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Determination of 19 sulfonamides residues in pork samples by combining QuEChERS with dispersive liquid–liquid microextraction followed by UHPLC–MS/MS

Published: Feb 24, 2017

Author(s): Xiaojing Li, Hong Yu, Rongfei Peng, Pingsheng Gan

Journal: Journal of Separation Science

A new simple and rapid pretreatment method for simultaneous determination of 19 sulfonamides in pork samples was developed through combining the QuEChERS method with dispersive liquid–liquid microextraction followed by ultra‐high performance liquid chromatography with tandem mass spectrometry. The sample preparation involves extraction/partitioning with QuEChERS method followed by dispersive liquid–liquid microextraction using...

Read More thumbnail image: Determination of 19 sulfonamides residues in pork samples by combining QuEChERS with dispersive liquidliquid microextraction followed by UHPLCMSMS

Evaluation of KIMS immunoassays on a cobas c 501 analyzer for drugs of abuse and ethyl glucuronide testing in urine for forensic abstinence control

Published: Feb 24, 2017

Author(s): Merja A. Neukamm, Arsham Bahrami, Volker Auwärter, Felix M.P. Mehne, Eva Höss

Journal: Drug Testing and Analysis

For the medico‐psychological assessment (MPA) during driving licence re‐granting in Germany, abstinence control including urine samples is required. In these programmes, even small amounts of markers for drug or alcohol abuse have to be detected. Thus, the concentrations of the target compounds are very low, and, in consequence, the sensitivity of the applied screening method has to be much higher than for clinical use. Modified drugs of...

Read More thumbnail image: Evaluation of KIMS immunoassays on a cobas c 501 analyzer for drugs of abuse and ethyl glucuronide testing in urine for forensic abstinence control

Identification and analytical characterization of six synthetic cannabinoids NNL‐3, 5F–NPB‐22‐7 N , 5F–AKB‐48‐7 N , 5F–EDMB‐PINACA, EMB‐FUBINACA, and EG‐018

Published: Feb 24, 2017

Author(s): Cuimei Liu, Wei Jia, Zhendong Hua, Zhenhua Qian

Journal: Drug Testing and Analysis

Clinical and forensic toxicology laboratories are continuously confronted by analytical challenges when dealing with the new psychoactive substances phenomenon. The number of synthetic cannabinoids, the chemical diversity, and the speed of emergence make this group of compounds particularly challenging in terms of detection, monitoring, and responding. Three indazole 7N positional isomer synthetic cannabinoids, two ethyl...

Read More thumbnail image: Identification and analytical characterization of six synthetic cannabinoids NNL3 5FNPB227 N  5FAKB487 N  5FEDMBPINACA EMBFUBINACA and EG018

PLS‐ROG: Partial least squares with rank order of groups

Published: Feb 24, 2017

Author(s): Hiroyuki Yamamoto

Journal: Journal of Chemometrics

Partial least squares (PLS) have been used widely in metabolomics. Partial least squares can distinguish between groups but do not always reflect rank order of groups (eg, severity of diseases). We extended PLS by adding a differential penalty between mean of groups in PLS subspace. We named this method partial least squares with rank order of groups (PLS‐ROG). The PLS‐ROG can distinguish between groups and also can reflect rank order of...

Read More thumbnail image: PLSROG Partial least squares with rank order of groups

Recent trends and applications in liquid‐phase chromatography enantioseparation of atropisomers

Published: Feb 24, 2017

Author(s): Paola Peluso, Victor Mamane, Emmanuel Aubert, Sergio Cossu

Journal: ELECTROPHORESIS

The term Atropisomerism defines a type of enantiomerism that arises from hindered rotation around an axis that makes two rotational isomers enantiomers. Atropisomeric compounds are present in nature, being important building blocks of many biologically active compounds. Atropisomers have been extensively studied in environmental and toxicological chemistry and, in particular, separating them has become a need in specific fields as organic...

