EarlyView Articles
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Development of a liquid chromatography–mass spectrometry method for determination of agrimol B in rat plasma: application to preclinical pharmacokinetics
Published: Jul 26, 2014
Author(s): Zhenglin Wang, Peng Liu, Pin Liang, Xiang Hu
Journal: Biomedical Chromatography
ABSTRACT A sensitive and accurate liquid chromatography coupled with mass spectrometry (LC‐MS) method was developed for the determination of agrimol B, a main active ingredient isolated from Agrimonia pilosa Ledeb., in rat plasma. Chromatographic separation was achieved on a Zorbax CN column (150 × 4.6 mm, 5 µm), with isocratic elution consisting of acetonitrile and water (15:85, v/v) at a flow rate of 0.6 mL/min. Agrimol B and dryocrassin...
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Determination of a novel phosphodiesterase4 inhibitor, 3‐[1‐(3cyclopropylmethoxy‐4‐difluoromethoxybenzyl)‐1H‐pyrazol‐3‐yl]‐benzoic acid (PDE‐423) in rat plasma using liquid chromatography–tandem mass spectrometry
Published: Jul 26, 2014
Author(s): Woon‐Ki Cho, Hyewon Seo, Sung Heum Choi, Hyun Jeong Kwak, Hyae Gyeong Cheon, Dong Ju Jeon, Sang Kyum Kim, Myung Ae Bae, Jin Sook Song
Journal: Biomedical Chromatography
ABSTRACT A method for determining a novel phosphodiesterase‐4 inhibitor, 3‐[1‐(3cyclopropylmethoxy‐4‐difluoromethoxybenzyl)‐1H‐pyrazol‐3‐yl]‐benzoic acid (PDE‐423), in rat plasma was developed and validated using liquid chromatography–tandem mass spectrometry for further pharmacokinetic study for development as a novel anti‐asthmatic drug. PDE‐423 in the concentration range of 0.02–10 µg/mL was linear with a correlation coefficient...
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Rapid and robust pulmonary proton ZTE imaging in the mouse
Published: Jul 26, 2014
Author(s): Markus Weiger, Mingming Wu, Moritz C. Wurnig, David Kenkel, Wolfgang Jungraithmayr, Andreas Boss, Klaas P. Pruessmann
Journal: NMR in Biomedicine
Pulmonary MRI is challenging because of the low proton density and rapid transverse relaxation in the lung associated with microscopic magnetic field inhomogeneities caused by tissue–air interfaces. Therefore, low signal is obtained in gradient and spin echo proton images. Alternatively, non‐proton MRI using hyperpolarized gases or radial techniques with ultrashort or zero TE have been proposed to image the lung. Also with the latter...
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Partial volume correction of brain perfusion estimates using the inherent signal data of time‐resolved arterial spin labeling
Published: Jul 26, 2014
Author(s): André Ahlgren, Ronnie Wirestam, Esben Thade Petersen, Freddy Ståhlberg, Linda Knutsson
Journal: NMR in Biomedicine
Quantitative perfusion MRI based on arterial spin labeling (ASL) is hampered by partial volume effects (PVEs), arising due to voxel signal cross‐contamination between different compartments. To address this issue, several partial volume correction (PVC) methods have been presented. Most previous methods rely on segmentation of a high‐resolution T1‐weighted morphological image volume that is coregistered to the low‐resolution ASL data, making the...
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Multi‐parametric MRI characterization of healthy human thigh muscles at 3.0 T – relaxation, magnetization transfer, fat/water, and diffusion tensor imaging
Published: Jul 26, 2014
Author(s): Ke Li, Richard D. Dortch, E. Brian Welch, Nathan D. Bryant, Amanda K. W. Buck, Theodore F. Towse, Daniel F. Gochberg, Mark D. Does, Bruce M. Damon, Jane H. Park
Journal: NMR in Biomedicine
Muscle diseases commonly have clinical presentations of inflammation, fat infiltration, fibrosis, and atrophy. However, the results of existing laboratory tests and clinical presentations are not well correlated. Advanced quantitative MRI techniques may allow the assessment of myo‐pathological changes in a sensitive and objective manner. To progress towards this goal, an array of quantitative MRI protocols was implemented for human thigh...
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Discrimination between glioblastoma multiforme and solitary metastasis using morphological features derived from the p : q tensor decomposition of diffusion tensor imaging
Published: Jul 26, 2014
Author(s): Guang Yang, Timothy L. Jones, Thomas R. Barrick, Franklyn A. Howe
Journal: NMR in Biomedicine
The management and treatment of high‐grade glioblastoma multiforme (GBM) and solitary metastasis (MET) are very different and influence the prognosis and subsequent clinical outcomes. In the case of a solitary MET, diagnosis using conventional radiology can be equivocal. Currently, a definitive diagnosis is based on histopathological analysis on a biopsy sample. Here, we present a computerised decision support framework for discrimination...
