EarlyView Articles

Skip to Navigation

The very latest articles from the scientific literature
on Wiley Online Library...


You can keep up-to date on these EarlyView articles, which focus on spectroscopy
and separation science:

Earlyview RSS Feed

rss

Filter by Journal

Browse By Journal

Intraventricular temperature measured by diffusion‐weighted imaging compared with brain parenchymal temperature measured by MRS in vivo

Published: Apr 29, 2016

Author(s): Kaoru Sumida, Noriko Sato, Miho Ota, Koji Sakai, Daichi Sone, Kota Yokoyama, Yukio Kimura, Norihide Maikusa, Etsuko Imabayashi, Hiroshi Matsuda, Akira Kunimatsu, Kuni Ohtomo

Journal: NMR in Biomedicine

We examined and compared the temperatures of the intraventricular cerebrospinal fluid (Tv) and the brain parenchyma (Tp) using MRI, with reference to the tympanic membrane temperature (Tt) in healthy subjects. We estimated Tv and Tp values from data gathered simultaneously by MR diffusion‐weighted imaging (DWI) and MRS, respectively, in 35 healthy volunteers (17 males, 18 females; age 25–78 years). We also obtained Tt values just before each MR examination to...

Read More thumbnail image: Intraventricular temperature measured by diffusionweighted imaging compared with brain parenchymal temperature measured by MRS in vivo

N‐ and O‐linked glycosylation site profiling of the human basic salivary proline‐rich protein 3M

Published: Apr 29, 2016

Author(s): Barbara Manconi, Tiziana Cabras, Monica Sanna, Valentina Piras, Barbara Liori, Elisabetta Pisano, Federica Iavarone, Federica Vincenzoni, Massimo Cordaro, Gavino Faa, Massimo Castagnola, Irene Messana

Journal: Journal of Separation Science

In the present study, we show that the heterogeneous mixture of glycoforms of the basic salivary proline‐rich protein 3M, encoded by PRB3‐M locus, is a major component of the acidic soluble fraction of human whole saliva in the first years of life. Reversed‐phase high‐performance liquid chromatography with high‐resolution electrospray ionization mass spectrometry analysis of the intact proteoforms before and after N‐deglycosylation with...

Read More thumbnail image: N and Olinked glycosylation site profiling of the human basic salivary prolinerich protein 3M

Evaluation of alternative sorbents for dispersive solid‐phase extraction clean‐up in the QuEChERS method for the determination of pesticide residues in rice by liquid chromatography with tandem mass spectrometry

Published: Apr 29, 2016

Author(s): Liziara da C. Cabrera, Sergiane S. Caldas, Osmar D. Prestes, Ednei G. Primel, Renato Zanella

Journal: Journal of Separation Science

Many compounds are used for pest control during the production and storage of rice, making it necessary to employ multiclass methods for pesticide residues determination. For this purpose, QuEChERS‐based methods are very efficient, fast and accurate, and improvements in the clean‐up step are important, especially for complex matrices, like cereals. In this work, different sorbents such as chitosan, florisil®, alumina, diatomaceous earth,...

Read More thumbnail image: Evaluation of alternative sorbents for dispersive solidphase extraction cleanup in the QuEChERS method for the determination of pesticide residues in rice by liquid chromatography with tandem mass spectrometry

Effect of carbon fiber surface functionality on the moisture absorption behavior of carbon fiber/epoxy resin composites

Published: Apr 29, 2016

Author(s): X. Qian, Y. G. Zhang, X. F. Wang, Y. J. Heng, J. H. Zhi

Journal: Surface and Interface Analysis

Polyacrylonitrile (PAN)‐based carbon fibers were electrochemically oxidized in aqueous ammonium bicarbonate with increasing current density. The electrochemical treatment led to significant changes of surface physical properties and chemical structures. The oxidized fibers showed much cleaner surfaces and increased levels of oxygen functionalities. However, it was found that there was no correlation between surface roughness and the...

