EarlyView Articles
The very latest articles from the scientific literature
on Wiley Online Library...
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Over‐discretized SENSE reconstruction and B 0 correction for accelerated non‐lipid‐suppressed 1 H FID MRSI of the human brain at 9.4 T
Published: Oct 18, 2018
Author(s): Sahar Nassirpour, Paul Chang, Thomas Kirchner, Anke Henning
Journal: NMR in Biomedicine
The aim of this work was to use post‐processing methods to improve the data quality of metabolite maps acquired on the human brain at 9.4 T with accelerated acquisition schemes. This was accomplished by combining an improved sensitivity encoding (SENSE) reconstruction with a B0 correction of spatially over‐discretized magnetic resonance spectroscopic imaging (MRSI) data. Since MRSI scans suffer from long scan...
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Proteomic fingerprinting of apple fruit, juice, and cider via combinatorial peptide ligand libraries and MS analysis
Published: Oct 18, 2018
Author(s): María Jesús Lerma‐García, Maria Nicoletti, Ernesto Francisco Simó‐Alfonso, Pier Giorgio Righetti, Elisa Fasoli
Journal: ELECTROPHORESIS
Abstract Combinatorial peptide ligand libraries coupled to MS was applied to extensively map the proteome of apple fruit, and to detect its presence in commercial apple juice and cider to evaluate their authenticity and genuineness. Using the Uniprot_Malus database, 96 proteins were detected in apples, among which 30 proteins were specifically captured via combinatorial peptide ligand libraries. Next, three proteins, previously recognized in...
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Ratiometric NOE(−1.6) contrast in brain tumors
Published: Oct 18, 2018
Author(s): Zhongliang Zu
Journal: NMR in Biomedicine
Recently, a new nuclear Overhauser enhancement (NOE)‐mediated saturation transfer effect at around −1.6 ppm from water, termed NOE(−1.6), was reported to show hypointense signals in brain tumors. Similar to chemical exchange saturation transfer or magnetization transfer (MT) effects, which depend on the solute pool concentration, the exchange/coupling rate, the solute transverse relaxation rate, etc., the NOE(−1.6) effect should also...
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Preparation and adhesive properties of colored Ti/Zr‐based conversion coating on aluminum foil for lithium battery packaging
Published: Oct 18, 2018
Author(s): Yingying Gu, Songnan Wang, Shiai Xu
Journal: Surface and Interface Analysis
In this study, an aluminum (Al) foil used for lithium ion battery packaging film was treated with titanium (Ti)/zirconium (Zr) solution containing hexafluorotitanic acid and hexafluorozirconic acid using tannic acid as a colorant and metavanadate as an accelerator, respectively, and a golden conversion coating was successfully deposited on the surface of Al foil. The morphology and composition of the coating were characterized by scanning...
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Cocaine adulteration with the anthelminthic tetramisole (levamisole/dexamisole): Long‐term monitoring of its intake by chiral LC–MS/MS analysis of cocaine‐positive hair samples
Published: Oct 17, 2018
Author(s): Milena M. Madry, Thomas Kraemer, Markus R. Baumgartner
Journal: Drug Testing and Analysis
Abstract Recent studies indicate that not only the anthelminthic levamisole but also the racemate tetramisole (R‐/S‐phenyltetraimidazothiazole, PTHIT) was found as an adulterant for cocaine. We herein report on the investigation of the prevalence of PTHIT among cocaine‐positive hair samples and the discrimination of the presence of its stereoisomers levamisole and dexamisole. Cocaine‐positive hair samples were collected in a forensic context in...
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Semi‐quantitative determination of designer steroids by high‐performance liquid chromatography with ultraviolet detection in the absence of reference material
Published: Oct 17, 2018
Author(s): Sarah E. Voelker, Lisa M. Lorenz, Jonathan J. Litzau
Journal: Drug Testing and Analysis
Abstract New designer steroids are continually being encountered in dietary supplements that claim to increase muscle mass, but quantitative analysis of such ingredients is challenging due to the availability, quality, or cost of commercial reference materials. Although standard reference material typically becomes available for these emerging compounds, laboratories often face the challenge of finding properly certified materials...
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Identification of the anabolic steroid 6β‐chlorotestosterone in a dietary supplement
Published: Oct 17, 2018
Author(s): Travis M. Falconer, Rick A. Flurer, Mary B. Jones, Lisa M. Lorenz, Sarah E. Voelker
Journal: Drug Testing and Analysis
Abstract Capsules that were labeled to be performance‐enhancing dietary supplements obtained during an investigation were found to contain an unrecognized steroid‐like substance. This compound was isolated by liquid chromatography (LC) fraction collection and characterized using several qualitative analytical techniques, including ultraviolet (UV) spectroscopy, gas chromatography–mass spectrometry (GC–MS), liquid chromatography‐high...