Read More thumbnail image: Recent trends and applications in liquidphase chromatography enantioseparation of atropisomers

Curve‐fitting regression: improving light element quantification with XRF

Published: Feb 23, 2017

Author(s): Philippe Kikongi, Joanny Salvas, Ryan Gosselin

Journal: X-Ray Spectrometry

Light elements are hard to quantify by X‐ray fluorescence (XRF) spectrometry because, after a photoelectric excitation, they predominantly relax emitting Auger electrons, greatly reducing the fluorescence count thus limiting the signal‐to‐noise ratios (SNR) observed. Low SNR values have deleterious outcomes in model building. Notable in ordinary least squares (OLS) regression based on peak height, they also affect more robust regression...

Read More thumbnail image: Curvefitting regression improving light element quantification with XRF

Modeling of dielectrophoretic particle motion: Point particle versus finite‐sized particle

Published: Feb 23, 2017

Author(s): Barbaros Çetin, S. Doğan Öner, Besim Baranoğlu

Journal: ELECTROPHORESIS

Dielectrophoresis (DEP) is a very popular technique for microfluidic bio‐particle manipulation. For the design of a DEP‐based microfluidic device, simulation of the particle trajectory within the microchannel network is crucial. There are basically two approaches: (i) point‐particle approach and (ii) finite‐sized particle approach. In this study, many aspects of both approaches are discussed for the simulation of direct current DEP,...

Read More thumbnail image: Modeling of dielectrophoretic particle motion Point particle versus finitesized particle

Developing a new nonbinary SNP fluorescent multiplex detection system for forensic application in China

Published: Feb 23, 2017

Author(s): Yanfang Liu, Huidan Liao, Ying Liu, Juanjuan Guo, Yi Sun, Xiaoliang Fu, Ding Xiao, Jifeng Cai, Lingmei Lan, Pingli Xie, Lagabaiyila Zha

Journal: ELECTROPHORESIS

Nonbinary single‐nucleotide polymorphisms (SNPs) are potential forensic genetic markers because their discrimination power is greater than that of normal binary SNPs, and that they can detect highly degraded samples. We previously developed a nonbinary SNP multiplex typing assay. In this study, we selected additional 20 nonbinary SNPs from the NCBI SNP database and verified them through pyrosequencing. These 20 nonbinary SNPs were...

Read More thumbnail image: Developing a new nonbinary SNP fluorescent multiplex detection system for forensic application in China

Isomotive dielectrophoresis for parallel analysis of individual particles

Published: Feb 23, 2017

Author(s): Daniel J. Allen, Robert P. Accolla, Stuart J. Williams

Journal: ELECTROPHORESIS

Two dielectrophoresis systems are introduced where the induced dielectrophoretic force is constant throughout the experimental region, resulting in uniform (isomotive) microparticle translation. Isomotive dielectrophoresis (isoDEP) is accomplished through a unique geometry where the gradient of the field‐squared (∇ E r m s ...

Read More thumbnail image: Isomotive dielectrophoresis for parallel analysis of individual particles

Selective precolumn derivatization of fatty acids with the fluorescent tag 6‐aminoquinoline and their determination in some food samples by reversed‐phase chromatography

Published: Feb 23, 2017

Author(s): Murthy Jonnada, Guadalupe Davila El Rassi, Ziad El Rassi

Journal: ELECTROPHORESIS

Fatty acids (FAs) have been selectively derivatized with a fluorescent tag, 6‐aminoquinoline (6AQ), which yielded fluorescent FA‐6AQ derivatives that have excitation (λexc = 270 nm) and emission (λemi = 495 nm) wavelengths that are farther apart. This precolumn derivatization is characterized by its simplicity occurring at room temperature between the carboxylic acid group of the FA and the amino group of 6AQ in the presence of a nonaqueous ...

Read More thumbnail image: Selective precolumn derivatization of fatty acids with the fluorescent tag 6aminoquinoline and their determination in some food samples by reversedphase chromatography

Quantitative analysis combined with chromatographic fingerprint and antioxidant activities for the comprehensive evaluation of Compound Danshen Tablets

Published: Feb 22, 2017

Author(s): Jiao Chen, Jiayue Gao, Guoxiang Sun

Journal: Journal of Separation Science

The composition of traditional Chinese medicine is extremely complex, so it is difficult to ensure quality consistency. We took Compound Danshen Tablets as the object of the study, by using high‐performance liquid chromatography to establish multiwavelength fusion fingerprints. Characteristic fingerprints of 30 batches of samples were generated at four wavelengths and evaluated by systematic quantified fingerprint method. An on‐line...

