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Transit time mapping in the mouse brain using time‐encoded pCASL

Published: Nov 21, 2017

Author(s): Lydiane Hirschler, Leon P. Munting, Artem Khmelinskii, Wouter M. Teeuwisse, Ernst Suidgeest, Jan M. Warnking, Louise Weerd, Emmanuel L. Barbier, Matthias J.P. Osch

Journal: NMR in Biomedicine

The cerebral blood flow (CBF) is a potential biomarker for neurological disease. However, the arterial transit time (ATT) of the labeled blood is known to potentially affect CBF quantification. Furthermore, ATT could be an interesting biomarker in itself, as it may reflect underlying macro‐ and microvascular pathologies. Currently, no optimized magnetic resonance imaging (MRI) sequence exists to measure ATT in mice. Recently, time‐encoded...

Read More thumbnail image: Transit time mapping in the mouse brain using timeencoded pCASL

Effects of electrothermal vortices on insulator‐based dielectrophoresis for circulating tumor cell separation

Published: Nov 20, 2017

Author(s): Arian Aghilinejad, Mohammad Aghaamoo, Xiaolin Chen, Jie Xu

Journal: ELECTROPHORESIS

Abstract Insulator‐based dielectrophoresis (iDEP) is a powerful technique for separation and manipulation of bioparticles. In recent years, iDEP designs using arrays of insulating posts have shown promising results toward reaching high‐efficiency bioparticle manipulation. Joule heating (JH) and electrothermal (ET) flows have been observed in iDEP microdevices and significantly affecting their performances. In this research, we...

Read More thumbnail image: Effects of electrothermal vortices on insulatorbased dielectrophoresis for circulating tumor cell separation

Addition of urea and thiourea to electrophoresis sample buffer improves efficiency of protein extraction from TCA/acetone‐treated smooth muscle tissues for phos‐tag SDS‐PAGE

Published: Nov 20, 2017

Author(s): Kosuke Takeya, Toshiyuki Kaneko, Motoi Miyazu, Akira Takai

Journal: ELECTROPHORESIS

Abstract Phosphorylation analysis by using phos‐tag technique has been reported to be suitable for highly sensitive quantification of smooth muscle myosin regulatory light chain (LC20) phosphorylation. However, there is another factor that will affect the sensitivity of phosphorylation analysis, that is, protein extraction. Here, we optimized the conditions for total protein extraction out of trichloroacetic acid (TCA)‐fixed ...

Read More thumbnail image: Addition of urea and thiourea to electrophoresis sample buffer improves efficiency of protein extraction from TCAacetonetreated smooth muscle tissues for phostag SDSPAGE

Raman scattering studies of graphene under high pressure

Published: Nov 20, 2017

Author(s): Denis Machon, Colin Bousige, Rafael Alencar, Abraao Torres‐Dias, Félix Balima, Jimmy Nicolle, Gardênia Sousa Pinheiro, Antonio Gomes Souza Filho, Alfonso San‐Miguel

Journal: Journal of Raman Spectroscopy

The effect of pressure – by definition a 3‐dimensional concept – on 2‐dimensional systems brings a number of fundamental questions, which have been partly answered through newly engineered samples and experimental setups. In this review of the high‐pressure Raman studies of graphene, we will in particular underline the importance of the presence of a supporting substrate and its role for the production of biaxial strain conditions in high...

Read More thumbnail image: Raman scattering studies of graphene under high pressure

Diagnostics of sintering processes on the basis of PCA and two‐level neural network model

Published: Nov 20, 2017

Author(s): E.G. Egorova, I.V. Rudakova, L.A. Rusinov, N.V. Vorobjev

Journal: Journal of Chemometrics

Abstract The application of chemometrics methods to continuous monitoring and diagnostics of sintering process faults for improving iron‐ore sinter quality is considered in the article. The sintering process is among complex multivariate processes. A number of agglomeration process faults have often similar symptoms, resulting in late fault detection by an operator and as a consequence, wrong process control...

