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High concentration measurements of U and Pu with nondestructive and standardless K ‐edge densitometer device

Published: Sep 14, 2017

Author(s): E. Esbelin, C. Rivier, G. Duhamel

Journal: X-Ray Spectrometry

In nuclear activities such as reprocessing plants, safeguard laboratories, or research centers, U and Pu are regularly analyzed. Fast and accurate analytical devices are favored such as K‐edge densitometer. This paper presents the results obtained by this device from assay samples with high U and Pu concentrations. Two processing methods without calibration (except energy calibration) are compared and discussed. Despite literature...

Read More thumbnail image: High concentration measurements of U and Pu with nondestructive and standardless K edge densitometer device

Anatomy and evolution of database search engines—a central component of mass spectrometry based proteomic workflows

Published: Sep 13, 2017

Author(s): Kenneth Verheggen, Helge Ræder, Frode S. Berven, Lennart Martens, Harald Barsnes, Marc Vaudel

Journal: Mass Spectrometry Reviews

Sequence database search engines are bioinformatics algorithms that identify peptides from tandem mass spectra using a reference protein sequence database. Two decades of development, notably driven by advances in mass spectrometry, have provided scientists with more than 30 published search engines, each with its own properties. In this review, we present the common paradigm behind the different implementations, and...

Read More thumbnail image: Anatomy and evolution of database search enginesa central component of mass spectrometry based proteomic workflows

From surface science research to high‐impact knowhows—Exemplars of Surface Science Western

Published: Sep 13, 2017

Author(s): Woon‐Ming Lau

Journal: Surface and Interface Analysis

Surface Science Western (SSW) is a Canadian center of excellence bearing a mandate to facilitate both interdisciplinary research in surface science and subsequent knowledge/technology transfer. Three exemplars of SSW's accomplishments in this context are here highlighted. The first exemplar began with fundamental studies of nucleation and growth of diamond via chemical vapor deposition. This yielded 2 US patents and the startup of CVD...

Read More thumbnail image: From surface science research to highimpact knowhowsExemplars of Surface Science Western

Advances in Capillary Electrophoretically Mediated Microanalysis for On‐line Enzymatic and Derivatization Reactions

Published: Sep 13, 2017

Author(s): Shengyun Huang, Prasanta Paul, Pranov Ramana, Erwin Adams, Patrick Augustijns, Ann Schepdael

Journal: ELECTROPHORESIS

Abstract This review summarizes recent developments, applications, and innovations of capillary electrophoretically mediated microanalysis methods. As a follow up of an earlier review, it covers the literature from early 2015 to early 2017. This article is divided into three parts. In the first part, different types of mixing procedures and applications of enzyme mediated microanalysis are discussed; the second part summarizes...

Read More thumbnail image: Advances in Capillary Electrophoretically Mediated Microanalysis for Online Enzymatic and Derivatization Reactions

Magnetic ionic liquid assisted single‐drop microextraction of ascorbic acid before its voltammetric determination

Published: Sep 13, 2017

Author(s): Zahra Jahromi, Ali Mostafavi, Tayebeh Shamspur, Maryam Mohamadim

Journal: Journal of Separation Science

Abstract For the first time, we coupled a microextraction technique using a magnetic ionic liquid with voltammetric determination. A hydrophobic magnetic ionic liquid that contains the tetrachloromanganate(II) anion, namely, aliquat tetrachloromanganate(II), was synthesized and used for the extraction of ascorbic acid from aqueous solutions followed by voltammetric determination. The extraction procedure was carried out using a...

Read More thumbnail image: Magnetic ionic liquid assisted singledrop microextraction of ascorbic acid before its voltammetric determination

Immobilized enzyme reactors based on monoliths: Effect of pore size and enzyme loading on biocatalytic process

Published: Sep 13, 2017

Author(s): Mariia V. Volokitina, Anna V. Nikitina, Tatiana B. Tennikova, Evgenia G. Korzhikova‐Vlakh

Journal: ELECTROPHORESIS

Abstract Macroporous monolithic columns with different mean pore size (from 360 to 2020 nm) and appropriate flow‐through properties were synthesized using free radical in situ copolymerization of glycidyl methacrylate, 2‐hydroxyethyl methacrylate and ethylene dimethacrylate. In order to predict the composition of porogen mixture to generate the pores in the interested size interval, the Hildebrand theory was used. Ribonuclease...