Read More thumbnail image: Quantitative analysis combined with chromatographic fingerprint and antioxidant activities for the comprehensive evaluation of Compound Danshen Tablets

Rapid determination of the critical micelle concentration by Taylor dispersion analysis in capillaries using both direct and indirect detection

Published: Feb 22, 2017

Author(s): Jan Petr

Journal: Journal of Separation Science

The critical micelle concentration is a basic characteristic of surfactants. In this article, the process of formation of micelles is studied by Taylor dispersion analysis using capillary electrophoresis instrumentation as a substituent of capillary liquid chromatography. New methods for determination of critical micelle concentration are presented. Sodium octylbenzene sulfonate and sodium dodecylsulfate are used as model compounds with...

Read More thumbnail image: Rapid determination of the critical micelle concentration by Taylor dispersion analysis in capillaries using both direct and indirect detection

Bioactivity screening, extraction, and separation of lactate dehydrogenase inhibitors from Polygala tenuifolia Willd. based on a hyphenated strategy

Published: Feb 22, 2017

Author(s): Sainan Li, Shu Liu, Zhiqiang Liu, Chunming Liu, Fengrui Song, Zifeng Pi

Journal: Journal of Separation Science

Stroke is the second leading cause of death worldwide. Lactate dehydrogenase inhibitors are currently widely used in the treatment of ischemic stroke, and natural products are considered promising sources of lactate dehydrogenase inhibitors. In this study, ultrafiltration liquid chromatography coupled with mass spectrometry was used for the screening and identification of lactate dehydrogenase inhibitors from Polygala tenuifolia....

Read More thumbnail image: Bioactivity screening extraction and separation of lactate dehydrogenase inhibitors from Polygala tenuifolia Willd_ based on a hyphenated strategy

Zinc sulfide nanosheets as a novel solid‐phase extraction material for flavonoids

Published: Feb 22, 2017

Author(s): Licheng Wang, Wei Fan, Shuman Li, Yong Jia, Xiudan Hou, Xusheng Wang, Shuai Wang, Yong Guo

Journal: Journal of Separation Science

As a novel solid‐phase extraction material, zinc sulfide nanosheets were prepared by a simple method and were used to extract flavonoids. We used scanning electron microscopy to show its nanosheet morphology and energy dispersive X‐ray spectroscopy and powder X‐ray diffraction to confirm its chemical and phase compositions. Coupled to a high‐performance liquid chromatography, the zinc sulfide nanosheets were packed into a microcolumn and...

Read More thumbnail image: Zinc sulfide nanosheets as a novel solidphase extraction material for flavonoids

Chemometrics‐assisted chromatographic fingerprinting: An illicit methamphetamine case study

Published: Feb 22, 2017

Author(s): Nafiseh Shekari, Maryam Vosough, Kourosh Tabar Heidar

Journal: Journal of Separation Science

The volatile chemical constituents in complex mixtures can be analyzed using gas chromatography with mass spectrometry. This analysis allows the tentative identification of diverse impurities of an illicit methamphetamine sample. The acquired two‐dimensional data of liquid–liquid extraction was resolved by multivariate curve resolution alternating curve resolution to elucidate the embedded peaks effectively. This is the first report on...