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Four‐dimensional MRI of renal function in the developing mouse
Published: Jul 26, 2014
Author(s): Luke Xie, Ergys Subashi, Yi Qi, Mark A. Knepper, G. Allan Johnson
Journal: NMR in Biomedicine
The major roles of filtration, metabolism and high blood flow make the kidney highly vulnerable to drug‐induced toxicity and other renal injuries. A method to follow kidney function is essential for the early screening of toxicity and malformations. In this study, we acquired high spatiotemporal resolution (four dimensional) datasets of normal mice to follow changes in kidney structure and function during development. The data were...
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Inert fluorinated gas MRI: a new pulmonary imaging modality
Published: Jul 26, 2014
Author(s): Marcus J. Couch, Iain K. Ball, Tao Li, Matthew S. Fox, Alexei V. Ouriadov, Birubi Biman, Mitchell S. Albert
Journal: NMR in Biomedicine
Fluorine‐19 (19F) MRI of the lungs using inhaled inert fluorinated gases can potentially provide high quality images of the lungs that are similar in quality to those from hyperpolarized (HP) noble gas MRI. Inert fluorinated gases have the advantages of being nontoxic, abundant, and inexpensive compared with HP gases. Due to the high gyromagnetic ratio of 19F, there is sufficient thermally polarized signal for imaging, and averaging within a single...
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Comparison of T 1 relaxation times in adipose tissue of severely obese patients and healthy lean subjects measured by 1.5 T MRI
Published: Jul 26, 2014
Author(s): Nikita Garnov, Nicolas Linder, Alexander Schaudinn, Matthias Blüher, Thomas Karlas, Tatjana Schütz, Arne Dietrich, Thomas Kahn, Harald Busse
Journal: NMR in Biomedicine
Subcutaneous (SAT) and visceral adipose tissue (VAT) differ in composition, endocrine function and localization in the body. VAT is considered to play a role in the pathogenesis of insulin resistance, type 2 diabetes, fatty liver disease, and other obesity‐related disorders. It has been shown that the amount, distribution, and (cellular) composition of adipose tissue (AT) correlate well with metabolic conditions. In this study, T1...
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PLS‐DA for compositional data with application to metabolomics
Published: Jul 25, 2014
Author(s): Alžběta Kalivodová, Karel Hron, Peter Filzmoser, Lukáš Najdekr, Hana Janečková, Tomáš Adam
Journal: Journal of Chemometrics
When quantifying information in metabolomics, the results are often expressed as data carrying only relative information. Vectors of these data have positive components, and the only relevant information is contained in the ratios between their parts; such observations are called compositional data. The aim of the paper is to demonstrate how partial least squares discriminant analysis (PLS‐DA)—the most widely used method in chemometrics...
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Raman microspectroscopy of gemstones from a chalice made in 1732
Published: Jul 25, 2014
Author(s): Miha Jeršek, Sabina Kramar
Journal: Journal of Raman Spectroscopy
The baroque chalice made in 1732 contains 456 embedded gemstones and is one the most richly decorated chalices in Slovenia. With the aid of Raman microspectroscopy, in combination with gemology microscopy and ultraviolet fluorescence, individual types of gemstones and certain inclusions were analysed and determined. The chalice was adorned with 24 diamonds, 93 rubies, 4 sapphires, 152 emeralds, 101 almandine garnets, 6 grossular garnets,...
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Interpretation of group‐level factors from a large population dataset in the determination of ethyl glucuronide in hair
Published: Jul 25, 2014
Author(s): Alberto Salomone, Valentina Pirro, Tonia Lombardo, Daniele Di Corcia, Sergio Pellegrino, Marco Vincenti
Journal: Drug Testing and Analysis
Ethyl glucuronide in hair (HEtG) is the most accredited marker to prove chronic alcohol abuse. In this study, we evaluate the comprehensive results of HEtG determination obtained during four years of activity (2009–2013) in our laboratory (Northwestern Italy) – across a large cohort of subjects (over 20 000 subjects mostly undergoing medical examination for driving re‐licensing) – to provide a general perspective on HEtG analysis and...
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Spatial distribution of theobromine – a low MW drug – in tissues via matrix‐free NALDI‐MS imaging
Published: Jul 25, 2014
Author(s): Alessandra Tata, Chiara Montemurro, Andreia M. Porcari, Kamila C. Silva, José B. Lopes de Faria, Marcos N. Eberlin
Journal: Drug Testing and Analysis
The ability of nano‐assisted laser desorption‐ionization mass spectrometry imaging (NALDI‐IMS) to provide selective chemical monitoring with appropriate spatial distribution of a low molecular drug in a biological tissue was investigated. NALDI‐IMS is a matrix‐free laser desorption ionization (LDI) protocol based on imprinting of tissue constituents on a nanostructured surface. Using the accumulation of theobromine in rat kidney as a...
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A novel UPLC‐MS/MS method for sensitive quantitation of boldine in plasma, a potential anti‐inflammatory agent: application to a pharmacokinetic study in rats
Published: Jul 25, 2014
Author(s): Rong‐Jie Zeng, Yu Li, Jian‐Zhong Chen, Gui‐Xin Chou, Yu Gao, Jing‐Wei Shao, Lee Jia, Sheng‐Dong Wu, Shui‐Sheng Wu
Journal: Biomedical Chromatography
ABSTRACT Boldine is a potential anti‐inflammatory agent found in several different plants. Published bioanalytical methods using HPLC with ultraviolet and fluorescent detection lacked enough sensitivity and required tedious sample preparation procedures. Herein, we describe the development of a novel ultra‐high performance LC with MS/MS for determination of boldine in plasma. Boldine in plasma was recovered by liquid–liquid...
