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Mammalian cell metabolomics: Experimental design and sample preparation
Published: May 13, 2013
Author(s): Zacarías León, Juan C. García‐Cañaveras, María Teresa Donato, Agustín Lahoz
Journal: ELECTROPHORESIS
Metabolomics represents the global assessment of metabolites in a biological sample and reports the closest information to the phenotype of the biological system under study. Mammalian cell metabolomics has emerged as a promising tool with potential applications in many biotechnology and research areas. Metabolomics workflow includes experimental design, sampling, sample processing, metabolite analysis, and data processing. Given their...
Read MoreUPLC‐PDA‐TOF/MS coupled with multivariate statistical analysis to rapidly analyze and evaluate Ginkgo biloba leaves from different origin
Published: May 10, 2013
Author(s): Xin Yao, Guisheng Zhou, Yuping Tang, Sheng Guo, Yefei Qian, Chun Jin, Yong Qin, Dawei Qian, Jin‐ao Duan
Journal: Drug Testing and Analysis
In the present study, an ultra performance liquid chromatography coupled with photodiode array detector and time‐of‐flight mass spectrometry (UPLC‐PDA‐TOF/MS) was proposed and validated for rapidly analyzing and evaluating Ginkgo biloba leaves from different origins by using multivariate statistical analysis. Batches of these kinds of G. biloba leaves were subjected to UPLC‐PDA‐TOF/MS analysis, the datasets of retention time (RT)‐m/z pairs, ion intensities and...
Read MorePreparation of sulfur reference materials that reproduce atmospheric particulate matter sample characteristics for XRF calibration
Published: May 9, 2013
Author(s): H. Indresand, W. H. White, K. Trzepla, A. M. Dillner
Journal: X-Ray Spectrometry
Energy‐dispersive X‐ray fluorescence (XRF) is an important tool used in routine elemental analysis of atmospheric particulate matter (PM) samples collected on polytetrafluoroethylene (PTFE) membrane filters. The method requires calibration against thin‐film standards of known elemental masses commonly obtained from commercial suppliers. These standards serve as a convenient and widely accepted interlaboratory reference but can differ...
Read MoreEffect of microstructure on the corrosion behaviour of extruded heat exchanger aluminium alloys
Published: May 9, 2013
Author(s): A. Laferrere, N. Parson, X. Zhou, G. Thompson
Journal: Surface and Interface Analysis
Aluminium extrusions used for heat transfer applications are exposed to corrosive environments, which can eventually lead to perforation of the tube by pitting. In this study, the effect of microstructure on the corrosion behaviour of extruded AA3XXX series alloys has been investigated. It was revealed that pits developed were purely crystallographic and a drop testing procedure was developed to simulate the seawater acetic acid test in a...
Read MoreA fatal case involving a caffeine‐containing fat burner
Published: May 9, 2013
Author(s): Ricarda Jantos, Kirsten Marion Stein, Christa Flechtenmacher, Gisela Skopp
Journal: Drug Testing and Analysis
Read MoreAnalytical methods for the detection of undeclared synthetic drugs in traditional herbal medicines as adulterants
Published: May 7, 2013
Author(s): Jamshed Haneef, Mohammad Shaharyar, Asif Husain, Mohd Rashid, Ravinesh Mishra, Nadeem A. Siddique, Manoj Pal
Journal: Drug Testing and Analysis
Traditional herbal medicines (THMs) are gaining popularity worldwide as an alternative approach to prescription drugs for many reasons including a general perception that they are safe. But recently there have been number of reported studies that reveal adulteration of THMs with undeclared synthetic drugs, which may potentially cause serious toxic adverse effects. This paper reviews the various classes of synthetic drugs that were found...
Read MoreQuantification of conjugated metabolites of drugs in biological matrices after the hydrolysis with β ‐glucuronidase and sufatase: a review of bio‐analytical methods
Published: May 6, 2013
Author(s): Yue Ding, Ming Peng, Tong Zhang, Jian‐Sheng Tao, Zhen‐Zhen Cai, Yong Zhang
Journal: Biomedical Chromatography
ABSTRACT Glucuronidation and sulfation represent two major pathways in phase II drug metabolism in humans and other mammalian species. The great majority of drugs, for example, polyphenols, flavonoids and anthraquinones, could be transformed into sulfated and glucuronidated conjugates simultaneously and extensively in vivo. The pharmacological activities of drug conjugations are normally decreased compared with those of their free forms....
