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DNA markers and disease: NMR and MS clues

Date: May 1, 2013

Author: David Bradley

Researchers have used NMR spectroscopy and mass spectrometry to help them understand the chemistry associated with modifications to DNA that are associated with autoimmune disease and cancer. The work offers new clues to the behaviour of modified bases and could open up avenues to new therapeutic agents.

Read More thumbnail image: DNA markers and disease NMR and MS clues

TNT, meet graphene: Explosive sensor

Date: May 1, 2013

Author: David Bradley

Another chemical pie in which graphene has its lacy carbon fingers is in the form of a sensitive and selective detection system for the common explosive trinitrotoluene (TNT). Silver nanoparticles functionalised with p-aminothiophenol (PATP) and supported on graphene sheets allow the straightforward surface-ehanced Raman spectroscopic SERS) detection of the explosive.

Read More thumbnail image: TNT meet graphene Explosive sensor

Psychopathic wiring: Disturbed differences

Date: May 1, 2013

Author: David Bradley

Psychopathy is characterised as a personality disorder in which the afflicted lacks empathy for other people, feels no remorse for their actions regardless of whether they cause harm and in extreme cases leads to criminality. Now, functional magnetic resonance imaging (fMRI) has been used to reveal that the "circuitry" in the brains of criminal psychopaths is different from that in others.

Read More thumbnail image: Psychopathic wiring Disturbed differences

Crystallography without the crystals: Porous for support

Date: May 1, 2013

Author: David Bradley

Makoto Fujita of the University of Tokyo, Japan, and Kari Rissanen of the University of Jyväskylä, Finland, have used a porous substrate to bring order to an uncrystallisable target molecule for X-ray diffraction studies, which precludes the need to develop a method for producing crystals of the material. The technique allows nanogram quantities of the target compound to be analysed, the researchers say.

Read More thumbnail image: Crystallography without the crystals Porous for support

Sweet red wine: Ultraviolet exposure

Date: May 1, 2013

Author: David Bradley

UV-Vis spectroscopy has been used for the first time to study phenolics and other compounds present in a type of sweet, red wine emerging from the North West of Spain. The approach could be used to study the components of other beverages too as well as offering quality analysis (QA) data on produce.

Read More thumbnail image: Sweet red wine Ultraviolet exposure

Journal Highlight: Graphene: A platform for surface-enhanced Raman spectroscopy

Date: Apr 29, 2013

Author: spectroscopyNOW

The multi-role of graphene played in SERS is overviewed, including as a Raman probe, a substrate, an additive, and a building block for a flat surface for SERS.

Read More thumbnail image: Journal Highlight Graphene A platform for surface-enhanced Raman spectroscopy

Journal Highlight: Elemental ion release from fixed restorative materials into patient saliva

Date: Apr 29, 2013

Author: spectroscopyNOW

The elemental ion release of Cu, Zn, Pd, Ag and Au from fixed gold alloy crowns and Al and Si from ceramic crowns into patient saliva was studied by inductively coupled plasma mass spectrometry.

Read More thumbnail image: Journal Highlight Elemental ion release from fixed restorative materials into patient saliva

Journal Highlight: Utilizing NMR and EPR spectroscopy to probe the role of copper in prion diseases

Date: Apr 29, 2013

Author: spectroscopyNOW

Current research on the role of copper in the conformational changes associated with prion diseases are reviewed with emphasis on the latest applications of NMR and EPR spectroscopy to probe the interactions of copper with prion proteins.

Read More thumbnail image: Journal Highlight Utilizing NMR and EPR spectroscopy to probe the role of copper in prion diseases

Journal Highlight: Frontal brain expansion during development using MRI and endocasts: Relation to microcephaly and Homo floresiensis

Date: Apr 22, 2013

Author: spectroscopyNOW

To determine if modern human brain evolution occurs via an expansion of the frontal lobes, the MRI scans of 118 living infants, children, and adolescents were reviewed and the frontal width, maximal cerebral width and maximal cerebral length were measured and compared.

Read More thumbnail image: Journal Highlight Frontal brain expansion during development using MRI and endocasts Relation to microcephaly and Homo floresiensis

Journal Highlight: Effects of acute exercise over heart proteome from monogenic obese (ob/ob) mice

Date: Apr 22, 2013

Author: spectroscopyNOW

To elucidate the effects of acute exercise in heart tissue from obese animals, 12-week-old obese (ob/ob) and non-obese (ob/OB) mice were submitted to a single bout of swimming and had their hearts analyzed by proteomic techniques.

Read More thumbnail image: Journal Highlight Effects of acute exercise over heart proteome from monogenic obese obob mice
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