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Performance characteristics of an ELISA screening assay for urinary synthetic cannabinoids

Published: Aug 28, 2014

Author(s): Eliani Spinelli, Allan J. Barnes, Sheena Young, Marisol S. Castaneto, Thomas M. Martin, Kevin L. Klette, Marilyn A. Huestis

Journal: Drug Testing and Analysis

Synthetic cannabinoids are marketed as legal alternatives to cannabis, as routine urine cannabinoid immunoassays do not detect synthetic cannabinoids. Laboratories are challenged to identify these new designer drugs that are widely available and represent a major public health and safety problem. Immunoassay testing offers rapid separation of presumptive positive and negative specimens, prior to more costly and time‐consuming...

Read More thumbnail image: Performance characteristics of an ELISA screening assay for urinary synthetic cannabinoids

Development and validation of a highly sensitive LC‐MS/MS method for the determination of dexamethasone in nude mice plasma and its application to a pharmacokinetic study

Published: Aug 28, 2014

Author(s): Yin Yuan, Xuan Zhou, Jian Li, Suofu Ye, Xiwei Ji, Liang Li, Tianyan Zhou, Wei Lu

Journal: Biomedical Chromatography

ABSTRACT In the current study, a simple, sensitive and rapid analytical method for the determination of dexamethasone was developed and applied to a pharmacokinetic study in nude mice. Using testosterone as an internal standard, a liquid chromatography–tandem mass spectrometry (LC‐MS/MS) approach after one‐step precipitation with acetonitrile was validated and used to determine the concentrations of dexamethasone in nude mice...

Read More thumbnail image: Development and validation of a highly sensitive LCMSMS method for the determination of dexamethasone in nude mice plasma and its application to a pharmacokinetic study

Determination of proline in human serum by a robust LC‐MS/MS method: application to identification of human metabolites as candidate biomarkers for esophageal cancer early detection and risk stratification

Published: Aug 28, 2014

Author(s): Su Liang, Beatriz Sanchez‐Espiridion, Huan Xie, Jing Ma, Xifeng Wu, Dong Liang

Journal: Biomedical Chromatography

ABSTRACT Altered serum proline levels are related to cancer metabolism. This study developed and validated a LC‐MS/MS method to analyze proline in human serum. Surrogate blank serum, coupled with stable isotope L‐proline‐13C5,15 N as internal standard, was used for generating standard curves ranging from 2.5 to 100 μg/mL. Proline was extracted from serum samples using methanol. A Phenomenex Lux 5u Cellulose‐1 column (250 × 4.6 mm) was used for...

Read More thumbnail image: Determination of proline in human serum by a robust LCMSMS method application to identification of human metabolites as candidate biomarkers for esophageal cancer early detection and risk stratification

Quantitative determination of metformin, glyburide and its metabolites in plasma and urine of pregnant patients by LC‐MS/MS

Published: Aug 27, 2014

Author(s): Xing Zhang, Xiaoming Wang, Daria I. Vernikovskaya, Valentina M. Fokina, Tatiana N. Nanovskaya, Gary D. V. Hankins, Mahmoud S. Ahmed

Journal: Biomedical Chromatography

ABSTRACT This report describes the development and validation of an LC‐MS/MS method for the quantitative determination of glyburide (GLB), its five metabolites (M1, M2a, M2b, M3 and M4) and metformin (MET) in plasma and urine of pregnant patients under treatment with a combination of the two medications. The extraction recovery of the analytes from plasma samples was 87–99%, and that from urine samples was 85–95%. The differences in...

Read More thumbnail image: Quantitative determination of metformin glyburide and its metabolites in plasma and urine of pregnant patients by LCMSMS

Simultaneous determination of caffeic acid and its major pharmacologically active metabolites in rat plasma by LC‐MS/MS and its application in pharmacokinetic study

Published: Aug 27, 2014

Author(s): Xiangyang Wang, Wei Li, Xiaohui Ma, Yang Chu, Shuming Li, Jiahua Guo, Yumeng Jia, Shuiping Zhou, Yonghong Zhu, Changxiao Liu

Journal: Biomedical Chromatography

ABSTRACT A simple, sensitive and selective high‐performance liquid chromatography electrospray ionization tandem mass spectrometry (LC‐MS/MS) method was developed for simultaneous determination and pharmacokinetic study of caffeic acid (CA) and its active metabolites. The separation with isocratic elution used a mobile phase composed of methanol and water (containing 0.1% formic acid) at a flow rate of 0.2 mL/min. The detection of...

