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On electrophoresis of a pH‐regulated nanogel with ion partitioning effects

Published: Sep 12, 2018

Author(s): P. S. Majee, Somnath Bhattacharyya, Prashanta Dutta

Journal: ELECTROPHORESIS

Abstract The electrophoresis of a polyelectrolyte nanoparticle, whose charge condition depends on the salt concentration and pH of the suspended medium as well as the dielectric permittivity difference, is analyzed. The present nonlinear model for the electrophoresis of this pH‐regulated polyelectrolyte (PE) particle is based on the consideration of full set of governing equations of fluid and ion transport coupled with the equation...

Read More thumbnail image: On electrophoresis of a pHregulated nanogel with ion partitioning effects

Suitability evaluation of new endogenous biomarkers for the identification of nitrite‐based urine adulteration in mass spectrometry methods

Published: Sep 12, 2018

Author(s): Andrea E. Steuer, Kim Arnold, Dominique Kamber, Thomas Kraemer

Journal: Drug Testing and Analysis

Abstract Urine adulteration to circumvent positive drug testing is a fundamental challenge for toxicological laboratories all over the world. Untargeted mass spectrometry (MS) methods used in metabolomics had previously revealed uric acid (UA), histidine, methylhistidine, and their oxidation products, for example 5‐hydroxyisourate (HIU) as potential biomarkers for urine adulteration using potassium nitrite (KNO2). These markers...

Read More thumbnail image: Suitability evaluation of new endogenous biomarkers for the identification of nitritebased urine adulteration in mass spectrometry methods

In situ surface‐enhanced Raman spectroscopic monitoring electrochemical and surface plasmon resonance synergetic catalysis on dehydroxylation of PHTP at Ag electrodes

Published: Sep 11, 2018

Author(s): Xu Li, Chenjie Zhang, Qian Wu, Jing Zhang, Minmin Xu, Yaxian Yuan, Jianlin Yao

Journal: Journal of Raman Spectroscopy

Abstract Surface plasmon resonance (SPR)‐driven heterogeneous catalytic reactions have attracted considerable interests. However, the application of SPR was restricted in few types of surface reaction; the extension of SPR‐catalyzed reaction still remains significant challenge. The introduction of additional external fields is expected to generate the synergetic effect for improving the performance of SPR catalytic reaction. Herein,...

Read More thumbnail image: In situ surfaceenhanced Raman spectroscopic monitoring electrochemical and surface plasmon resonance synergetic catalysis on dehydroxylation of PHTP at Ag electrodes

Oxytocin analysis from human serum, urine, and saliva by orbitrap liquid chromatography–mass spectrometry

Published: Sep 11, 2018

Author(s): Adrian A. Franke, Xingnan Li, Ariane Menden, Mary R. Lee, Jennifer F. Lai

Journal: Drug Testing and Analysis

Abstract Oxytocin (OT) is a neurohormone that has gained interest recently due to its emerging role in cognition and social/emotional behaviors, including possibly depression and autism. OT is commonly measured using enzyme‐ or radio‐based immunoassays (RIA, ELISA), which lack specificity or are complicated to perform and involve hazardous radioactive material. We have developed a high resolution accurate‐mass (HRAM) liquid...

Read More thumbnail image: Oxytocin analysis from human serum urine and saliva by orbitrap liquid chromatographymass spectrometry

Glycine‐modified growth hormone secretagogues identified in seized doping material

Published: Sep 11, 2018

Author(s): Paulina Marta Gajda, Niels Bjerre Holm, Lars Jakobsen Hoej, Brian Schou Rasmussen, Petur Weihe Dalsgaard, Lotte Ask Reitzel, Kristian Linnet

Journal: Drug Testing and Analysis

Abstract A number of unknown pharmaceutical preparations seized by Danish customs authorities were submitted for liquid chromatography–high resolution mass spectrometry (LC–HRMS) analysis. Comparison with reference standards unequivocally identified the content of the powders as analogs of the growth hormone secretagogues GHRP‐2 (Pralmorelin), GHRP‐6, Ipamorelin, and modified growth hormone releasing factor (modified GRF 1–29),...