Read More thumbnail image: Effect of carbon fiber surface functionality on the moisture absorption behavior of carbon fiberepoxy resin composites

Iron oxide nanotube film formed on carbon steel for photoelectrochemical water splitting: effect of annealing temperature

Published: Apr 29, 2016

Author(s): Hongda Deng, Mao‐Chia Huang, Wei‐Heng Weng, Jing‐Chie Lin

Journal: Surface and Interface Analysis

Carbon steels (CSs) were anodized in an ethylene glycol solution containing 3 vol.% H2O and 0.1 m NH4F to coat with nanotube arrays film. The as anodized nanotube arrays film were annealed in argon atmosphere at various temperatures ranging from 250 to 550 °C for 4 h. The morphology and crystal phases of the film developed after annealing processes were examined using field emission scanning electron microscopy, X‐ray diffraction. Morphology...

Read More thumbnail image: Iron oxide nanotube film formed on carbon steel for photoelectrochemical water splitting effect of annealing temperature

LC‐MS/MS analysis of permethylated free oligosaccharides and N‐glycans derived from human, bovine, and goat milk samples

Published: Apr 29, 2016

Author(s): Xue Dong, Shiyue Zhou, Yehia Mechref

Journal: ELECTROPHORESIS

Oligosaccharides in milk not only provide nutrition to the infants but also have significant immune biofunctions such as inhibition of pathogen binding to the host cell. The main component in milk oligosaccharides is free oligosaccharides. Since the proteins in milk are highly glycosylated, N‐glycans in milk also play an import role. In this study, we investigated the permethylated free oligosaccharides and N‐glycans extracted from...

Read More thumbnail image: LCMSMS analysis of permethylated free oligosaccharides and Nglycans derived from human bovine and goat milk samples

Simultaneous dispersive liquid–liquid microextraction based on a low‐density solvent and derivatization followed by gas chromatography for the simultaneous determination of chloroanisoles and the precursor 2,4,6‐trichlorophenol in water samples

Published: Apr 29, 2016

Author(s): Xiuzhi Bai, Ting Zhang, Haipu Li, Zhaoguang Yang

Journal: Journal of Separation Science

Chloroanisoles, particularly 2,4,6‐trichloroanisole, are commonly identified as major taste and odor compounds in water. In the present study, a simple and efficient method was established for the simultaneous determination of chloroanisoles and the precursor 2,4,6‐trichlorophenol in water by using low‐density‐solvent‐based simultaneous dispersive liquid–liquid microextraction and derivatization followed by gas chromatography with...

Read More thumbnail image: Simultaneous dispersive liquidliquid microextraction based on a lowdensity solvent and derivatization followed by gas chromatography for the simultaneous determination of chloroanisoles and the precursor 246trichlorophenol in water samples

Quantitative determination of regorafenib and its two major metabolites in human plasma with high‐performance liquid chromatography and ultraviolet detection

Published: Apr 28, 2016

Author(s): Kazuma Fujita, Masatomo Miura, Hiroyuki Shibata

Journal: Biomedical Chromatography

Abstract A simple, highly sensitive and specific high‐performance liquid chromatography (HPLC) method was developed for the simultaneous quantitation of regorafenib, N‐oxidemetabolite (M‐2) and the desmethyl N‐oxide metabolite (M‐5) in human plasma. Regorafenib, M‐2, M‐5 and the internal standard sorafenib were separated using a mobile phase of 0.5% KH2PO4 (pH 3.5)–acetonitrile (30:70, v/v), on a Capcell PAK MG II column at a flow rate of...

