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Mixed-mode model made for medicinal antibodies

Date: Sep 16, 2017

Author: Ryan De Vooght-Johnson

Mixed-mode chromatography (MMC), which combines the properties of ion-exchange chromatography (IEC) and hydrophobic interaction chromatography (HIC), is increasingly used for the purification of various proteins, such as medicinal antibodies. Scientists from Mannheim University of Applied Sciences and Roche Pharmaceuticals’ Munich site developed equations to predict the elution of a bispecific antibody from an MMC column.

Read More thumbnail image: Mixed-mode model made for medicinal antibodies

New psychoactive substance screening: Wastewater from city festival

Date: Sep 15, 2017

Author: Steve Down

European scientists have used high-resolution mass spectrometry to screen for new psychoactive substances in wastewater during a city festival in Amsterdam, finding that traditional drugs are still dominant in the Dutch illicit drug scene.

Read More thumbnail image: New psychoactive substance screening Wastewater from city festival

Dialysis membranes: Adsorbed proteins

Date: Sep 15, 2017

Author: Steve Down

The effects of protein adsorption on two types of hemodialysis membrane have been studied by Chinese scientists to identify the unwanted biochemical reactions that occur in an effort to design more efficient membrane materials.

Read More thumbnail image: Dialysis membranes Adsorbed proteins

Journal Highlight: Detection of copper bisguanidine NO adducts by UV-vis spectroscopy and a SuperFocus mixer

Date: Sep 11, 2017

Author: spectroscopyNOW

The reaction of Cu(I) bisguanidine complexes with nitric oxide and the formation of intermediate species were monitored via UV-vis spectroscopy at low temperature and the limits of the SuperFocus mixer for this reaction were explored.

Read More thumbnail image: Journal Highlight Detection of copper bisguanidine NO adducts by UV-vis spectroscopy and a SuperFocus mixer

Journal Highlight: Imaging mass spectrometry for metabolites: technical progress, multimodal imaging, and biological interactions

Date: Sep 11, 2017

Author: spectroscopyNOW

Recent developments in the use of imaging mass spectrometry for metabolite analysis, focusing specifically on technological advancement and their applications, have been reviewed, including technical advances and recent applications.

Read More thumbnail image: Journal Highlight Imaging mass spectrometry for metabolites technical progress multimodal imaging and biological interactions

Journal Highlight: Chiral gold nanoclusters: Atomic level origins of chirality

Date: Sep 11, 2017

Author: spectroscopyNOW

The use of single-crystal X-ray crystallography to study the chirality of atomically precise thiolate-protected gold nanoclusters, which have emerged as a new class of nanomaterial, has been reviewed.

Read More thumbnail image: Journal Highlight Chiral gold nanoclusters Atomic level origins of chirality

MS muddle made manageable by mulitplierz software

Date: Sep 6, 2017

Author: Ryan De Vooght-Johnson

The diversity of current mass spectrometry methods and software tools has led to multiple arrays of data that are not readily comparable. Researchers from Harvard Medical School and the Dana-Farber Cancer Institute in Boston have reported on the latest version of their multiplierz software, which aims to provide a common platform for mass spectrometry proteomic data.

Read More thumbnail image: MS muddle made manageable by mulitplierz software

Journal Highlight: T1 Nuclear magnetic relaxation dispersion of hyperpolarized sodium and cesium hydrogencarbonate-13C

Date: Sep 4, 2017

Author: spectroscopyNOW

The T1 dispersion from low to clinical magnetic fields of different hyperpolarized hydrogencarbonate formulations previously proposed in the literature for in vivo pH measurements has been measured to aid pH mapping in tissue.

Read More thumbnail image: Journal Highlight T1 Nuclear magnetic relaxation dispersion of hyperpolarized sodium and cesium hydrogencarbonate-13C

Journal Highlight: Applying portable Raman spectrometers for field discrimination of sulfates: Training for successful extraterrestrial detection

Date: Sep 4, 2017

Author: spectroscopyNOW

Portable miniature Raman spectrometers operating in the near-infrared (785 nm) and in the green (532 nm, currently selected for the ExoMars mission) were used on-site to estimate the mineralogical compositions of sulfate weathering crusts at Valachov (Bohemian Massif, Czech Republic).

Read More thumbnail image: Journal Highlight Applying portable Raman spectrometers for field discrimination of sulfates Training for successful extraterrestrial detection

Journal Highlight: First evidence of the use of freshwater pearls as a cosmetic in ancient China: Analysis of white makeup powder from a Northern Song dynasty Lv tomb (Lantian, Shaanxi Province, China)

Date: Sep 4, 2017

Author: spectroscopyNOW

A white powder identified as women's makeup found in a porcelain dish in a Chinese tomb has been identified as a product of freshwater pearls following analysis by ICP-AES, FTIR spectroscopy, SEM, X-ray diffraction and DSC-TG.

Read More thumbnail image: Journal Highlight First evidence of the use of freshwater pearls as a cosmetic in ancient China Analysis of white makeup powder from a Northern Song dynasty Lv tomb Lantian Shaanxi Province China
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