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Effect of solvent on the extraction of phenolic compounds and antioxidant capacity of hazelnut kernel

Published: Apr 16, 2018

Author(s): Chiara Fanali, Giusy Tripodo, Marina Russo, Susanna Della Posta, Valentina Pasqualetti, Laura Gara

Journal: ELECTROPHORESIS

Abstract Hazelnut kernel phenolic compounds were recovered applying two different extraction approaches, namely ultrasound‐assisted solid/liquid extraction (UA‐SLE) and solid‐phase extraction (SPE). Different solvents were tested evaluating total phenolic compounds and total flavonoids contents together to antioxidant activity. The optimum extraction conditions, in terms of the highest value of total phenolic compounds extracted...

Read More thumbnail image: Effect of solvent on the extraction of phenolic compounds and antioxidant capacity of hazelnut kernel

Comparison between centrifugal partition chromatography and preparative liquid chromatography as first dimensions in off‐line two‐dimensional separation: Application to the isolation of multi‐targeted compounds from Edelweiss plant

Published: Apr 16, 2018

Author(s): Léa Marlot, Magali Batteau, Karine Faure

Journal: ELECTROPHORESIS

Abstract Preparative two‐dimensional chromatography is gaining interest in the elucidation of complex samples as it allows the recovery of a large number of molecules without the risks inherent to tedious multi‐step sample preparation. While the second dimension is often selected to be liquid chromatography, it may be of interest to compare the specificities of two different techniques, namely liquid chromatography and centrifugal...

Read More thumbnail image: Comparison between centrifugal partition chromatography and preparative liquid chromatography as first dimensions in offline twodimensional separation Application to the isolation of multitargeted compounds from Edelweiss plant

Determination of oxalate and citrate in urine by capillary electrophoresis using solid‐phase extraction and capacitively coupled contactless conductivity based on an improved mini‐cell

Published: Apr 16, 2018

Author(s): Shengnan Zhao, Dan Yin, Huifang Du, Xiangyu Tian, Yanlong Chen, Wenfen Zhang, Ajuan Yu, Shusheng Zhang

Journal: Journal of Separation Science

Abstract A new method for the rapid determination of the metabolites oxalate and citrate in urine samples was based on capillary electrophoresis and capacitively coupled contactless conductivity detection coupled with solid‐phase extraction. The detection cell for capacitively coupled contactless conductivity detection was improved with a smaller inner volume (1.5 nL), reduced noise (0.2∼0.5 mV) and better reproducibility...

Read More thumbnail image: Determination of oxalate and citrate in urine by capillary electrophoresis using solidphase extraction and capacitively coupled contactless conductivity based on an improved minicell

Free radical‐initiated peptide sequencing (FRIPS)‐based cross‐linkers for improved peptide and protein structure analysis

Published: Apr 16, 2018

Author(s): Claudio Iacobucci, Mathias Schäfer, Andrea Sinz

Journal: Mass Spectrometry Reviews

Free radical‐initiated peptide sequencing (FRIPS) has recently been introduced as an analytical strategy to create peptide radical ions in a predictable and effective way by collisional activation of specifically modified peptides ions. FRIPS is based on the unimolecular dissociation of open‐shell ions and yields fragments that resemble those obtained by electron capture dissociation (ECD) or electron transfer dissociation (ETD)....

Read More thumbnail image: Free radicalinitiated peptide sequencing FRIPSbased crosslinkers for improved peptide and protein structure analysis

Metabolism study for CUMYL‐4CN‐BINACA in human hepatocytes and authentic urine specimens: Free cyanide is formed during the main metabolic pathway

Published: Apr 15, 2018

Author(s): Anna Åstrand, Svante Vikingsson, Daniel Lindstedt, Gunilla Thelander, Henrik Gréen, Robert Kronstrand, Ariane Wohlfarth

Journal: Drug Testing and Analysis

Abstract To further elucidate the metabolism of CUMYL‐4CN‐BINACA, a new synthetic cannabinoid with a cyano group, and to evaluate biomarkers, we incubated the substance in human hepatocytes and analysed 9 authentic urine specimens. We also quantified CUMYL‐4CN‐BINACA and cyanide in blood and provide comprehensive data on the 7 autopsy cases, 5 of them determined CUMYL‐4CN‐BINACA intoxications. For metabolite elucidation,...

