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Development of a liquid chromatography–mass spectrometry method for determination of agrimol B in rat plasma: application to preclinical pharmacokinetics

Published: Jul 26, 2014

Author(s): Zhenglin Wang, Peng Liu, Pin Liang, Xiang Hu

Journal: Biomedical Chromatography

ABSTRACT A sensitive and accurate liquid chromatography coupled with mass spectrometry (LC‐MS) method was developed for the determination of agrimol B, a main active ingredient isolated from Agrimonia pilosa Ledeb., in rat plasma. Chromatographic separation was achieved on a Zorbax CN column (150 × 4.6 mm, 5 µm), with isocratic elution consisting of acetonitrile and water (15:85, v/v) at a flow rate of 0.6 mL/min. Agrimol B and dryocrassin...

Read More thumbnail image: Development of a liquid chromatographymass spectrometry method for determination of agrimol B in rat plasma application to preclinical pharmacokinetics

Determination of a novel phosphodiesterase4 inhibitor, 3‐[1‐(3cyclopropylmethoxy‐4‐difluoromethoxybenzyl)‐1H‐pyrazol‐3‐yl]‐benzoic acid (PDE‐423) in rat plasma using liquid chromatography–tandem mass spectrometry

Published: Jul 26, 2014

Author(s): Woon‐Ki Cho, Hyewon Seo, Sung Heum Choi, Hyun Jeong Kwak, Hyae Gyeong Cheon, Dong Ju Jeon, Sang Kyum Kim, Myung Ae Bae, Jin Sook Song

Journal: Biomedical Chromatography

ABSTRACT A method for determining a novel phosphodiesterase‐4 inhibitor, 3‐[1‐(3cyclopropylmethoxy‐4‐difluoromethoxybenzyl)‐1H‐pyrazol‐3‐yl]‐benzoic acid (PDE‐423), in rat plasma was developed and validated using liquid chromatography–tandem mass spectrometry for further pharmacokinetic study for development as a novel anti‐asthmatic drug. PDE‐423 in the concentration range of 0.02–10 µg/mL was linear with a correlation coefficient...

Read More thumbnail image: Determination of a novel phosphodiesterase4 inhibitor 313cyclopropylmethoxy4difluoromethoxybenzyl1Hpyrazol3ylbenzoic acid PDE423 in rat plasma using liquid chromatographytandem mass spectrometry

Rapid and robust pulmonary proton ZTE imaging in the mouse

Published: Jul 26, 2014

Author(s): Markus Weiger, Mingming Wu, Moritz C. Wurnig, David Kenkel, Wolfgang Jungraithmayr, Andreas Boss, Klaas P. Pruessmann

Journal: NMR in Biomedicine

Pulmonary MRI is challenging because of the low proton density and rapid transverse relaxation in the lung associated with microscopic magnetic field inhomogeneities caused by tissue–air interfaces. Therefore, low signal is obtained in gradient and spin echo proton images. Alternatively, non‐proton MRI using hyperpolarized gases or radial techniques with ultrashort or zero TE have been proposed to image the lung. Also with the latter...

Read More thumbnail image: Rapid and robust pulmonary proton ZTE imaging in the mouse

Partial volume correction of brain perfusion estimates using the inherent signal data of time‐resolved arterial spin labeling

Published: Jul 26, 2014

Author(s): André Ahlgren, Ronnie Wirestam, Esben Thade Petersen, Freddy Ståhlberg, Linda Knutsson

Journal: NMR in Biomedicine

Quantitative perfusion MRI based on arterial spin labeling (ASL) is hampered by partial volume effects (PVEs), arising due to voxel signal cross‐contamination between different compartments. To address this issue, several partial volume correction (PVC) methods have been presented. Most previous methods rely on segmentation of a high‐resolution T1‐weighted morphological image volume that is coregistered to the low‐resolution ASL data, making the...

Read More thumbnail image: Partial volume correction of brain perfusion estimates using the inherent signal data of timeresolved arterial spin labeling

Multi‐parametric MRI characterization of healthy human thigh muscles at 3.0 T – relaxation, magnetization transfer, fat/water, and diffusion tensor imaging

Published: Jul 26, 2014

Author(s): Ke Li, Richard D. Dortch, E. Brian Welch, Nathan D. Bryant, Amanda K. W. Buck, Theodore F. Towse, Daniel F. Gochberg, Mark D. Does, Bruce M. Damon, Jane H. Park

Journal: NMR in Biomedicine

Muscle diseases commonly have clinical presentations of inflammation, fat infiltration, fibrosis, and atrophy. However, the results of existing laboratory tests and clinical presentations are not well correlated. Advanced quantitative MRI techniques may allow the assessment of myo‐pathological changes in a sensitive and objective manner. To progress towards this goal, an array of quantitative MRI protocols was implemented for human thigh...

