EarlyView Articles

Skip to Navigation

The very latest articles from the scientific literature
on Wiley Online Library...


You can keep up-to date on these EarlyView articles, which focus on spectroscopy
and separation science:

Earlyview RSS Feed

rss

Filter by Journal

Browse By Journal

Efficient UPLC and CE methods for the simultaneous determination of azelastine hydrochloride and its genotoxic impurity

Published: Aug 20, 2018

Author(s): Nada S. Abdelwahab, Nehal F. Farid, Mohamed Elagawany, Esraa H. Abdelmomen

Journal: Biomedical Chromatography

Abstract A novel stability‐indicating UPLC and CE method was established and validated for the determination of azelastine hydrochloride (AZL) and its genotoxic impurity, benzohydrazide, in the presence of benzalkonium chloride. The developed UPLC method was based on chromatographic separation using a C18 column as a stationary phase and acetonitrile–(0.1% w/v) aqueous sodium lauryl sulfate (55:45, v/v, pH 5 with phosphoric acid) as...

Read More thumbnail image: Efficient UPLC and CE methods for the simultaneous determination of azelastine hydrochloride and its genotoxic impurity

Vibrating Sharp‐edge Spray Ionization (VSSI) for voltage‐free direct analysis of samples using mass spectrometry

Published: Aug 20, 2018

Author(s): Xiaojun Li, Kushani Attanayake, Stephen J. Valentine, Peng Li

Journal: Rapid Communications in Mass Spectrometry

Rationale The development of miniaturized and field portable mass spectrometers could not succeed without a simple, compact, and robust ionization source. Here we present a voltage‐free ionization method, Vibrating Sharp‐edge Spray Ionization (VSSI), which can generate a spray of liquid samples using only one standard microscope glass slide to which a piezoelectric transducer is attached. Compared with...

Read More thumbnail image: Vibrating Sharpedge Spray Ionization VSSI for voltagefree direct analysis of samples using mass spectrometry

Simultaneous Quantification of the Acetylome and Succinylome by ‘One‐Pot’ Affinity Enrichment

Published: Aug 20, 2018

Author(s): Nathan Basisty, Jesse G Meyer, Lei Wei, Bradford W Gibson, Birgit Schilling

Journal: PROTEOMICS

Abstract Protein posttranslational modifications (PTMs) are of increasing interest in biomedical research, yet studies rarely examine more than one PTM. One barrier to multi‐PTM studies is the time cost for both sample preparation and data acquisition, which scale linearly with the number of modifications. The most prohibitive requirement is often the need for large amounts of sample, which must be increased proportionally with the...

Read More thumbnail image: Simultaneous Quantification of the Acetylome and Succinylome by OnePot Affinity Enrichment

Highly Efficient Identification of O‐GalNAc Glycosylation by an Acid‐Assisted Glycoform Simplification Approach

Published: Aug 20, 2018

Author(s): Xin You, Hongqiang Qin, Jiawei Mao, Yu Tian, Mingming Dong, Zhimou Guo, Xinmiao Liang, Liming Wang, Yan Jin, Mingliang Ye

Journal: PROTEOMICS

Abstract Compared with N‐linked glycosylation, the analysis of O‐GalNAc glycosylation is extremely challenging due to the high structure diversity of glycans and lack of glycosidases to release O‐GalNAc glycans. In this work, a glycoform simplification strategy by combining HILIC enrichment with chemical de‐sialylation to characterize O‐GalNAc glycosylation of human serum is presented. This method is first validated by using the...

Read More thumbnail image: Highly Efficient Identification of OGalNAc Glycosylation by an AcidAssisted Glycoform Simplification Approach

Special issue on MR elastography

Published: Aug 20, 2018

Author(s): Ralph Sinkus

Journal: NMR in Biomedicine

Read More thumbnail image: Special issue on MR elastography

In vitro phase I metabolism of three phenethylamines 25D‐NBOMe, 25E‐NBOMe and 25N‐NBOMe using microsomal and microbial models

Published: Aug 19, 2018

Author(s): Katharina Elisabeth Grafinger, Katja Stahl, Andreas Wilke, Stefan König, Wolfgang Weinmann

Journal: Drug Testing and Analysis

Abstract Numerous 2,5‐dimethoxy‐N‐benzylphenethylamines (NBOMe), carrying a variety of lipophilic substituents at the 4‐position, are potent agonists at 5‐hydroxytryptamine (5HT2A) receptors and show hallucinogenic effects. The present study investigated the metabolism of 25D‐NBOMe, 25E‐NBOMe, and 25N‐NBOMe using the microsomal model of pooled human liver microsomes (pHLM) and the microbial model of the fungi Cunninghamella elegans (C....