Read More thumbnail image: Immobilized enzyme reactors based on monoliths Effect of pore size and enzyme loading on biocatalytic process

Use of Ionic liquids as additives in ion exchange chromatography for the analysis of cations

Published: Sep 13, 2017

Author(s): Huawei Di, Xiashi Zhu

Journal: Journal of Separation Science

Abstract The behavior of acids (citric acid, nitric acid, oxalic acid, tartaric acid) as a mobile phase and imidazolium ionic liquids (the bromides, tetrafluoroborates and hexafluorophosphates of 1‐ethyl, 1‐butyl, and 1‐hexyl‐3‐methylimidazolium) as additives in ion exchange chromatography for cations (Na+, K+, Mg2+, Ca2+) separation were studied. The results showed that nitric acid and 1‐hexyl‐3‐methyl‐imidazolium hexafluorophosphate offered ...

Read More thumbnail image: Use of Ionic liquids as additives in ion exchange chromatography for the analysis of cations

The stochastic resonance algorithm with the direct current signal as external force and its application to the detection of weak chromatographic peaks

Published: Sep 13, 2017

Author(s): Rui Li, Bingren Xiang, Haishan Deng, Shaofei Xie

Journal: Journal of Separation Science

Abstract As a potential tool for amplifying weak chromatographic peaks, the stochastic resonance algorithm was developed based upon a counterintuitive physical phenomenon. Therefore, the essential step, parameter optimization, was perplexing and difficult for analysts. In order to avoid optimizing the system parameters on a case‐by‐case basis, an improved algorithm was proposed by introducing a constant or direct current signal into...

Read More thumbnail image: The stochastic resonance algorithm with the direct current signal as external force and its application to the detection of weak chromatographic peaks

Recent advances in amino acid analysis by capillary electromigration methods: June 2015–May 2017

Published: Sep 13, 2017

Author(s): Véréna Poinsot, Varravaddheay Ong‐Meang, Audrey Ric, Pierre Gavard, Lucie Perquis, François Couderc

Journal: ELECTROPHORESIS

Abstract In the tenth edition of this article focused on recent advances in amino acid analysis using capillary electrophoresis, we describe the most important research articles published on this topic during the period from June 2015 to May 2017. This article follows the format of the previous articles published in Electrophoresis. The new developments in amino acid analysis with CE mainly describe improvements in CE associated...

Read More thumbnail image: Recent advances in amino acid analysis by capillary electromigration methods June 2015May 2017

Affinity chromatography on monolithic supports for simultaneous and high‐throughput isolation of immunoglobulins from human serum

Published: Sep 13, 2017

Author(s): Tamara Martinović, Uroš Andjelković, Marko Klobučar, Urh Černigoj, Jana Vidič, Marina Lučić, Krešimir Pavelić, Djuro Josić

Journal: ELECTROPHORESIS

Abstract Posttranslational modifications of immunoglobulins have been a topic of great interest and have been repeatedly reported as a major factor in disease pathology. Cost‐effective, reproducible, and high‐throughput (HTP) isolation of immunoglobulins from human serum is vital for studying the changes in protein structure and the following understanding of disease development. Although there are many methods for the isolation of...

Read More thumbnail image: Affinity chromatography on monolithic supports for simultaneous and highthroughput isolation of immunoglobulins from human serum

A flow‐through column electrolytic cell for supercritical fluid chromatography *

Published: Sep 12, 2017

Author(s): Kazuhiro Yamamoto, Tatsuya Ueki, Naoyuki Higuchi, Kouji Takahashi, Akira Kotani, Hideki Hakamata

Journal: Journal of Separation Science

Abstract A novel flow‐through column electrolytic cell was proposed as a detector to obtain current signals for supercritical fluid chromatography. The electrochemical cell consisted of two electrodes and its holder, and a working and a counter electrode were fabricated from 192 carbon strings, which were composed of 400 carbon fibers of 10 μm in diameter filled into a heat‐shrinkable tube. These electrodes were placed in the...

