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Characterization of forsythoside A metabolites in rats by a combination of UHPLC‐LTQ‐Orbitrap mass spectrometer with multiple data processing techniques

Published: Jan 23, 2018

Author(s): Fei Wang, Guang‐shang Cao, Yun Li, Lu‐lu Xu, Zhi‐bin Wang, Ying Liu, Jian‐qiu Lu, Jia‐yu Zhang

Journal: Biomedical Chromatography

Abstract Forsythoside A (FTA), the main active constituent isolated from Fructus Forsythiae, has various biological functions including anti‐oxidant, anti‐viral and anti‐microbial activities. However, while research on FTA has been mainly focused on the treatment of diseases on a material basis, FTA metabolites in vivo have not been comprehensively evaluated. Here, a rapid and sensitive method using a UHPLC‐LTQ‐Orbitrap mass spectrometer ...

Read More thumbnail image: Characterization of forsythoside A metabolites in rats by a combination of UHPLCLTQOrbitrap mass spectrometer with multiple data processing techniques

UPLC‐MS/MS based diagnostics for epithelial ovarian cancer using fully sialylated C4‐binding protein

Published: Jan 23, 2018

Author(s): Kazuhiro Tanabe, Koji Matsuo, Masaki Miyazawa, Masaru Hayashi, Masae Ikeda, Masako Shida, Takeshi Hirasawa, Ryuichiro Sho, Mikio Mikami

Journal: Biomedical Chromatography

Abstract Serum levels of fully sialylated C4‐binding protein (FS‐C4BP) are remarkably elevated in patients with epithelial ovarian cancer (EOC) and can be used as a marker to distinguish ovarian clear cell carcinoma from endometrioma. This study aimed to develop a stable, robust and reliable liquid chromatography–hybrid mass spectrometry (UPLC‐MS/MS) based diagnostic method that would generalize FS‐C4BP as a clinical EOC biomarker....

Read More thumbnail image: UPLCMSMS based diagnostics for epithelial ovarian cancer using fully sialylated C4binding protein

Interpreting technical evidence from spectral imaging of paintings by Édouard Manet in the Courtauld Gallery

Published: Jan 23, 2018

Author(s): Silvia Rita Amato, Aviva Burnstock, Maureen Cross, Koen Janssens, Francesca Rosi, Laura Cartechini, Raffaella Fontana, Alice Dal Fovo, Marco Paolantoni, Chiara Grazia, Aldo Romani, Anne Michelin, Christine Andraud, Aurélie Tournié, Joris Dik

Journal: X-Ray Spectrometry

The paintings by Édouard Manet in The Courtauld Gallery Déjeuner sur l'herbe (1863–68), Marguerite de Conflans en Toilette de Bal (1870–1880), Banks of the Seine at Argenteuil (1874), and A Bar at the Folies–Bergère (1882) were investigated for the first time using a range of non‐invasive in situ analyses. The aims of the study were to investigate the painting techniques and materials used for this group of works and to critically ...

Read More thumbnail image: Interpreting technical evidence from spectral imaging of paintings by Edouard Manet in the Courtauld Gallery

MA‐XRF investigation of the Altenberg Retable from 1330

Published: Jan 22, 2018

Author(s): P. Hoffmann, S. Flege, W. Ensinger, F. Wolf, C. Weber, S. Seeberg, J. Sander, J. Schultz, C. Krekel, R. Tagle, A. Wittkopp

Journal: X-Ray Spectrometry

The Altenberg Retable is one of the most important works of German art from the early 14th century. Composed of a shrine, a Madonna figure, and painted wings, it once adorned the high altar of the convent church in Altenberg/Lahn. The side and rear walls of the shrine were overpainted in 1609. Although conventional methods such as infrared reflectography and X‐ray radiography could not reveal the underlying medieval paint layer, we...

Read More thumbnail image: MAXRF investigation of the Altenberg Retable from 1330

A DFT study of H2O dissociation on metal‐precovered Fe (100) surface

Published: Jan 22, 2018

Author(s): Chuan‐Hui Zhang, Bao Chen, Dong‐Bai Sun

Journal: Surface and Interface Analysis

The H2O adsorption and dissociation on the Fe (100) surface with different precovered metals are studied by density functional theory. On both kinds of metal‐precovered surface, H2O molecules prefer adsorb on hollow sites than bridge and top sites. The impurity energy difference is proportional to the adsorption energy, but the adsorbates are not sensitive to the adsorption orientation and height relative to the surface. The Hirshfeld...

