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Subtoxic and toxic concentrations of benzene and toluene induce Nrf2‐mediated antioxidative stress response and affect the central carbon metabolism in lung epithelial cells A549
Published: Oct 16, 2013
Author(s): Kalaimathi Murugesan, Sven Baumann, Dirk K. Wissenbach, Stefanie Kliemt, Stefan Kalkhof, Wolfgang Otto, Iljana Mögel, Tibor Kohajda, Martin Bergen, Janina M. Tomm
Journal: PROTEOMICS
Since people in industrialized countries spend most of their time indoors, the effects of indoor contaminants such as volatile organic compounds become more and more relevant. Benzene and toluene are among the most abundant compounds in the highly heterogeneous group of indoor volatile organic compounds. In order to understand their effects on lung epithelial cells (A549) representing lung's first line of defense, we chose a global...
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An on‐line sample pretreatment technique for the HPLC analysis of plant samples
Published: Oct 16, 2013
Author(s): Cui Yang, Chunyan Ren, Xiangfan Piao, Narayanan Kannan, Donghao Li
Journal: Journal of Separation Science
A continuous‐flow, on‐line sample pretreatment technique using a silica gel microsyringe extractor has been developed. All steps including extraction, separation, clean‐up, and concentration occur in the microsyringe. The overall sample pretreatment process takes <10 min per sample. Different polarity chemicals in the plant sample are successively extracted and separated, and analyzed in parallel using HPLC–UV and HPLC–UV–MS/MS....
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Preparation and application of carbon nanotubes/poly( o ‐toluidine) composite fibers for the headspace solid‐phase microextraction of benzene, toluene, ethylbenzene, and xylenes
Published: Oct 16, 2013
Author(s): Mansoureh Behzadi, Ebrahim Noroozian, Mohammad Mirzaei
Journal: Journal of Separation Science
A novel nanocomposite coating of poly(o‐toluidine) and oxidized multiwalled CNTs (MWCNTs, where CNTs is carbon nanotubes) was electrochemically prepared on a stainless‐steel wire. The applicability of the fiber was assessed for the headspace solid‐phase microextraction of benzene, toluene, ethylbenzene, and xylenes in aqueous samples followed by GC with flame ionization detection. In order to obtain an adherent and stable composite ...
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SERS‐based detection of barcoded gold nanoparticle assemblies from within animal tissue
Published: Oct 15, 2013
Author(s): Priyanka Dey, William Olds, Idriss Blakey, Kristofer J. Thurecht, Emad L. Izake, Peter M. Fredericks
Journal: Journal of Raman Spectroscopy
We have explored the potential of deep Raman spectroscopy, specifically surface‐enhanced spatially offset Raman spectroscopy (SESORS), for non‐invasive detection from within animal tissue, by employing SERS‐barcoded nanoparticle (NP) assemblies as the diagnostic agent. This concept has been experimentally verified in a clinically‐relevant backscattered Raman system with an excitation line of 785 nm under ex vivo conditions. We have shown...
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A methamphetamine analog ( N,α ‐diethyl‐phenylethylamine) identified in a mainstream dietary supplement
Published: Oct 14, 2013
Author(s): Pieter A. Cohen, John C. Travis, Bastiaan J. Venhuis
Journal: Drug Testing and Analysis
Pharmaceuticals and banned substances have been detected in hundreds of purportedly natural supplements. Recently, several athletes have been disqualified from competition after testing positive for the methamphetamine analog N,α‐diethyl‐phenylethylamine (N,α‐DEPEA). Athletes have claimed they unknowingly consumed the banned stimulant in workout supplements. Three samples from different lot numbers of Craze, a workout supplement, were analyzed to...
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Trace analysis of alkaline flavors in cut tobacco by heart‐cutting multidimensional GC – GC – MS
Published: Oct 14, 2013
Author(s): Xiaoyu Wang, Shaofeng Liu, Qiaoling Xia, Ge Zhao, Jizhao Guo, Fuwei Xie
Journal: Journal of Separation Science
Tobacco is a complex chemical matrix. The analysis of trace alkaline flavors in tobacco is very difficult because of the limited peak capacity of monodimensional GC. In the present study, a home‐assembled twin‐oven GC–GC–MS system, with MS detection in both dimensions, has been applied to the analysis of 20 alkaline volatiles in a variety of cut‐tobacco samples. By transferring nine and six heart‐cuts from the first apolar column to the...
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Purification and analysis of mono‐ PEG ylated HSA by hydrophobic interaction membrane chromatography
Published: Oct 14, 2013
Author(s): Xiaojiao Shang, William Wittbold, Raja Ghosh
Journal: Journal of Separation Science
We discuss the purification of mono‐PEGylated HSA by hydrophobic interaction membrane chromatography. The hydrophobicity difference between the different fractionated species was induced by the addition of a lyotropic salt that caused phase transition of PEG (hydrophilic under normal condition) to a mildly hydrophobic form. The HSA PEGylation reaction mixture was mixed with lyotropic salt and passed through a stack of hydrophilized...