Read More thumbnail image: A flowthrough column electrolytic cell for supercritical fluid chromatography

Recent advances in microscale separation

Published: Sep 12, 2017

Author(s): Yuanyuan Liu, Weiwei Wang, Mengqi Jia, Rangdong Liu, Qing Liu, Han Xiao, Jing Li, Yun Xue, Yan Wang, Chao Yan

Journal: ELECTROPHORESIS

Abstract This review focuses on the recent advances on microscale separation technology, particularly on the new development on column and detection technologies in electrophoretic and chromatographic separation modes (i.e., CE, CEC, cLC, etc.). Representative examples illustrate also applications on the small molecules, peptides, proteins, polysaccharides, chiral and so on. 246 relevant articles are cited covering the literature...

Read More thumbnail image: Recent advances in microscale separation

Pencil graphite leads as simple amperometric sensors for microchip electrophoresis

Published: Sep 12, 2017

Author(s): Eiva Natiele Tiago da Silva, Jacqueline Marques Petroni, Bruno Gabriel Lucca, Valdir Souza Ferreira

Journal: ELECTROPHORESIS

Abstract In this work we demonstrate, for the first time, the use of inexpensive commercial pencil graphite leads as simple amperometric sensors for microchip electrophoresis. A PDMS support containing one channel was fabricated through soft lithography and sanded pencil graphite leads were inserted into this channel to be used as working electrodes. The electrochemical and morphological characterization of the sensor was carried...

Read More thumbnail image: Pencil graphite leads as simple amperometric sensors for microchip electrophoresis

Sensitive liquid chromatography/tandem mass spectrometry method for the determination of two novel highly lipophilic anticancer drug candidates in rat plasma and tissues

Published: Sep 12, 2017

Author(s): Shirin Hooshfar, Michael R. Linzey, Daqing Wu, Lajos Gera, Kenza Mamouni, Xin Li, Yanhua Chen, Yang Yang, Oluwasegun Olorunyolemi, Michael G. Bartlett

Journal: Biomedical Chromatography

Abstract A simple and sensitive liquid chromatography/electrospray ionization tandem mass spectrometry (LC‐ESI‐MS/MS) method was developed and validated for determination of two highly lipophilic anticancer drug candidates, LG1980 and GH501, in rat plasma and tissues (liver, kidney and femur bones). LG1980 and GH501 were extracted from rat plasma and tissue homogenates using liquid–liquid extraction. The method provided a linear...

Read More thumbnail image: Sensitive liquid chromatographytandem mass spectrometry method for the determination of two novel highly lipophilic anticancer drug candidates in rat plasma and tissues

Proteomic Analysis of Neuroblastoma‐Derived Exosomes: New Insights into a Metastatic Signature

Published: Sep 12, 2017

Author(s): Marta Colletti, Andrea Petretto, Angela Galardi, Virginia Di Paolo, Luigi Tomao, Chiara Lavarello, Elvira Inglese, Maurizio Bruschi, Ana Amor Lopez, Luisa Pascucci, Birgit Geoerger, Hector Peinado, Franco Locatelli, Angela Di Giannatale

Journal: PROTEOMICS

Abstract Neuroblastoma (NB) is the most common extracranial pediatric solid tumor. Around 70% of patients with metastatic disease at diagnosis present bone‐marrow infiltration, which is considered a marker of poor outcome; however, the mechanism underlying this specific tropism has to be elucidated. Tumor‐derived exosomes may support metastatic progression in several tumors by interacting with the microenvironment, and may serve as...

Read More thumbnail image: Proteomic Analysis of NeuroblastomaDerived Exosomes New Insights into a Metastatic Signature

Evaluation of poly([2‐(acryloyloxy)ethyl]trimethylammonium chloride) cationic polymer capillary coating for capillary electrophoresis and electrokinetic chromatography separations

Published: Sep 11, 2017

Author(s): Julie R. McGettrick, Christopher P. Palmer

Journal: Journal of Separation Science

Abstract Capillary electrophoresis and electrokinetic chromatography are typically carried out in unmodified fused‐silica capillaries under conditions that result in a strong negative zeta potential at the capillary wall and a robust cathodic electroosmotic flow. Modification of the capillary wall to reverse the zeta potential and mask silanol sites can improve separation performance by reducing or eliminating analyte adsorption,...

