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Liquid chromatography‐electron ionization tandem mass spectrometry with the Direct‐EI interface in the fast determination of diazepam and flunitrazepam in alcoholic beverages

Published: Feb 5, 2016

Author(s): Giorgio Famiglini, Veronica Termopoli, Pierangela Palma, Achille Cappiello

Journal: ELECTROPHORESIS

This is the first application based on electron ionization (EI) using a Direct‐EI LC interface and MS/MS to detect unequivocally target compounds in a very small real sample. The determination and quantification of benzodiazepines in very small residues of beverages, collected at the scene of drug‐facilitated crimes are mandatory in legal procedures. A specific and sensitive analytical instrumentation is needed, involving little or no...

Read More thumbnail image: Liquid chromatographyelectron ionization tandem mass spectrometry with the DirectEI interface in the fast determination of diazepam and flunitrazepam in alcoholic beverages

Deconvolution of distinct lithology chemistry through oversampling with the Mars Science Laboratory Alpha Particle X‐Ray Spectrometer

Published: Feb 5, 2016

Author(s): Scott J. VanBommel, Ralf Gellert, Jeff A. Berger, John L. Campbell, Lucy M. Thompson, Kenneth S. Edgett, Marie J. McBride, Michelle E. Minitti, Irina Pradler, Nicholas I. Boyd

Journal: X-Ray Spectrometry

The Alpha Particle X‐Ray Spectrometer (APXS) determines the chemical composition of Martian rocks and soils on‐board both active National Aeronautics and Space Administration (NASA) rovers using X‐ray emission spectroscopy through complementary particle‐induced X‐ray emission (PIXE) and X‐ray fluorescence (XRF) excitation methods. A single APXS spectrum represents the sum of the signals from within the instrument's field of...

Read More thumbnail image: Deconvolution of distinct lithology chemistry through oversampling with the Mars Science Laboratory Alpha Particle XRay Spectrometer

Raman spectroscopy as suitable tool for the field study of recent volcanic environments

Published: Feb 5, 2016

Author(s): G. Guimbretière, A. Canizarès, A. Finizola, E. Delcher, N. Raimboux, A. Di Muro, P. Simon, B. Devouard, A. Bertil

Journal: Journal of Raman Spectroscopy

In 2013, a portable Raman setup was implemented for on‐site and rear‐base characterization of volcanic products. Silica and rutile rock coatings, sulfate incrustations and speleothems, plagioclase, clinopyroxene, and (Fe, Ti, Cr) oxides lava minerals were identified on the young lava flows of Piton de la Fournaise volcano. These analytical abilities opens the way of in situ study of the first aging and weathering steps of recent lava flows. This...

Read More thumbnail image: Raman spectroscopy as suitable tool for the field study of recent volcanic environments

Rapid identification of the quality decoction pieces by partial least squares ‐based pattern recognition: grade classification of the decoction pieces of Saposhnikovia divaricata

Published: Feb 4, 2016

Author(s): Ying Liu, Li Li, Yongqing Xiao, Jiaqi Yao, Pengyuan Li, Liang Chen, Dingrong Yu, Yinlian Ma

Journal: Biomedical Chromatography

Abstract Herbal medicines are commonly used in many countries after they undergo processing. Quality decoction pieces are a guarantee of the efficacy and safety of the herbal medical products. Here, a strategy based on chemical analysis combined with chemometric techniques was proposed for the classification and prediction of the different grades of the decoction pieces. Considering the necessity for a shared and simple method for...

Read More thumbnail image: Rapid identification of the quality decoction pieces by partial least squares based pattern recognition grade classification of the decoction pieces of Saposhnikovia divaricata

Epitope located N ‐glycans impair the MHC‐I epitope generation and presentation

Published: Feb 3, 2016

Author(s): Gabriela N. Chiritoiu, Camilla Jandus, Cristian V.A. Munteanu, Simona Ghenea, Philippe O. Gannon, Pedro Romero, Stefana M. Petrescu

Journal: ELECTROPHORESIS

The degradation process of the antigens specific to MHC‐I presentation depends mainly on the proteasomal proteases in the cytosol. However, since many antigens are glycoproteins, including tumor antigens or viruses envelope proteins, their glycosylation status could also affect their processing and presentation. Here, we investigate the processing of tyrosinase, a multiple glycosylated tumor antigen overexpressed in human malignant...