Read More thumbnail image: Metabolism study for CUMYL4CNBINACA in human hepatocytes and authentic urine specimens Free cyanide is formed during the main metabolic pathway

The structure identification of a diphenhydramine‐related impurity in methamphetamine

Published: Apr 13, 2018

Author(s): Cuimei Liu, Wei Jia, Yu Han, Zhendong Hua

Journal: Drug Testing and Analysis

Abstract Some methamphetamine (MA) crystals contain pharmaceutical impurities resulting from the co‐ingredients of medicines used for extracting ephedrine/pseudoephedrine. These pharmaceutical impurities and their related byproducts can reflect the trends in precursor chemicals and manufacturing sources. In this research, 1 pharmaceutical‐impurity‐related byproduct was detected in several seized MA samples synthesized by I/P (Nagai,...

Read More thumbnail image: The structure identification of a diphenhydraminerelated impurity in methamphetamine

Geographical discrimination of Glechomae Herba based on fifteen phenolic constituents determined by LC–MS/MS method combined with chemometric methods

Published: Apr 12, 2018

Author(s): Ting Tan, Jing Zhang, Xu Xu, Wen‐Ping Huang, Yun Luo

Journal: Biomedical Chromatography

Abstract Glechomae Herba (GH) is rich in bioactive phenolic constituents and is widely used for treatment of cholelithiasis, urolithiasis and dropsy. The simultaneous determination of phenolic constituents in GH from different geographical origins is significant for authentication and quality control purposes. In this study, we developed a strategy integrating targeted analysis and chemometric methods for quality evaluation and...

Read More thumbnail image: Geographical discrimination of Glechomae Herba based on fifteen phenolic constituents determined by LCMSMS method combined with chemometric methods

Quantification of cystine in human renal proximal tubule cells using liquid chromatography–tandem mass spectrometry

Published: Apr 11, 2018

Author(s): Amer Jamalpoor, Rolf W. Sparidans, Carla Pou Casellas, Johannes J.M. Rood, Mansi Joshi, Rosalinde Masereeuw, Manoe J. Janssen

Journal: Biomedical Chromatography

Abstract Nephropathic cystinosis is characterized by abnormal intralysosomal accumulation of cystine throughout the body, causing irreversible damage to various organs, particularly the kidneys. Cysteamine, the currently available treatment, can reduce lysosomal cystine and postpone disease progression. However, cysteamine poses serious side effects and does not address all of the symptoms of cystinosis. To screen for new treatment...

Read More thumbnail image: Quantification of cystine in human renal proximal tubule cells using liquid chromatographytandem mass spectrometry

Gaining Insight Into Posttranslationally Modified HIV Antigens and Their Underlying Characteristics

Published: Apr 11, 2018

Author(s): Fabio Marino

Journal: PROTEOMICS

Abstract Mass spectrometry (MS)‐based immunopeptidomics has developed as one of the leading methodologies for comprehensive characterization of in vivo presented human leukocyte antigen (HLA)‐bound peptides. Unveiling the identity of HLA‐bound peptides derived from diseased cells is crucial to gain knowledge on the constitution of efficient disease‐specific T cell responses. The HLA‐presented peptidome reflects the status of the...

Read More thumbnail image: Gaining Insight Into Posttranslationally Modified HIV Antigens and Their Underlying Characteristics

Complex investigation of extraction techniques applied for cyclitols and sugars isolation from different species of Solidago genus

Published: Apr 11, 2018

Author(s): Ileana‐Andreea Ratiu, Hossam Al‐Suod, Magdalena Ligor, Tomasz Ligor, Viorica Railean‐Plugaru, Bogusław Buszewski

Journal: ELECTROPHORESIS

Abstract Cyclitols are phytochemicals naturally occurring in plant material, which attracted an increasing interest due to multiple medicinal attributes, among which the most important are the antidiabetic, antioxidant, and anticancer properties. Due to their valuable properties, sugars are used in the food industry as sweeteners, preservatives, texture modifiers, fermentation substrates, and flavoring and coloring agents. In this...

