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Mass spectrometry and associated technologies delineate the advantageously biomedical capacity of siderophores in different pathogenic contexts

Published: Jul 23, 2018

Author(s): Xialin Luo, Rui Guo, Xin Xu, Xian Li, Li Yao, Xijun Wang, Haitao Lu

Journal: Mass Spectrometry Reviews

Siderophores are chemically diverse small molecules produced by microorganisms for chelation of irons to maintain their survival and govern some important biological functions, especially those cause that infections in hosts. Still, siderophores can offer new insight into a better understanding of the diagnosis and treatments of infectious diseases from the siderophore biosynthesis and regulation perspective. Thus,...

Read More thumbnail image: Mass spectrometry and associated technologies delineate the advantageously biomedical capacity of siderophores in different pathogenic contexts

The combined use of Raman and micro‐X‐ray diffraction analysis in the study of archaeological glass beads

Published: Jul 22, 2018

Author(s): Mafalda Costa, Ana Margarida Arruda, Luís Dias, Rui Barbosa, José Mirão, Peter Vandenabeele

Journal: Journal of Raman Spectroscopy

Abstract This study proposes a new nondestructive methodology that combines micro‐Raman spectroscopy and micro‐X‐ray diffraction (μ‐XRD), complemented by variable pressure scanning electron microscopy coupled with energy dispersive X‐ray spectrometry, to determine the composition of glass artifacts and the manufacturing techniques employed in their production. The use of micro‐Raman spectroscopy revealed that most samples belong to...

Read More thumbnail image: The combined use of Raman and microXray diffraction analysis in the study of archaeological glass beads

Analysis of N,N‐dimethylamphetamine in wastewater – a pyrolysis marker and synthesis impurity of methamphetamine

Published: Jul 20, 2018

Author(s): Frederic Been, Jake O'Brien, Foon Yin Lai, Marie Morelato, Peter Vallely, Jenny McGowan, Alexander L. N. Nuijs, Adrian Covaci, Jochen F. Mueller

Journal: Drug Testing and Analysis

Abstract The increased availability of high purity crystalline methamphetamine (MA) in Australia raised concerns because of high dosages and its potential consumption through inhalation. The present work investigates the possibility of using wastewater levels of N,N‐dimethylamphetamine (DMA), a pyrolysis by‐product, as an indirect indicator of MA smoking. A dedicated liquid chromatography quadrupole‐time‐of‐flight mass spectrometry...

Read More thumbnail image: Analysis of NNdimethylamphetamine in wastewater  a pyrolysis marker and synthesis impurity of methamphetamine

Raman microscopy for the identification of pearlescent pigments in acrylic works of art

Published: Jul 20, 2018

Author(s): Eva Mariasole Angelin, Sara Babo, Joana Lia Ferreira, Maria João Melo

Journal: Journal of Raman Spectroscopy

Abstract In this work, pearlescent pigments used to create luster in poly(methyl methacrylate) artworks by Ângelo de Sousa (1938–2011) were identified in an effort to predict their possible degradation. Raman microscopy was used, in situ, to identify plumbonacrite and bismuth oxychloride. Unequivocal characterization of plumbonacrite and bismuth oxychloride was made possible by comparison with reference materials, synthesized for...

Read More thumbnail image: Raman microscopy for the identification of pearlescent pigments in acrylic works of art

Model‐based and data‐driven with multiscale sum of squares double EWMA control chart for fault detection in biological systems

Published: Jul 20, 2018

Author(s): Majdi Mansouri, Mohamed Faouzi Harkat, Sin Yin Teh, Ayman Al‐khazraji, Hazem Nounou, Mohamed Nounou

Journal: Journal of Chemometrics

Abstract The objectives of this paper will be sought. First, an enhanced technique that can accurately model biological processes will be developed. To deal with scenarios where a process model is available, the particle filter method will be developed to better handle the nonlinear and high‐dimensional state estimation problem. Second, a multiscale sum of squares double exponentially weighted moving average (MS‐SS‐DEWMA) chart will...