Read More thumbnail image: Glycinemodified growth hormone secretagogues identified in seized doping material

Production of certified reference materials for the sports doping control of the REV‐ERB agonist SR9009

Published: Sep 11, 2018

Author(s): Stephen R. Davies, Benjamin K.H. Chan, Michael Moawad, Taylor R. Garrett, Lance Brooker, Rima Chakrabarty

Journal: Drug Testing and Analysis

Abstract Two human metabolites of the REV‐ERB agonist SR9009, identified by researchers with an interest in sports doping control, have been synthesized and assessed for purity. The synthesis employed was a modification of published procedures for the parent SR9009, careful attention to the purification of intermediates and the final product ensuring materials of the highest purity were available for certification. For each...

Read More thumbnail image: Production of certified reference materials for the sports doping control of the REVERB agonist SR9009

Hair EtG: Alterations in segment levels accompanying hair growth

Published: Sep 11, 2018

Author(s): Jan Toralf Fosen, Gudrun Høiseth, Cristina Sempio, Nefele Giarratana, Asle Enger, Jørg Mørland, Luca Morini

Journal: Drug Testing and Analysis

Abstract Hair levels of the direct ethanol biomarker ethyl glucuronide (EtG) are used to evaluate history of alcohol intake. The proximal 3 cm of the hair sample is most often analyzed and this is assumed to represent the intake of ethanol over approximately the past three months. The aim of this study was to investigate change of EtG levels during hair growth in an ethanol‐abstinent period. Twenty‐seven patients were recruited from...

Read More thumbnail image: Hair EtG Alterations in segment levels accompanying hair growth

A sensitive and validated HPLC‐UV method for the quantitative determination of the new antifungal drug isavuconazole in human plasma

Published: Sep 11, 2018

Author(s): Giulio Nannetti, Silvana Pagni, Giorgio Palù, Arianna Loregian

Journal: Biomedical Chromatography

Abstract Isavuconazole is a broad‐spectrum triazole antifungal drug recently approved for the therapy of both invasive aspergillosis and mucormycosis. To support a widespread therapeutic drug monitoring of isavuconazole, a simple, sensitive, and precise high‐performance liquid chromatography method with UV detection was developed and fully validated for the quantification of this drug in human plasma. The method involved a combined...

Read More thumbnail image: A sensitive and validated HPLCUV method for the quantitative determination of the new antifungal drug isavuconazole in human plasma

Determination of glucosamine and monitoring of its mutarotation by hydrophilic interaction liquid chromatography with evaporative light scattering detector

Published: Sep 11, 2018

Author(s): Jiří Pazourek

Journal: Biomedical Chromatography

Abstract Saccharides and their derivatives are typical polar analytes without a suitable UV‐chromophore that are nowadays analyzed by HPLC (high‐performance liquid chromatography) under HILIC (hydrophilic interaction liquid chromatography) mode. Usually an evaporative light scattering detector (ELSD) is utilized which, however, gives a nonlinear response. A procedure to overcome the problem of mutarotating (time‐varying) analytes...

Read More thumbnail image: Determination of glucosamine and monitoring of its mutarotation by hydrophilic interaction liquid chromatography with evaporative light scattering detector

Raman and time of flight secondary ion mass spectrometry investigation answers specific conservation questions on Bosch painting Saint Wilgefortis Triptych

Published: Sep 11, 2018

Author(s): Armida Sodo, Luca Tortora, Paola Biocca, Annalaura Casanova Municchia, Enrico Fiorin, Maria Antonietta Ricci

Journal: Journal of Raman Spectroscopy

Abstract Raman spectroscopy and time of flight secondary ion mass spectrometry (ToF‐SIMS) were used to answer conservation questions left open after the preliminary analysis performed by the restoration team on the Bosch painting Saint Wilgefortis Triptych, within the project “Bosch in Venice.” In this work, we present the results obtained by combining these two techniques on five cross sections, concerning a detailed study of pigments and...

