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Characterization of human reflex tear proteome reveals high expression of lacrimal proline‐rich protein 4 (PRR4)

Published: Aug 28, 2015

Author(s): Natarajan Perumal, Sebastian Funke, Dominik Wolters, Norbert Pfeiffer, Franz H. Grus

Journal: PROTEOMICS

In‐depth studies on the proteome of reflex tears are still inadequate. Hence, further studies on this subject will unravel the key proteins which are conjectured to possess vital functions in the protection of the ocular surface. Therefore, this study investigated the differences in the expression levels in proteome of reflex compared to basal tears. Basal (n = 10) and reflex (n = 10) tear samples from healthy subjects were collected employing the...

Read More thumbnail image: Characterization of human reflex tear proteome reveals high expression of lacrimal prolinerich protein 4 PRR4

Distinct serum proteome profiles associated with collagen‐induced arthritis and complete Freund's adjuvant‐induced inflammation in CD38−/− mice: The discriminative power of protein species or proteoforms

Published: Aug 28, 2015

Author(s): Antonio Rosal‐Vela, Sonia García‐Rodríguez, Jorge Postigo, Marcos Iglesias, Victoria Longobardo, Antonio Lario, Jesús Merino, Ramón Merino, Mercedes Zubiaur, Jaime Sancho

Journal: PROTEOMICS

Collagen‐type‐II‐induced arthritis (CIA) is an autoimmune disease, which involves a complex host systemic response including inflammatory and autoimmune reactions. CIA is milder in CD38−/− than in wild‐type (WT) mice. ProteoMiner‐equalized serum samples were subjected to 2D‐DiGE and MS‐MALDI‐TOF/TOF analyses to identify proteins that changed in their relative abundances in CD38−/− versus WT mice either with arthritis (CIA+), with no arthritis (CIA−),...

Read More thumbnail image: Distinct serum proteome profiles associated with collageninduced arthritis and complete Freunds adjuvantinduced inflammation in CD38 mice The discriminative power of protein species or proteoforms

Reproducibility and effect of tissue composition on cerebellar γ‐aminobutyric acid (GABA) MRS in an elderly population

Published: Aug 28, 2015

Author(s): Zaiyang Long, Jonathan P. Dyke, Ruoyun Ma, Chaorui C. Huang, Elan D. Louis, Ulrike Dydak

Journal: NMR in Biomedicine

MRS provides a valuable tool for the non‐invasive detection of brain γ‐aminobutyric acid (GABA) in vivo. GABAergic dysfunction has been observed in the aging cerebellum. The study of cerebellar GABA changes is of considerable interest in understanding certain age‐related motor disorders. However, little is known about the reproducibility of GABA MRS in an aged population. Therefore, this study aimed to explore the feasibility and reproducibility of...

Read More thumbnail image: Reproducibility and effect of tissue composition on cerebellar aminobutyric acid GABA MRS in an elderly population

Effect of J coupling on 1.3‐ppm lipid methylene signal acquired with localised proton MRS at 3 T

Published: Aug 28, 2015

Author(s): Dylan Y. Breitkreutz, B. Gino Fallone, Atiyah Yahya

Journal: NMR in Biomedicine

The purpose of this work was to investigate the effect of J‐coupling interactions on the quantification and T2 determination of 1.3‐ppm lipid methylene protons at 3 T. The response of the 1.3‐ppm protons of hexanoic, heptanoic, octanoic, linoleic and oleic acid was measured as a function of point‐resolved spectroscopy (PRESS) and stimulated echo acquisition mode (STEAM) TE. In addition, a narrow‐bandwidth refocusing PRESS sequence designed to rewind...

Read More thumbnail image: Effect of J coupling on 1_3ppm lipid methylene signal acquired with localised proton MRS at 3T

Determination of five sesquiterpenoids in Xingnaojing injection by quantitative analysis of multiple components with a single marker

Published: Aug 27, 2015

Author(s): Weidong Pan, Lixin Yang, Weihong Feng, Limei Lin, Chun Li, Weiwei Liu, Guofeng Gan, Junhong Fan, Jigao Zou, Zhimin Wang, Haifeng Pan

Journal: Journal of Separation Science

A quantitative analysis of multiple components with a single‐marker method was established for the simultaneous determination of five sesqutiterpenoids in Xingnaojing injection. This method was established with Xingnaojing injection determined by high‐performance liquid chromatography coupled with diode array detection. The durability and system suitability of the established method were evaluated, and the reliable relative correction...