Read More thumbnail image: Simultaneous determination of caffeic acid and its major pharmacologically active metabolites in rat plasma by LCMSMS and its application in pharmacokinetic study

Early 20th C Russian painting? Raman identification of modern pigments on a pastel supposedly Painted by the renowned artist Natalia Goncharova

Published: Aug 27, 2014

Author(s): Tracey D. Chaplin, Robin J. H. Clark, Brian W. Singer

Journal: Journal of Raman Spectroscopy

A pastel painting considered to have been painted by renowned Russian artist Natalia Goncharova in c. 1913 has been shown by Raman microscopy of the pigments to have been painted after 1952, with the identification of dioxazine violet. The implications of this discovery are discussed. This result highlights the need for reliable and perceptive dating procedures for valuation purposes. Copyright © 2014 John Wiley & Sons, Ltd. ...

Read More thumbnail image: Early 20th C Russian painting Raman identification of modern pigments on a pastel supposedly Painted by the renowned artist Natalia Goncharova

Simultaneous determination and pharmacokinetic study of gambogic acid and gambogenic acid in rat plasma after oral administration of Garcinia hanburyi extracts by LC‐MS/MS

Published: Aug 26, 2014

Author(s): Xiangdong Hua, Chuang Liang, Lei Dong, Xiaotong Qu, Tong Zhao

Journal: Biomedical Chromatography

ABSTRACT Gambogic acid and gambogenic acid are two major bioactive components of Garcinia hanburyi, and play a pivotal role in biologic activity. In this study, a specific and sensitive liquid chromatography–tandem mass spectrometry was developed and validated for simultaneous determination of gambogic acid and gambogenic acid in rat plasma. Chromatographic separation was achieved on a C18 column using an isocratic elution with methanol–10 mm...

Read More thumbnail image: Simultaneous determination and pharmacokinetic study of gambogic acid and gambogenic acid in rat plasma after oral administration of Garcinia hanburyi extracts by LCMSMS

Determination of fexofenadine in Hank's balanced salt solution by high‐performance liquid chromatography with ultraviolet detection: application to Caco‐2 cell permeability studies

Published: Aug 26, 2014

Author(s): Marco Antônio dos. Reis Júnior, Ana Cláudia Miranda Faria, Eudes da. Silva Velozo, Teresa Dalla Costa, Frank Pereira Andrade, Whocely Victor Castro

Journal: Biomedical Chromatography

ABSTRACT The drug‐transporting proteins can affect the pharmacokinetics and pharmacodymanics of many drugs, resulting in an erratic and unpredictable pharmacological response. The Caco‐2 monolayer is routinely applied to investigate the carrier‐mediated transport of drugs. Therefore, the selection of a marker compound able to characterize the activity of such transporters is crucial. Fexofenadine (FEX), a P‐gp/OATP substrate, can be...

Read More thumbnail image: Determination of fexofenadine in Hanks balanced salt solution by highperformance liquid chromatography with ultraviolet detection application to Caco2 cell permeability studies

Correlation of structure and spin–phonon coupling in (La, Nd) doped BiFeO 3 films

Published: Aug 25, 2014

Author(s): Anju Ahlawat, S. Satapathy, Satish Maan, V. G. Sathe, P. K. Gupta

Journal: Journal of Raman Spectroscopy

We studied the effect of structural change on the spin–phonon coupling in doped BiFeO3 (BFO) films (Bi0.8La0.1Nd0.1FeO3) grown on SrTiO3 (001) substrate. The temperature‐dependent Raman studies show phonon anomalies in the vicinity of magnetic ordering temperature TN owing to the spin–phonon coupling. Doped films exhibit strong anomalies in the line widths of Raman bands around TN revealing the presence of strong spin–lattice coupling. The modification in...

Read More thumbnail image: Correlation of structure and spinphonon coupling in La Nd doped BiFeO 3 films

Label‐free optical detection of type II diabetes based on surface‐enhanced Raman spectroscopy and multivariate analysis

Published: Aug 25, 2014

Author(s): Jinyong Lin, Zufang Huang, Shangyuan Feng, Juqiang Lin, Nenrong Liu, Jing Wang, Ling Li, Yongyi Zeng, Buhong Li, Haishan Zeng, Rong Chen

Journal: Journal of Raman Spectroscopy

Surface‐enhanced Raman scattering (SERS) spectroscopy was first employed to detect oxyhemoglobin (OxyHb, the common type of hemoglobin) variation in type II diabetic development without using exogenous reagents. Using silver nanoparticles as SERS‐active substrate, high‐quality SERS spectra are obtained from blood OxyHb samples of 49 diabetic patients and 40 healthy volunteers. Tentative assignment of the observed SERS bands indicates...