Read More thumbnail image: Diagnostics of sintering processes on the basis of PCA and twolevel neural network model

Sol–gel/nanoclay composite as a sorbent for microextraction in packed syringe combined with corona discharge ionization ion mobility spectrometry for the determination of diazinon in water samples

Published: Nov 20, 2017

Author(s): Mohammad Saraji, Mohammad Taghi Jafari, Mohammad Mehdi Amooshahi

Journal: Journal of Separation Science

Abstract In this work, the microextraction in packed syringe technique combined with corona discharge ion mobility spectrometry was used for determining diazinon in water samples. A new porous composite of nanoclay and polysiloxane was prepared using a sol–gel process. An amount of 2.0 mg of the sorbent was packed in a 250 μL syringe and used for extraction. A volume of 2 mL of the sample was passed through the sorbent...

Read More thumbnail image: Solgelnanoclay composite as a sorbent for microextraction in packed syringe combined with corona discharge ionization ion mobility spectrometry for the determination of diazinon in water samples

Spectroscopic characterization of historical building materials: The case study of the Biblioteca Nazionale Marciana (Venice, Italy)

Published: Nov 20, 2017

Author(s): Giulia Carolina Lodi, Lavinia De Ferri, Giulio Pojana

Journal: Journal of Raman Spectroscopy

Abstract The building designed by Sansovino in 1532 as the new Mint of Venice underwent a change in its intended use, becoming in 1900 the Biblioteca Nazionale Marciana. A spectroscopic study concerning the surface stone materials of the current reading room (previously a courtyard) was attempted since the transformation lead to heavy micro‐ and macroclimatic variations. Many alterations were observed, such as...

Read More thumbnail image: Spectroscopic characterization of historical building materials The case study of the Biblioteca Nazionale Marciana Venice Italy

Comparative Proteomic Analysis of Three Xanthomonas spp. Cultured in Minimal and Rich Media

Published: Nov 20, 2017

Author(s): Hye‐Jee Park, Nahee Bae, Hanbi Park, Dae‐Wi Kim, Sang‐Wook Han

Journal: PROTEOMICS

Abstract Bacteria change their gene expression when exposed to different nutrient conditions. The levels of proteins do not always correlate with those of RNAs, hence proteomic analysis is required for understanding how bacteria adapt to different conditions. Herein, differentially abundant proteins from Xanthomonas oryzae pv. oryzae (Xoo), X. campestris pv. vesicatoria (Xcv), and X. axonopodis pv. glycines (Xag), which were cultured in rich...

Read More thumbnail image: Comparative Proteomic Analysis of Three Xanthomonas spp_ Cultured in Minimal and Rich Media

Raman‐scattering studies of pressure‐induced phase transitions in perovskite‐like acetamidninium manganese formate

Published: Nov 20, 2017

Author(s): Mirosław Mączka, Tercio Almeida Silva, Waldeci Paraguassu

Journal: Journal of Raman Spectroscopy

Abstract We report high‐pressure Raman scattering studies of acetamidninium manganese formate, which show evidence for two pressure‐induced phase transitions between 0.7 and 1.4 GPa and above 5.3 GPa. The first transition is related to distortion of the manganese formate framework whereas the second one affects significantly the structure of the acetamidinium cation. Significant narrowing of the lattice bands suggests that...

Read More thumbnail image: Ramanscattering studies of pressureinduced phase transitions in perovskitelike acetamidninium manganese formate

In vitro metabolism of the synthetic cannabinoids CUMYL‐PINACA, 5F–CUMYL‐PINACA, CUMYL‐4CN‐BINACA, 5F–CUMYL‐P7AICA and CUMYL‐4CN‐B7AICA

Published: Nov 20, 2017

Author(s): Sandra N. Staeheli, Michael Poetzsch, Veronica P. Veloso, Michael Bovens, Christian Bissig, Andrea E. Steuer, Thomas Kraemer

Journal: Drug Testing and Analysis

Abstract Synthetic cannabinoid consumption trends underlie fast changes and provide several challenges to clinical and forensic toxicologists. Due to their extensive metabolism, parent compounds are hardly detectable in urine. Therefore, knowledge of the metabolism of synthetic cannabinoids is essential to allow their detection in biological matrices. The aim of the present study was the elucidation of the metabolism of...