Read More thumbnail image: Raman and time of flight secondary ion mass spectrometry investigation answers specific conservation questions on Bosch painting Saint Wilgefortis Triptych

Determination of tocopherols and tocotrienols in human breast adipose tissue with the use of high performance liquid chromatography–fluorescence detection

Published: Sep 10, 2018

Author(s): Ewa Bartosińska, Julia Jacyna, Agnieszka Borsuk-De Moor, Michał Kaliszan, Karolina Kondej, Jerzy Jankau, Alicja Renkielska, Wiesław Janusz Kruszewski, Michał Jan Markuszewski, Danuta Siluk

Journal: Biomedical Chromatography

Abstract Tocopherols and tocotrienols have been extensively studied owing to their anticancer potential, especially against breast cancer. Therefore, the aim of this study was to quantitatively determine tocochromanols in human breast adipose tissue with the use of HPLC–FLD. The sample preparation procedure included homogenization and solvent extraction with isopropanol–ethanol–0.1% formic acid mixture prior to solid‐phase...

Read More thumbnail image: Determination of tocopherols and tocotrienols in human breast adipose tissue with the use of high performance liquid chromatographyfluorescence detection

Unified strategy for HPLC–MS evaluation of bioactive compounds for quality control of herbal products

Published: Sep 10, 2018

Author(s): Polina Turova, Elena Stekolshchikova, Timur Baygildiev, Oleg Shpigun, Igor Rodin, Andrey Stavrianidi

Journal: Biomedical Chromatography

Abstract Evaluation of safety, quality and composition of herbal products and food supplements based on botanical ingredients is a matter of serious concern. For screening of botanicals in herbal products multitargeted and group‐targeted approaches may be applied. In the group‐targeted approach botanicals are characterized by means of an appropriate group of structurally related biomarkers compared with the multitargeted approach...

Read More thumbnail image: Unified strategy for HPLCMS evaluation of bioactive compounds for quality control of herbal products

Quantitative determination of levonorgestrel in beagle dog plasma after vaginal administration of intravaginal ring by high‐performance liquid chromatography–tandem mass spectrometry

Published: Sep 10, 2018

Author(s): Zhenqi Liu, Shunchen Qiu, Yiqun Gu, Meiying Ning

Journal: Biomedical Chromatography

Abstract A specific and sensitive high‐performance liquid chromatography–tandem mass spectrometry method that could be used to determine the concentration of levonorgestrel (LNG) in beagle dog plasma was developed. Specifically, terfenadine was used as the internal standard (IS). The separation was achieved on a Kinetex‐C18 110A column (3 × 30 mm i.d., 2.6 um, Phenomenex) and a gradient mobile phase consists of methanol (0.1% formic acid) and ...

Read More thumbnail image: Quantitative determination of levonorgestrel in beagle dog plasma after vaginal administration of intravaginal ring by highperformance liquid chromatographytandem mass spectrometry

Single‐step purification and characterization of antifreeze proteins from leaf and berry of a freeze‐tolerant shrub seabuckthorn ( Hippophae rhamnoides )

Published: Sep 10, 2018

Author(s): Bhavana Sharma, Dinabandhu Sahoo, Renu Deswal

Journal: Journal of Separation Science

Abstract Seabuckthorn is a freeze‐tolerant Himalayan shrub, capable of withstanding temperatures below −40°C. Antifreeze proteins prevent freezing associated damage by restricting ice crystals growth. In the present study, homogenous purification of two antifreeze proteins (41 and 39 kDa) from Hippophae rhamnoides leaf and one (41 kDa) from berry was performed using ice‐affinity chromatography. MS identification and Basic Local...

Read More thumbnail image: Singlestep purification and characterization of antifreeze proteins from leaf and berry of a freezetolerant shrub seabuckthorn  Hippophae rhamnoides

A simple, sensitive, and straightforward LC–MS approach for rapid analysis of three potential genotoxic impurities in rabeprazole formulations

Published: Sep 10, 2018

Author(s): Veera Manohara Reddy Yenugu, Vijaya Bhaskar Reddy Ambavaram, Muhammad Moniruzzaman, Gajulapalle Madhavi

Journal: Journal of Separation Science

Abstract In the present study, a sensitive and fully validated liquid chromatography with mass spectrometry method was developed for the quantification of three potential genotoxic impurities in rabeprazole drug substance. The separation was achieved on Symmetry C18 column (100 × 4.6 mm, 3.5 μm) using 0.1% formic acid in water as mobile phase A and acetonitrile as mobile phase B in gradient elution mode at...

