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Mercury lights up swordfish: UV fluorophore

Date: Mar 1, 2017

Author: David Bradley

A fluorescent polymer that lights up when it comes into contact with mercury has been developed to test levels of the metal in edible fish, such as tuna and swordfish, according to researchers in Spain.

Read More thumbnail image: Mercury lights up swordfish UV fluorophore

Living catalysis: Gold complex imaged with NIR in mice

Date: Mar 1, 2017

Author: David Bradley

The propargyl ester imaging probe Cy7.5-OProp was used as a near-infrared imaging probe for whole-body imaging to reveal how catalysis with a gold complex can be carried out in live mice, according to research published in the journal Angewandte Chemie.

Read More thumbnail image: Living catalysis Gold complex imaged with NIR in mice

Fab separations for Fab antibodies predicted by QSAR?

Date: Mar 1, 2017

Author: Ryan De Vooght-Johnson

Since an increasing array of separation methods are now used for proteins, interest is growing in using computational methods, such as quantitative structure–activity relationship (QSAR) calculations, to predict the likely response of proteins of interest to different systems, so that separations can be predicted. Researchers have used QSAR to predict the response of various antibody Fragment antigen-binding (Fab) fragments in different separation systems, with varying degrees of success.

Read More thumbnail image: Fab separations for Fab antibodies predicted by QSAR

Influenza attack: Raman to reveal hijack

Date: Mar 1, 2017

Author: David Bradley

Laura Fabris of Rutgers University, New York state, USA, and her colleagues are using surface enhanced Raman scattering (SERS) spectroscopy to investigate the role that might be played by TIPs - therapeutic interfering particles in defending us against influenza, flu.

Read More thumbnail image: Influenza attack Raman to reveal hijack

Reversing resistance: Rose myrtle extracts analysed by NMR

Date: Mar 1, 2017

Author: David Bradley

Novel natural products found in rose myrtle could hold promise of a new way to make breast cancer cells that have become resistant to the conventional anticancer drug doxorubicin susceptible once more. Nuclear magnetic resonance (NMR) spectroscopy, electronic circular dichroism (ECD) and X-ray crystallography were used to determine the structures and absolute configurations of the compounds.

Read More thumbnail image: Reversing resistance Rose myrtle extracts analysed by NMR

Cellular fusion: Protein X-ray insights

Date: Mar 1, 2017

Author: David Bradley

X-ray crystallography reveals that two closely related proteins, the HAP2 protein from the single-celled alga Chlamydomonas reinhardtii and the fusion protein from dengue virus are essential for fusion with a cell membrane and thus both sexual reproduction and viral invasion of a host cell. The proteins probably emerged very early in the history of life on Earth.

Read More thumbnail image: Cellular fusion Protein X-ray insights

New light on MRI: Contrast boost

Date: Mar 1, 2017

Author: David Bradley

A new technology platform can effectively tune the magnetic resonance imaging (MRI) signals in a scan switch on a contrast-boosting lamp on diseased tissue. Details are published in the journal Nature Materials suggesting that the approach might overcome some of the limitations of MRI contrast agents.

Read More thumbnail image: New light on MRI Contrast boost

Journal Highlight: Extracellular proteasomes are deficient in 19S subunits as revealed by iTRAQ quantitative proteomics

Date: Feb 20, 2017

Author: spectroscopyNOW

To gain insight into the molecular and functional differences between extracellular and cellular proteasomes, the subunit compositions have been compared using iTRAQ-based quantitative proteomics.

Read More thumbnail image: Journal Highlight Extracellular proteasomes are deficient in 19S subunits as revealed by iTRAQ quantitative proteomics

Journal Highlight: The neurobiology of addiction: the perspective from magnetic resonance imaging present and future

Date: Feb 20, 2017

Author: spectroscopyNOW

This review considers the role of MRI in addiction research and what future technological improvements might offer, using a hermeneutic strategy supplemented by an expansive, systematic search of PubMed, Scopus and Web of Science databases.

Read More thumbnail image: Journal Highlight The neurobiology of addiction the perspective from magnetic resonance imaging present and future

Superhard: Calculating a nitrogen fix

Date: Feb 15, 2017

Author: David Bradley

An international team has used chemical computation to predict the existence of a novel superhard material that also has unusual electrical properties.

Read More thumbnail image: Superhard Calculating a nitrogen fix
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