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Over‐discretized SENSE reconstruction and B 0 correction for accelerated non‐lipid‐suppressed 1 H FID MRSI of the human brain at 9.4 T

Published: Oct 18, 2018

Author(s): Sahar Nassirpour, Paul Chang, Thomas Kirchner, Anke Henning

Journal: NMR in Biomedicine

The aim of this work was to use post‐processing methods to improve the data quality of metabolite maps acquired on the human brain at 9.4 T with accelerated acquisition schemes. This was accomplished by combining an improved sensitivity encoding (SENSE) reconstruction with a B0 correction of spatially over‐discretized magnetic resonance spectroscopic imaging (MRSI) data. Since MRSI scans suffer from long scan...

Read More thumbnail image: Overdiscretized SENSE reconstruction and B 0 correction for accelerated nonlipidsuppressed 1 H FID MRSI of the human brain at 9_4 T

Proteomic fingerprinting of apple fruit, juice, and cider via combinatorial peptide ligand libraries and MS analysis

Published: Oct 18, 2018

Author(s): María Jesús Lerma‐García, Maria Nicoletti, Ernesto Francisco Simó‐Alfonso, Pier Giorgio Righetti, Elisa Fasoli

Journal: ELECTROPHORESIS

Abstract Combinatorial peptide ligand libraries coupled to MS was applied to extensively map the proteome of apple fruit, and to detect its presence in commercial apple juice and cider to evaluate their authenticity and genuineness. Using the Uniprot_Malus database, 96 proteins were detected in apples, among which 30 proteins were specifically captured via combinatorial peptide ligand libraries. Next, three proteins, previously recognized in...

Read More thumbnail image: Proteomic fingerprinting of apple fruit juice and cider via combinatorial peptide ligand libraries and MS analysis

Ratiometric NOE(−1.6) contrast in brain tumors

Published: Oct 18, 2018

Author(s): Zhongliang Zu

Journal: NMR in Biomedicine

Recently, a new nuclear Overhauser enhancement (NOE)‐mediated saturation transfer effect at around −1.6 ppm from water, termed NOE(−1.6), was reported to show hypointense signals in brain tumors. Similar to chemical exchange saturation transfer or magnetization transfer (MT) effects, which depend on the solute pool concentration, the exchange/coupling rate, the solute transverse relaxation rate, etc., the NOE(−1.6) effect should also...

Read More thumbnail image: Ratiometric NOE1_6 contrast in brain tumors

Preparation and adhesive properties of colored Ti/Zr‐based conversion coating on aluminum foil for lithium battery packaging

Published: Oct 18, 2018

Author(s): Yingying Gu, Songnan Wang, Shiai Xu

Journal: Surface and Interface Analysis

In this study, an aluminum (Al) foil used for lithium ion battery packaging film was treated with titanium (Ti)/zirconium (Zr) solution containing hexafluorotitanic acid and hexafluorozirconic acid using tannic acid as a colorant and metavanadate as an accelerator, respectively, and a golden conversion coating was successfully deposited on the surface of Al foil. The morphology and composition of the coating were characterized by scanning...

Read More thumbnail image: Preparation and adhesive properties of colored TiZrbased conversion coating on aluminum foil for lithium battery packaging

Cocaine adulteration with the anthelminthic tetramisole (levamisole/dexamisole): Long‐term monitoring of its intake by chiral LC–MS/MS analysis of cocaine‐positive hair samples

Published: Oct 17, 2018

Author(s): Milena M. Madry, Thomas Kraemer, Markus R. Baumgartner

Journal: Drug Testing and Analysis

Abstract Recent studies indicate that not only the anthelminthic levamisole but also the racemate tetramisole (R‐/S‐phenyltetraimidazothiazole, PTHIT) was found as an adulterant for cocaine. We herein report on the investigation of the prevalence of PTHIT among cocaine‐positive hair samples and the discrimination of the presence of its stereoisomers levamisole and dexamisole. Cocaine‐positive hair samples were collected in a forensic context in...