Read More thumbnail image: Modelbased and datadriven with multiscale sum of squares double EWMA control chart for fault detection in biological systems

Denaturing high‐performance liquid chromatography and principal component analysis for identification of DNA point mutations in breast cancer and lymphoma samples

Published: Jul 20, 2018

Author(s): Yocanxóchitl Perfecto‐Avalos, Raquel Cuevas‐Díaz Durán, Luis Villela, Alejandro Garcia‐Gonzalez, Ricardo Javier Díaz‐Domínguez, Tania Loyo, Miguel Ángel Gutiérrez‐Monreal, Juan Manuel Esparza‐Treviño, Carlos Rocha‐Inclán, Rocío Rojo, Eduardo Cárdenas‐Cantú, Jezreel Pantaléon‐García, Sean‐Patrick Scott

Journal: Journal of Chemometrics

Abstract DNA mutations are identified by techniques that use the knowledge of the wild‐type DNA sequence and its mutated variant. The involved analytic methods must be accurate, rapid, and sustainable, if a clinical application is pursued. High‐performance liquid chromatography under denaturing conditions is a useful technique to screen mutations. Denaturing high‐performance liquid chromatography resultant chromatograms are suitable...

Read More thumbnail image: Denaturing highperformance liquid chromatography and principal component analysis for identification of DNA point mutations in breast cancer and lymphoma samples

The Vouros Odyssey. Liquid chromatography/mass spectrometry from a chromatographic perspective and a Theseus Paradox

Published: Jul 19, 2018

Author(s): Thomas Covey

Journal: Mass Spectrometry Reviews

This article tracts Paul Vouro's contributions to the field of liquid chromatography ‐ mass spectrometry in the context of the history of the development of modern day LC/MS.

Read More thumbnail image: The Vouros Odyssey_ Liquid chromatographymass spectrometry from a chromatographic perspective and a Theseus Paradox

The integration of LC‐MS and NMR for the analysis of low molecular weight trace analytes in complex matrices

Published: Jul 19, 2018

Author(s): Rose M. Gathungu, Roger Kautz, Bruce S. Kristal, Susan S. Bird, Paul Vouros

Journal: Mass Spectrometry Reviews

This review discusses the integration of liquid chromatography (LC), mass spectrometry (MS), and nuclear magnetic resonance (NMR) in the comprehensive analysis of small molecules from complex matrices. We first discuss the steps taken toward making the three technologies compatible, so as to create an efficient analytical platform. The development of online LC‐MS‐NMR, highlighted by successful applications in the...

Read More thumbnail image: The integration of LCMS and NMR for the analysis of low molecular weight trace analytes in complex matrices

Quality of the antimalarial medicine artemether – lumefantrine in 8 cities of the Democratic Republic of the Congo

Published: Jul 18, 2018

Author(s): Jean‐Pierre Mufusama, Karine Ndjoko Ioset, Doris Feineis, Ludwig Hoellein, Ulrike Holzgrabe, Gerhard Bringmann

Journal: Drug Testing and Analysis

Abstract In the context of post‐marketing surveillance supporting public‐health authorities to take evidence‐based decisions to fight the spread of poor‐quality medicines, the quality of antimalarial artemether‐lumefantrine (AL) medicines was assessed in the Democratic Republic of the Congo (DRC). A total of 150 samples of AL‐containing products was collected from private pharmaceutical outlets in 8 main cities: Goma, Kikwit,...

Read More thumbnail image: Quality of the antimalarial medicine artemether  lumefantrine in 8 cities of the Democratic Republic of the Congo

First identification of a diuretic, hydrochlorothiazide, in hair: Application to a doping case and interpretation of the results

Published: Jul 18, 2018

Author(s): L. Gheddar, JS. Raul, P. Kintz

Journal: Drug Testing and Analysis

Abstract An athlete contested an adverse analytical finding involving hydrochlorothiazide, and requested our laboratory for testing his hair. As there is no reference in the literature about identification of hydrochlorothiazide in hair, several volunteers were first enrolled (4 after a single 25 mg administration and 10 with daily therapeutic treatment). A specific method was developed by ultra‐performance liquid...