Read More thumbnail image: Labelfree optical detection of type II diabetes based on surfaceenhanced Raman spectroscopy and multivariate analysis

Abnormal Raman spectra in Er‐doped BaTiO 3 ceramics

Published: Aug 25, 2014

Author(s): Da‐Yong Lu, Wei Cheng, Xiu‐Yun Sun, Qiao‐Li Liu, De‐Xu Li, Zhong‐Yu Li

Journal: Journal of Raman Spectroscopy

Greatly enhanced and abnormal Raman spectra were discovered in the nominal (Ba1 − xErx)Ti1 − x/4O3 (x = 0.01) (BET) ceramic for the first time and investigated in relation to the site occupations of Er3+ ions. BaTiO3 doped with Ti‐site Er3+ mainly exhibited the common Raman phonon modes of the tetragonal BaTiO3. Er3+ ions substituted for Ba sites are responsible for the abnormal Raman spectra, but the formation of Er ...

Read More thumbnail image: Abnormal Raman spectra in Erdoped BaTiO 3 ceramics

Ar cluster ion beam sputtering of InSb investigated by ToF‐SIMS

Published: Aug 25, 2014

Author(s): Toyomitsu Miyasaka, Takeshi Yamauchi, Takaharu Nagatomi, Teiichiro Kono

Journal: Surface and Interface Analysis

Ar gas cluster ion beam (GCIB) sputtering of InSb was investigated, and the sputtering rate and depth resolution of time‐of‐flight secondary ion mass spectrometry sputter depth profiling were examined. The practical sputtering rate for InSb using 20 keV Ar2500+ irradiation was confirmed at the incident angles of 0°, 40°, and 60°, and the sputtering rate was too low to perform sputtering at 80°. The preferential sputtering and surface...

Read More thumbnail image: Ar cluster ion beam sputtering of InSb investigated by ToFSIMS

Combined SIMS and AFM study of complex structures of streamers on metallic multilayers

Published: Aug 25, 2014

Author(s): J.‐N. Audinot, A. Hamdan, P. Grysan, Y. Fleming, C. Noel, F. Kosior, G. Henrion, T. Belmonte

Journal: Surface and Interface Analysis

The discharge between a platinum electrode and different metallic monolayers on a silicon substrate produced sub‐micrometric structures. The scanning electron microscope images showed the formation of craters with cones, holes, corona, and other exotic structures. The atomic force microscopy images allowed evaluating the depth and height of these complex structures together with the chemical information as determined by NanoSIMS imaging....

Read More thumbnail image: Combined SIMS and AFM study of complex structures of streamers on metallic multilayers

Reusable thin film photocatalyst of Fe‐doped TiO 2 deposited by ECR plasma

Published: Aug 25, 2014

Author(s): Avinash S. Bansode, Supriya More, S. V. Bhoraskar, V. L. Mathe

Journal: Surface and Interface Analysis

The paper presents an improved method of depositing nanocrystalline thin films of Fe‐doped TiO2 to be used as a reusable cyclic photocatalyst for degrading the organic pollutants. The technique of electron cyclotron resonance plasma‐enhanced chemical vapor deposition was employed with titanium tetra‐isopropoxide (C12H28O4Ti) and ferrocene (C10H10Fe) as precursors of Ti and Fe, respectively. Optical emission spectroscopy was used to identify the reactive species,...

Read More thumbnail image: Reusable thin film photocatalyst of Fedoped TiO 2 deposited by ECR plasma

Anatomical, functional and metabolic imaging of radiation‐induced lung injury using hyperpolarized MRI

Published: Aug 25, 2014

Author(s): Giles Santyr, Matthew Fox, Kundan Thind, Elaine Hegarty, Alexei Ouriadov, Michael Jensen, Timothy J. Scholl, Jacob Van Dyk, Eugene Wong

Journal: NMR in Biomedicine

MRI of hyperpolarized 129Xe gas and 13C‐enriched substrates (e.g. pyruvate) presents an unprecedented opportunity to map anatomical, functional and metabolic changes associated with lung injury. In particular, inhaled hyperpolarized 129Xe gas is exquisitely sensitive to changes in alveolar microanatomy and function accompanying lung inflammation through decreases in the apparent diffusion coefficient (ADC) of alveolar gas and increases in the...