Read More thumbnail image: Epitope located N glycans impair the MHCI epitope generation and presentation

A wavelet‐PCA method saves high mass resolution information in data treatment of SIMS molecular depth profiles

Published: Feb 3, 2016

Author(s): Nunzio Tuccitto, Gabriella Zappalà, Stefania Vitale, Alberto Torrisi, Antonino Licciardello

Journal: Surface and Interface Analysis

A detailed depth characterization of multilayered polymeric systems is a very attractive topic. Currently, the use of cluster primary ion beams in time‐of‐flight secondary ion mass spectrometry allows molecular depth profiling of organic and polymeric materials. Because typical raw data may contain thousands of peaks, the amount of information to manage grows rapidly and widely, so that data reduction techniques become indispensable in...

Read More thumbnail image: A waveletPCA method saves high mass resolution information in data treatment of SIMS molecular depth profiles

The comparative pharmacokinetics of four bioactive ingredients after administration of Ramulus CinnamomiRadix Glycyrrhizae herb pair extract, Ramulus Cinnamomi extract and Radix Glycyrrhizae extract

Published: Feb 2, 2016

Author(s): Shengnan Wang, Lijiao Sun, Liqiang Gu, Yuanyuan Zhang, Simin Zhao, Long‐shan Zhao, Kai‐shun Bi, Xiaohui Chen

Journal: Biomedical Chromatography

Abstract Ramulus Cinnamomi (RC)–Radix Glycyrrhizae (RG) is a classic herb pair, which is commonly used as a fixed form to treat cardiovascular disease in the clinic. Our work aimed to compare the pharmacokinetic difference of cinnamic acid, liquiritin, isoliquiritigenin and glycyrrhetinic acid in rats after oral administration of the RC–RG herb pair extracts [Guizhigancao Decoction (GGD) and Lingguizhugan Decoction (LGZGD)] and the...

Read More thumbnail image: The comparative pharmacokinetics of four bioactive ingredients after administration of Ramulus Cinnamomi  Radix Glycyrrhizae herb pair extract Ramulus Cinnamomi extract and Radix Glycyrrhizae extract

Microparticles manipulation and enhancement of their separation in pinched flow fractionation by insulator‐based dielectrophoresis

Published: Feb 2, 2016

Author(s): Hesamodin Khashei, Hamid Latifi, Mohsen Jamshidi Seresht, Amir Hossein Baradaran Ghasemi

Journal: ELECTROPHORESIS

The separation and manipulation of microparticles in lab on a chip devices have importance in point of care diagnostic tools and analytical applications. The separation and sorting of particles from biological and clinical samples can be performed using active and passive techniques. In passive techniques, no external force is applied while in active techniques by applying external force (e.g. electrical), higher separation efficiency is...

Read More thumbnail image: Microparticles manipulation and enhancement of their separation in pinched flow fractionation by insulatorbased dielectrophoresis

One‐pot synthesis of a new high vinyl content hybrid silica monolith dedicated to nanoliquid chromatography

Published: Feb 2, 2016

Author(s): El‐Debs Racha, Pauline Gay, Vincent Dugas, Claire Demesmay

Journal: Journal of Separation Science

A new vinyltrimethoxysilane‐based hybrid silica monolith was developed and used as a reversed‐phase capillary column. The synthesis of this rich vinyl hybrid macroporous monolith, by cocondensation of vinyltrimethoxysilane with tetramethoxysilane, was investigated using an unconventional (formamide, nitric acid) porogen/catalyst system. A macroporous hybrid silica monolith with 80% in mass of vinyltrimethoxysilane in the feeding silane...

Read More thumbnail image: Onepot synthesis of a new high vinyl content hybrid silica monolith dedicated to nanoliquid chromatography

Vortex‐ and CO 2 ‐gas‐assisted liquid–liquid microextraction with salt addition for the high‐performance liquid chromatographic determination of furanic compounds in concentrated juices and dried fruits

Published: Feb 2, 2016

Author(s): Nur‐Bahiyah Abu‐Bakar, Ahmad Makahleh, Bahruddin Saad

Journal: Journal of Separation Science

A novel microextraction method based on vortex‐ and CO2‐assisted liquid–liquid microextraction with salt addition for the isolation of furanic compounds (5‐hydroxymethyl‐2‐furaldehyde, 5‐methyl‐2‐furaldehyde, 2‐furaldehyde, 3‐furaldehyde, 2‐furoic and 3‐furoic acids) was developed. Purging the sample with CO2 was applied after vortexing to enhance the phase separation and mass transfer of the analytes. The optimum extraction conditions ...