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Simultaneous determination of three major lignans in rat plasma by LC‐MS/MS and its application to a pharmacokinetic study after oral administration of Diphylleia sinensis extract
Published: Oct 14, 2013
Author(s): Chengliang Zhao, Nan Zhang, Weiyan He, Rui Li, Dan Shi, Li Pang, Ning Dong, Hong Xu, Honglei Ji
Journal: Biomedical Chromatography
ABSTRACT A sensitive and selective liquid chromatography tandem mass spectrometry was developed and validated for the simultaneous determination of three major lignans (podophyllotoxin, epipodophyllotoxin, and 4′‐demethylpodophyllotoxin) in rat plasma using diphenhydramine as the internal standard. The analytes were detected using a triple quadrupole mass spectrometer that was equipped with an electrospray ionization source in the...
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Determination of a novel diacylglycerol acyltransferase 1 inhibitor, 2‐[4‐(4‐{5‐[2‐phenyl‐5‐(trifluoromethyl) oxazole‐4‐carboxamido]‐1H‐benzo[d]imidazol‐2‐yl} phenyl) cyclohexyl] acetic acid (KR‐69232) in rat plasma using liquid chromatography–tandem mass
Published: Oct 14, 2013
Author(s): Hyewon Seo, Sung Heum Choi, Eun‐Young Kwak, Zhi Zheng, Hyun Jung Kwak, Jin Hee Ahn, Yong‐Moon Lee, Sung‐Hoon Ahn, Myung Ae Bae, Jin Sook Song
Journal: Biomedical Chromatography
ABSTRACT A liquid chromatography–tandem mass spectrometry method was developed and validated for the quantification of KR‐69232, a diacyltransferase 1 inhibitor, in rat plasma. KR‐69232 in the concentration range of 0.004–4 µg/mL was linear. The intra‐and inter‐day precision and accuracy were acceptable (<20%). KR‐69232 was stable under various storage and handling conditions. The method was applied successfully in a...
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Simultaneous quantification of methylene blue and its major metabolite, azure B, in plasma by LC‐MS/MS and its application for a pharmacokinetic study
Published: Oct 14, 2013
Author(s): Soo‐Jin Kim, Dong‐Jin Ha, Tae‐Sung Koo
Journal: Biomedical Chromatography
ABSTRACT A simple and sensitive liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) method was developed for the quantification of methylene blue (MB) and its major metabolite, azure B (AZB), in rat plasma. A simple protein precipitation using acetonitrile was followed by injection of the supernatant on to a Zorbax HILIC Plus column (3.5 µm, 2.1 × 100 mm) with isocratic mobile phase consisting of 5 mM ammonium acetate in 10:90...
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Reduction in microparticle adsorption using a lateral interconnection method in a PDMS ‐based microfluidic device
Published: Oct 14, 2013
Author(s): Do‐Hyun Lee, Je‐Kyun Park
Journal: ELECTROPHORESIS
Microparticle adsorption on microchannel walls occurs frequently due to nonspecific interactions, decreasing operational performance in pressure‐driven microfluidic systems. However, it is essential for delicate manipulation of microparticles or cells to maintain smooth fluid traffic. Here, we report a novel microparticle injection technique, which prevents particle loss, assisted by sample injection along the direction of fluid flow....
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Fast determination of aldehyde preservatives by miniaturized capillary electrophoresis with amperometric detection
Published: Oct 14, 2013
Author(s): Ying Li, Fang Chen, Jinyuan Ge, Fanghong Tong, Zhaoyue Deng, Fengwu Shen, Qianxia Gu, Jiannong Ye, Qingcui Chu
Journal: ELECTROPHORESIS
A novel miniaturized CE with amperometric detection (mini‐CE‐AD) method has been developed for fast determination of aliphatic aldehyde preservatives, namely formaldehyde and glyoxal, in commodities. After derivatization with an electroactive compound 2‐thiobarbituric acid, these two nonelectroactive aldehydes were converted to electroactive adducts, therefore detectable by mini‐CE‐AD approach. Under the optimum conditions, two aldehydes...
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Theoretical advances on coefficients of relational agreement: application to cheminformatics as k ‐way biomolecular similarity measures
Published: Oct 13, 2013
Author(s): Oscar Miguel Rivera‐Borroto, José Manuel García‐de la Vega, Yoandy Hernández‐Díaz
Journal: Journal of Chemometrics
We provide formal proofs on the partial ordering among chance‐corrected bivariate coefficients of relational agreement. Moreover, we prove that the non‐corrected (chance‐corrected) general formula of multivariate relational agreement is the weighted average of the corresponding non‐corrected (chance‐corrected) general formula of bivariate relational agreement, thus allowing to obtain a specific relationship between each multivariate...