Read More thumbnail image: Multiparametric MRI characterization of healthy human thigh muscles at 3_0 T  relaxation magnetization transfer fatwater and diffusion tensor imaging

Discrimination between glioblastoma multiforme and solitary metastasis using morphological features derived from the p : q tensor decomposition of diffusion tensor imaging

Published: Jul 26, 2014

Author(s): Guang Yang, Timothy L. Jones, Thomas R. Barrick, Franklyn A. Howe

Journal: NMR in Biomedicine

The management and treatment of high‐grade glioblastoma multiforme (GBM) and solitary metastasis (MET) are very different and influence the prognosis and subsequent clinical outcomes. In the case of a solitary MET, diagnosis using conventional radiology can be equivocal. Currently, a definitive diagnosis is based on histopathological analysis on a biopsy sample. Here, we present a computerised decision support framework for discrimination...

Read More thumbnail image: Discrimination between glioblastoma multiforme and solitary metastasis using morphological features derived from the p  q tensor decomposition of diffusion tensor imaging

Four‐dimensional MRI of renal function in the developing mouse

Published: Jul 26, 2014

Author(s): Luke Xie, Ergys Subashi, Yi Qi, Mark A. Knepper, G. Allan Johnson

Journal: NMR in Biomedicine

The major roles of filtration, metabolism and high blood flow make the kidney highly vulnerable to drug‐induced toxicity and other renal injuries. A method to follow kidney function is essential for the early screening of toxicity and malformations. In this study, we acquired high spatiotemporal resolution (four dimensional) datasets of normal mice to follow changes in kidney structure and function during development. The data were...

Read More thumbnail image: Fourdimensional MRI of renal function in the developing mouse

Inert fluorinated gas MRI: a new pulmonary imaging modality

Published: Jul 26, 2014

Author(s): Marcus J. Couch, Iain K. Ball, Tao Li, Matthew S. Fox, Alexei V. Ouriadov, Birubi Biman, Mitchell S. Albert

Journal: NMR in Biomedicine

Fluorine‐19 (19F) MRI of the lungs using inhaled inert fluorinated gases can potentially provide high quality images of the lungs that are similar in quality to those from hyperpolarized (HP) noble gas MRI. Inert fluorinated gases have the advantages of being nontoxic, abundant, and inexpensive compared with HP gases. Due to the high gyromagnetic ratio of 19F, there is sufficient thermally polarized signal for imaging, and averaging within a single...

Read More thumbnail image: Inert fluorinated gas MRI a new pulmonary imaging modality

Comparison of T 1 relaxation times in adipose tissue of severely obese patients and healthy lean subjects measured by 1.5 T MRI

Published: Jul 26, 2014

Author(s): Nikita Garnov, Nicolas Linder, Alexander Schaudinn, Matthias Blüher, Thomas Karlas, Tatjana Schütz, Arne Dietrich, Thomas Kahn, Harald Busse

Journal: NMR in Biomedicine

Subcutaneous (SAT) and visceral adipose tissue (VAT) differ in composition, endocrine function and localization in the body. VAT is considered to play a role in the pathogenesis of insulin resistance, type 2 diabetes, fatty liver disease, and other obesity‐related disorders. It has been shown that the amount, distribution, and (cellular) composition of adipose tissue (AT) correlate well with metabolic conditions. In this study, T1...

Read More thumbnail image: Comparison of T 1 relaxation times in adipose tissue of severely obese patients and healthy lean subjects measured by 1_5T MRI

PLS‐DA for compositional data with application to metabolomics

Published: Jul 25, 2014

Author(s): Alžběta Kalivodová, Karel Hron, Peter Filzmoser, Lukáš Najdekr, Hana Janečková, Tomáš Adam

Journal: Journal of Chemometrics

When quantifying information in metabolomics, the results are often expressed as data carrying only relative information. Vectors of these data have positive components, and the only relevant information is contained in the ratios between their parts; such observations are called compositional data. The aim of the paper is to demonstrate how partial least squares discriminant analysis (PLS‐DA)—the most widely used method in chemometrics...