Read More thumbnail image: In vitro metabolism of the synthetic cannabinoids CUMYLPINACA 5FCUMYLPINACA CUMYL4CNBINACA 5FCUMYLP7AICA and CUMYL4CNB7AICA

Submicron Raman spectroscopy mapping of serpentinite fault rocks

Published: Nov 20, 2017

Author(s): Jeremy S. Rooney, Matthew S. Tarling, Steven A.F. Smith, Keith C. Gordon

Journal: Journal of Raman Spectroscopy

Abstract Submicron Raman spectroscopy mapping is able to unambiguously distinguish the main serpentine minerals within their in situ microstructural context. The high spatial resolution (~370 nm), large‐area coverage (up to hundreds of micrometres in each dimension), and ability to map directly on polished thin sections allows novel interpretations to be made regarding the nature and evolution of serpentinite fault rock...

Read More thumbnail image: Submicron Raman spectroscopy mapping of serpentinite fault rocks

Screening and separation of α‐amylase inhibitors from Solanum nigrum with amylase‐functionalized magnetic graphene oxide combined with high‐speed counter‐current chromatography

Published: Nov 20, 2017

Author(s): Yin Cen, Aiping Xiao, Xiaoqing Chen, Liangliang Liu

Journal: Journal of Separation Science

Abstract A screening method using α‐amylase‐functionalized magnetic graphene oxide combined with high‐speed counter‐current chromatography was proposed and utilized to screen and separate α‐amylase inhibitors from extract of Solanum nigrum. The α‐amylase‐functionalized magnetic graphene oxide was characterized and found to demonstrate satisfactory structure, magnetic response (24.5 emu/g), and reusability (retained 90% of initial activity...

Read More thumbnail image: Screening and separation of amylase inhibitors from Solanum nigrum with amylasefunctionalized magnetic graphene oxide combined with highspeed countercurrent chromatography

The role of graphene‐based sorbents in modern sample preparation techniques

Published: Nov 20, 2017

Author(s): Ana Lúcia de Toffoli, Edvaldo Vasconcelos Soares Maciel, Bruno Henrique Fumes, Fernando Mauro Lanças

Journal: Journal of Separation Science

Abstract The application of graphene‐based sorbents in sample preparation techniques has increased significantly since 2011. These materials have good physicochemical properties to be used as sorbent and have shown excellent results in different sample preparation techniques. Graphene and its precursor graphene oxide have been considered to be good candidates to improve the extraction and concentration of different classes of target...

Read More thumbnail image: The role of graphenebased sorbents in modern sample preparation techniques

LC–MS/MS method for quantification of baclofen in hair: A useful tool to assess compliance in alcohol dependent patients?

Published: Nov 17, 2017

Author(s): I.A. Larabi, N. Fabresse, A. Knapp, M. Forcet, F.J. Baud, G. Lorin de la Grandmaison, J.C. Alvarez

Journal: Drug Testing and Analysis

Abstract To evaluate adherence to treatment, we developed and validated a novel liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for baclofen quantification in hair.Twenty mg was washed twice with dichloromethane, incubated in phosphate buffer (pH 5) for 10 minutes at 95°C, then extracted by liquid‐liquid extraction in alkaline condition. Baclofen‐d4 was used as the internal standard. This method was applied to assess compliance...

Read More thumbnail image: LCMSMS method for quantification of baclofen in hair A useful tool to assess compliance in alcohol dependent patients

PTCA (1H‐pyrrole‐2,3,5‐tricarboxylic acid) as a marker for oxidative hair treatment

Published: Nov 17, 2017

Author(s): Silvana Petzel‐Witt, Sylvia I. Meier, Manfred Schubert‐Zsilavecz, Stefan W. Toennes

Journal: Drug Testing and Analysis

Abstract Hair analysis for the assessment of alcohol or drug abstinence has become a routine procedure in forensic toxicology. Hair coloration leading to loss of incorporated xenobiotics and to false negative results has turned out to be a major problem. Currently only colored extracts provide hints of manipulations but not bleaching. A liquid chromatographic–tandem mass spectrometric (LC–MS/MS) method was developed and validated to...