Read More thumbnail image: Determination of five sesquiterpenoids in Xingnaojing injection by quantitative analysis of multiple components with a single marker

Multivariate analysis of extremely large ToFSIMS imaging datasets by a rapid PCA method

Published: Aug 27, 2015

Author(s): Peter J. Cumpson, Naoko Sano, Ian W. Fletcher, Jose F. Portoles, Mariela Bravo‐Sanchez, Anders J. Barlow

Journal: Surface and Interface Analysis

Principal component analysis (PCA) and other multivariate analysis methods have been used increasingly to analyse and understand depth profiles in X‐ray photoelectron spectroscopy (XPS), Auger electron spectroscopy (AES) and secondary ion mass spectrometry (SIMS). These methods have proved equally useful in fundamental studies as in applied work where speed of interpretation is very valuable. Until now these methods have been difficult to...

Read More thumbnail image: Multivariate analysis of extremely large ToFSIMS imaging datasets by a rapid PCA method

Streaking artifact reduction for quantitative susceptibility mapping of sources with large dynamic range

Published: Aug 27, 2015

Author(s): Hongjiang Wei, Russell Dibb, Yan Zhou, Yawen Sun, Jianrong Xu, Nian Wang, Chunlei Liu

Journal: NMR in Biomedicine

Quantitative susceptibility mapping (QSM) is a novel MRI technique for the measurement of tissue magnetic susceptibility in three dimensions. Although numerous algorithms have been developed to solve this ill‐posed inverse problem, the estimation of susceptibility maps with a wide range of values is still problematic. In cases such as large veins, contrast agent uptake and intracranial hemorrhages, extreme susceptibility values in focal...

Read More thumbnail image: Streaking artifact reduction for quantitative susceptibility mapping of sources with large dynamic range

Ultrashort‐TE stimulated echo acquisition mode (STEAM) improves the quantification of lipids and fatty acid chain unsaturation in the human liver at 7 T

Published: Aug 27, 2015

Author(s): Martin Gajdošík, Grzegorz L. Chadzynski, Gilbert Hangel, Vladimír Mlynárik, Marek Chmelík, Ladislav Valkovič, Wolfgang Bogner, Rolf Pohmann, Klaus Scheffler, Siegfried Trattnig, Martin Krššák

Journal: NMR in Biomedicine

Ultrahigh‐field, whole‐body MR systems increase the signal‐to‐noise ratio (SNR) and improve the spectral resolution. Sequences with a short TE allow fast signal acquisition with low signal loss as a result of spin–spin relaxation. This is of particular importance in the liver for the precise quantification of the hepatocellular content of lipids (HCL). In this study, we introduce a spoiler Gradient‐switching Ultrashort STimulated Echo...

Read More thumbnail image: UltrashortTE stimulated echo acquisition mode STEAM improves the quantification of lipids and fatty acid chain unsaturation in the human liver at 7T

1  H MRS: a potential biomarker of in utero placental function

Published: Aug 27, 2015

Author(s): Gillian Macnaught, Calum Gray, Jane Walker, Mary Simpson, Jane Norman, Scott Semple, Fiona Denison

Journal: NMR in Biomedicine

The placenta is a temporary organ that is essential for a healthy pregnancy. It performs several important functions, including the transport of nutrients, the removal of waste products and the metabolism of certain substances. Placental disorders have been found to account for over 50% of stillbirths. Despite this, there are currently no methods available to directly and non‐invasively assess placental function in utero. The primary aim...

Read More thumbnail image: 1 H MRS a potential biomarker of in utero placental function

Hemisphere, gender and age‐related effects on iron deposition in deep gray matter revealed by quantitative susceptibility mapping

Published: Aug 27, 2015

Author(s): Nan‐Jie Gong, Chun‐Sing Wong, Edward S. Hui, Chun‐Chung Chan, Lam‐Ming Leung

Journal: NMR in Biomedicine

The purpose of this work was to investigate the effects of hemispheric location, gender and age on susceptibility value, as well as the association between susceptibility value and diffusional metrics, in deep gray matter. Iron content was estimated in vivo using quantitative susceptibility mapping. Microstructure was probed using diffusional kurtosis imaging. Regional susceptibility and diffusional metrics were...

Read More thumbnail image: Hemisphere gender and agerelated effects on iron deposition in deep gray matter revealed by quantitative susceptibility mapping

Micro‐EDXRF study of Chalcolithic copper‐based artefacts from Southern Portugal

Published: Aug 27, 2015

Author(s): R. Orestes Vidigal, P. Valério, M. F. Araújo, A. M. M. Soares, R. Mataloto

Journal: X-Ray Spectrometry

A collection of 39 metallic artefacts recovered in archaeological sites of Southern Portugal was studied by micro‐EDXRF to identify their compositions and the use of metal among ancient communities. Artefacts presented different typologies such as tools (e.g. awls, chisels and a saw) and weapons (e.g. daggers and arrowheads) mostly belonging to 2500–2000 BC. The results show copper with variable amounts of As and very low content of other...