Read More thumbnail image: A DFT study of H2O dissociation on metalprecovered Fe 100 surface

Surface mass spectrometry as a new approach for the characterisation of coffee

Published: Jan 22, 2018

Author(s): Gustavo F. Trindade, Lucio L. F. S. Rosa, Elis M. Stori, Carla E. L. Dos Santos, John F. Watts

Journal: Surface and Interface Analysis

Coffee is the most widely traded tropical agricultural commodity in the world with global production for 2016 of over 151 million 60‐kg bags, according to the International Coffee Organization. Such popularity and its chemical complexity demand the development of analytical chemistry methodologies for the characterisation of different coffee compounds. This paper proposes the use of time‐of‐flight secondary ion mass spectrometry...

Read More thumbnail image: Surface mass spectrometry as a new approach for the characterisation of coffee

An investigation into drug partitioning behaviour in simulated pulmonary surfactant monolayers with associated molecular modelling

Published: Jan 22, 2018

Author(s): Michael J. Davies, Andrew G. Leach, Fatima Riley

Journal: Surface and Interface Analysis

Drug delivery to the body via the inhaled route is dependent upon patient status, device use, and respirable formulation characteristics. Further to inhalation, drug‐containing particles interact and dissolve within pulmonary fluid leading to the desired pharmacological response. Pulmonary surfactant stabilises the alveolar air‐liquid interface and permits optimal respiratory mechanics. This material represents the initial contacting...

Read More thumbnail image: An investigation into drug partitioning behaviour in simulated pulmonary surfactant monolayers with associated molecular modelling

Trimethyl borate‐treated polytetrafluoroethylene micropowders with improved hydrophilic and adhesive properties based on coordination bond theory

Published: Jan 22, 2018

Author(s): XiaoYun Long, LiFen He, Yan Zhang, Mingqiao Ge

Journal: Surface and Interface Analysis

Based on coordination bond theory, the current study proposes a novel method to modify the surface of the polytetrafluoroethylene (PTFE) micropowders. The samples were treated with trimethyl borate in the n‐hexane solution, and this improves the hydrophilic and adhesive properties of PTFE micropowders. The surface properties of treated samples were evaluated by using X‐ray photoelectron spectrometry, contact angle measurement, settling...

Read More thumbnail image: Trimethyl boratetreated polytetrafluoroethylene micropowders with improved hydrophilic and adhesive properties based on coordination bond theory

Validation of a chiral LC‐MS/MS‐ESI method for the simultaneous quantification of darolutamide diastereomers in mouse plasma and its application to a stereoselective pharmacokinetic study in mice

Published: Jan 22, 2018

Author(s): Narayanan Balaji, Suresh P. Sulochana, Neeraj Kumar Saini, Siva Kumar A, Ramesh Mullangi

Journal: Biomedical Chromatography

Abstract A simple, selective and reliable LC‐MS/MS method was validated for simultaneous quantitation of darolutamide diastereomers in 50 μL mouse plasma using warfarin as an internal standard (IS) as per regulatory guidelines. Plasma samples were extracted by liquid–liquid extraction and the chromatographic separation was achieved on a Chiralpak IA column with an isocratic mobile phase 5 mm ammonium acetate–absolute alcohol (20:80,...

Read More thumbnail image: Validation of a chiral LCMSMSESI method for the simultaneous quantification of darolutamide diastereomers in mouse plasma and its application to a stereoselective pharmacokinetic study in mice

New approach for determination of the degradation products of fenspiride hydrochloride found in oral liquid formulations

Published: Jan 22, 2018

Author(s): Bogdan I. Cioroiu, Ioana C. Caba, Irina Prisăcaru, Mona E. Cioroiu, Mihai I. Lazar, Marius Niculaua

Journal: Biomedical Chromatography

Abstract Fenspiride hydrochloride (FNS) is used in treating chronic inflammatory diseases, most commonly as a liquid oral solution. FNS produces degradation products along with fenspiride N‐oxide (FNO) and 1‐phenylethyl‐4‐hydroxy‐4‐aminomethyl piperidine hydrochloride (PHAP). We aimed to develop and validate a chromatographic method in order to identify the main degradation products in the presence of other compounds from a liquid ...

