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In vitro penetration through the skin layers of topically applied glucocorticoids

Published: Jun 20, 2018

Author(s): Victor Carrer, Cristina Alonso, Marc Adrià Oliver, Luisa Coderch

Journal: Drug Testing and Analysis

Abstract Corticoids are actives widely used in the treatment of skin diseases. This work aims to study the penetration of 3 corticoids (betamethasone, clobetasol, and flurandrenolide), their relationship with their Log D values and the effects of the vehicles. The 3 compounds were applied on a Franz‐type diffusion cell in propylene glycol solution and their respective commercial creams and ointments. The active amounts found in the...

Read More thumbnail image: In vitro penetration through the skin layers of topically applied glucocorticoids

Surface‐enhanced R aman scattering study of PP/Ag nanocomposite developed to prevent postsurgery infection

Published: Jun 20, 2018

Author(s): Cyrine El Baher Dhafer, Manel Dhahri, Amine Mezni, Leila Samia Smiri

Journal: Journal of Raman Spectroscopy

Abstract Wide varieties of antibacterial medical materials coated with silver nanoparticles (AgNPs) are developed. However, studies about coating surgical are scare. Stable coated polypropylene (PP) surgical suture with spherical AgNPs (PP/Ag nanocomposite) was prepared using an optimized aqueous dipping method. Homogenous and linear distribution of AgNPs on the PP surface was verified by scanning electron microscope and atomic...

Read More thumbnail image: Surfaceenhanced R aman scattering study of PPAg nanocomposite developed to prevent postsurgery infection

Enantioselective micellar electrokinetic chromatography of dl ‐amino acids using (+)‐1‐(9‐fluorenyl)‐ethyl chloroformate derivatization and UV‐induced fluorescence detection

Published: Jun 19, 2018

Author(s): Amir Prior, Erik de Nieuwenhuijzen, Gerhardus J. Jong, Govert W. Somsen

Journal: Journal of Separation Science

Abstract Chiral analysis of dl‐amino acids was achieved by micellar electrokinetic chromatography coupled with UV‐excited fluorescence detection. The fluorescent reagent (+)‐1‐(9‐fluorenyl)ethyl chloroformate was employed as chiral amino acid derivatizing agent and sodium dodecyl sulfate served as pseudo‐stationary phase for separating the formed amino acid diastereomers. Sensitive analysis of (+)‐1‐(9‐fluorenyl)ethyl ...

Read More thumbnail image: Enantioselective micellar electrokinetic chromatography of dl amino acids using 19fluorenylethyl chloroformate derivatization and UVinduced fluorescence detection

Development and validation of a fast and sensitive UHPLC‐ESI‐MS method for the simultaneous quantification of spironolactone and its metabolites in ocular tissues

Published: Jun 19, 2018

Author(s): Naoual Dahmana, Doris Gabriel, Robert Gurny, Yogeshvar N. Kalia

Journal: Biomedical Chromatography

Abstract Glucocorticoids are a mainstay for the treatment of immune‐mediated conditions and inflammatory diseases. However, their chronic use causes numerous side‐effects including delays in corneal and cutaneous wound healing. This is attributed to off‐target agonism of the mineralocorticoid receptor, which can be reduced by co‐administration of a mineralocorticoid receptor antagonist such as spironolactone. The aim of this study...

Read More thumbnail image: Development and validation of a fast and sensitive UHPLCESIMS method for the simultaneous quantification of spironolactone and its metabolites in ocular tissues

Systematic optimisation of ethyl glucuronide extraction conditions from scalp hair by design of experiments and its potential effect on cut‐off values appraisal

Published: Jun 19, 2018

Author(s): Eugenio Alladio, Giulia Biosa, Fabrizio Seganti, Daniele Di Corcia, Alberto Salomone, Marco Vincenti, Markus R. Baumgartner

Journal: Drug Testing and Analysis

Abstract The quantitative determination of ethyl glucuronide (EtG) in hair samples is consistently used throughout the world to assess chronic excessive alcohol consumption. For administrative and legal purposes, the analytical results are compared with cut‐off values recognised by regulatory authorities and scientific societies. However, it has been recently recognised that the analytical results depend on the hair sample...