Read More thumbnail image: Quantitative determination of regorafenib and its two major metabolites in human plasma with highperformance liquid chromatography and ultraviolet detection

Compatible stability study of panax notoginseng saponin injection (xueshuantong®) in combination with 47 different injectables

Published: Apr 28, 2016

Author(s): Meng Wang, Huijie Zhang, Ranran Dong, Lejun Tan, Zhidong Liu, Yan Zhu, Xiumei Gao, Xiaoliang Ren

Journal: Biomedical Chromatography

Abstract Panax Notoginseng Saponin (PNS) injection (Xueshuantong®, XST) plays an important role in acute and chronic treatment of cardiovascular disease in China. XST, a freeze‐dried powder injection of PNS, contains ginsenosides, Rg1, Rb1, Re, Rd. and notoginsenoside, R1. Study of the stability of herbal medicine injections is limited. The degradation products may contribute to adverse drug reactions (ADRs). The stability kinetics...

Read More thumbnail image: Compatible stability study of panax notoginseng saponin injection xueshuantong in combination with 47 different injectables

Drug–drug interactions between moxifloxacin and rifampicin based on pharmacokinetics in vivo in rats

Published: Apr 28, 2016

Author(s): Lifei Huang, Jiajun Liu, Xin Yu, Lei Shi, Jian Liu, Heping Xiao, Yi Huang

Journal: Biomedical Chromatography

Abstract Moxifloxacin and rifampicin are all the first‐line options for the treatment of active tuberculosis, which are often combined for the treatment of multidrug resistance pulmonary tuberculosis in clinic. However, the potential drug–drug interactions between moxifloxacin and rifampicin were unknown. The aim of this study was to investigate the drug–drug interactions between moxifloxacin and rifampicin based on their...

Read More thumbnail image: Drugdrug interactions between moxifloxacin and rifampicin based on pharmacokinetics in vivo in rats

Development and validation of a sensitive LC–MS/MS assay for quantification of bruceine D in rat plasma

Published: Apr 28, 2016

Author(s): Yining Zhang, Yong Zhen, Ying Zhang, Shouyue Liu

Journal: Biomedical Chromatography

Abstract A sensitive LC–MS/MS method for the determination of bruceine D in rat plasma was developed. The analyte and IS were separated on a Luna C18 column (2.1 × 50 mm, 1.7 μm) using a mobile phase of acetonitrile and 0.1% formic acid in water (40:60, v/v) at a flow rate of 0.25 mL/min. The selected reaction monitoring mode was chosen to monitor the precursor‐to‐product ion transitions of m/z 409.2 → 373.2 for bruceine D and m/z 469.2 → 229.3...

Read More thumbnail image: Development and validation of a sensitive LCMSMS assay for quantification of bruceine D in rat plasma

Validation of a headspace trap gas chromatography and mass spectrometry method for the quantitative analysis of volatile compounds from degraded rapeseed oil

Published: Apr 28, 2016

Author(s): Lilia Sghaier, Christophe B. Y. Cordella, Douglas N. Rutledge, Mickaël Watiez, Sylvie Breton, Patrick Sassiat, Didier Thiebaut, Jérôme Vial

Journal: Journal of Separation Science

Due to lipid oxidation, off‐flavors, characterized by a fishy odor, are emitted during the heating of rapeseed oil in a fryer and affect the flavor of rapeseed oil even at low concentrations. Thus, there is a need for analytical methods to identify and quantify these products. To study the headspace composition of degraded rapeseed oil, and more specifically the compounds responsible for the fishy odor, a headspace trap gas chromatography...

Read More thumbnail image: Validation of a headspace trap gas chromatography and mass spectrometry method for the quantitative analysis of volatile compounds from degraded rapeseed oil

Quantification and semiquantification of multiple representative components for the holistic quality control of Allii Macrostemonis Bulbus by ultra high performance liquid chromatography with quadrupole time‐of‐flight tandem mass spectrometry

Published: Apr 28, 2016

Author(s): Zifei Qin, Pei Lin, Yi Dai, Zhihong Yao, Li Wang, Xinsheng Yao, Liyin Liu, Haifeng Chen

Journal: Journal of Separation Science

Allii Macrostemonis Bulbus (named Xiebai in China) is a folk medicine with medicinal values for the treatment of thoracic obstruction and cardialgia, and a food additive as well. However, there is even no quantitative standard for Allii Macrostemonis Bulbus recorded in the current edition of the Chinese Pharmacopeia. Hence, simultaneous assay of multiple components is urgent. In this study, chemometric methods were firstly applied to discover the...