Read More thumbnail image: New approach for determination of the degradation products of fenspiride hydrochloride found in oral liquid formulations

A rapid, maskless 3D prototyping for fabrication of capillary circuits: Toward urinary protein detection

Published: Jan 22, 2018

Author(s): Sheng Yan, Yuanqing Zhu, Shi‐Yang Tang, Yuxing Li, Qianbin Zhao, Dan Yuan, Guolin Yun, Jun Zhang, Shiwu Zhang, Weihua Li

Journal: ELECTROPHORESIS

Abstract Proteinuria is an established risk marker for progressive renal function loss and patients would significantly benefit from a point‐of‐care testing. Although extensive work has been done to develop the microfluidic devices for the detection of urinary protein, they need the complicated operation and bulky peripherals. Here, we present a rapid, maskless 3D prototyping for fabrication of capillary fluidic circuits using laser...

Read More thumbnail image: A rapid maskless 3D prototyping for fabrication of capillary circuits Toward urinary protein detection

Study of isomeric pentacyclic triterpene acids in traditional Chinese medicine of Forsythiae Fructus and their binding constants with β‐cyclodextrin by capillary electrophoresis

Published: Jan 22, 2018

Author(s): Tingjun Ren, Zhongqi Xu

Journal: ELECTROPHORESIS

Abstract In this study, a capillary zone electrophoresis (CZE) method was first developed to identify three microconstituents of isomeric pentacyclic triterpene acids (PTAs including oleanolic acid (OA), ursolic acid (UA) and betulinic acid (BA)) in Forsythiae Fructus (FF). The baseline separation of PTAs by CZE were eventually achieved in a background electrolyte (BGE) containing 50.0 mmol/L borax and 0.5 mmol/L β‐cyclodextrin (β‐CD)...

Read More thumbnail image: Study of isomeric pentacyclic triterpene acids in traditional Chinese medicine of Forsythiae Fructus and their binding constants with cyclodextrin by capillary electrophoresis

Electrophoretic large volume sample stacking for sensitive determination of the anti‐microbial agent pentamidine in rat plasma for pharmacological studies

Published: Jan 22, 2018

Author(s): Petr Tůma, Petr Heneberg, Šimon Vaculín, Dušan Koval

Journal: ELECTROPHORESIS

Abstract A sensitive capillary electrophoretic method with on‐line sample preconcentration by large volume sample stacking has been developed for determination of the anti‐microbial agent pentamidine. The separation is performed in a fused silica capillary coated with covalently bound hydroxypropyl cellulose, with an internal diameter of 50 μm and length of 31.5 cm; the background electrolyte was 100 mM acetic...

Read More thumbnail image: Electrophoretic large volume sample stacking for sensitive determination of the antimicrobial agent pentamidine in rat plasma for pharmacological studies

Enhanced cell trapping throughput using DC‐biased AC electric field in a dielectrophoresis‐based fluidic device with densely packed silica beads

Published: Jan 22, 2018

Author(s): Nuttawut Lewpiriyawong, Guolin Xu, Chun Yang

Journal: ELECTROPHORESIS

Abstract This paper presents the use of DC‐biased AC electric field for enhancing cell trapping throughput in an insulator‐based dielectrophoretic (iDEP) fluidic device with densely packed silica beads. Cell suspension is carried through the iDEP device by a pressure‐driven flow. Under an applied DC‐biased AC electric field, DEP trapping force is produced as a result of non‐uniform electric field induced by the gap of electrically...

Read More thumbnail image: Enhanced cell trapping throughput using DCbiased AC electric field in a dielectrophoresisbased fluidic device with densely packed silica beads

Optimization of pressurized liquid extraction by response surface methodology of Goji berry ( Lycium barbarum L .) phenolic bioactive compounds

Published: Jan 22, 2018

Author(s): Giusy Tripodo, Elena Ibáñez, Alejandro Cifuentes, Bienvenida Gilbert‐López, Chiara Fanali

Journal: ELECTROPHORESIS

Abstract Pressurized liquid extraction (PLE) has been used for the first time in this work to extract phenolic compounds from Goji berries according to a multilevel factorial design using response surface methodology. The global yield (% w/dw, weight/dry‐weight), total phenolic content (TPC), total flavonoid (TF) and antioxidant activity (determined via ABTS assay, expressed as TEAC value) were used as response variables to study...