Read More thumbnail image: Cocaine adulteration with the anthelminthic tetramisole levamisoledexamisole Longterm monitoring of its intake by chiral LCMSMS analysis of cocainepositive hair samples

Semi‐quantitative determination of designer steroids by high‐performance liquid chromatography with ultraviolet detection in the absence of reference material

Published: Oct 17, 2018

Author(s): Sarah E. Voelker, Lisa M. Lorenz, Jonathan J. Litzau

Journal: Drug Testing and Analysis

Abstract New designer steroids are continually being encountered in dietary supplements that claim to increase muscle mass, but quantitative analysis of such ingredients is challenging due to the availability, quality, or cost of commercial reference materials. Although standard reference material typically becomes available for these emerging compounds, laboratories often face the challenge of finding properly certified materials...

Read More thumbnail image: Semiquantitative determination of designer steroids by highperformance liquid chromatography with ultraviolet detection in the absence of reference material

Identification of the anabolic steroid 6β‐chlorotestosterone in a dietary supplement

Published: Oct 17, 2018

Author(s): Travis M. Falconer, Rick A. Flurer, Mary B. Jones, Lisa M. Lorenz, Sarah E. Voelker

Journal: Drug Testing and Analysis

Abstract Capsules that were labeled to be performance‐enhancing dietary supplements obtained during an investigation were found to contain an unrecognized steroid‐like substance. This compound was isolated by liquid chromatography (LC) fraction collection and characterized using several qualitative analytical techniques, including ultraviolet (UV) spectroscopy, gas chromatography–mass spectrometry (GC–MS), liquid chromatography‐high...

Read More thumbnail image: Identification of the anabolic steroid 6chlorotestosterone in a dietary supplement

Lomerizine, trimetazidine and bis‐(4‐fluorophenyl)‐methylpiperazine in human urine after oral administration of lomerizine dihydrochloride: analysis by liquid chromatography‐high resolution‐tandem mass spectrometry

Published: Oct 17, 2018

Author(s): Masato Okano, Mitsuhiko Sato, Shinji Kageyama

Journal: Drug Testing and Analysis

Abstract In sports drugs testing, the differentiation between the abuse of the prohibited substance trimetazidine and that of the permitted drug lomerizine is required because trimetazidine is one of the metabolites of lomerizine. Therefore, it is important to identify a lomerizine‐specific metabolite in urine that allows making the distinction. In this study, a simple dilute‐and‐shoot method employing liquid chromatography–high...

Read More thumbnail image: Lomerizine trimetazidine and bis4fluorophenylmethylpiperazine in human urine after oral administration of lomerizine dihydrochloride analysis by liquid chromatographyhigh resolutiontandem mass spectrometry

Effects of Centella asiatica extract on antioxidant status and liver metabolome of rotenone‐treated rats using GC–MS

Published: Oct 17, 2018

Author(s): Thidarat Intararuchikul, Narudol Teerapattarakan, Ratchanee Rodsiri, Mayuree Tantisira, Gert Wohlgemuth, Oliver Fiehn, Rossarin Tansawat

Journal: Biomedical Chromatography

Abstract Centella asiatica has been used as a culinary vegetable or medicinal herb. In this study, the hepatoprotective effect of the standardized extract of C. asiatica (ECa233) in rotenone‐treated rats was examined using a GC–MS‐based metabolomic approach. ECa233 contains >80% triterpenoids with a ratio of madecassoside to asiaticoside of 1.5(±0.5):1. Rats were randomly divided into three groups (with six rats/group): sham...

Read More thumbnail image: Effects of Centella asiatica extract on antioxidant status and liver metabolome of rotenonetreated rats using GCMS

Ultra‐performance liquid chromatography tandem mass spectrometry for the rapid, simultaneous analysis of ziprasidone and its impurities

Published: Oct 17, 2018

Author(s): Marija Čarapić, Katarina Nikolic, Bojan Marković, Miloš Petković, Milena Pavlovic, Danica Agbaba

Journal: Biomedical Chromatography

Abstract The separation and characterization of the unknown degradation product of second‐generation antipsychotic drug ziprasidone are essential for defining the genotoxic potential of the compound. The aim of this study was to develop a simple UHPLC method coupled with tandem mass spectrometry (MS/MS) for chemical characterization of an unknown degradant, and the separation and quantification of ziprasidone and its five main...