Read More thumbnail image: Anatomical functional and metabolic imaging of radiationinduced lung injury using hyperpolarized MRI

Apparent rate constant mapping using hyperpolarized [1– 13 C]pyruvate

Published: Aug 25, 2014

Author(s): O. Khegai, R. F. Schulte, M. A. Janich, M. I. Menzel, E. Farrell, A. M. Otto, J. H. Ardenkjaer‐Larsen, S. J. Glaser, A. Haase, M. Schwaiger, F. Wiesinger

Journal: NMR in Biomedicine

Hyperpolarization of [1‐13C]pyruvate in solution allows real‐time measurement of uptake and metabolism using MR spectroscopic methods. After injection and perfusion, pyruvate is taken up by the cells and enzymatically metabolized into downstream metabolites such as lactate, alanine, and bicarbonate. In this work, we present comprehensive methods for the quantification and interpretation of hyperpolarized 13C metabolite signals. First, a...

Read More thumbnail image: Apparent rate constant mapping using hyperpolarized 1 13 Cpyruvate

Increased sensitivity of 31 P MRSI using direct detection integrated with multi‐echo polarization transfer (DIMEPT)

Published: Aug 22, 2014

Author(s): W. J. M. Kemp, V. O. Boer, P. R. Luijten, D. W. J. Klomp

Journal: NMR in Biomedicine

Here, we show that the sensitivity of 31P MRSI of 31P spins J‐coupled to protons can be increased by almost a factor of three when compared with an optimal direct detection free induction decay. By direct detection integrated with multi‐echo polarization transfer (DIMEPT), multiple signals from polarization transfer and direct detection can be acquired in one repetition time, with minimal mutual interference, provided that the number of ...

Read More thumbnail image: Increased sensitivity of 31 P MRSI using direct detection integrated with multiecho polarization transfer DIMEPT

Rapid PCR protocols for forensic DNA typing on six thermal cycling platforms

Published: Aug 22, 2014

Author(s): Erica L. R. Butts, Peter M. Vallone

Journal: ELECTROPHORESIS

Rapid PCR protocols for the amplification of typing STR multiplexes were evaluated on six different thermal cyclers. Through the use of a faster DNA polymerase coupled with the use of rapid thermal cyclers the amplification cycling times were reduced down to as little as 14 min using PCR primers from the commercially available multiplex STR typing kit Identifiler. Previously described two‐step and three‐step thermal cycling protocols were...

Read More thumbnail image: Rapid PCR protocols for forensic DNA typing on six thermal cycling platforms

Assessment of lung function in asthma and COPD using hyperpolarized 129 Xe chemical shift saturation recovery spectroscopy and dissolved‐phase MRI

Published: Aug 22, 2014

Author(s): Kun Qing, John P. Mugler, Talissa A. Altes, Yun Jiang, Jaime F. Mata, G. Wilson Miller, Iulian C. Ruset, F. William Hersman, Kai Ruppert

Journal: NMR in Biomedicine

Magnetic‐resonance spectroscopy and imaging using hyperpolarized xenon‐129 show great potential for evaluation of the most important function of the human lung ‐‐ gas exchange. In particular, chemical shift saturation recovery (CSSR) xenon‐129 spectroscopy provides important physiological information for the lung as a whole by characterizing the dynamic process of gas exchange, while dissolved‐phase (DP) xenon‐129 imaging captures the...

Read More thumbnail image: Assessment of lung function in asthma and COPD using hyperpolarized 129 Xe chemical shift saturation recovery spectroscopy and dissolvedphase MRI

Enantiomeric separation by microchip electrophoresis using bovine serum albumin conjugated magnetic core‐shell Fe 3 O 4 @Au nanocomposites as stationary phase

Published: Aug 22, 2014

Author(s): Ru‐Ping Liang, Xiao‐Ni Wang, Li Wang, Jian‐Ding Qiu

Journal: ELECTROPHORESIS

In this work, a novel enantioselective MCE was developed employing BSA‐conjugated Fe3O4@Au nanoparticles (Fe3O4@Au NPs) as stationary phase. Fe3O4@Au NPs with high magnetic responsively, excellent solubility, and high dispersibility in water were prepared through a sonochemical synthesis strategy. BSA was then immobilized onto the Fe3O4@Au NPs surfaces through the well‐developed interaction between Au NPs and amine groups of BSA to form Fe3O4@Au NPs‐BSA...

Read More thumbnail image: Enantiomeric separation by microchip electrophoresis using bovine serum albumin conjugated magnetic coreshell Fe 3 O 4 Au nanocomposites as stationary phase
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