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β ‐Methylphenylethylamines: common fragmentation pathways with amphetamines in electrospray ionization collision‐induced dissociation

Published: May 26, 2015

Author(s): David H. Brown, Robert Hansson, Francois Oosthuizen, Nathan Sumner

Journal: Drug Testing and Analysis

β‐Methylphenylethylamines are positional isomers of amphetamines and have been discovered in sporting supplements. Although the fragmentation of the β‐methylphenylethylamine and N‐methyl‐β‐methylphenylethylamine in gas chromatography‐electron ionization‐mass spectrometry (GC‐EI‐MS) systems is significantly different to their amphetamine and methylamphetamine isomers, under electrospray ionization commonly used in liquid chromatography‐mass ...

Read More thumbnail image:  Methylphenylethylamines common fragmentation pathways with amphetamines in electrospray ionization collisioninduced dissociation

Vibrational analysis of cinchona alkaloids in the solid state and aqueous solutions

Published: May 26, 2015

Author(s): Maciej Roman, Katarzyna Chruszcz‐Lipska, Malgorzata Baranska

Journal: Journal of Raman Spectroscopy

Cinchona alkaloids are well‐known antimalarial compounds also used in asymmetric synthesis in organic chemistry. In this work, vibrational spectra of quinine, quinidine, cinchonine, and cinchonidine were acquired and interpreted on the basis of theoretical calculations. Normal Raman spectra of the alkaloids in solution exhibit similar patterns and cannot be used for differentiation between the derivatives (e.g. quinine and cinchonidine)...

Read More thumbnail image: Vibrational analysis of cinchona alkaloids in the solid state and aqueous solutions

Surface‐enhanced Raman spectroscopy of various madder species on wool fibers: the role of pseudopurpurin in the interpretation of the spectra

Published: May 26, 2015

Author(s): Diana C. Rambaldi, Federica Pozzi, Nobuko Shibayama, Marco Leona, Frank D. Preusser

Journal: Journal of Raman Spectroscopy

Madder has been used as a textile dye and pigment in works of art since antiquity. Madder dyes from different botanical species are characterized by different series of anthraquinone derivatives. The occurrence of one or more of these compounds in various relative amounts may provide a useful indication of the plant species used to obtain the dye. In this work, surface‐enhanced Raman spectroscopy (SERS) was applied to the analysis of...

Read More thumbnail image: Surfaceenhanced Raman spectroscopy of various madder species on wool fibers the role of pseudopurpurin in the interpretation of the spectra

Energy band alignment of SnO 2 /SrTiO 3 epitaxial heterojunction studied by X‐ray photoelectron spectroscopy

Published: May 26, 2015

Author(s): Chang Ke, Weiguang Zhu, Zheng Zhang, Eng Soon Tok, Jisheng Pan

Journal: Surface and Interface Analysis

(200) SnO2//(111) SrTiO3 (STO) epitaxial heterojunctions were fabricated using the laser molecular epitaxy technique. Sharp junction interface was confirmed by the high‐resolution transmission electron microscopy. The valence band offset and conduction band offset of the SnO2/STO heterojunction were determined to be 0.85 ± 0.20 and 0.45 ± 0.20 eV using XPS, respectively. It is found that a type‐II band alignment forms at the SnO2/STO...

Read More thumbnail image: Energy band alignment of SnO 2 SrTiO 3 epitaxial heterojunction studied by Xray photoelectron spectroscopy

Cleaning of pyrolytic hexagonal boron nitride surfaces

Published: May 26, 2015

Author(s): Sean W. King, Robert J. Nemanich, Robert F. Davis

Journal: Surface and Interface Analysis

Hexagonal boron nitride (h‐BN) has recently garnered significant interest as a substrate and dielectric for two‐dimensional materials and devices based on graphene or transition metal dichalcogenides such as molybdenum disulfide (MoS2). As substrate surface impurities and defects can negatively impact the structure and properties of two‐dimensional materials, h‐BN surface preparation and cleaning are a critical consideration. In this regard, we have...