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Facile preparation of boronic acid‐functionalized magnetic nanoparticles with a high capacity and their use in the enrichment of cis ‐diol‐containing compounds from plasma
Published: Jul 25, 2014
Author(s): Jin Du, Maofang He, Xiaomeng Wang, Hua Fan, Yinmao Wei
Journal: Biomedical Chromatography
ABSTRACT The use of bronate affinity adsorbents is a new separation method that appeared recently with great potential for specific extraction of cis‐diol‐containing compounds. In this work,a new strategy for the facile construction of boronic acid‐functionalized Fe3O4 magnetic nanoparticles (Fe3O4@FPBA MNPs) with a high capacity was described. The extraction capacity of the Fe3O4@FPBA MNPs was determined to be 66.0 ± 2.7 µmol/g for catechol and 80.6 ± 2.0...
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Combining analysis of variance and three‐way factor analysis methods for studying additive and multiplicative effects in sensory panel data
Published: Jul 24, 2014
Author(s): Rosaria Romano, Tormod Næs, Per Bruun Brockhoff
Journal: Journal of Chemometrics
Data from descriptive sensory analysis are essentially three‐way data with assessors, samples and attributes as the three ways in the data set. Because of this, there are several ways that the data can be analysed. The paper focuses on the analysis of sensory characteristics of products while taking into account the individual differences among assessors. In particular, we will be interested in considering the multiplicative assessor...
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A dispersive liquid–liquid micellar microextraction for the determination of pharmaceutical compounds in wastewaters using ultra‐high‐performace liquid chromatography with DAD detection
Published: Jul 24, 2014
Author(s): Sarah Montesdeoca‐Esponda, Cristina Mahugo‐Santana, Zoraida Sosa‐Ferrera, José Juan Santana‐Rodríguez
Journal: Biomedical Chromatography
ABSTRACT A dispersive liquid–liquid micellar microextraction (DLLMME) method coupled with ultra‐high‐performance liquid chromatography (UHPLC) using Diode Array Detector (DAD) detector was developed for the analysis of five pharmaceutical compounds of different nature in wastewaters. A micellar solution of a surfactant, polidocanol, as extraction solvent (100 μL) and chloroform as dispersive solvent (200 μL) were used to extract and...
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Cerebral blood volume estimation by ferumoxytol‐enhanced steady‐state MRI at 9.4 T reveals microvascular impact of α 1 ‐adrenergic receptor antibodies
Published: Jul 24, 2014
Author(s): Andreas Pohlmann, Peter Karczewski, Min‐Chi Ku, Babette Dieringer, Helmar Waiczies, Natali Wisbrun, Stefanie Kox, Irina Palatnik, Henning Matthias Reimann, Christina Eichhorn, Sonia Waiczies, Petra Hempel, Bernd Lemke, Thoralf Niendorf, Marion Bimmler
Journal: NMR in Biomedicine
Cerebrovascular abnormality is frequently accompanied by cognitive dysfunctions, such as dementia. Antibodies against the α1‐adrenoceptor (α1‐AR) can be found in patients with Alzheimer's disease with cerebrovascular disease, and have been shown to affect the larger vessels of the brain in rodents. However, the impact of α1‐AR antibodies on the cerebral vasculature remains unclear. In the present study, we established a neuroimaging method to ...
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Quality assessment of Cinnamomi Ramulus by the simultaneous analysis of multiple active components using high‐performance thin‐layer chromatography and high‐performance liquid chromatography
Published: Jul 24, 2014
Author(s): Xiaoxue Wu, Jiao He, Huarong Xu, Kaishun Bi, Qing Li
Journal: Journal of Separation Science
A novel and improved method for the quality assessment of Cinnamomi Ramulus was developed and completely validated. The method was established using fingerprint technology and simultaneous quantitative determination of six main marker compounds including coumarin, cinnamic alcohol, cinnamic acid, 2‐methoxy cinnamic acid, cinnamaldehyde, and 2‐methoxy cinnamaldehyde in the herbal medicine for the first time. A newly developed...
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Fast separation of warfarin and 7‐hydroxywarfarin enantiomers by cyclodextrin‐assisted capillary electrophoresis
Published: Jul 24, 2014
Author(s): Paweł Nowak, Magdalena Garnysz, Michał Woźniakiewicz, Paweł Kościelniak
Journal: Journal of Separation Science
The enantioseparation of warfarin and its main metabolite has been achieved using several cyclodextrin types and buffers at different pH, including conditions that have not been attempted so far. Methyl‐β‐cyclodextrin, highly sulfated‐β‐cyclodextrin and highly sulfated‐γ‐cyclodextrin were the most efficient chiral selectors. The pH range, within which particular cyclodextrins support chiral separation, has been approximately determined...
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