Read More thumbnail image: Complex investigation of extraction techniques applied for cyclitols and sugars isolation from different species of Solidago genus

A preliminary origin‐tracking study of different densities urinary exosomes

Published: Apr 11, 2018

Author(s): Tao Lan, Xingjun Xi, Qiao Chu, Liang Zhao, Apeng Chen, Joann J. Lu, Fenghe Wang, Weibing Zhang

Journal: ELECTROPHORESIS

Abstract Based on density differences of different subpopulations of exosomes, two kinds of micro‐vesicles with different densities were captured from urine by a modified sucrose density gradient ultracentrifuge separation method. Verified by transmission electron microscope (TEM) and western blot, the results showed these two kinds of micro‐vesicles were all exosomes. And these two kinds of exosomes were analyzed by TEM, 2D...

Read More thumbnail image: A preliminary origintracking study of different densities urinary exosomes

Determination of ellagic acid by capillary electrophoresis in Argentinian wines

Published: Apr 11, 2018

Author(s): Adrian Spisso, Federico J. V. Gomez, María Fernanda Silva

Journal: ELECTROPHORESIS

Abstract Rising interest in ellagic acid (EA) present in functional foods is supported by its antimutagenic, anticarcinogenic, antiviral, antibacterial and antioxidative effects. The present approach presents for the first time the determination of ellagic acid and other phenolics in wines by miniaturized solid phase extraction prior to capillary zone electrophoresis (CZE) with UV. The extraction was performed using a home‐made...

Read More thumbnail image: Determination of ellagic acid by capillary electrophoresis in Argentinian wines

Tandem HILIC‐RP liquid chromatography for increased polarity coverage in food analysis

Published: Apr 11, 2018

Author(s): Daniel Hemmler, Silke S. Heinzmann, Katrin Wöhr, Philippe Schmitt‐Kopplin, Michael Witting

Journal: ELECTROPHORESIS

Abstract Comprehensive non‐targeted analysis of food products normally requires two complementary chromatographic runs to achieve maximum compound coverage. In this study, we present a sensitive tandem‐LC method, which combines RP and HILIC separation in a single run. The setup consists of a C18 trap column and two subsequently coupled analytical columns (HILIC and C18) which are operated in parallel. First, hydrophobic compounds...

Read More thumbnail image: Tandem HILICRP liquid chromatography for increased polarity coverage in food analysis

Adsorbed hollow fiber‐based biological fingerprinting for the discovery of platelet aggregation inhibitors from Danshen–Honghua decoction

Published: Apr 11, 2018

Author(s): Qian Zhang, Cheng‐Ning Tan, Ya‐li Wang, Wen‐Jing Liu, Feng‐Qing Yang, Hua Chen, Zhi‐Ning Xia

Journal: Journal of Separation Science

Abstract For lead compound discovery from natural products, hollow fiber cell fishing with chromatographic analysis is a newly developed method. In this study, an adsorbed hollow fiber‐based biological fingerprinting method was firstly developed to discover potential platelet aggregation inhibitors from Danshen–Honghua decoction. Platelets were seeded on the fiber and their survival rate was tested. Results indicated that more than...

Read More thumbnail image: Adsorbed hollow fiberbased biological fingerprinting for the discovery of platelet aggregation inhibitors from DanshenHonghua decoction

A laser Raman tweezers study of eryptosis

Published: Apr 11, 2018

Author(s): Surekha Barkur, Deepak Mathur, Santhosh Chidangil

Journal: Journal of Raman Spectroscopy

Abstract Eryptosis—the suicidal death of erythrocytes—is characterized by membrane blebbing and cell shrinkage. Eryptosis can be triggered by various xenobiotics such as carbon monoxide, lead, and amyloid, and by stressors such as oxidative stress, osmotic shock, and rapid alteration of ambient conditions. We have used Raman tweezers spectroscopy to study eryptosis in single, live cells and have attempted to explore the underlying...