Read More thumbnail image: PLSDA for compositional data with application to metabolomics

Raman microspectroscopy of gemstones from a chalice made in 1732

Published: Jul 25, 2014

Author(s): Miha Jeršek, Sabina Kramar

Journal: Journal of Raman Spectroscopy

The baroque chalice made in 1732 contains 456 embedded gemstones and is one the most richly decorated chalices in Slovenia. With the aid of Raman microspectroscopy, in combination with gemology microscopy and ultraviolet fluorescence, individual types of gemstones and certain inclusions were analysed and determined. The chalice was adorned with 24 diamonds, 93 rubies, 4 sapphires, 152 emeralds, 101 almandine garnets, 6 grossular garnets,...

Read More thumbnail image: Raman microspectroscopy of gemstones from a chalice made in 1732

Interpretation of group‐level factors from a large population dataset in the determination of ethyl glucuronide in hair

Published: Jul 25, 2014

Author(s): Alberto Salomone, Valentina Pirro, Tonia Lombardo, Daniele Di Corcia, Sergio Pellegrino, Marco Vincenti

Journal: Drug Testing and Analysis

Ethyl glucuronide in hair (HEtG) is the most accredited marker to prove chronic alcohol abuse. In this study, we evaluate the comprehensive results of HEtG determination obtained during four years of activity (2009–2013) in our laboratory (Northwestern Italy) – across a large cohort of subjects (over 20 000 subjects mostly undergoing medical examination for driving re‐licensing) – to provide a general perspective on HEtG analysis and...

Read More thumbnail image: Interpretation of grouplevel factors from a large population dataset in the determination of ethyl glucuronide in hair

Spatial distribution of theobromine – a low MW drug – in tissues via matrix‐free NALDI‐MS imaging

Published: Jul 25, 2014

Author(s): Alessandra Tata, Chiara Montemurro, Andreia M. Porcari, Kamila C. Silva, José B. Lopes de Faria, Marcos N. Eberlin

Journal: Drug Testing and Analysis

The ability of nano‐assisted laser desorption‐ionization mass spectrometry imaging (NALDI‐IMS) to provide selective chemical monitoring with appropriate spatial distribution of a low molecular drug in a biological tissue was investigated. NALDI‐IMS is a matrix‐free laser desorption ionization (LDI) protocol based on imprinting of tissue constituents on a nanostructured surface. Using the accumulation of theobromine in rat kidney as a...

Read More thumbnail image: Spatial distribution of theobromine  a low MW drug  in tissues via matrixfree NALDIMS imaging

A novel UPLC‐MS/MS method for sensitive quantitation of boldine in plasma, a potential anti‐inflammatory agent: application to a pharmacokinetic study in rats

Published: Jul 25, 2014

Author(s): Rong‐Jie Zeng, Yu Li, Jian‐Zhong Chen, Gui‐Xin Chou, Yu Gao, Jing‐Wei Shao, Lee Jia, Sheng‐Dong Wu, Shui‐Sheng Wu

Journal: Biomedical Chromatography

ABSTRACT Boldine is a potential anti‐inflammatory agent found in several different plants. Published bioanalytical methods using HPLC with ultraviolet and fluorescent detection lacked enough sensitivity and required tedious sample preparation procedures. Herein, we describe the development of a novel ultra‐high performance LC with MS/MS for determination of boldine in plasma. Boldine in plasma was recovered by liquid–liquid...

Read More thumbnail image: A novel UPLCMSMS method for sensitive quantitation of boldine in plasma a potential antiinflammatory agent application to a pharmacokinetic study in rats

Facile preparation of boronic acid‐functionalized magnetic nanoparticles with a high capacity and their use in the enrichment of cis ‐diol‐containing compounds from plasma

Published: Jul 25, 2014

Author(s): Jin Du, Maofang He, Xiaomeng Wang, Hua Fan, Yinmao Wei

Journal: Biomedical Chromatography

ABSTRACT The use of bronate affinity adsorbents is a new separation method that appeared recently with great potential for specific extraction of cis‐diol‐containing compounds. In this work,a new strategy for the facile construction of boronic acid‐functionalized Fe3O4 magnetic nanoparticles (Fe3O4@FPBA MNPs) with a high capacity was described. The extraction capacity of the Fe3O4@FPBA MNPs was determined to be 66.0 ± 2.7 µmol/g for catechol and 80.6 ± 2.0...

