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rssDNA markers and disease: NMR and MS clues
Date: May 1, 2013
Author: David Bradley
Researchers have used NMR spectroscopy and mass spectrometry to help them understand the chemistry associated with modifications to DNA that are associated with autoimmune disease and cancer. The work offers new clues to the behaviour of modified bases and could open up avenues to new therapeutic agents.
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TNT, meet graphene: Explosive sensor
Date: May 1, 2013
Author: David Bradley
Another chemical pie in which graphene has its lacy carbon fingers is in the form of a sensitive and selective detection system for the common explosive trinitrotoluene (TNT). Silver nanoparticles functionalised with p-aminothiophenol (PATP) and supported on graphene sheets allow the straightforward surface-ehanced Raman spectroscopic SERS) detection of the explosive.
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Psychopathic wiring: Disturbed differences
Date: May 1, 2013
Author: David Bradley
Psychopathy is characterised as a personality disorder in which the afflicted lacks empathy for other people, feels no remorse for their actions regardless of whether they cause harm and in extreme cases leads to criminality. Now, functional magnetic resonance imaging (fMRI) has been used to reveal that the "circuitry" in the brains of criminal psychopaths is different from that in others.
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Crystallography without the crystals: Porous for support
Date: May 1, 2013
Author: David Bradley
Makoto Fujita of the University of Tokyo, Japan, and Kari Rissanen of the University of Jyväskylä, Finland, have used a porous substrate to bring order to an uncrystallisable target molecule for X-ray diffraction studies, which precludes the need to develop a method for producing crystals of the material. The technique allows nanogram quantities of the target compound to be analysed, the researchers say.
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Sweet red wine: Ultraviolet exposure
Date: May 1, 2013
Author: David Bradley
UV-Vis spectroscopy has been used for the first time to study phenolics and other compounds present in a type of sweet, red wine emerging from the North West of Spain. The approach could be used to study the components of other beverages too as well as offering quality analysis (QA) data on produce.
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Journal Highlight: Graphene: A platform for surface-enhanced Raman spectroscopy
Date: Apr 29, 2013
Author: spectroscopyNOW
The multi-role of graphene played in SERS is overviewed, including as a Raman probe, a substrate, an additive, and a building block for a flat surface for SERS.
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Journal Highlight: Elemental ion release from fixed restorative materials into patient saliva
Date: Apr 29, 2013
Author: spectroscopyNOW
The elemental ion release of Cu, Zn, Pd, Ag and Au from fixed gold alloy crowns and Al and Si from ceramic crowns into patient saliva was studied by inductively coupled plasma mass spectrometry.
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Journal Highlight: Utilizing NMR and EPR spectroscopy to probe the role of copper in prion diseases
Date: Apr 29, 2013
Author: spectroscopyNOW
Current research on the role of copper in the conformational changes associated with prion diseases are reviewed with emphasis on the latest applications of NMR and EPR spectroscopy to probe the interactions of copper with prion proteins.
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Journal Highlight: Frontal brain expansion during development using MRI and endocasts: Relation to microcephaly and Homo floresiensis
Date: Apr 22, 2013
Author: spectroscopyNOW
To determine if modern human brain evolution occurs via an expansion of the frontal lobes, the MRI scans of 118 living infants, children, and adolescents were reviewed and the frontal width, maximal cerebral width and maximal cerebral length were measured and compared.
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Journal Highlight: Effects of acute exercise over heart proteome from monogenic obese (ob/ob) mice
Date: Apr 22, 2013
Author: spectroscopyNOW
To elucidate the effects of acute exercise in heart tissue from obese animals, 12-week-old obese (ob/ob) and non-obese (ob/OB) mice were submitted to a single bout of swimming and had their hearts analyzed by proteomic techniques.
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