Read MoreReview of the quantitative analysis of cholesteryl ester transfer protein inhibitors
Published: May 6, 2013
Author(s): Ramesh Mullangi, Nuggehally R. Srinivas
Journal: Biomedical Chromatography
ABSTRACT Clinical investigations of choleteryl ester transfer protein (CETP) inhibitors are still underway owing to its promise of reducing risk factors in patients with cardiovascular disease. Although several CETP inhibitors have reached late phase clinical testing, there is a paucity of publications that describe the determination of various CETP inhibitors in human and/or animal matrices. An attempt is made in this review to...
Read MoreMeasuring anisotropic muscle stiffness properties using elastography
Published: May 3, 2013
Author(s): M. A. Green, G. Geng, E. Qin, R. Sinkus, S. C. Gandevia, L. E. Bilston
Journal: NMR in Biomedicine
Physiological and pathological changes to the anisotropic mechanical properties of skeletal muscle are still largely unknown, with only a few studies quantifying changes in vivo. This study used the noninvasive MR elastography (MRE) technique, in combination with diffusion tensor imaging (DTI), to measure shear modulus anisotropy in the human skeletal muscle in the lower leg. Shear modulus measurements parallel and perpendicular to the...
Read MoreMetallographic effects of pure aluminum on properties of nanoporous anodic alumina (NPAA)
Published: May 3, 2013
Author(s): Fereshteh Rashidi, Tatsuya Masuda, Hidetaka Asoh, Sachiko Ono
Journal: Surface and Interface Analysis
The microstructure of aluminum substrates was investigated during the quality control of grain sizes determination and crystal orientation analysis before and after preheat (recrystallization) treatment at 500 °C, in relation to the microstructure and heat stability of nanoporous anodic alumina (NPAA) membranes formed on various preheated aluminum substrates and subsequently detached. Depending on the preheating conditions, the average...
Read MoreSurface treatment of aluminium automotive sheet: Mythology and technology
Published: May 3, 2013
Author(s): G. M. Scamans, P. R. Andrews, C. Butler, A. Hall, G. E. Thompson, Y. Ma, X. Zhou
Journal: Surface and Interface Analysis
The use of aluminium automotive sheet to save weight, fuel and carbon emissions is increasing as EU OEMS strive to reach progressively tougher targets and from the need to avoid fleet average penalty payments. Surface finishing of structural sheet for alloys like AA5754 generally involves cleaning and pretreatment followed by roll coating with a lubricant. For alloys supplied for body panels like AA6016 and its variants, surface...
Read MoreAssessment of the surface reactivity of AA1050 aluminium alloy
Published: May 1, 2013
Author(s): Malgorzata Witkowska, George Edward Thompson, Teruo Hashimoto, Elena Koroleva
Journal: Surface and Interface Analysis
During processing from cast slab to thin gauge material, the AA1050 aluminium alloy proceeds through various stages of thermomechanical processing, with the conditions at each processing stage influencing the microstructure of the final coil. The reactivity of the material in defined chemical and electrochemical processes has been demonstrated as a useful method to describe variance in the microstructure and surface chemical properties of...
Read MoreCharacterization of aluminum alloys environmentally friendly surface treatments for aircraft and aerospace industry
Published: Apr 30, 2013
Author(s): T. Monetta, A. Acquesta, V. Maresca, R. Signore, F. Bellucci, P. Di Petta, M. Lo Masti
Journal: Surface and Interface Analysis
Due to risk connected to the chromium use, several companies try to find ‘true’ chromium free products to treat aluminum surfaces. Aim of this work was to evaluate and test some treatment systems for avionics applications, in order to replace standard chromate processes based on CrVI. AA2014‐T3 and AA6082‐T6 aluminum alloys were subjected to conversion coating processes based on lithium or zirconium salts. Results were compared to those...