Read More thumbnail image: MicroEDXRF study of Chalcolithic copperbased artefacts from Southern Portugal

Metaproteomics and metabolomics analyses of chronically petroleum‐polluted sites reveal the importance of general anaerobic processes uncoupled with degradation

Published: Aug 27, 2015

Author(s): Rafael Bargiela, Florian‐Alexander Herbst, Mónica Martínez‐Martínez, Jana Seifert, David Rojo, Simone Cappello, María Genovese, Francesca Crisafi, Renata Denaro, Tatyana N. Chernikova, Coral Barbas, Martin Bergen, Michail M. Yakimov, Manuel Ferrer, Peter N. Golyshin

Journal: PROTEOMICS

Crude oil is one of the most important natural assets for humankind, yet it is a major environmental pollutant, notably in marine environments. One of the largest crude oil polluted areas in the word is the semi‐enclosed Mediterranean Sea, in which the metabolic potential of indigenous microbial populations towards the large‐scale chronic pollution is yet to be defined, particularly in anaerobic and micro‐aerophilic sites. Here, we...

Read More thumbnail image: Metaproteomics and metabolomics analyses of chronically petroleumpolluted sites reveal the importance of general anaerobic processes uncoupled with degradation

Unveiling differences between patients with acute coronary syndrome with and without ST elevation through fingerprinting with CE‐MS and HILIC‐MS targeted analysis

Published: Aug 27, 2015

Author(s): Shama Naz, Ángela Algaba Calderón, Antonia García, Jessica Gallafrio, Rodrigo Teijeiro Mestre, Elena González González, Carlos Muñoz Cabo, Mari Cruz Martín Delgado, José Ángel Lorente Balanza, Ana Valéria Colnaghi Simionato, Nicolás Nin Vaeza, Coral Barbas, Francisco J. Rupérez

Journal: ELECTROPHORESIS

Differences in the degree and severity of Acute Coronary Syndrome, associated to differences in the electrocardiogram, together with blood tests of biomarkers classify patients for diagnosis and treatment. Cases where the electrocardiogram and/or biomarkers are not conclusive still appear, and there is a need for complementary biomarkers for routine determinations. Metabolomics approaches with blind fingerprinting could reveal differences...

Read More thumbnail image: Unveiling differences between patients with acute coronary syndrome with and without ST elevation through fingerprinting with CEMS and HILICMS targeted analysis

Determination of taurine in human tear fluid by capillary electrophoresis with indirect amperometric detection based on electrogenerated bromine

Published: Aug 27, 2015

Author(s): Fuying Du, Wenfeng Zhao, Shunan Cao, Ying‐Sing Fung

Journal: Journal of Separation Science

A new method for the determination of taurine was developed based on indirect amperometric detection after capillary electrophoresis. A serial dual‐electrode detector comprising an on column Pt film electrode (upstream electrode) and an end column Pt microdisk electrode (downstream electrode) was utilized to conduct the indirect amperometric detection. Bromide is oxidized to bromine at upstream electrode and reduced back to bromide at...

Read More thumbnail image: Determination of taurine in human tear fluid by capillary electrophoresis with indirect amperometric detection based on electrogenerated bromine

The sensitive capillary electrophoretic‐LIF method for simultaneous determination of curcuminoids in turmeric by enhancing fluorescence intensities of molecules upon inclusion into (2‐hydroxypropyl)‐β‐cyclodextrin

Published: Aug 27, 2015

Author(s): Zeynep Kalaycıoğlu, Parya Hashemi, Keriman Günaydın, F. Bedia Erim

Journal: ELECTROPHORESIS

Curcuminoids have received great attention in the past decades due to their health benefit properties. The aim of this study is to develop a very simple, rapid, and sensitive capillary zone electrophoresis technique coupled with a laser induced fluorescence detector (LIF) for the simultaneous determination of three major curcuminoids of turmeric, namely, curcumin, demethoxy curcumin (DMC), and bisdemethoxy curcumin (BDMC). Background...