Read More thumbnail image: Cleaning of pyrolytic hexagonal boron nitride surfaces

Multi‐instrument characterization of poly(divinylbenzene) microspheres for use in liquid chromatography: as received, air oxidized, carbonized, and acid treated

Published: May 26, 2015

Author(s): Chuan‐Hsi Hung, Bhupinder Singh, Michael G. Landowski, Mohammed Ibrahim, Andrew J. Miles, David S. Jensen, Michael A. Vail, Andrew E. Dadson, Stacey J. Smith, Matthew R. Linford

Journal: Surface and Interface Analysis

We report a multi‐instrument characterization of the carbon particles in carbon/polymer/nanodiamond core‐shell materials used for high‐performance liquid chromatography. These particles are prepared by the carbonization/pyrolysis of poly(divinylbenzene) (PDVB) microspheres. Scanning electron microscopy showed that the particles (4.9 µm initially) decreased in size after air oxidation (to 4.4 µm) and again after carbonization (down to...

Read More thumbnail image: Multiinstrument characterization of polydivinylbenzene microspheres for use in liquid chromatography as received air oxidized carbonized and acid treated

Quantification of myo ‐inositol, 1,5‐anhydro‐ D ‐sorbitol, and D ‐chiro‐inositol using high‐performance liquid chromatography with electrochemical detection in very small volume clinical samples

Published: May 26, 2015

Author(s): Karen J. Schimpf, Claudia C. Meek, Richard D. Leff, Dale L. Phelps, Daniel J. Schmitz, Christopher T. Cordle

Journal: Biomedical Chromatography

Abstract Inositol is a six‐carbon sugar alcohol and is one of nine biologically significant isomers of hexahydroxycyclohexane. Myo‐inositol is the primary biologically active form and is present in higher concentrations in the fetus and newborn than in adults. It is currently being examined for the prevention of retinopathy of prematurity in newborn preterm infants. A robust method for quantifying myo‐inositol (MI), D‐chiro‐inositol (DCI) and...

Read More thumbnail image: Quantification of myo inositol 15anhydro D sorbitol and D chiroinositol using highperformance liquid chromatography with electrochemical detection in very small volume clinical samples

Experimentally validated Raman Monte Carlo simulation for a cuboid object to obtain Raman spectroscopic signatures for hidden material

Published: May 26, 2015

Author(s): Vijitha Periyasamy, Sanchita Sil, Gagan Dhal, Freek Ariese, Siva Umapathy, Manojit Pramanik

Journal: Journal of Raman Spectroscopy

In conventional Raman spectroscopic measurements of liquids or surfaces the preferred geometry for detection of the Raman signal is the backscattering (or reflection) mode. For non‐transparent layered materials, sub‐surface Raman signals have been retrieved using spatially offset Raman spectroscopy (SORS), usually with light collection in the same plane as the point of excitation. However, as a result of multiple scattering in a turbid...

Read More thumbnail image: Experimentally validated Raman Monte Carlo simulation for a cuboid object to obtain Raman spectroscopic signatures for hidden material

Cerebrovascular MRI: a review of state‐of‐the‐art approaches, methods and techniques

Published: May 26, 2015

Author(s): Matthew Ethan MacDonald, Richard Frayne

Journal: NMR in Biomedicine

Cerebrovascular imaging is of great interest in the understanding of neurological disease. MRI is a non‐invasive technology that can visualize and provide information on: (i) the structure of major blood vessels; (ii) the blood flow velocity in these vessels; and (iii) the microcirculation, including the assessment of brain perfusion. Although other medical imaging modalities can also interrogate the cerebrovascular system, MR provides a...

Read More thumbnail image: Cerebrovascular MRI a review of stateoftheart approaches methods and techniques

Potential of prodendronic polyamines with modulated segmental charge density as novel coating for fast and efficient analysis of peptides and basic proteins by CE and CE‐MS

Published: May 26, 2015

Author(s): Tanize Acunha, Clara Ibáñez, María Isabel Pascual Reguera, Mariagiovanna Sarò, Rodrigo Navarro, Juan Alfonso Redondo, Helmut Reinecke, Alberto Gallardo, Carolina Simó, Alejandro Cifuentes

Journal: ELECTROPHORESIS

In this work, the suitability of a new polymer family has been investigated as capillary coatings for the analysis of peptides and basic proteins by CE. This polymer family has been designed to minimize or completely prevent protein–capillary wall interactions and to modify the EOF. These coating materials are linear polymeric chains bearing as side cationizable moiety a dentronic triamine derived from...