Read More thumbnail image: Optimization of pressurized liquid extraction by response surface methodology of Goji berry  Lycium barbarum L _ phenolic bioactive compounds

What is the best ethanol‐water ratio for the extraction of antioxidants from rosemary? Impact of the solvent on yield, composition, and activity of the extracts

Published: Jan 22, 2018

Author(s): Magali Jacotet‐Navarro, Mickaël Laguerre, Anne‐Sylvie Fabiano‐Tixier, Mathieu Tenon, Nicolas Feuillère, Antoine Bily, Farid Chemat

Journal: ELECTROPHORESIS

Abstract Extracts rich in antioxidants, such as rosemary extracts, are currently obtained by extraction of the plant material using hydro‐alcoholic mixtures with high ethanol content. As this ratio is generally chosen by default and scarcely optimized, we intended to investigate the impact of the hydro‐alcoholic composition on extract characteristics such as extraction yield, composition profile in selected compounds, and...

Read More thumbnail image: What is the best ethanolwater ratio for the extraction of antioxidants from rosemary Impact of the solvent on yield composition and activity of the extracts

On the properties of residual dipolar coupling alignment tensors: Simulations illuminate how residual dipolar couplings depend on the relative orientations of the magnetic field, the director of the alignment phase and the bond vectors

Published: Jan 22, 2018

Author(s): Chris P. Lepper, Martin A.K. Williams, Patrick J.B. Edwards

Journal: Concepts in Magnetic Resonance Part A

Abstract The measurement of residual dipolar couplings (RDCs) exhibited by samples prepared in suitable alignment media can help in the elucidation of macromolecular structures. For any dipolar interactions that are not averaged to zero by molecular reorientations RDCs provide information about the possible orientations of the averaged interactions to the magnetic field. As such they contain information about the permitted relative...

Read More thumbnail image: On the properties of residual dipolar coupling alignment tensors Simulations illuminate how residual dipolar couplings depend on the relative orientations of the magnetic field the director of the alignment phase and the bond vectors

An improved design to capture magnetic microparticles for capillary electrophoresis based immobilized microenzyme reactors

Published: Jan 19, 2018

Author(s): Pranov Ramana, Jan Schejbal, Kristof Houthoofd, Johan Martens, Erwin Adams, Patrick Augustijns, Zdenĕk Glatz, Ann Schepdael

Journal: ELECTROPHORESIS

Abstract In this paper, we demonstrate the effectiveness of a new 3D printed magnet holder that enables capture of magnetic microparticles in commercially available capillary electrophoresis equipment with a liquid or air based coolant system. The design as well as the method to capture magnetic microparticles inside the capillary are discussed. This setup was tested at temperature and pH values suitable for performing enzymatic...

Read More thumbnail image: An improved design to capture magnetic microparticles for capillary electrophoresis based immobilized microenzyme reactors

An improved design to capture magnetic microparticles for capillary electrophoresis based immobilized microenzyme reactors

Published: Jan 19, 2018

Author(s): Pranov Ramana, Jan Schejbal, Kristof Houthoofd, Johan Martens, Erwin Adams, Patrick Augustijns, Zdenĕk Glatz, Ann Schepdael

Journal: ELECTROPHORESIS

Abstract In this paper, we demonstrate the effectiveness of a new 3D printed magnet holder that enables capture of magnetic microparticles in commercially available capillary electrophoresis equipment with a liquid or air based coolant system. The design as well as the method to capture magnetic microparticles inside the capillary are discussed. This setup was tested at temperature and pH values suitable for performing enzymatic...

Read More thumbnail image: An improved design to capture magnetic microparticles for capillary electrophoresis based immobilized microenzyme reactors

Synthesis of boronate‐functionalized organic‐inorganic hybrid monolithic column for the separation of cis‐diol containing compounds at low pH

Published: Jan 19, 2018

Author(s): Heqing Zhao, Haixia Lyu, Wenfei Qin, Zenghong Xie

Journal: ELECTROPHORESIS

Abstract In this work, an organic‐inorganic hybrid boronate affinity monolithic column was prepared via “one‐pot” process using 4‐vinylphenylboronic acid as organic monomer and divinylbenzene as cross‐linker. The effects of reaction temperature, solvents and composition of organic monomers on the column properties (e.g. morphology, permeability, and mechanical stability) were investigated. A series of test compounds including small...

Read More thumbnail image: Synthesis of boronatefunctionalized organicinorganic hybrid monolithic column for the separation of cisdiol containing compounds at low pH
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