Read More thumbnail image: Ultraperformance liquid chromatography tandem mass spectrometry for the rapid simultaneous analysis of ziprasidone and its impurities

Establishment and application of a method for screening the therapeutic drugs of ethanol‐induced liver injury based on cellular metabonomics

Published: Oct 17, 2018

Author(s): Linghao Zhang, Lina Zhang, Qingping Hu, Jianteng Wei, Ningli Wang, Duolong Di, Dong Pei, Yewei Liu

Journal: Biomedical Chromatography

Abstract A drug‐screening method to test the capacity of drugs to protect against ethanol‐induced liver injury based on cellular metabonomics was established and applied in this study. It screens for the ability to protect against ethanol‐induced liver injury by considering changes in the cellular metabolites of human normal liver L‐02 cells subjected to ethanol treatment. This method considers cellular metabolites as the main...

Read More thumbnail image: Establishment and application of a method for screening the therapeutic drugs of ethanolinduced liver injury based on cellular metabonomics

Multi‐component profiles through the blood–brain barrier in rat after oral administration of over‐the‐counter drug Keke capsule by ultra‐performance liquid chromatography/quadrupole‐ time‐of‐flight MS E method

Published: Oct 17, 2018

Author(s): Pengfei Xu, Yonggui Song, Bingwei Feng, Qiang Zeng, Baixi Shan, Kuangyi Liu, Dan Su

Journal: Biomedical Chromatography

Abstract Keke capsule as a traditional Chinese medicine formulation is used to relieve cough, for analgesia and to reduce bronchial asthma. The multi‐components are absorbed into the blood and brain after oral administration of Keke capsule, with no systematic investigation so far. A reliable and rapid UPLC–QTOF–MSE combined with a data processing software platform was used to characterize the components of Keke capsule and simultaneously ...

Read More thumbnail image: Multicomponent profiles through the bloodbrain barrier in rat after oral administration of overthecounter drug Keke capsule by ultraperformance liquid chromatographyquadrupole timeofflight MS E method

Residual detection of naproxen, methyltestosterone and 17 α ‐hydroxyprogesterone caproate in aquatic products by simple liquid–liquid extraction method coupled with liquid chromatography–tandem mass spectrometry

Published: Oct 17, 2018

Author(s): Weijia Zheng, Kyung‐Hee Yoo, Jeong‐Min Choi, Da‐Hee Park, Seong‐Kwan Kim, Young‐Sun Kang, A. M. Abd El‐Aty, Ahmet Hacımüftüoğlu, Jing Wang, Jae‐Han Shim, Ho‐Chul Shin

Journal: Biomedical Chromatography

Abstract In the present study, we aimed to develop a reliable screening method based on liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS) for the detection and quantification of naproxen, methyltestosterone and 17α‐hydroxyprogesterone caproate residues. The target analytes were extracted from samples of eel, flatfish and shrimp using acetonitrile with 1% acetic acid, followed by liquid–liquid purification with n‐hexane....

Read More thumbnail image: Residual detection of naproxen methyltestosterone and 17  hydroxyprogesterone caproate in aquatic products by simple liquidliquid extraction method coupled with liquid chromatographytandem mass spectrometry

A new validated HPLC method for the determination of levodopa: Application to study the impact of ketogenic diet on the pharmacokinetics of levodopa in Parkinson's participants

Published: Oct 17, 2018

Author(s): Fawzy Elbarbry, Van Nguyen, Alar Mirka, Heather Zwickey, Richard Rosenbaum

Journal: Biomedical Chromatography

Abstract A simple, accurate, and reproducible HPLC‐UV method has been developed and validated for the quantification of levodopa (l‐Dopa) in human plasma. The method involves a simple protein precipitation procedure to extract both l‐Dopa and methyldopa, the internal standard. The chromatographic analysis was achieved on a Shimadzu LC 20A HPLC system equipped with a Zorbax Eclipse XDB C18 column and an isocratic mobile phase consisting of 20 mm KH2PO4...

Read More thumbnail image: A new validated HPLC method for the determination of levodopa Application to study the impact of ketogenic diet on the pharmacokinetics of levodopa in Parkinsons participants

Application of a micro plasma collection card for the detection of homocysteine by liquid chromatography with tandem mass spectrometry

Published: Oct 17, 2018

Author(s): Xiangmei Yuan, Youli Lu, Can Xiao, Jianmin Zhu, Wei Zhang, Chen Yu, Shuijun Li

Journal: Journal of Separation Science

Abstract Generally, it is recommended that blood samples for homocysteine detection should be centrifuged immediately to separate plasma in order to avoid continuous synthesis by blood cells. The use of a micro plasma collection card may improve sample stability and result accuracy by offering automatic and instant plasma separation. We compare a micro plasma collection method with routine wet plasma to explore applications of the...