Read More thumbnail image: In vitro phase I metabolism of three phenethylamines 25DNBOMe 25ENBOMe and 25NNBOMe using microsomal and microbial models

Synthesis, antitumor activity and pharmacokinetic study of 10‐propionyloxy camptothecin in rats

Published: Aug 19, 2018

Author(s): Jian Zheng, Changmin Shao, Bo Fan, Lijia Jing, Siyang Li, Xiufeng Yan, Yang Wang

Journal: Biomedical Chromatography

Abstract In the present study, a 10‐position modified of camptothecin, 10‐propionyloxy camptothecin (PCPT) was esterified from 10‐hydroxcamptothecin (HCPT), which could metabolize to HCPT in vivo. PCPT displayed a relatively stronger antitumor activity in vitro and in vivo. Thereafter a simple, sensitive and rapid HPLC method coupled with a fluorescence detector was developed and validated for the assay of PCPT and its active metabolite HCPT in...

Read More thumbnail image: Synthesis antitumor activity and pharmacokinetic study of 10propionyloxy camptothecin in rats

A hybrid method for the determination of tubeimoside I in rat plasma after oral administration by LC‐IT‐TOF and UPLC‐MS/MS

Published: Aug 19, 2018

Author(s): Ying Li, Lifang Wang, Xianzhao Yang, Yongan Ye, Pengfei Tu, Jinling Wang

Journal: Biomedical Chromatography

Abstract Tubeimoside I (Tub) is a triterpenoid saponin isolated from Bolbostemma paniculatum[Maxim]Franquet. A sensitive and validated method was developed to determine Tub in rat plasma. This method combined the qualitative and quantitative advantages from liquid chromatography coupled with hybrid ion trap‐time of flight mass spectrometer (HPLC‐DAD‐IT‐TOF‐MS) and a triple quadrupole–linear ion trap mass spectrometer 5500 (Qtrap 5500), owing to...

Read More thumbnail image: A hybrid method for the determination of tubeimoside I in rat plasma after oral administration by LCITTOF and UPLCMSMS

New insights into the degradation mechanism of cellulose nitrate in cinematographic films by Raman microscopy

Published: Aug 19, 2018

Author(s): Artur Neves, Eva Mariasole Angelin, Élia Roldão, Maria João Melo

Journal: Journal of Raman Spectroscopy

Abstract The degradation of cellulose nitrate cinematographic films stored inside an aluminum can was studied by infrared spectroscopy and Raman microscopy. Cellulose nitrate image heritage is strongly susceptible to degradation, being a major conservation challenge. Infrared spectroscopy has been the traditional technique in the assessment of the polymer degradation, but new in situ diagnostic tools to monitor the initial stages of...

Read More thumbnail image: New insights into the degradation mechanism of cellulose nitrate in cinematographic films by Raman microscopy

Application of multivariate statistical techniques to assess the phenolic compounds and the in vitro antioxidant activity of commercial grape cultivars

Published: Aug 19, 2018

Author(s): Kandi Sridhar, Albert Linton Charles

Journal: Journal of Chemometrics

Abstract Multivariate statistical techniques were used to differentiate two popularly consumed grape cultivars in Taiwan, Kyoho (Vitis labruscana) and American wild bunch (Vitis aestivalis), based on their phenolic content and antioxidant properties. Total phenol and flavonoid contents, and polyphenolic profile were estimated by the Folin‐Ciocalteu, colorimetric method, and ultra performance liquid chromatography, respectively. Antioxidant ...