Read More thumbnail image: Chemometricsassisted chromatographic fingerprinting An illicit methamphetamine case study

Separation and purification of two taxanes and one xylosyl‐containing taxane from Taxus wallichiana Zucc.: A comparison between high‐speed countercurrent chromatography and reversed‐phase flash chromatography

Published: Feb 22, 2017

Author(s): Junfei Tao, Rongwei Yan, Leilei Zhao, Dongmei Wang, Xinjun Xu

Journal: Journal of Separation Science

10‐Deacetylbaccatin III, an important semisynthetic precursor of paclitaxel and docetaxel, can be extracted from Taxus wallichiana Zucc. A process for the isolation and purification of 10‐deacetylbaccatin III (1), baccatin III (2), and 7β‐xylosyl‐10‐deacetyltaxol (3) from the leaves and branches of Taxus wallichiana Zucc. via macroporous resin column chromatography combined with high‐speed countercurrent chromatography or reversed‐phase flash chromatography was...

Read More thumbnail image: Separation and purification of two taxanes and one xylosylcontaining taxane from Taxus wallichiana Zucc_ A comparison between highspeed countercurrent chromatography and reversedphase flash chromatography

New procedure for the examination of the degradation of volatile organonitrogen compounds during the treatment of industrial effluents

Published: Feb 22, 2017

Author(s): Grzegorz Boczkaj, Patrycja Makoś, Andre Fernandes, Andrzej Przyjazny

Journal: Journal of Separation Science

We present a new procedure for the determination of 32 volatile organonitrogen compounds in samples of industrial effluents with a complex matrix. The procedure, based on dispersive liquid–liquid microextraction followed by gas chromatography with nitrogen‐phosphorus and mass spectrometric detection, was optimized and validated. Optimization of the extraction included the type of extraction and disperser solvent, disperser solvent volume,...

Read More thumbnail image: New procedure for the examination of the degradation of volatile organonitrogen compounds during the treatment of industrial effluents

Centrifugal partition chromatography – A review of recent applications and some classic references

Published: Feb 22, 2017

Author(s): Małgorzata Bojczuk, Dorota Żyżelewicz, Paweł Hodurek

Journal: Journal of Separation Science

Countercurrent chromatography, based on liquid–liquid partitioning, has many technological variants. One of them is centrifugal partition chromatography, introduced by Wataru Murayama and Kanichi Nunogaki in 1982. This technique, like other countercurrent chromatography techniques, is based on the phenomenon of liquid–liquid partitioning between two immiscible liquid phases that stay at equilibrium. But the significant difference between...

Read More thumbnail image: Centrifugal partition chromatography  A review of recent applications and some classic references

Comparison of targeted proteomics approaches for detecting and quantifying proteins derived from human cancer tissues

Published: Feb 22, 2017

Author(s): Jakub Faktor, Rita Sucha, Vendula Paralova, Yansheng Liu, Pavel Bouchal

Journal: PROTEOMICS

Targeted mass spectrometry‐based proteomics approaches enable the simultaneous and reproducible quantification of multiple protein analytes across numerous conditions in biology and clinical studies. These approaches involve e.g. selected reaction monitoring (SRM) typically conducted on a triple quadrupole mass spectrometer, its high‐resolution variant named pseudo‐SRM (p‐SRM), carried out in a quadrupole coupled with an TOF analyzer...

Read More thumbnail image: Comparison of targeted proteomics approaches for detecting and quantifying proteins derived from human cancer tissues

Comparison of the origin and phenolic contents of Lycium ruthenicum Murr. by high‐performance liquid chromatography fingerprinting combined with quadrupole time‐of‐flight mass spectrometry and chemometrics

Published: Feb 22, 2017

Author(s): Irma Belinda Yossa Nzeuwa, Yuanyuan Xia, Zhou Qiao, Feng Feng, Junxing Bian, Wenyuan Liu, Wei Qu

Journal: Journal of Separation Science

The fruits of Lycium ruthenicum Murr. have long been used in folk medicine. Nevertheless, detailed information related to its phenolic composition and its quality control remains scarce. In this study, a simple and reproducible method, based on high‐performance liquid chromatography combined with chemometrics, was developed to authenticate 18 samples of L. ruthenicum Murr. collected from different parts of China through fingerprint analysis. The main...

Read More thumbnail image: Comparison of the origin and phenolic contents of Lycium ruthenicum Murr_ by highperformance liquid chromatography fingerprinting combined with quadrupole timeofflight mass spectrometry and chemometrics
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