Read More thumbnail image: A laser Raman tweezers study of eryptosis

Multiclass partial least squares discriminant analysis: Taking the right way—A critical tutorial

Published: Apr 11, 2018

Author(s): Alexey L. Pomerantsev, Oxana Ye. Rodionova

Journal: Journal of Chemometrics

Abstract Here, the theory of the multi‐class partial least squares discriminant analysis (PLS‐DA) is presented. A distinct feature of this theory is that it does not utilize PLS scores but is entirely based on the predicted dummy responses. It is shown that the results of the multi‐class PLS‐DA can be presented in a straightforward way by projecting the response matrix on the “super‐score” space by means of principal component...

Read More thumbnail image: Multiclass partial least squares discriminant analysis Taking the right wayA critical tutorial

Phosphodiesterase (PDE5) inhibition assay for rapid detection of erectile dysfunction drugs and analogs in sexual enhancement products

Published: Apr 10, 2018

Author(s): Michael F. Santillo, Mapa S.T. Mapa

Journal: Drug Testing and Analysis

Abstract Products marketed as dietary supplements for sexual enhancement are frequently adulterated with phosphodiesterase‐5 (PDE5) inhibitors, which are erectile dysfunction drugs or their analogs that can cause adverse health effects. Due to widespread adulteration, a rapid screening assay was developed to detect PDE5 inhibitors in adulterated products. The assay employs fluorescence detection and is based on measuring inhibition...

Read More thumbnail image: Phosphodiesterase PDE5 inhibition assay for rapid detection of erectile dysfunction drugs and analogs in sexual enhancement products

Structural and electronics properties of Rh‐doped SnO 2 (110) surfaces: Ab‐initio calculations

Published: Apr 10, 2018

Author(s): F. Bouamra, A. Boumeddiene

Journal: Surface and Interface Analysis

Structural and electronics properties of SnO2(110)‐doped Rh surfaces have been calculated for different atomic Rh/Sn ratio: 9.09%, 14.28%, 20%, and 26.31% using a density functional theory (DFT) at B3LYP level with CRYSTAL09 program. These structures are obtained by substitution of Rh atoms with tin Sn atoms of the most outer atomic faces of SnO2(110) surfaces, which contain Sn and O atoms. Relaxation parameters, band structures, and projected...

Read More thumbnail image: Structural and electronics properties of Rhdoped SnO 2 110 surfaces Abinitio calculations

Development and characterization of hydrophobic anodized aluminum layer to act as a long‐lasting protective film in corrosion

Published: Apr 10, 2018

Author(s): R. Jaimes‐Ramírez, A. Covelo, S. E. Rodil, P. Corona‐Lira, A. C. Ramírez‐Reivich, M. Hernández

Journal: Surface and Interface Analysis

This work focuses on the development of a novel hydrophobic process for anodized aluminum AA2024‐T3 which consists of a combination of corrosion inhibitors: sodium metavanadate with a γ‐irradiated fluoropolymer. The anodizing films, formed in sulfuric acid media, were sealed by using different aqueous solutions such as boiling water, potassium dichromate, and cerium nitrate. The corrosion resistance results obtained by electrochemical...

Read More thumbnail image: Development and characterization of hydrophobic anodized aluminum layer to act as a longlasting protective film in corrosion

Identification of Native and Posttranslationally Modified HLA‐B*57:01‐Restricted HIV Envelope Derived Epitopes Using Immunoproteomics

Published: Apr 6, 2018

Author(s): Sri H. Ramarathinam, Stephanie Gras, Sheilajen Alcantara, Amanda W.S. Yeung, Nicole A. Mifsud, Secondo Sonza, Patricia T. Illing, Elias N. Glaros, Robert J. Center, Shane R. Thomas, Stephen J. Kent, Nicola Ternette, Damian F. J. Purcell, Jamie Rossjohn, Anthony W. Purcell

Journal: PROTEOMICS

Abstract The recognition of pathogen‐derived peptides by T lymphocytes is the cornerstone of adaptive immunity, whereby intracellular antigens are degraded in the cytosol and short peptides assemble with class I human leukocyte antigen (HLA) molecules in the ER. These peptide‐HLA complexes egress to the cell surface and are scrutinized by cytotoxic CD8+ T‐cells leading to the eradication of the infected cell. Here, naturally...

Read More thumbnail image: Identification of Native and Posttranslationally Modified HLAB5701Restricted HIV Envelope Derived Epitopes Using Immunoproteomics
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