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Lomerizine, trimetazidine and bis‐(4‐fluorophenyl)‐methylpiperazine in human urine after oral administration of lomerizine dihydrochloride: analysis by liquid chromatography‐high resolution‐tandem mass spectrometry
Published: Oct 17, 2018
Author(s): Masato Okano, Mitsuhiko Sato, Shinji Kageyama
Journal: Drug Testing and Analysis
Abstract In sports drugs testing, the differentiation between the abuse of the prohibited substance trimetazidine and that of the permitted drug lomerizine is required because trimetazidine is one of the metabolites of lomerizine. Therefore, it is important to identify a lomerizine‐specific metabolite in urine that allows making the distinction. In this study, a simple dilute‐and‐shoot method employing liquid chromatography–high...
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Effects of Centella asiatica
Published: Oct 17, 2018
Author(s): Thidarat Intararuchikul, Narudol Teerapattarakan, Ratchanee Rodsiri, Mayuree Tantisira, Gert Wohlgemuth, Oliver Fiehn, Rossarin Tansawat
Journal: Biomedical Chromatography
Abstract Centella asiatica has been used as a culinary vegetable or medicinal herb. In this study, the hepatoprotective effect of the standardized extract of C. asiatica (ECa233) in rotenone‐treated rats was examined using a GC–MS‐based metabolomic approach. ECa233 contains >80% triterpenoids with a ratio of madecassoside to asiaticoside of 1.5(±0.5):1. Rats were randomly divided into three groups (with six rats/group): sham...
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Ultra‐performance liquid chromatography tandem mass spectrometry for the rapid, simultaneous analysis of ziprasidone and its impurities
Published: Oct 17, 2018
Author(s): Marija Čarapić, Katarina Nikolic, Bojan Marković, Miloš Petković, Milena Pavlovic, Danica Agbaba
Journal: Biomedical Chromatography
Abstract The separation and characterization of the unknown degradation product of second‐generation antipsychotic drug ziprasidone are essential for defining the genotoxic potential of the compound. The aim of this study was to develop a simple UHPLC method coupled with tandem mass spectrometry (MS/MS) for chemical characterization of an unknown degradant, and the separation and quantification of ziprasidone and its five main...
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Establishment and application of a method for screening the therapeutic drugs of ethanol‐induced liver injury based on cellular metabonomics
Published: Oct 17, 2018
Author(s): Linghao Zhang, Lina Zhang, Qingping Hu, Jianteng Wei, Ningli Wang, Duolong Di, Dong Pei, Yewei Liu
Journal: Biomedical Chromatography
Abstract A drug‐screening method to test the capacity of drugs to protect against ethanol‐induced liver injury based on cellular metabonomics was established and applied in this study. It screens for the ability to protect against ethanol‐induced liver injury by considering changes in the cellular metabolites of human normal liver L‐02 cells subjected to ethanol treatment. This method considers cellular metabolites as the main...
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Multi‐component profiles through the blood–brain barrier in rat after oral administration of over‐the‐counter drug Keke capsule by ultra‐performance liquid chromatography/quadrupole‐ time‐of‐flight MS E method
Published: Oct 17, 2018
Author(s): Pengfei Xu, Yonggui Song, Bingwei Feng, Qiang Zeng, Baixi Shan, Kuangyi Liu, Dan Su
Journal: Biomedical Chromatography
Abstract Keke capsule as a traditional Chinese medicine formulation is used to relieve cough, for analgesia and to reduce bronchial asthma. The multi‐components are absorbed into the blood and brain after oral administration of Keke capsule, with no systematic investigation so far. A reliable and rapid UPLC–QTOF–MSE combined with a data processing software platform was used to characterize the components of Keke capsule and simultaneously ...
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Residual detection of naproxen, methyltestosterone and 17 α ‐hydroxyprogesterone caproate in aquatic products by simple liquid–liquid extraction method coupled with liquid chromatography–tandem mass spectrometry
Published: Oct 17, 2018
Author(s): Weijia Zheng, Kyung‐Hee Yoo, Jeong‐Min Choi, Da‐Hee Park, Seong‐Kwan Kim, Young‐Sun Kang, A. M. Abd El‐Aty, Ahmet Hacımüftüoğlu, Jing Wang, Jae‐Han Shim, Ho‐Chul Shin
Journal: Biomedical Chromatography
Abstract In the present study, we aimed to develop a reliable screening method based on liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS) for the detection and quantification of naproxen, methyltestosterone and 17α‐hydroxyprogesterone caproate residues. The target analytes were extracted from samples of eel, flatfish and shrimp using acetonitrile with 1% acetic acid, followed by liquid–liquid purification with n‐hexane....