Read More thumbnail image: Vortex and CO 2 gasassisted liquidliquid microextraction with salt addition for the highperformance liquid chromatographic determination of furanic compounds in concentrated juices and dried fruits

Online solid‐phase extraction with high‐performance liquid chromatography and mass spectrometry for the determination of five tannins in traditional Chinese medicine injections

Published: Feb 2, 2016

Author(s): Meng Sun, Yuanyuan Lin, Jie Zhang, Shaohua Zheng, Sicen Wang

Journal: Journal of Separation Science

A rapid analytical method based on online solid‐phase extraction with high‐performance liquid chromatography and mass spectrometry has been established and applied to the determination of tannin compounds that may cause adverse effects in traditional Chinese medicine injections. Different solid‐phase extraction sorbents have been compared and the elution buffer was optimized. The performance of the method was verified by evaluation of...

Read More thumbnail image: Online solidphase extraction with highperformance liquid chromatography and mass spectrometry for the determination of five tannins in traditional Chinese medicine injections

Effects of formalin fixation and temperature on MR relaxation times in the human brain

Published: Feb 2, 2016

Author(s): Christoph Birkl, Christian Langkammer, Nicole Golob‐Schwarzl, Marlene Leoni, Johannes Haybaeck, Walter Goessler, Franz Fazekas, Stefan Ropele

Journal: NMR in Biomedicine

Post‐mortem MRI of the brain is increasingly applied in neuroscience for a better understanding of the contrast mechanisms of disease induced tissue changes. However, the influence of chemical processes caused by formalin fixation and differences in temperature may hamper the comparability with results from in vivo MRI. In this study we investigated how formalin fixation and temperature affect T1, T2 and T2*...

Read More thumbnail image: Effects of formalin fixation and temperature on MR relaxation times in the human brain

In vivo observation of quadrupolar splitting in 39 K magnetic resonance spectroscopy of human muscle tissue

Published: Feb 2, 2016

Author(s): M. B. Rösler, A. M. Nagel, R. Umathum, P. Bachert, N. Benkhedah

Journal: NMR in Biomedicine

The purpose of this work was to explore the origin of oscillations of the T*2 decay curve of 39K observed in studies of 39K magnetic resonance imaging of the human thigh. In addition to their magnetic dipole moment, spin‐3/2 nuclei possess an electric quadrupole moment. Its interaction with non‐vanishing electrical field gradients leads to oscillations in the free induction decay and to splitting of the resonance. All...

Read More thumbnail image: In vivo observation of quadrupolar splitting in 39 K magnetic resonance spectroscopy of human muscle tissue

Rapid brain MRI acquisition techniques at ultra‐high fields

Published: Feb 2, 2016

Author(s): Kawin Setsompop, David A. Feinberg, Jonathan R. Polimeni

Journal: NMR in Biomedicine

Ultra‐high‐field MRI provides large increases in signal‐to‐noise ratio (SNR) as well as enhancement of several contrast mechanisms in both structural and functional imaging. Combined, these gains result in a substantial boost in contrast‐to‐noise ratio that can be exploited for higher‐spatial‐resolution imaging to extract finer‐scale information about the brain. With increased spatial resolution, however, there is a concurrent increased...

Read More thumbnail image: Rapid brain MRI acquisition techniques at ultrahigh fields

Metabolism of hyperpolarized [1‐ 13 C]pyruvate through alternate pathways in rat liver

Published: Feb 2, 2016

Author(s): Eunsook S. Jin, Karlos X. Moreno, Jian‐Xiong Wang, Leila Fidelino, Matthew E. Merritt, A. Dean Sherry, Craig R. Malloy

Journal: NMR in Biomedicine

The source of hyperpolarized (HP) [13C]bicarbonate in the liver during metabolism of HP [1‐13C]pyruvate is uncertain and likely changes with physiology. Multiple processes including decarboxylation through pyruvate dehydrogenase or pyruvate carboxylase followed by subsequent decarboxylation via phosphoenolpyruvate carboxykinase (gluconeogenesis) could play a role. Here we tested which metabolic fate of pyruvate contributed to the appearance of HP...