Read More thumbnail image: Potential of prodendronic polyamines with modulated segmental charge density as novel coating for fast and efficient analysis of peptides and basic proteins by CE and CEMS

Proteomic profiling of lysine acetylation in Pseudomonas aeruginosa reveals the diversity of acetylated proteins

Published: May 26, 2015

Author(s): Tassadit Ouidir, Pascal Cosette, Thierry Jouenne, Julie Hardouin

Journal: PROTEOMICS

Protein lysine acetylation is a reversible and highly regulated post‐translational modification with the well demonstrated physiological relevance in eukaryotes. Recently, its important role in the regulation of metabolic processes in bacteria was highlighted. Here, we reported the lysine acetylproteome of Pseudomonas aeruginosa using a proteomic approach. We identified 430 unique peptides corresponding to 320 acetylated proteins. In addition to the ...

Read More thumbnail image: Proteomic profiling of lysine acetylation in Pseudomonas aeruginosa reveals the diversity of acetylated proteins

Comparative proteomic analyses of two reovirus T3D subtypes and comparison to T1L identifies multiple novel proteins in key cellular pathogenic pathways

Published: May 26, 2015

Author(s): Alicia R. Berard, Alberto Severini, Kevin M. Coombs

Journal: PROTEOMICS

Viruses induce changes in the host to facilitate replication and evade the immune response. These changes are reflected by the host's proteome, including differences in protein abundance. Focusing on up and down regulated proteins after a virus infects the cell will lead to a characterization of the host response to infection, and may give insight into how viruses modulate proteins to evade host defense responses. We previously used SILAC...

Read More thumbnail image: Comparative proteomic analyses of two reovirus T3D subtypes and comparison to T1L identifies multiple novel proteins in key cellular pathogenic pathways

Proteomic profiling identifies the SIM‐associated complex of KSHV‐encoded LANA

Published: May 26, 2015

Author(s): Jin Gan, Chong Wang, Yanling Jin, Yi Guo, Feng Xu, Qing Zhu, Ling Ding, Hong Shang, Junwen Wang, Fang Wei, Qiliang Cai, Erle S. Robertson

Journal: PROTEOMICS

The Kaposi's sarcoma‐associated herpesvirus (KSHV) encoded latent nuclear antigen latency‐associated nuclear antigen (LANA) plays an essential role in viral episome maintenance. LANA also contributes to DNA replication and tumorigenesis during latency. Recent studies suggested that LANA was involved in regulation of SUMOylation, which results in chromatin silencing. To examine the pleiotropic effects of LANA protein on host cell gene...

Read More thumbnail image: Proteomic profiling identifies the SIMassociated complex of KSHVencoded LANA

Comparative proteomics of a tor inducible Aspergillus fumigatus mutant reveals involvement of the Tor kinase in iron regulation

Published: May 26, 2015

Author(s): Clara Baldin, Vito Valiante, Thomas Krüger, Lukas Schafferer, Hubertus Haas, Olaf Kniemeyer, Axel A. Brakhage

Journal: PROTEOMICS

The Tor (target of rapamycin) kinase is one of the major regulatory nodes in eukaryotes. Here, we analyzed the Tor kinase in Aspergillus fumigatus, which is the most important airborne fungal pathogen of humans. Because deletion of the single tor gene was apparently lethal, we generated a conditional lethal tor mutant by replacing the endogenous tor gene by the inducible xylp–tor gene cassette. By both 2DE and gel‐free LC‐MS/MS, we found that Tor controls a...