Read More thumbnail image: First identification of a diuretic hydrochlorothiazide in hair Application to a doping case and interpretation of the results

Assessing high‐intensity focused ultrasound treatment of prostate cancer with hyperpolarized 13 C dual‐agent imaging of metabolism and perfusion

Published: Jul 18, 2018

Author(s): Jessie E. Lee, Chris J. Diederich, Robert Bok, Renuka Sriram, Romelyn Delos Santos, Susan M. Noworolski, Vasant A. Salgaonkar, Matthew S. Adams, Daniel B. Vigneron, John Kurhanewicz

Journal: NMR in Biomedicine

The goal of the study was to establish early hyperpolarized (HP) 13C MRI metabolic and perfusion changes that predict effective high‐intensity focused ultrasound (HIFU) ablation and lead to improved adjuvant treatment of partially treated regions. To accomplish this a combined HP dual‐agent (13C pyruvate and 13C urea) 13C MRI/multiparametric 1H MRI approach was used to measure prostate cancer metabolism and perfusion 3–4 h, 1 d, and 5 d after exposure to...

Read More thumbnail image: Assessing highintensity focused ultrasound treatment of prostate cancer with hyperpolarized 13 C dualagent imaging of metabolism and perfusion

Optical sectioning in multifoci Raman hyperspectral imaging

Published: Jul 18, 2018

Author(s): Zhiyu Liao, Faris Sinjab, Hany M. Elsheikha, Ioan Notingher

Journal: Journal of Raman Spectroscopy

Abstract In this study, we compared the depth discrimination and speed performance of multifoci Raman hyperspectral imaging with the reference standard of a single laser point confocal Raman mapping. A liquid crystal spatial light modulator was employed for the generation of multifoci laser beams, and a digital micromirror device was used as a software‐configurable reflective pinhole array. The patterns of the laser foci and pinhole...

Read More thumbnail image: Optical sectioning in multifoci Raman hyperspectral imaging

Deep ultraviolet initiated excited state dynamics of riboflavin and flavin mononucleotide

Published: Jul 17, 2018

Author(s): Sudeb Ghosh, Mrinalini Puranik

Journal: Journal of Raman Spectroscopy

Abstract Flavins are cofactors in several light‐activated enzymes and therefore their excited states are found to involve in many photobiological processes. Excited state dynamics of flavin compounds corresponding to their first singlet state (S1) has been studied using a plethora of techniques, whereas studies related to highly absorbing ultraviolet excited states are lacking. Here, we study the ultrafast excited state dynamics of riboflavin...

Read More thumbnail image: Deep ultraviolet initiated excited state dynamics of riboflavin and flavin mononucleotide

Early detection of zinc deficit with confocal Raman spectroscopy

Published: Jul 17, 2018

Author(s): Xiaoyu Zhao, Lijing Cai

Journal: Journal of Raman Spectroscopy

Abstract Zinc deficit is one of the most important reasons for botanical disease. It can occur in many forms, for example, as rice blast, bacterial stripe, bacterial blight, and false smut. All these diseases will greatly lead to lower yields during rice harvest. In these paper, we show that Raman spectroscopy provides a single, fast, and sensitive method for detecting zinc deficit, especially during early forms of zinc deficiency....

Read More thumbnail image: Early detection of zinc deficit with confocal Raman spectroscopy

Development of plasmonic U‐bent plastic optical fiber probes for surface enhanced Raman scattering based biosensing

Published: Jul 17, 2018

Author(s): Christina Grace Danny, A. Subrahmanyam, V.V.R. Sai

Journal: Journal of Raman Spectroscopy

Abstract Evanescent wave‐based excitation of noble metal nanostructures on fiber core surface allows simultaneous excitation over a larger area in comparison with free space coupling, and hence highly suitable for development of surface‐enhanced Raman scattering (SERS)‐based sensor applications. This study describes the development of plasmonically active U‐bent plastic optical fiber (POF) probes for SERS‐based sensing. The SERS...