Read More thumbnail image: A simple sensitive and straightforward LCMS approach for rapid analysis of three potential genotoxic impurities in rabeprazole formulations

Enantioselective monitoring of chiral fungicide famoxadone enantiomers in tomato, apple, and grape by chiral liquid chromatography with tandem mass spectrometry

Published: Sep 10, 2018

Author(s): Guofeng Xu, Xiaohui Jia, Xiaohu Wu, Jun Xu, Xingang Liu, Xinglu Pan, Runan Li, Xinghai Li, Fengshou Dong

Journal: Journal of Separation Science

Abstract Famoxadone is a widely used chiral fungicide on tomato, apple, and grape. But it is still being employed as a racemic mixture without distinguishing the difference between enantiomers, which often leads to its inaccurate risk assessment. In this study, a rapid, sensitive, and reliable chiral analytical method was developed for famoxadone enantiomers by ultra high performance liquid chromatography/tandem mass spectrometry,...

Read More thumbnail image: Enantioselective monitoring of chiral fungicide famoxadone enantiomers in tomato apple and grape by chiral liquid chromatography with tandem mass spectrometry

Interactions between the Intrinsically Disordered Proteins β‐Synuclein and α‐Synuclein

Published: Sep 10, 2018

Author(s): Jonathan K. Williams, Xue Yang, Jean Baum

Journal: PROTEOMICS

Abstract Several intrinsically disordered proteins have been implicated in the process of amyloid fibril formation in neurodegenerative disease, and developing approaches to inhibit the aggregation of these intrinsically disordered proteins is critical for establishing effective therapies against disease progression. The aggregation pathway of the intrinsically disordered protein alpha‐synuclein, which is implicated in several...

Read More thumbnail image: Interactions between the Intrinsically Disordered Proteins Synuclein and Synuclein

Hyperpolarized 13 C spectroscopic imaging using single‐shot 3D sequences with unpaired adiabatic refocusing pulses

Published: Sep 10, 2018

Author(s): Jiazheng Wang, Richard L. Hesketh, Alan J. Wright, Kevin M. Brindle

Journal: NMR in Biomedicine

Hyperpolarized MRI with 13C‐labeled metabolites has enabled metabolic imaging of tumors in vivo. The heterogeneous nature of tumors and the limited lifetime of the hyperpolarization require high resolution, both temporally and spatially. We describe two sequences that make more efficient use of the 13C polarization than previously described single‐shot 3D sequences. With these sequences, the target metabolite resonances were excited using...

Read More thumbnail image: Hyperpolarized 13 C spectroscopic imaging using singleshot 3D sequences with unpaired adiabatic refocusing pulses

Influence of temperature on the surface property of ABS resin in KMnO 4 etching solution

Published: Sep 10, 2018

Author(s): Xinchen Han, Guixiang Wang, Jinmeng He, Jingyi Guan, Yandong He

Journal: Surface and Interface Analysis

The KMnO4‐H3PO4‐H2SO4 system was used to roughen and hydrophilically modify on the surface of ABS resin at different etching temperatures, and then, electroless nickel plating process was carried out. The surface of ABS resin after etching was characterized by XPS and SEM. It is found that the surface etching effect of ABS resin is relatively good when the etching temperature is 65°C. The resin surface generates ─OH and ─COOH hydrophilic...

Read More thumbnail image: Influence of temperature on the surface property of ABS resin in KMnO 4 etching solution

Probe electrospray ionization of mixture solutions using metal needles with different tip conditions

Published: Sep 10, 2018

Author(s): Satoshi Ninomiya, Shunpei Iwamoto, Lee Chuin Chen, Kenzo Hiraoka

Journal: Surface and Interface Analysis

Time‐dependent mass spectra of mixture solutions of cytochrome c and cholesterol were measured by probe electrospray ionization (PESI) mass spectrometry and the PESI characteristics for several metal needles were investigated with different tip conditions. For a mixture solution of cytochrome c and cholesterol in 0.1% formic acid methanol/water (1/1) at a motion frequency of 1 Hz, an acupuncture needle with a sharp tip and...

Read More thumbnail image: Probe electrospray ionization of mixture solutions using metal needles with different tip conditions
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