Read More thumbnail image: Quantification and semiquantification of multiple representative components for the holistic quality control of Allii Macrostemonis Bulbus by ultra high performance liquid chromatography with quadrupole timeofflight tandem mass spectrometry

Evaluation of magnetic matrix solid‐phase dispersion for the determination of polychlorinated biphenyls in water samples by gas chromatography with electron capture detection

Published: Apr 28, 2016

Author(s): Chun‐peng Diao, Xiaoting Yu, Cong Li, Xiao Yang, Aling Sun, Renmin Liu

Journal: Journal of Separation Science

A vortex‐assisted magnetic matrix solid‐phase dispersion method was proposed for the determination of polychlorinated biphenyls in different matrix water samples by gas chromatography with electron capture detection. Magnetic bamboo charcoal (MBC) was synthesized for the adsorption of polychlorinated biphenyls in water samples. Complete separation of the liquid phase and the solid magnetic bamboo charcoal was easily achieved by using a...

Read More thumbnail image: Evaluation of magnetic matrix solidphase dispersion for the determination of polychlorinated biphenyls in water samples by gas chromatography with electron capture detection

Mixed‐mode chromatography integrated with high‐performance liquid chromatography for protein analysis and separation: Using bovine serum albumin and lysozyme as the model target

Published: Apr 28, 2016

Author(s): Hai‐Feng Xia, Bin‐Bin Don, Meng‐Jie Zheng

Journal: Journal of Separation Science

A type of mixed‐mode chromatography was integrated with high‐performance liquid chromatography for protein analysis and separation. The chromatographic behavior was tested using bovine serum albumin and lysozyme as model proteins. For the mixed‐mode column, the silica beads were activated with γ‐(2,3‐epoxypropoxy)‐propytrimethoxysilane and coupled with 4‐mercaptopyridine as the functional ligand. The effects of pH, salt, and the...

Read More thumbnail image: Mixedmode chromatography integrated with highperformance liquid chromatography for protein analysis and separation Using bovine serum albumin and lysozyme as the model target

Determination of nine volatile N‐nitrosamines in tobacco and smokeless tobacco products by dispersive solid‐phase extraction with gas chromatography and tandem mass spectrometry

Published: Apr 28, 2016

Author(s): Fang Lv, Junwei Guo, Fei Yu, Tingting Zhang, Shimin Zhang, Huapeng Cui, Xianjun Liu, Li Chen, Leiyu Liu, Shaofeng Liu, Fuwei Xie

Journal: Journal of Separation Science

A method was developed for the determination of nine volatile N‐nitrosamines in tobacco and smokeless tobacco products. The targets are N‐nitrosodimethylamine, N‐nitrosopyrrolidine, N‐nitrosopiperidine, N‐nitrosomorpholine, N‐nitrosoethylmethylamine, N‐nitrosodiethylamine, N‐nitrosodipropylamine, N‐nitrosobuylmethylmine, and N‐nitrosodibutylamine. The samples were treated by dispersive solid‐phase extraction using 1 g of primary secondary amine and ...

Read More thumbnail image: Determination of nine volatile Nnitrosamines in tobacco and smokeless tobacco products by dispersive solidphase extraction with gas chromatography and tandem mass spectrometry

Automatic on‐line solid‐phase extraction with ultra‐high performance liquid chromatography and tandem mass spectrometry for the determination of ten antipsychotics in human plasma

Published: Apr 28, 2016

Author(s): Qisheng Zhong, Lingling Shen, Jiaqi Liu, Dianbao Yu, Simin Li, Zhiru Li, Jinting Yao, Taohong Huang, Shin‐ichi Kawano, Yuki Hashi, Ting Zhou

Journal: Journal of Separation Science

An automatic on‐line solid‐phase extraction with ultra‐high performance liquid chromatography and tandem mass spectrometry method was developed for the simultaneous determination of ten antipsychotics in human plasma. The plasma sample after filtration was injected directly into the system without any pretreatment. A Shim‐pack MAYI‐C8 (G) column was used as a solid‐phase extraction column, and all the analytes were separated on a Shim‐pack XR‐ODS III...