Read More thumbnail image: Metabolism of hyperpolarized 1 13 Cpyruvate through alternate pathways in rat liver

Quantitative shotgun proteomics reveals extensive changes to the proteome of the orbitofrontal cortex in rats that are hyperactive following withdrawal from a high sugar diet

Published: Feb 2, 2016

Author(s): Jane L. Franklin, Mehdi Mirzaei, Travis A. Wearne, Melanie K. Sauer, Judi Homewood, Ann K. Goodchild, Paul A. Haynes, Jennifer L. Cornish

Journal: PROTEOMICS

In most Westernized societies, there has been an alarming increase in the consumption of sugar‐sweetened drinks. For many adults these drinks represent a substantial proportion of their total daily caloric intake. Here we investigated whether extended exposure to sugar changes behavior and protein expression in the orbitofrontal cortex (OFC). Male adult Sprague‐Dawley rats (n = 8 per group) were treated for 26 days with either water or a...

Read More thumbnail image: Quantitative shotgun proteomics reveals extensive changes to the proteome of the orbitofrontal cortex in rats that are hyperactive following withdrawal from a high sugar diet

Covalent perturbation as a tool for validation of identifications and PTM mapping applied to bovine alpha‐crystallin

Published: Feb 2, 2016

Author(s): Jakob Bunkenborg, Lasse Gaarde Falkenby, Lea Mørch Harder, Henrik Molina

Journal: PROTEOMICS

Proteomic identifications hinge on the measurement of both parent and fragment masses and matching these to amino acid sequences via database search engines. The correctness of the identifications is assessed by statistical means. Here we present an experimental approach to test identifications. Chemical modification of all peptides in a sample leads to shifts in masses depending on the chemical properties of each peptide. The...

Read More thumbnail image: Covalent perturbation as a tool for validation of identifications and PTM mapping applied to bovine alphacrystallin

New azidation methods for the functionalization of silicon nitride and application in copper‐catalyzed azide‐alkyne cycloaddition (CuAAC)

Published: Feb 2, 2016

Author(s): N. Lange, P. M. Dietrich, A. Lippitz, N. Kulak, W. E. S. Unger

Journal: Surface and Interface Analysis

In this study, a new direct functionalization method of silicon nitride (Si3N4) using azidation and click chemistry is presented. First, amino groups (NHx) were created on a Si3N4 substrate by fluoride etching. These NHx‐terminated Si3N4 surfaces were analyzed by chemical derivatization X‐ray photoelectron spectroscopy with 4‐trifluoromethylbenzaldehyde, and a derivatization yield of 20% was concluded. In the second step, freshly prepared NHx surfaces were...

Read More thumbnail image: New azidation methods for the functionalization of silicon nitride and application in coppercatalyzed azidealkyne cycloaddition CuAAC

Medium energy ion irradiation of Ge surface – search for a better understanding of the surface nano‐patterning

Published: Feb 2, 2016

Author(s): Pravin Kumar, Priyanka Jain, Indra Sulania

Journal: Surface and Interface Analysis

We report the morphological changes on Ge surfaces upon 50 keV Ar+ and 100 keV Kr+ beam irradiation at 60° angle of incidence. The Ge surfaces having three different amorphous–crystalline (a/c) interfaces achieved by the pre‐irradiation of 50 keV Ar+ beam at 0°, 30° and 60° with a constant fluence of 5 × 1016 ions/cm2 were further processed by the same beam at higher fluences viz. 3 × 1017, 5 × 1017, 7 × 1017 and 9 × 1017 ions/cm2 to understand the mechanism of...

Read More thumbnail image: Medium energy ion irradiation of Ge surface  search for a better understanding of the surface nanopatterning

Optimal conditions for gas cluster ion beams in studying inorganic interface species: improved chemical information at a ZnO interface

Published: Feb 2, 2016

Author(s): Naoko Sano, Anders J. Barlow, Costas Tsakonas, Wayne Cranton, Peter J. Cumpson

Journal: Surface and Interface Analysis

We have observed for the first time a subtle chemical change in the oxidation state of Zn at the interface between a ZnO thin film and a glass substrate using gas cluster ion beam (GCIB) depth‐profiling. A combination of monoatomic and gas clusters was used for etching, allowing the removal of the surface rapidly using the monoatomic ion beam yet still yield a less damaged surface by removing the damaged layer using the argon GCIB as a...

Read More thumbnail image: Optimal conditions for gas cluster ion beams in studying inorganic interface species improved chemical information at a ZnO interface
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