction model showing a 91% accuracy rate.

Read More thumbnail image: Journal Highlight Feasibility of desorption electrospray ionization mass spectrometry for diagnosis of oral tongue squamous cell carcinoma

Alternative tobacco products: Dokha is not as safe as people might think

Date: Jan 15, 2018

Author: Steve Down

A comprehensive analysis of Dokha tobacco, an increasing popular alternative smoking product, has identified harmful amounts of toxic metals in the ash and a number of toxic organic compounds in the smoke, including carcinogens and irritants.

Read More thumbnail image: Alternative tobacco products Dokha is not as safe as people might think

The dawn of life: NMR has (some of) the details

Date: Jan 15, 2018

Author: David Bradley

Nuclear magnetic resonance (NMR) spectroscopy and other techniques have been used to study the linked cycles of oxidative decarboxylation of glyoxylate. Such cycles could be perceived as being proto-metabolic analogues of the citric acid cycle on which life depends and might provide a new clue as to how life on earth emerged from the primordial soup.

Read More thumbnail image: The dawn of life NMR has some of the details

Monoclonal against Marburg: X-rays track antiviral effect

Date: Jan 15, 2018

Author: David Bradley

X-ray studies have revealed how a human monoclonal antibody known as MR191, neutralizes the Marburg virus by mimicking the host receptor and plugging into a spot on the viral surface through a receptor binding site.

Read More thumbnail image: Monoclonal against Marburg X-rays track antiviral effect

Gluten free: Mineral free? LIBS reveals all

Date: Jan 15, 2018

Author: David Bradley

Laser-induced breakdown spectroscopy (LIBS) has been used for the rapid analysis of concentrations of ash, potassium, and magnesium in gluten free flour.

Read More thumbnail image: Gluten free Mineral free LIBS reveals all

Astronomically aromatic: Organics in space

Date: Jan 15, 2018

Author: David Bradley

Astronomers using information from the Green Bank Telescope and a lot of chemical nous have made the first definitive interstellar detection of benzonitrile, an aromatic molecule that could provide a missing link between simpler organic compounds and polycyclic aromatic hydrocarbons.

Read More thumbnail image: Astronomically aromatic Organics in space
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