Read More thumbnail image: Facile preparation of boronic acidfunctionalized magnetic nanoparticles with a high capacity and their use in the enrichment of cis diolcontaining compounds from plasma

Combining analysis of variance and three‐way factor analysis methods for studying additive and multiplicative effects in sensory panel data

Published: Jul 24, 2014

Author(s): Rosaria Romano, Tormod Næs, Per Bruun Brockhoff

Journal: Journal of Chemometrics

Data from descriptive sensory analysis are essentially three‐way data with assessors, samples and attributes as the three ways in the data set. Because of this, there are several ways that the data can be analysed. The paper focuses on the analysis of sensory characteristics of products while taking into account the individual differences among assessors. In particular, we will be interested in considering the multiplicative assessor...

Read More thumbnail image: Combining analysis of variance and threeway factor analysis methods for studying additive and multiplicative effects in sensory panel data

A dispersive liquid–liquid micellar microextraction for the determination of pharmaceutical compounds in wastewaters using ultra‐high‐performace liquid chromatography with DAD detection

Published: Jul 24, 2014

Author(s): Sarah Montesdeoca‐Esponda, Cristina Mahugo‐Santana, Zoraida Sosa‐Ferrera, José Juan Santana‐Rodríguez

Journal: Biomedical Chromatography

ABSTRACT A dispersive liquid–liquid micellar microextraction (DLLMME) method coupled with ultra‐high‐performance liquid chromatography (UHPLC) using Diode Array Detector (DAD) detector was developed for the analysis of five pharmaceutical compounds of different nature in wastewaters. A micellar solution of a surfactant, polidocanol, as extraction solvent (100 μL) and chloroform as dispersive solvent (200 μL) were used to extract and...

Read More thumbnail image: A dispersive liquidliquid micellar microextraction for the determination of pharmaceutical compounds in wastewaters using ultrahighperformace liquid chromatography with DAD detection

Cerebral blood volume estimation by ferumoxytol‐enhanced steady‐state MRI at 9.4 T reveals microvascular impact of α 1 ‐adrenergic receptor antibodies

Published: Jul 24, 2014

Author(s): Andreas Pohlmann, Peter Karczewski, Min‐Chi Ku, Babette Dieringer, Helmar Waiczies, Natali Wisbrun, Stefanie Kox, Irina Palatnik, Henning Matthias Reimann, Christina Eichhorn, Sonia Waiczies, Petra Hempel, Bernd Lemke, Thoralf Niendorf, Marion Bimmler

Journal: NMR in Biomedicine

Cerebrovascular abnormality is frequently accompanied by cognitive dysfunctions, such as dementia. Antibodies against the α1‐adrenoceptor (α1‐AR) can be found in patients with Alzheimer's disease with cerebrovascular disease, and have been shown to affect the larger vessels of the brain in rodents. However, the impact of α1‐AR antibodies on the cerebral vasculature remains unclear. In the present study, we established a neuroimaging method to ...

Read More thumbnail image: Cerebral blood volume estimation by ferumoxytolenhanced steadystate MRI at 9_4T reveals microvascular impact of  1 adrenergic receptor antibodies

Quality assessment of Cinnamomi Ramulus by the simultaneous analysis of multiple active components using high‐performance thin‐layer chromatography and high‐performance liquid chromatography

Published: Jul 24, 2014

Author(s): Xiaoxue Wu, Jiao He, Huarong Xu, Kaishun Bi, Qing Li

Journal: Journal of Separation Science

A novel and improved method for the quality assessment of Cinnamomi Ramulus was developed and completely validated. The method was established using fingerprint technology and simultaneous quantitative determination of six main marker compounds including coumarin, cinnamic alcohol, cinnamic acid, 2‐methoxy cinnamic acid, cinnamaldehyde, and 2‐methoxy cinnamaldehyde in the herbal medicine for the first time. A newly developed...

Read More thumbnail image: Quality assessment of Cinnamomi Ramulus by the simultaneous analysis of multiple active components using highperformance thinlayer chromatography and highperformance liquid chromatography

Fast separation of warfarin and 7‐hydroxywarfarin enantiomers by cyclodextrin‐assisted capillary electrophoresis

Published: Jul 24, 2014

Author(s): Paweł Nowak, Magdalena Garnysz, Michał Woźniakiewicz, Paweł Kościelniak

Journal: Journal of Separation Science

The enantioseparation of warfarin and its main metabolite has been achieved using several cyclodextrin types and buffers at different pH, including conditions that have not been attempted so far. Methyl‐β‐cyclodextrin, highly sulfated‐β‐cyclodextrin and highly sulfated‐γ‐cyclodextrin were the most efficient chiral selectors. The pH range, within which particular cyclodextrins support chiral separation, has been approximately determined...

Read More thumbnail image: Fast separation of warfarin and 7hydroxywarfarin enantiomers by cyclodextrinassisted capillary electrophoresis
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