Read More thumbnail image: Automatic online solidphase extraction with ultrahigh performance liquid chromatography and tandem mass spectrometry for the determination of ten antipsychotics in human plasma

Rapid screening, identification, and purification of neuraminidase inhibitors from Lithospermum erythrorhizon Sieb.et Zucc. by ultrafiltration with HPLC–ESI‐TOF‐MS combined with semipreparative HPLC

Published: Apr 28, 2016

Author(s): Minmin Zhang, Hengqiang Zhao, Zhiguo Zhao, Huijiao Yan, Ruimin Lv, Li Cui, Jinpeng Yuan, Daijie Wang, Yanling Geng, Daicheng Liu, Xiao Wang

Journal: Journal of Separation Science

We put forward an efficient strategy based on bioassay guidance for the rapid screening, identification, and purification of the neuraminidase inhibitors from traditional Chinese medicines, and apply to the discovery of anti‐influenza components from Lithospermiun erythrorhizon Sieb.et Zucc. Ultrafiltration with high‐performance liquid chromatography and electrospray ionization time‐of‐flight mass spectrometry was employed for the rapid...

Read More thumbnail image: Rapid screening identification and purification of neuraminidase inhibitors from Lithospermum erythrorhizon Sieb_et Zucc_ by ultrafiltration with HPLCESITOFMS combined with semipreparative HPLC

Mechanistic study of the anti‐cancer effect of Gynostemma pentaphyllum saponins in the Apc Min /+ mouse model

Published: Apr 28, 2016

Author(s): William Chi‐Shing Tai, Wing‐Yan Wong, Magnolia Muk‐Lan Lee, Brandon Dow Chan, Cheng Lu, Wen‐Luan Wendy Hsiao

Journal: PROTEOMICS

Gynostemma pentaphyllum saponins (GpS) have been shown to have anti‐cancer activity. However, the underlying mechanisms remain unclear. In this study, we used the ApcMin/+ colorectal cancer (CRC) mouse model to investigate the anti‐cancer effect of GpS and we demonstrated that GpS treatment could significantly reduce the number and size of intestinal polyps in ApcMin/+ mice. In order to identify the potential targets and mechanisms involved, a...

Read More thumbnail image: Mechanistic study of the anticancer effect of Gynostemma pentaphyllum saponins in the Apc Min  mouse model

Speeding up pyrogenicity testing: Identification of suitable cell components and readout parameters for an accelerated monocyte activation test (MAT)

Published: Apr 28, 2016

Author(s): Sandra Stoppelkamp, Noriana Würschum, Katharina Stang, Jasmin Löder, Meltem Avci‐Adali, Leila Toliashvili, Christian Schlensak, Hans Peter Wendel, Stefan Fennrich

Journal: Drug Testing and Analysis

Pyrogen testing represents a crucial safety measure for parental drugs and medical devices, especially in direct contact with blood or liquor. The European Pharmacopoeia regulates these quality control measures for parenterals. Since 2010, the monocyte activation test (MAT) has been an accepted pyrogen test that can be performed with different human monocytic cell sources: whole blood, isolated monocytic cells or monocytic cell lines with...

Read More thumbnail image: Speeding up pyrogenicity testing Identification of suitable cell components and readout parameters for an accelerated monocyte activation test MAT
Page:   1 2 3 4 5 6 Next

Social Links

Share This Links

Bookmark and Share

Microsites

Suppliers Selection
Societies Selection

Banner Ad

Click here to see
all job opportunities

Most Viewed

Copyright Information

Interested in separation science? Visit our sister site separationsNOW.com

Copyright © 2016 John Wiley & Sons, Inc. All Rights Reserved