Read More thumbnail image: Application of a micro plasma collection card for the detection of homocysteine by liquid chromatography with tandem mass spectrometry

Dielectrophoretic manipulation of nanomaterials: A review

Published: Oct 17, 2018

Author(s): Linbo Liu, Ke Chen, Nan Xiang, Zhonghua Ni

Journal: ELECTROPHORESIS

Abstract Nanomaterials manipulation using dielectrophoresis (DEP) is one of the major research areas that could potentially benefit the micro/nano science for diverse applications, such as microfluidics, nanomachine, and biosensor. The innovation and development of basic theories, methods or applications will have a huge impact on the entire related field. Specifically, for DEP manipulation of nanomaterials, improvements in...

Read More thumbnail image: Dielectrophoretic manipulation of nanomaterials A review

Metabolic profiling of listeria rhombencephalitis in small ruminants by 1 H high‐resolution magic angle spinning NMR spectroscopy

Published: Oct 17, 2018

Author(s): Christina Precht, Gaëlle Diserens, Martina Vermathen, Anna Oevermann, Josiane Lauper, Peter Vermathen

Journal: NMR in Biomedicine

Listeria rhombencephalitis is caused by infection with Listeria monocytogenes and is associated with a high mortality rate in humans and ruminants. Little is known about the metabolic changes associated with neurolisteriosis in particular and infectious central nervous system (CNS) diseases in general. The purpose of our study was to investigate the metabolic changes associated with listeria rhombencephalitis in small ruminants (goats and sheep) as ...

Read More thumbnail image: Metabolic profiling of listeria rhombencephalitis in small ruminants by 1 H highresolution magic angle spinning NMR spectroscopy

Fault detection method based on principal component difference associated with DPCA

Published: Oct 17, 2018

Author(s): Cheng Zhang, Qingxiu Guo, Yuan Li

Journal: Journal of Chemometrics

Abstract Aiming at the fault detection in a dynamic process with nonlinear or multimodal features, a new fault detection strategy based on principal component difference associated with dynamic PCA (Diff‐DPCA) is proposed in this paper. First, augment the training data set using the time lag, and then obtain an augmented training data set. Second, find the K‐nearest neighbor set of each sample in the augmented training set and...

Read More thumbnail image: Fault detection method based on principal component difference associated with DPCA

The mechanism of the preventive effect of Shen’an capsule on the calcium oxalate crystal‐induced early renal injury based on metabolomics

Published: Oct 17, 2018

Author(s): Wei Fan, Jiebin Hou, Weiye Zhu, Shuyue Zhang, Keda Shao, Feiyu Quan, Wei Chen

Journal: Biomedical Chromatography

Abstract Kidney stone disease is a worldwide metabolism‐associated disorder with a high incidence of renal dysfunction. However, effective methods to prevent crystalline nephropathy are still lacking owing to the absence of aetiological research. Shen’an (SA) capsules are prepared from Chinese medicinal compounds and are considered a promising treatment for the prevention of crystal‐induced renal injury. In this study, 24 mice were...

Read More thumbnail image: The mechanism of the preventive effect of Shenan capsule on the calcium oxalate crystalinduced early renal injury based on metabolomics

A general gas‐assisted three‐liquid‐phase extraction method for separation and concentration of puerarin, 3′‐methoxydaidzin, puerarinxyloside, daidzin and daidzein from puerariae extract

Published: Oct 16, 2018

Author(s): Weilun Hu, Qian Shao, Xingjun Xi, Qiao Chu, Tao Lan, Fenfang Che, Yuanyuan Liu, Yanzhen Lu, Yun Wei

Journal: Biomedical Chromatography

Abstract In this work, a general and novel separation technique gas‐assisted three‐liquid‐phase extraction was established and applied in separating and concentrating isoflavonoids from the actual sample of puerariae extract by one step. For the gas‐assisted three‐liquid‐phase extraction method, optimal conditions were selected: polyethylene glycol 2000 and ethyl acetate as the flotation solvent, pH 5, (NH4)2SO4 concentration...

Read More thumbnail image: A general gasassisted threeliquidphase extraction method for separation and concentration of puerarin 3methoxydaidzin puerarinxyloside daidzin and daidzein from puerariae extract
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