Read More thumbnail image: Application of multivariate statistical techniques to assess the phenolic compounds and the in vitro antioxidant activity of commercial grape cultivars

Massive parallel sequencing of short tandem repeats in the Korean population

Published: Aug 17, 2018

Author(s): Se‐Yong Kim, Han‐Chul Lee, Ukhee Chung, Seon‐Kyu Ham, Ho Yeon Lee, Su Jeong Park, Ye Jee Roh, Seung Hwan Lee

Journal: ELECTROPHORESIS

Abstract STR analysis using capillary electrophoresis has been the most widely used method for forensic DNA typing. Recently, massive parallel sequencing (MPS) technique has been emerging as an innovative tool to supplement or replace the conventional CE process. In this study, we evaluated the application of commercial MiSeqFGx™ forensic signature kit (Illumina Inc., San Diego, CA, USA) in the Korean population, including...

Read More thumbnail image: Massive parallel sequencing of short tandem repeats in the Korean population

Proteomic and metabolomic study of wax apple ( Syzygium samarangense ) fruit during ripening process

Published: Aug 17, 2018

Author(s): Jameel R. Al‐Obaidi, Nor Azreen Mohd Jamil, Norasfaliza Rahmad, Nurul Hafiza Mohd Rosli

Journal: ELECTROPHORESIS

Abstract Wax apple is one of the underutilized fruits that is considered a good source of fibers, vitamins, minerals as well as antioxidants. In this study, a comparative analysis of the developments of wax fruit ripening at the proteomic and metabolomic level was reported. 2D electrophoresis coupled with MALDI–TOF/TOF was used to compare the proteome profile from three developmental stages named immature, young, and mature fruits....

Read More thumbnail image: Proteomic and metabolomic study of wax apple  Syzygium samarangense  fruit during ripening process

Recent progress of sample stacking in capillary electrophoresis (2016–2018)

Published: Aug 17, 2018

Author(s): Andrea Šlampová, Zdena Malá, Petr Gebauer

Journal: ELECTROPHORESIS

Abstract Electrophoretic sample stacking comprises a group of capillary electrophoretic techniques where trace analytes from the sample are concentrated into a short zone (stack). This paper is a continuation of our previous reviews on the topic and brings a survey of more than 120 papers published approximately since the second quarter of 2016 till the first quarter of 2018. It is organized according to the particular stacking...

Read More thumbnail image: Recent progress of sample stacking in capillary electrophoresis 20162018

Development of a SNP panel for predicting biogeographical ancestry and phenotype using massively parallel sequencing

Published: Aug 17, 2018

Author(s): Ozlem Bulbul, Gonul Filoglu

Journal: ELECTROPHORESIS

Abstract Inferring ancestry and physical characteristics of an unknown individual can contribute to the direction of the investigation and to clarify the event for unknown contributors, cold cases or identification of missing persons and disaster victims. The objective of this study is to develop a custom SNP panel on massively parallel sequencing devices for predicting the biogeographic ancestry and phenotype of an individual. We...

Read More thumbnail image: Development of a SNP panel for predicting biogeographical ancestry and phenotype using massively parallel sequencing

Monolithic column functionalized with quinine derivative for anion‐exchange capillary electrochromatography

Published: Aug 17, 2018

Author(s): Zhenkun Mao, Xiaoning Qin, Zilin Chen

Journal: ELECTROPHORESIS

Abstract A novel anion‐exchange organic polymer monolithic column based on monomers N‐benzylquininium chloride and acrylamide were firstly prepared by in situ copolymerization for capillary electrochromatography. Moreover, N‐benzylquininium was firstly introduced as a strong anion‐exchange functional group. A relatively strong anodic EOF was obtained in the pH values from 4.0 to 9.0, which was in the same direction with the electrophoretic...

Read More thumbnail image: Monolithic column functionalized with quinine derivative for anionexchange capillary electrochromatography

Analysis of volatile organic compounds in crumb and crust of different baked and toasted gluten‐free breads by direct PTR‐ToF‐MS and fast‐GC‐PTR‐ToF‐MS

Published: Aug 17, 2018

Author(s): Joana Pico, Iuliia Khomenko, Vittorio Capozzi, Luciano Navarini, José Bernal, Manuel Gómez, Franco Biasioli

Journal: Journal of Mass Spectrometry

Abstract Proton transfer reaction (PTR)‐time of fight (ToF)‐mass spectrometry (MS) has been recently employed as a quick, easy, and sensitive alternative to gas chromatography MS for the analysis of volatile compounds in food. In the present work, PTR‐ToF‐MS was applied to the characterization of the volatile profiles of the baked and toasted crumbs and crusts of 5 gluten‐free breads elaborated with quinoa, teff, and rice flours as...