Read MoreRatiometric analysis in hyperpolarized NMR (I): test of the two‐site exchange model and the quantification of reaction rate constants
Published: Apr 29, 2013
Author(s): Lin Z. Li, Stephen Kadlececk, He N. Xu, Dania Daye, Benjamin Pullinger, Harrilla Profka, Lewis Chodosh, Rahim Rizi
Journal: NMR in Biomedicine
Conventional methods for the analysis of in vivo hyperpolarized 13C NMR data from the lactate dehydrogenase (LDH) reaction usually make assumptions on the stability of rate constants and/or the validity of the two‐site exchange model. In this study, we developed a framework to test the validity of the assumption of stable reaction rate constants and the two‐site exchange model in vivo via ratiometric fitting of the time courses of the signal ratio...
Read MoreLooking back into the future: 30 years of metabolomics at TNO
Published: Apr 29, 2013
Author(s): Jan van der Greef, Herman van Wietmarschen, Ben van Ommen, Elwin Verheij
Journal: Mass Spectrometry Reviews
Abstract Metabolites have played an essential role in our understanding of life, health, and disease for thousands of years. This domain became much more important after the concept of metabolism was discovered. In the 1950s, mass spectrometry was coupled to chromatography and made the technique more application‐oriented and allowed the development of new profiling technologies. Since 1980, TNO has performed system‐based metabolic...
Read MoreNon‐Markovian nature of the fluctuation of the polarizability in molecular liquids by time‐domain and frequency‐domain measurements
Published: Apr 29, 2013
Author(s): Yuji Sakai, Junji Watanabe, Shuichi Kinoshita
Journal: Journal of Raman Spectroscopy
We measured the low‐frequency regions of several molecular liquids at various temperatures using time‐domain and frequency‐domain spectroscopy to investigate the origin of the relaxation mode. We employed high‐resolution light scattering spectroscopy in the frequency domain and femtosecond optical Kerr effect spectroscopy in the time domain. By comparing the light scattering spectra of a relaxation mode with a Lorentzian function fitted...
Read MoreMicro‐Raman spectroscopy identifies crocidolite and erionite fibers in tissue sections
Published: Apr 28, 2013
Author(s): Alessandro Croce, Maya Musa, Mario Allegrina, Caterina Rinaudo, Y. Izzettin Baris, A. Umran Dogan, Amy Powers, Zeyana Rivera, Pietro Bertino, Haining Yang, Giovanni Gaudino, Michele Carbone
Journal: Journal of Raman Spectroscopy
Exposure to asbestos or erionite is associated with malignant mesothelioma (MM) and other diseases. Micro‐Raman spectroscopy and Variable Pressure Scanning Electron Microscopy/Energy Dispersive Spectroscopy were used to identify mineral fibers in histological sections of various tissues taken from mice injected with crocidolite asbestos and erionite fibers. Routine diagnostic histopathological slides of biopsies from erionite‐exposed MM...
Read MoreFeasibility of measuring prostate perfusion with arterial spin labeling
Published: Apr 26, 2013
Author(s): Xiufeng Li, Gregory J. Metzger
Journal: NMR in Biomedicine
Read MoreAccelerating hyperpolarized metabolic imaging of the heart by exploiting spatiotemporal correlations
Published: Apr 25, 2013
Author(s): Kilian Weiss, Andreas Sigfridsson, Lukas Wissmann, Julia Busch, Michael Batel, Marcin Krajewski, Matthias Ernst, Sebastian Kozerke
Journal: NMR in Biomedicine
Hyperpolarized 13C‐labeled pyruvate is a promising tool to investigate cardiac metabolism. It has been shown that changes in substrate metabolism occur following the induction of ischemia. To investigate the metabolic changes that are confined to spatial regions, high spatiotemporal resolution is required. The present work exploits both spatial and temporal correlations using k–t principal component analysis (PCA) to undersample the spatiotemporal...
Read MoreMRI of tissues with short T2s and T2*s . Wiley ISBN 978‐0‐470‐68835‐9
Published: Apr 25, 2013
Author(s): Martyn Paley
Journal: NMR in Biomedicine
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