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A new validated HPLC method for the determination of levodopa: Application to study the impact of ketogenic diet on the pharmacokinetics of levodopa in Parkinson's participants
Published: Oct 17, 2018
Author(s): Fawzy Elbarbry, Van Nguyen, Alar Mirka, Heather Zwickey, Richard Rosenbaum
Journal: Biomedical Chromatography
Abstract A simple, accurate, and reproducible HPLC‐UV method has been developed and validated for the quantification of levodopa (l‐Dopa) in human plasma. The method involves a simple protein precipitation procedure to extract both l‐Dopa and methyldopa, the internal standard. The chromatographic analysis was achieved on a Shimadzu LC 20A HPLC system equipped with a Zorbax Eclipse XDB C18 column and an isocratic mobile phase consisting of 20 mm KH2PO4...
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Application of a micro plasma collection card for the detection of homocysteine by liquid chromatography with tandem mass spectrometry
Published: Oct 17, 2018
Author(s): Xiangmei Yuan, Youli Lu, Can Xiao, Jianmin Zhu, Wei Zhang, Chen Yu, Shuijun Li
Journal: Journal of Separation Science
Abstract Generally, it is recommended that blood samples for homocysteine detection should be centrifuged immediately to separate plasma in order to avoid continuous synthesis by blood cells. The use of a micro plasma collection card may improve sample stability and result accuracy by offering automatic and instant plasma separation. We compare a micro plasma collection method with routine wet plasma to explore applications of the...
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Dielectrophoretic manipulation of nanomaterials: A review
Published: Oct 17, 2018
Author(s): Linbo Liu, Ke Chen, Nan Xiang, Zhonghua Ni
Journal: ELECTROPHORESIS
Abstract Nanomaterials manipulation using dielectrophoresis (DEP) is one of the major research areas that could potentially benefit the micro/nano science for diverse applications, such as microfluidics, nanomachine, and biosensor. The innovation and development of basic theories, methods or applications will have a huge impact on the entire related field. Specifically, for DEP manipulation of nanomaterials, improvements in...
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Metabolic profiling of listeria rhombencephalitis in small ruminants by 1 H high‐resolution magic angle spinning NMR spectroscopy
Published: Oct 17, 2018
Author(s): Christina Precht, Gaëlle Diserens, Martina Vermathen, Anna Oevermann, Josiane Lauper, Peter Vermathen
Journal: NMR in Biomedicine
Listeria rhombencephalitis is caused by infection with Listeria monocytogenes and is associated with a high mortality rate in humans and ruminants. Little is known about the metabolic changes associated with neurolisteriosis in particular and infectious central nervous system (CNS) diseases in general. The purpose of our study was to investigate the metabolic changes associated with listeria rhombencephalitis in small ruminants (goats and sheep) as ...
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Fault detection method based on principal component difference associated with DPCA
Published: Oct 17, 2018
Author(s): Cheng Zhang, Qingxiu Guo, Yuan Li
Journal: Journal of Chemometrics
Abstract Aiming at the fault detection in a dynamic process with nonlinear or multimodal features, a new fault detection strategy based on principal component difference associated with dynamic PCA (Diff‐DPCA) is proposed in this paper. First, augment the training data set using the time lag, and then obtain an augmented training data set. Second, find the K‐nearest neighbor set of each sample in the augmented training set and...
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The mechanism of the preventive effect of Shen’an capsule on the calcium oxalate crystal‐induced early renal injury based on metabolomics
Published: Oct 17, 2018
Author(s): Wei Fan, Jiebin Hou, Weiye Zhu, Shuyue Zhang, Keda Shao, Feiyu Quan, Wei Chen
Journal: Biomedical Chromatography
Abstract Kidney stone disease is a worldwide metabolism‐associated disorder with a high incidence of renal dysfunction. However, effective methods to prevent crystalline nephropathy are still lacking owing to the absence of aetiological research. Shen’an (SA) capsules are prepared from Chinese medicinal compounds and are considered a promising treatment for the prevention of crystal‐induced renal injury. In this study, 24 mice were...
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A general gas‐assisted three‐liquid‐phase extraction method for separation and concentration of puerarin, 3′‐methoxydaidzin, puerarinxyloside, daidzin and daidzein from puerariae extract
Published: Oct 16, 2018
Author(s): Weilun Hu, Qian Shao, Xingjun Xi, Qiao Chu, Tao Lan, Fenfang Che, Yuanyuan Liu, Yanzhen Lu, Yun Wei
Journal: Biomedical Chromatography
Abstract In this work, a general and novel separation technique gas‐assisted three‐liquid‐phase extraction was established and applied in separating and concentrating isoflavonoids from the actual sample of puerariae extract by one step. For the gas‐assisted three‐liquid‐phase extraction method, optimal conditions were selected: polyethylene glycol 2000 and ethyl acetate as the flotation solvent, pH 5, (NH4)2SO4 concentration...
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