Read More thumbnail image: Evaluation of poly2acryloyloxyethyltrimethylammonium chloride cationic polymer capillary coating for capillary electrophoresis and electrokinetic chromatography separations

Simple and rapid determination of zaltoprofen in human plasma by manual‐shaking‐assisted dispersive liquid–liquid microextraction followed by liquid chromatography with ultraviolet detection

Published: Sep 11, 2017

Author(s): Se Young Han, Kyung Min Jeong, Da Eun Yoo, Yan Jin, Eun Mi Kim, Su Hyun Kim, Seok‐Yong Lee, Se‐Hyung Kim, Jing Zhao, Jeongmi Lee

Journal: Journal of Separation Science

Abstract A readily applicable method was developed to determine the concentration level of zaltoprofen, a non‐steroidal antiinflammatory drug from the propionic acid family, in human plasma. This method is based on manual‐shaking‐assisted dispersive liquid–liquid microextraction coupled with liquid chromatography with ultraviolet detection. Factors affecting the extraction efficiency were screened and optimized by experimental...

Read More thumbnail image: Simple and rapid determination of zaltoprofen in human plasma by manualshakingassisted dispersive liquidliquid microextraction followed by liquid chromatography with ultraviolet detection

Determination of fat‐ and water‐soluble vitamins by supercritical fluid chromatography: A review

Published: Sep 11, 2017

Author(s): Katarzyna Tyśkiewicz, Agnieszka Dębczak, Roman Gieysztor, Tomasz Szymczak, Edward Rój

Journal: Journal of Separation Science

Abstract Vitamins are compounds that take part in all basic functions of an organism but also are subject of number of studies performed by different researchers. Two groups of vitamins are distinguished taking into consideration their solubility. Chromatography with supercritical CO2 has found application in the determination, separation, and quantitative analyses of both fat‐ and water‐soluble vitamins. The methods of vitamins...

Read More thumbnail image: Determination of fat and watersoluble vitamins by supercritical fluid chromatography A review

Simultaneous determination of ferulic acid and gastrodin of Tianshu Capsule in rat plasma by ultra‐fast liquid chromatography with tandem mass spectrometry and its application to a comparative pharmacokinetic study in normal and migraine rats

Published: Sep 11, 2017

Author(s): Jiao Guan, Xiurong Zhang, Bo Feng, Donghai Zhao, Tong Zhao, Sheng Chang, Liming Wang, Heyun Zhu

Journal: Journal of Separation Science

Abstract Tianshu Capsule, consisting of Ligusticum chuanxiong Hort and Gastrodia elata Blume, is a widely used Traditional Chinese Medicine preparation for the treatment of migraine. Ferulic acid and gastrodin are main active constituents in Ligusticum chuanxiong Hort and Gastrodia elata Blume, and have been used as marker components for quality control of Tianshu Capsule. In this study, a selective, sensitive, and reliable...

Read More thumbnail image: Simultaneous determination of ferulic acid and gastrodin of Tianshu Capsule in rat plasma by ultrafast liquid chromatography with tandem mass spectrometry and its application to a comparative pharmacokinetic study in normal and migraine rats

Evaluation and quantitative analysis of 11 compounds in Morinda officinalis using ultra‐high performance liquid chromatography and photodiode array detection coupled with chemometrics

Published: Sep 11, 2017

Author(s): Xiangsheng Zhao, Weijun Kong, Yakui Zhou, Jianhe Wei, Meihua Yang

Journal: Journal of Separation Science

Abstract Morinda officinalis (Rubiaceae) is a traditional Chinese medicine widely used for the treatment of impotence and osteoporosis in clinical therapy. In the present study, a rapid and simple ultra‐high performance liquid chromatography with photodiode array detection method was developed and validated for the simultaneous determination of 11 bioactive compounds in M. officinalis. This assay method was validated with respect to linearity...

Read More thumbnail image: Evaluation and quantitative analysis of 11 compounds in Morinda officinalis using ultrahigh performance liquid chromatography and photodiode array detection coupled with chemometrics
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