Read More thumbnail image: Systematic optimisation of ethyl glucuronide extraction conditions from scalp hair by design of experiments and its potential effect on cutoff values appraisal

In‐house validation and small‐scale collaborative study to evaluate analytical performances of multimycotoxin screening methods based on liquid chromatography–high‐resolution mass spectrometry: Case study on Fusarium toxins in wheat

Published: Jun 19, 2018

Author(s): Biancamaria Ciasca, Michelangelo Pascale, Valerio Guido Altieri, Francesco Longobardi, Michele Suman, Dante Catellani, Veronica M.T. Lattanzio

Journal: Journal of Mass Spectrometry

Abstract A strong trend toward using highly selective mass spectrometry technologies for screening of multiple mycotoxins has been observed in recent years. In the present study, the process of validation of a multimycotoxin screening method based on liquid chromatography–high‐resolution mass spectrometry method is presented. The method was intended for the simultaneous screening of the major Fusarium toxins (deoxynivalenol, 3‐ and...

Read More thumbnail image: Inhouse validation and smallscale collaborative study to evaluate analytical performances of multimycotoxin screening methods based on liquid chromatographyhighresolution mass spectrometry Case study on Fusarium toxins in wheat

Analytical performance of the various acquisition modes in Orbitrap MS and MS/MS

Published: Jun 19, 2018

Author(s): Anton Kaufmann

Journal: Journal of Mass Spectrometry

Abstract Quadrupole Orbitrap instruments (Q Orbitrap) permit high‐resolution mass spectrometry‐based full scan acquisitions and have a number of acquisition modes where the quadrupole isolates a particular mass range prior to a possible fragmentation and high‐resolution mass spectrometry‐based acquisition. Selecting the proper acquisition mode(s) is essential if trace analytes are to be quantified in complex matrix extracts....

Read More thumbnail image: Analytical performance of the various acquisition modes in Orbitrap MS and MSMS

Assay of lovastatin containing dietary supplement by LC‐MS/MS under MRM condition

Published: Jun 19, 2018

Author(s): Leonardo Di Donna, Lucia Bartella, Anna Napoli, Giovanni Sindona, Fabio Mazzotti

Journal: Journal of Mass Spectrometry

Abstract Monacolin K, the active ingredient present in dietary supplement, is a nutraceutical whose health benefits have been widely documented. A fast approach for the assay of lovastatin in both forms, lactone and acid, by mass spectrometry is presented. The quantitative assay is carried out by high‐performance liquid chromatography‐tandem mass spectrometry by using the multiple reaction monitoring mode and simvastatin and...

Read More thumbnail image: Assay of lovastatin containing dietary supplement by LCMSMS under MRM condition

Assay of lovastatin containing dietary supplement by LC‐MS/MS under MRM condition

Published: Jun 19, 2018

Author(s): Leonardo Di Donna, Lucia Bartella, Anna Napoli, Giovanni Sindona, Fabio Mazzotti

Journal: Journal of Mass Spectrometry

Abstract Monacolin K, the active ingredient present in dietary supplement, is a nutraceutical whose health benefits have been widely documented. A fast approach for the assay of lovastatin in both forms, lactone and acid, by mass spectrometry is presented. The quantitative assay is carried out by high‐performance liquid chromatography‐tandem mass spectrometry by using the multiple reaction monitoring mode and simvastatin and...

Read More thumbnail image: Assay of lovastatin containing dietary supplement by LCMSMS under MRM condition

A similarity index for comparing coupled matrices

Published: Jun 19, 2018

Author(s): Ulf G. Indahl, Tormod Næs, Kristian Hovde Liland

Journal: Journal of Chemometrics

Abstract Application of different multivariate measurement technologies to the same set of samples is an interesting challenge in many fields of applied data analysis. Our proposal is a 2‐stage similarity index framework for comparing 2 matrices in this type of situation. The first step is to identify factors (and associated subspaces) of the matrices by methods such as principal component analysis or partial least squares...