Read More thumbnail image: PTCA 1Hpyrrole235tricarboxylic acid as a marker for oxidative hair treatment

Raman spectroscopic measurements of ν 1 band of hydrogen sulfide over a wide range of temperature and density in fused‐silica optical cells

Published: Nov 17, 2017

Author(s): Lei Jiang, Yang Xin, I‐Ming Chou, Ying Chen

Journal: Journal of Raman Spectroscopy

Abstract A method was developed to determine the fluid density of pure hydrogen sulfide (H2S) at a fixed temperature using Raman spectroscopic measurements. The positions of the H2S Raman ν1 band were measured at a wide range of temperatures (188.15 K ≤ T ≤ 633.15 K) and pressures (P ≤ 506 bar) using fused‐silica capillary capsules and high‐pressure optical cells. The relation among H2S density (ρ), H2S ν1 peak position,...

Read More thumbnail image: Raman spectroscopic measurements of  1 band of hydrogen sulfide over a wide range of temperature and density in fusedsilica optical cells

Retention behavior of flavonoids on immobilized artificial membrane chromatography and correlation with cell‐based permeability

Published: Nov 17, 2017

Author(s): Fotios Tsopelas, Maria Tsagkrasouli, Pavlos Poursanidis, Maria Pitsaki, George Vasios, Panagiotis Danias, Irene Panderi, Anna Tsantili‐Kakoulidou, Constantinos Giaginis

Journal: Biomedical Chromatography

Abstract The aim of the study was to investigate the immobilized artificial membrane (IAM) retention mechanism for a set of flavonoids and to evaluate the potential of IAM chromatography to model Caco‐2 permeability. For this purpose, the retention behavior of 41 flavonoid analogs on two IAM stationary phases, IAM.PC.MG and IAM.PC.DD2, was investigated. Correlations between retention factors, logkw(IAM) and octanol–water...

Read More thumbnail image: Retention behavior of flavonoids on immobilized artificial membrane chromatography and correlation with cellbased permeability

Probing nitrite ion dynamics in Na NO 2 crystals by solid‐state 17 O NMR

Published: Nov 17, 2017

Author(s): Yizhe Dai, Ivan Hung, Zhehong Gan, Gang Wu

Journal: Concepts in Magnetic Resonance Part A

Abstract We report a solid‐state 17O (I = 5/2) NMR study of the nitrite ion dynamics in crystalline NaNO2. Variable temperature (VT) 17O NMR spectra were recorded at 3 magnetic fields, 11.7, 14.1, and 21.1 T. The VT 17O NMR data suggest that the NO 2 − ion in the ferroelectric phase of NaNO2 undergoes 2‐fold flip...

Read More thumbnail image: Probing nitrite ion dynamics in Na NO 2 crystals by solidstate 17 O NMR

Advanced online mass spectrometry detection of proteins separated by capillary isoelectric focusing after sequential injection

Published: Nov 17, 2017

Author(s): Csilla Páger, Nikoleta Biherczová, Roland Ligetvári, Balázs Viktor Berkics, Tamás Pongrácz, Viktor Sándor, Anita Bufa, Viktória Poór, Andrea Vojs Staňová, Ferenc Kilár

Journal: Journal of Separation Science

Abstract Capillary isoelectric focusing hyphenated with mass spectrometry detection, following the sequential injection of the carrier ampholytes and the sample zone, is highly efficient for the characterization of proteins. The main advantage of the sequential injection protocol is that ampholytes, with pH ranges, which are not supposed to cover the isoelectric points of the sample components, can be used for separation. The method...

Read More thumbnail image: Advanced online mass spectrometry detection of proteins separated by capillary isoelectric focusing after sequential injection

How to model temporal changes in nontargeted metabolomics study? A Bayesian multilevel perspective

Published: Nov 17, 2017

Author(s): Paweł Wiczling, Emilia Daghir‐Wojtkowiak, Arlette Yumba Mpanga, Damian Szczesny, Roman Kaliszan, Michał Jan Markuszewski

Journal: Journal of Separation Science

Abstract Analysis of time series data addresses the question on mechanisms underlying normal physiology and its alteration under pathological conditions. However, adding time variable to high‐dimension, collinear, noisy data is a challenge in terms of mining and analysis. Here, we used Bayesian multilevel modeling for time series metabolomics in vivo study to model different levels of random effects occurring as a consequence of...

Read More thumbnail image: How to model temporal changes in nontargeted metabolomics study A Bayesian multilevel perspective
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