Read More thumbnail image: The sensitive capillary electrophoreticLIF method for simultaneous determination of curcuminoids in turmeric by enhancing fluorescence intensities of molecules upon inclusion into 2hydroxypropylcyclodextrin

An LC‐MS/MS method for simultaneous determination of cefprozil diastereomers in human plasma and its application for the bioequivalence study of two cefprozil tablets in healthy Chinese volunteers

Published: Aug 27, 2015

Author(s): Min Liu, Jing‐Yi Ma, Yanan Zhang, Xiaolin Wang, Hongna Zhao, Aihua Du, Man Yang, Lingjie Meng, Ming Deng, Huichen Liu

Journal: Biomedical Chromatography

Abstract A rapid and sensitive liquid chromatography–tandem mass spectrometric method was developed for the first time and validated for the determination of cefprozil diastereomers in human plasma. The plasma samples were prepared by protein precipitation using acetonitrile. Detection was performed using an electronic spray ion source in the negative ion mode, operating in the multiple reaction monitoring of the transitions m/z...

Read More thumbnail image: An LCMSMS method for simultaneous determination of cefprozil diastereomers in human plasma and its application for the bioequivalence study of two cefprozil tablets in healthy Chinese volunteers

Serum metabolomics analysis reveals changes in signaling lipids in breast cancer patients

Published: Aug 27, 2015

Author(s): Min Cui, Qiaolian Wang, Guang Chen

Journal: Biomedical Chromatography

Abstract Breast cancer is the most commonly diagnosed cancer and one of the leading causes of cancer death among women worldwide. It is a biologically variable disease with different molecular subtypes, risk factors, clinical behaviors and responses to treatment. Better understanding of the molecular changes associated with each subtype is essential for identifying new therapeutic targets and markers for the monitoring of treatment...

Read More thumbnail image: Serum metabolomics analysis reveals changes in signaling lipids in breast cancer patients

Comparative pharmacokinetics and brain distribution of magnolol and honokiol after oral administration of Magnolia officinalis cortex extract and its compatibility with other herbal medicines in Zhi‐Zi‐Hou‐Po Decoction to rats

Published: Aug 27, 2015

Author(s): Yuan Liu, Dan Wang, Gongjun Yang, Qingshui Shi, Fang Feng

Journal: Biomedical Chromatography

Abstract Zhi‐Zi‐Hou‐Po decoction (ZZHPD) is one of the famous antidepressant Chinese formulas and is composed of Magnolia officinalis cortex (HP), Gardenia jasminoides Ellis (ZZ) and Citrus aurantium L. (ZS). Magnolol (MN) and honokiol (HN) from HP are the major active ingredients responsible for the therapeutic effects of ZZHPD. The aim of this study is to compare the pharmacokinetics and rat brain distribution of MN and HN after oral administration ...

Read More thumbnail image: Comparative pharmacokinetics and brain distribution of magnolol and honokiol after oral administration of Magnolia officinalis cortex extract and its compatibility with other herbal medicines in ZhiZiHouPo Decoction to rats

Measurement of ceftazidime concentration in human plasma by ultra‐performance liquid chromatography–tandem mass spectrometry. Application to critically ill patients and patients with osteoarticular infections

Published: Aug 27, 2015

Author(s): Raül Rigo‐Bonnin, Sara Cobo‐Sacristán, Ariadna Padullés, Alba Ribera, Ariadna Arbiol‐Roca, Óscar Murillo, Joan Sabater‐Riera, Pedro Alía

Journal: Biomedical Chromatography

Abstract Ceftazidime is an antibiotic belonging to the third generation of the cephalosporin family. It is indicated in the treatment of serious, simple or mixed bacterial infections, and its administration in continuous or intermittent infusion allows optimization of the concentration of antibiotic to keep it above the minimum inhibitory concentration. We developed and validated a chromatographic method by ultra‐performance liquid...

Read More thumbnail image: Measurement of ceftazidime concentration in human plasma by ultraperformance liquid chromatographytandem mass spectrometry_ Application to critically ill patients and patients with osteoarticular infections

A high‐performance liquid chromatography assay with a triazole‐bonded column for evaluation of d ‐amino acid oxidase activity

Published: Aug 27, 2015

Author(s): Megumi Iwasaki, Yoshiyuki Kashiwaguma, Chihiro Nagashima, Mao Izumi, Ayano Uekusa, Sumiko Iwasa, Mayu Onozato, Hideaki Ichiba, Takeshi Fukushima

Journal: Biomedical Chromatography

Abstract Elution profiles of kynurenic acid (KYNA) and 7‐chlorokynurenic acid (Cl‐KYNA) were examined by high‐performance liquid chromatography (HPLC) using a triazole‐bonded stationary phase column (Cosmosil® HILIC) under isocratic elution of a mobile phase consisting of CH3CN–aqueous 10 mm ammonium formate between pH 3.0 and 6.0. The capacity factors of KYNA and Cl‐KYNA varied with both the CH3CN content and the pH of the mobile phase. The...

Read More thumbnail image: A highperformance liquid chromatography assay with a triazolebonded column for evaluation of d amino acid oxidase activity
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