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A multi‐technique approach for the characterization of decorative stones and non‐destructive method for the discrimination of similar rocks
Published: Oct 11, 2013
Author(s): Germana Barone, Vincenza Crupi, Francesca Longo, Domenico Majolino, Paolo Mazzoleni, Simona Raneri, Valentina Venuti
Journal: X-Ray Spectrometry
In this paper, a multi‐technique approach, at different scale of observation, is used to characterize a group of decorative stones and to permit to distinguish rocks with similar aspect but coming from different areas. In particular, the samples under study are sedimentary and metamorphic rocks, widely used as building blocks of modern and historical constructions and sculptures. The petrographic and mineralogical features of such rocks...
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Quantitative analysis of five tobacco‐specific N ‐nitrosamines in urine by liquid chromatography–atmospheric pressure ionization tandem mass spectrometry
Published: Oct 11, 2013
Author(s): Baoyun Xia, Yang Xia, Joshua Wong, Keegan J. Nicodemus, Meng Xu, John Lee, Tonya Guillot, James Li
Journal: Biomedical Chromatography
ABSTRACT A liquid chromatography tandem mass spectrometry (LC/MS/MS) method was developed and validated for the determination of five total tobacco‐specific N‐nitrosamines (TSNA), including free and conjugated forms in urine. The limits of detection for 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanol, N′‐nitrosonornicotine, 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone, N′‐nitrosoanatabine and N′‐nitrosoanabasine were 0.6, 0.6, 10.0, 0.4 and 0.4...
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Structure‐guided RP‐HPLC chromatography of diastereomeric α ‐helical peptide analogs substituted with single amino acid stereoisomers
Published: Oct 11, 2013
Author(s): YiBing Huang, Ling Pan, LianJing Zhao, Colin T. Mant, Robert S. Hodges, Yuxin Chen
Journal: Biomedical Chromatography
ABSTRACT An α‐helical model peptide (Ac‐EAEKAAKE‐X‐EKAAKEAEK‐amide) was used as a template to examine the efficacy of conventional reversed‐phase high‐performance liquid chromatography (RP‐HPLC) in separating peptide analogs with single substitutions (at position X) of diasteromeric amino acids Ile, allo‐Ile, d‐Ile and d‐allo‐Ile. We compared differences in peptide retention behavior on a C8 column and a C18 column at different temperatures. We...
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Using resonance Raman cross‐section data to estimate the spin‐state populations of cytochromes P450
Published: Oct 11, 2013
Author(s): Piotr J. Mak, Qianhong Zhu, James R. Kincaid
Journal: Journal of Raman Spectroscopy
The cytochromes P450 (CYPs) are heme proteins responsible for the oxidation of xenobiotics and pharmaceuticals and the biosynthesis of essential steroid products. In all cases, substrate binding initiates the enzymatic cycle, converting ferric low‐spin to high‐spin state, with the efficiency of the conversion varying widely for different substrates, so documentation of this conversion for a given substrate is an important objective....
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Au@SiO 2 core/shell nanoparticle assemblage used for highly sensitive SERS‐based determination of glucose and uric acid
Published: Oct 11, 2013
Author(s): Tran Thi Bich Quyen, Wei‐Nien Su, Kuan‐Jung Chen, Chun‐Jern Pan, John Rick, Chun‐Chao Chang, Bing‐Joe Hwang
Journal: Journal of Raman Spectroscopy
The use of Au@SiO2 core/shell nanoparticle (NP) assemblage with highly sensitive surface‐enhanced Raman scattering (SERS) was investigated for the determination of glucose and uric acid in this study. Rhodamine 6G dye molecules were used to evaluate the SERS enhancement factor for the synthesized Au@SiO2 core/shell NPs with various silica shell thicknesses. The enhancement of SERS signal from Rhodamine 6G was found to increase with a...
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Birth of room‐temperature magnons and Raman line enhancement in ZnO nanostructures containing cobalt oxide
Published: Oct 11, 2013
Author(s): T. Pandiyarajan, B. Karthikeyan
Journal: Journal of Raman Spectroscopy
Cobalt (Co) addition and thermal annealing induced structural and vibrational properties of ZnO nanostructures were analysed. X‐ray diffraction pattern reveals that the nanostructures are in hexagonal wurtzite type and the formation of Co3O4. The Co ion induced morphology changes have been studied by high‐resolution scanning electron microscope images and energy dispersive spectroscopy measurements confirm the presence of Co ions. CoO‐related magnon...
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Influencing factors of external fluorescence seeding enhancing stimulated Raman scattering in liquid‐core optical fiber
Published: Oct 11, 2013
Author(s): Rui Yang, Hong‐lei Ma, Hai‐peng Jin
Journal: Journal of Raman Spectroscopy
This paper reports an external fluorescence seeding technology enhancing the stimulated Raman scattering (SRS) in liquid‐core optical fiber (LCOF). By surrounding a small section of LCOF with a glass capillary and a solution of Rhodamine 6G filled between them to separate fluorescent dye and Raman medium, the initial intensity of SRS is linearly amplified by external fluorescence seeding, and then the SRS of LCOF can be enhanced...
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