Read More thumbnail image: A similarity index for comparing coupled matrices

Towards polypotent natural products: The Derringer desirability approach and nonparametric ranking for multicriteria evaluation of essential oils

Published: Jun 19, 2018

Author(s): Filip Lj. Andrić

Journal: Journal of Chemometrics

Abstract Chemical complexity of natural products often results in their pharmacological polypotency. However, selecting a natural product with desirable activity profile is not a straightforward task, especially if optimization of one feature results in deterioration of other facets. Recently, in the field of multiobjective optimization, the sum of ranking differences (SRD) has emerged as a simple and...

Read More thumbnail image: Towards polypotent natural products The Derringer desirability approach and nonparametric ranking for multicriteria evaluation of essential oils

Determination of protein charge variants with (imaged) capillary isoelectric focusing and capillary zone electrophoresis

Published: Jun 19, 2018

Author(s): Julia Kahle, Hermann Wätzig

Journal: ELECTROPHORESIS

Abstract Biopharmaceuticals are increasingly present in pharmaceutical therapy. These highly complex molecules are still challenging for development and quality control. Charge heterogeneity is next to size heterogeneity, glycan analysis, or peptide mapping one main aspect of their thorough characterization. This review focuses on the charge‐based analysis of biopharmaceuticals through CE. An overview is given about the three...

Read More thumbnail image: Determination of protein charge variants with imaged capillary isoelectric focusing and capillary zone electrophoresis

Assessment of ethyl sulphate in hair as a marker for alcohol consumption using liquid chromatography–tandem mass spectrometry

Published: Jun 19, 2018

Author(s): Delphine Cappelle, Foon Yin Lai, Adrian Covaci, Annemie Vermassen, Cleo L. Crunelle, Hugo Neels, Alexander L.N. Nuijs

Journal: Drug Testing and Analysis

Abstract Ethyl glucuronide (EtG) and ethyl sulphate (EtS) are 2 non‐oxidative and direct metabolites of ethanol. EtG is known to accumulate in hair and has proved to be a reliable biomarker for detection of chronic alcohol consumption. EtS has been analysed in blood and urine but has never been reported in hair. This article presents the first analytical assay based on liquid chromatography coupled to tandem mass spectrometry for...

Read More thumbnail image: Assessment of ethyl sulphate in hair as a marker for alcohol consumption using liquid chromatographytandem mass spectrometry

Multivariate analysis applied to particle‐induced X‐ray emission mapping

Published: Jun 17, 2018

Author(s): Tiago F. Silva, Gustavo F. Trindade, Marcia A. Rizzutto

Journal: X-Ray Spectrometry

The use of particle‐induced X‐ray emission (PIXE) for elemental speciation and quantification has gained new attention thanks to mapping capabilities. Microprobes are able to raster a proton beam and produce elemental maps on the micrometre scale. Moreover, recent developments of in‐air PIXE instrumentation have enabled the acquisition of large area elemental maps. However, the amount of data produced is very large, and the data...

Read More thumbnail image: Multivariate analysis applied to particleinduced Xray emission mapping

Study of detection limit and sensitivity of K and L spectral lines of 47Ag 48Cd and 50Sn elements using polychromatic wavelength dispersive X ray spectrometer

Published: Jun 17, 2018

Author(s): Harpreet Singh Kainth

Journal: X-Ray Spectrometry

The purpose of this work was to evaluate the instrumental detection limit and sensitivity for determination of elemental composition of 47Ag, 48Cd, and 50Sn elements in the standard liquid solution with highly advanced polychromatic wavelength dispersive X‐ray fluorescence (PC‐WDXRF) spectrometer equipped with 45Rh X‐ray tube. To improve the sensitivity and detection limit, the bremsstrahlung coming from 45Rh source were reduced by choosing suitable...