Read More thumbnail image: Comparative proteomics of a tor inducible Aspergillus fumigatus mutant reveals involvement of the Tor kinase in iron regulation

Phosphoproteomics of the goat milk fat globule membrane: New insights into lipid droplet secretion from the mammary epithelial cell

Published: May 26, 2015

Author(s): Céline Henry, Besma Saadaoui, Frédéric Bouvier, Christelle Cebo

Journal: PROTEOMICS

Mechanisms of milk lipid secretion are highly controversial. Analyzing the fine protein composition of the “milk fat globule membrane” (MFGM), the triple‐layered membrane surrounding milk lipid droplets (LDs) can provide mechanistic clues to better understand LD biosynthesis and secretion pathways in mammary epithelial cells (MECs). We therefore combined a high‐sensitive Q‐Exactive LC‐MS/MS analysis of MFGM‐derived peptides to the use of...

Read More thumbnail image: Phosphoproteomics of the goat milk fat globule membrane New insights into lipid droplet secretion from the mammary epithelial cell

Bioorthogonal mimetics of palmitoyl‐CoA and myristoyl‐CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host‐proteins modified by HIV‐1 infection

Published: May 26, 2015

Author(s): David R. Colquhoun, Alexey E. Lyashkov, Ceereena Ubaida Mohien, Veronica N. Aquino, Brandon T. Bullock, Rhoel R. Dinglasan, Brian J. Agnew, David R. M. Graham

Journal: PROTEOMICS

Protein acylation plays a critical role in protein localization and function. Acylation is essential for human immunodeficiency virus 1 (HIV‐1) assembly and budding of HIV‐1 from the plasma membrane in lipid raft microdomains and is mediated by myristoylation of the Gag polyprotein and the copackaging of the envelope protein is facilitated by colocalization mediated by palmitoylation. Since the viral accessory protein NEF has been shown...

Read More thumbnail image: Bioorthogonal mimetics of palmitoylCoA and myristoylCoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated hostproteins modified by HIV1 infection

A primer for carbon‐detected NMR applications to intrinsically disordered proteins in solution

Published: May 26, 2015

Author(s): Monique Bastidas, Eric B. Gibbs, Debashish Sahu, Scott A. Showalter

Journal: Concepts in Magnetic Resonance Part A

Characterization of intrinsically disordered proteins (IDPs) has grown tremendously over the past two decades. NMR‐based structural characterization has been widely embraced by the IDP community, largely because this technique is amenable to highly flexible biomolecules. Particularly, carbon‐detect nuclear magnetic resonance (NMR) experiments provide a straight forward and expedient method for completing backbone assignments, thus...

Read More thumbnail image: A primer for carbondetected NMR applications to intrinsically disordered proteins in solution

Combined unsupervised–supervised classification of multiparametric PET/MRI data: application to prostate cancer

Published: May 26, 2015

Author(s): Sergios Gatidis, Markus Scharpf, Petros Martirosian, Ilja Bezrukov, Thomas Küstner, Jörg Hennenlotter, Stephan Kruck, Sascha Kaufmann, Christina Schraml, Christian Fougère, Nina F. Schwenzer, Holger Schmidt

Journal: NMR in Biomedicine

Multiparametric medical imaging data can be large and are often complex. Machine learning algorithms can assist in image interpretation when reliable training data exist. In most cases, however, knowledge about ground truth (e.g. histology) and thus training data is limited, which makes application of machine learning algorithms difficult. The purpose of this study was to design and implement a learning algorithm for...

Read More thumbnail image: Combined unsupervisedsupervised classification of multiparametric PETMRI data application to prostate cancer

Signature of protein unfolding in chemical exchange saturation transfer imaging

Published: May 26, 2015

Author(s): Steffen Goerke, Moritz Zaiss, Patrick Kunz, Karel D. Klika, Johannes D. Windschuh, Axel Mogk, Bernd Bukau, Mark E. Ladd, Peter Bachert

Journal: NMR in Biomedicine

Chemical exchange saturation transfer (CEST) allows the detection of metabolites of low concentration in tissue with nearly the sensitivity of MRI with water protons. With this spectroscopic imaging approach, several tissue‐specific CEST effects have been observed in vivo. Some of these originate from exchanging sites of proteins, such as backbone amide protons, or from aliphatic protons within the hydrophobic protein core. In this work,...

Read More thumbnail image: Signature of protein unfolding in chemical exchange saturation transfer imaging
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