Read More thumbnail image: Analysis of volatile organic compounds in crumb and crust of different baked and toasted glutenfree breads by direct PTRToFMS and fastGCPTRToFMS

Phytoestrogens in soy‐based meat substitutes: Comparison of different extraction methods for the subsequent analysis by liquid chromatography‐tandem mass spectrometry

Published: Aug 17, 2018

Author(s): Barbara Benedetti, Marina Di Carro, Emanuele Magi

Journal: Journal of Mass Spectrometry

Abstract This paper presents the development of an efficient extraction procedure followed by a high performance liquid chromatography‐tandem mass spectrometry (HPLC‐MS/MS) method for the determination of five phytoestrogens (genistein, daidzein, formononetin, biochanin A, and coumestrol) in soy‐based meat substitutes. Phytoestrogens are considered endocrine disrupting compounds, and their quantification is important in soy‐based...

Read More thumbnail image: Phytoestrogens in soybased meat substitutes Comparison of different extraction methods for the subsequent analysis by liquid chromatographytandem mass spectrometry

A systematic approach toward comparing electrospray ionization efficiencies of derivatized and non‐derivatized amino acids and biogenic amines

Published: Aug 17, 2018

Author(s): Artur Gornischeff, Jaanus Liigand, Riin Rebane

Journal: Journal of Mass Spectrometry

Abstract Ionization efficiency (IE) in mass spectrometry (MS) has been studied for many different compounds, and different IE scales have been constructed in order to quantitatively characterize IE. In the case of MS, derivatization has been used to increase the sensitivity of the method and to lower the limits of detection. However, the influence of derivatization on IE across different compounds and different derivatization...

Read More thumbnail image: A systematic approach toward comparing electrospray ionization efficiencies of derivatized and nonderivatized amino acids and biogenic amines

Determination of halquinol residual levels in animal‐derived food products using liquid chromatography–tandem mass spectrometry

Published: Aug 17, 2018

Author(s): Weijia Zheng, Jeong‐Min Choi, Seong‐Kwan Kim, Jae‐Han Shim, Young‐Sun Kang, A. M. Abd El‐Aty, Ahmet Hacımüftüoğlu, Ho‐Chul Shin

Journal: Biomedical Chromatography

Abstract A reliable and highly sensitive detection method based on liquid chromatography coupled with triple quadrupole electrospray tandem mass spectrometry (LC‐MS/MS) analysis has been developed for determination and quantification of halquinol, including 5,7‐dichloroquinolin‐8‐ol and 5‐chloroquinolin‐8‐ol. The target analytes were extracted from porcine muscle, egg, milk, eel, flatfish and shrimp using a mixture of acetonitrile...

Read More thumbnail image: Determination of halquinol residual levels in animalderived food products using liquid chromatographytandem mass spectrometry

Stability, degradation impurities and decomposition kinetics for paliperidone from osmotic tablets

Published: Aug 17, 2018

Author(s): José Pedro Etchepare Cassol, Fábio Souza Barbosa, Cássia V. Garcia, Andreas S.L. Mendez

Journal: Biomedical Chromatography

Abstract The antipsychotic paliperidone was investigated with a focus on stability, degradation impurities and kinetics reaction profile. Osmotic tablets 3 mg (OROS®) were subjected to extraction in an ultrasonic bath and the resulting acidic solution was stressed by forced conditions. Degraded samples were monitored by HPLC–DAD in different storage times for acidic and alkaline hydrolysis, oxidation, heat and photolysis. Photolysis...

Read More thumbnail image: Stability degradation impurities and decomposition kinetics for paliperidone from osmotic tablets
Page:   1 2 3 4 5 6 Next

Social Links

Share This Links

Bookmark and Share

Microsites

Suppliers Selection
Societies Selection

Banner Ad

Click here to see
all job opportunities

Most Viewed

Copyright Information

Interested in separation science? Visit our sister site separationsNOW.com

Copyright © 2018 John Wiley & Sons, Inc. All Rights Reserved