Read More thumbnail image: Study of detection limit and sensitivity of K  and L  spectral lines of 47Ag  48Cd and 50Sn elements using polychromatic wavelength dispersive X ray spectrometer

Influence of photoinduced isomerization on the chiral separation of novel liquid crystalline materials with a diazene moiety

Published: Jun 15, 2018

Author(s): Terézia Jurkovičová Vojtylová, Martin Cigl, Petra Tomášková, Věra Hamplová, David Sýkora

Journal: Journal of Separation Science

Abstract The influence of photoinduced isomerization on the enantiomeric separation of two newly synthesized liquid crystalline materials, liquid crystals 1 and 2, was studied by high‐performance liquid chromatography on a chiral stationary phase Chiralpack AD‐3. Both materials have one chiral center and one diazene moiety. The compounds were separated into their E and Z isomeric forms. The conditions and time scale of the...

Read More thumbnail image: Influence of photoinduced isomerization on the chiral separation of novel liquid crystalline materials with a diazene moiety

Rapid analysis of ultraviolet filters using dispersive liquid–liquid microextraction coupled to headspace gas chromatography and mass spectrometry

Published: Jun 15, 2018

Author(s): Stephen A. Pierson, María J. Trujillo‐Rodríguez, Jared L. Anderson

Journal: Journal of Separation Science

Abstract An ionic‐liquid‐based in situ dispersive liquid–liquid microextraction method coupled to headspace gas chromatography and mass spectrometry was developed for the rapid analysis of ultraviolet filters. The chemical structures of five ionic liquids were specifically designed to incorporate various functional groups for the favorable extraction of the target analytes. Extraction parameters including ionic liquid mass, molar...

Read More thumbnail image: Rapid analysis of ultraviolet filters using dispersive liquidliquid microextraction coupled to headspace gas chromatography and mass spectrometry

Fabrication of polymer‐modified magnetic nanoparticle based adsorbents for the capture and release of quinolones by manipulating the metal–coordination interaction

Published: Jun 15, 2018

Author(s): Mingming Zhang, Juan Qiao, Zhenwen Zhao, Shufeng Zhang, Li Qi

Journal: Journal of Separation Science

Abstract Functional polymers with a metal–coordination interaction have been fabricated for sample pretreatment. Poly(N‐4‐vinyl‐benzyl iminodiacetic acid‐co‐methacrylic acid‐co‐styrene)‐modified magnetic nanoparticles were prepared and used as solid‐phase extraction adsorbents for the analysis of quinolones by tuning the metal–coordination interaction. In the construction of the polymer‐based adsorbents, functional monomer (N‐(4‐vinyl)‐benzyl...

Read More thumbnail image: Fabrication of polymermodified magnetic nanoparticle based adsorbents for the capture and release of quinolones by manipulating the metalcoordination interaction

Mass spectrometry is a multifaceted weapon to be used in the battle against Alzheimer's disease: Amyloid beta peptides and beyond

Published: Jun 15, 2018

Author(s): Giuseppe Grasso

Journal: Mass Spectrometry Reviews

Amyloid‐β peptide (Aβ) accumulation and aggregation have been considered for many years the main cause of Alzheimer's disease (AD), and therefore have been the principal target of investigation as well as of the proposed therapeutic approaches (Grasso [2011] Mass Spectrom Rev. 30: 347‐365). However, the amyloid cascade hypothesis, which considers Aβ accumulation the only causative agent of the disease, has proven to...

Read More thumbnail image: Mass spectrometry is a multifaceted weapon to be used in the battle against Alzheimers disease Amyloid beta peptides and beyond

Important considerations for the utilisation of methanolysis in steroid analysis

Published: Jun 14, 2018

Author(s): Marjaana Viljanto, Catarina Horro Pita, James Scarth, Christopher J. Walker, Andrew T. Kicman, Mark C. Parkin

Journal: Drug Testing and Analysis

Abstract The effective analysis of anabolic‐androgenic steroids in urine usually requires a suitable deconjugation method for the analysis of phase II metabolites such as sulphates and glucuronides. Acid hydrolysis using methanolysis is one adopted method of deconjugation that efficiently and rapidly cleaves both sulphates and glucuronides contemporaneously. The formation of artefactual by‐products is a known disadvantage of this...

Read More thumbnail image: Important considerations for the utilisation of methanolysis in steroid analysis
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