Read More thumbnail image: Development of plasmonic Ubent plastic optical fiber probes for surface enhanced Raman scattering based biosensing

Exploring street art paintings by microspatially offset Raman spectroscopy

Published: Jul 17, 2018

Author(s): Alessandra Botteon, Chiara Colombo, Marco Realini, Susanna Bracci, Donata Magrini, Pavel Matousek, Claudia Conti

Journal: Journal of Raman Spectroscopy

Abstract Microspatially offset Raman spectroscopy (micro‐SORS) is a recently developed analytical technique combining SORS with microscopy. With this method, highly diffusely scattering microlayers such as painted stratigraphies can be noninvasively probed. In this study, we explore micro‐SORS for identifying the chemical composition of subsurface layers in real, street art mural paintings as a new nondestructive method for the...

Read More thumbnail image: Exploring street art paintings by microspatially offset Raman spectroscopy

Development and validation of HPTLC and green HPLC methods for determination of furosemide, spironolactone and canrenone, in pure forms, tablets and spiked human plasma

Published: Jul 16, 2018

Author(s): Ibrahim A. Naguib, Eglal A. Abdelaleem, Aml A. Emam, Nouruddin W. Ali, Fatma F. Abdallah

Journal: Biomedical Chromatography

Abstract Two selective and accurate chromatographic methods are presented for simultaneous quantitation of spironolactone (SP) and furosemide (FR) and canrenone (CN), the main degradation product and the main active metabolite of SP. Method A was HPTLC, where separation was completed on silica gel HPTLC F254 plates using ethyl acetate–triethylamine–acetic acid (9:0.7:0.5, by volume) as a developing system and UV detection at 254 nm. ...

Read More thumbnail image: Development and validation of HPTLC and green HPLC methods for determination of furosemide spironolactone and canrenone in pure forms tablets and spiked human plasma

Simultaneous determination of tapentadol and its carbamate prodrug in rat plasma by UPLC‐MS/MS and its application to a pharmacokinetic study

Published: Jul 16, 2018

Author(s): Cuiru Liu, Yingchao Li, Rujie Yang, Shuqi Zhang, Longshan Zhao, Tianhong Zhang

Journal: Biomedical Chromatography

Abstract A prodrug of tapentadol, namely tapentadol carbamate (WWJ01), was synthesized to improve the bioavailability of tapentadol owing to its extensive first‐pass metabolism. In this study, a highly rapid and sensitive UPLC‐MS/MS method was developed and validated for the simultaneous determination of tapentadol and WWJ01 in rat plasma with fluconazole as an internal standard. The analytes and internal standard were treated by...

Read More thumbnail image: Simultaneous determination of tapentadol and its carbamate prodrug in rat plasma by UPLCMSMS and its application to a pharmacokinetic study

Enhanced HPLC‐MS/MS method for the quantitative determination of the co‐administered drugs ceftriaxone sodium and lidocaine hydrochloride in human plasma following an intramuscular injection and application to a pharmacokinetic study

Published: Jul 16, 2018

Author(s): Dalia Mohamed, Maha Kamal

Journal: Biomedical Chromatography

Abstract A sensitive HPLC–MS/MS method was established for the quantification of ceftriaxone sodium (CFT) and lidocaine HCl (LDC) in human plasma utilizing cefixime (CFX) and tadalafil (TDA) as internal standards. The analytes were extracted from human plasma by protein precipitation using acetonitrile. Chromatographic separation was performed on Kinetex C18 (50.0 × 4.6 mm, 5 μm particle size) column with methanol–0.01 M ammonium acetate...

Read More thumbnail image: Enhanced HPLCMSMS method for the quantitative determination of the coadministered drugs ceftriaxone sodium and lidocaine hydrochloride in human plasma following an intramuscular injection and application to a pharmacokinetic study

Multimodal integration of diffusion MRI for better characterization of tissue biology

Published: Jul 16, 2018

Author(s): Chunlei Liu, Evren Özarslan

Journal: NMR in Biomedicine

The contrast in diffusion‐weighted MR images is due to variations of diffusion properties within the examined specimen. Certain microstructural information on the underlying tissues can be inferred through quantitative analyses of the diffusion‐sensitized MR signals. In the first part of the paper, we review two types of approach for characterizing diffusion MRI signals: Bloch's equations with diffusion terms, and statistical...

Read More thumbnail image: Multimodal integration of diffusion MRI for better characterization of tissue biology
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