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Soft tissue rheology and its implications for elastography: Challenges and opportunities

Published: Oct 9, 2017

Author(s): Lynne E. Bilston

Journal: NMR in Biomedicine

Abstract Magnetic resonance elastography and related shear wave ultrasound elastography techniques can be used to estimate the mechanical properties of soft tissues in vivo by using the relationships between wave propagation and the elastic properties of materials. These techniques have found numerous clinical and research applications, tracking changes in tissue properties as a result of disease or other interventions. Most dynamic...

Read More thumbnail image: Soft tissue rheology and its implications for elastography Challenges and opportunities

Recent advances in capillary electrophoresis separation of monosaccharides, oligosaccharides, and polysaccharides

Published: Oct 9, 2017

Author(s): Veronica Mantovani, Fabio Galeotti, Francesca Maccari, Nicola Volpi

Journal: ELECTROPHORESIS

Abstract This article illustrates the basis and applications of methodologies for the analysis of simple and complex carbohydrates by means of CE. After a description of the most common and novel approaches useful for the analysis and characterization of carbohydrates, this review covers the recent advances in CE separation of monosaccharides, oligosaccharides, and polysaccharides. Various CE techniques are also illustrated for the...

Read More thumbnail image: Recent advances in capillary electrophoresis separation of monosaccharides oligosaccharides and polysaccharides

Optimization of capillary zone electrophoresis for charge heterogeneity testing of biopharmaceuticals using enhanced method development principles

Published: Oct 9, 2017

Author(s): Bernd Moritz, Valentina Locatelli, Michele Niess, Andrea Bathke, Steffen Kiessig, Barbara Entler, Christof Finkler, Harald Wegele, Jan Stracke

Journal: ELECTROPHORESIS

Abstract CZE is a well‐established technique for charge heterogeneity testing of biopharmaceuticals. It is based on the differences between the ratios of net charge and hydrodynamic radius. In an extensive intercompany study, it was recently shown that CZE is very robust and can be easily implemented in labs that did not perform it before. However, individual characteristics of some examined proteins resulted in suboptimal...

Read More thumbnail image: Optimization of capillary zone electrophoresis for charge heterogeneity testing of biopharmaceuticals using enhanced method development principles

Chromatographic approaches for the characterization and quality control of therapeutic oligonucleotide impurities

Published: Oct 4, 2017

Author(s): N. M. El Zahar, N. Magdy, A. M. El‐Kosasy, Michael G. Bartlett

Journal: Biomedical Chromatography

Abstract Phosphorothioate (PS) oligonucleotides are a rapidly rising class of drugs with significant therapeutic applications. However, owing to their complex structure and multistep synthesis and purification processes, generation of low‐level impurities and degradation products are common. Therefore, they require significant investment in quality control and impurity identification. This requires the development of advanced...

Read More thumbnail image: Chromatographic approaches for the characterization and quality control of therapeutic oligonucleotide impurities

Affinity capillary electrophoresis for the assessment of binding affinity of carbohydrate‐based cholera toxin inhibitors

Published: Oct 4, 2017

Author(s): Oier Aizpurua‐Olaizola, Javier Sastre Torano, Aliaksei Pukin, Ou Fu, Geert Jan Boons, Gerhardus J. Jong, Roland J. Pieters

Journal: ELECTROPHORESIS

Abstract Developing tools for the study of protein carbohydrate interactions is an important goal in glycobiology. Cholera toxin inhibition is an interesting target in this context, as its inhibition may help to fight against cholera. For the study of novel ligands an affinity capillary electrophoresis (ACE) method was optimized and applied. The method uses unlabeled cholera toxin B‐subunit (CTB) and unlabeled carbohydrate ligands...

Read More thumbnail image: Affinity capillary electrophoresis for the assessment of binding affinity of carbohydratebased cholera toxin inhibitors

Screening bioactive compounds from natural product and its preparations using capillary electrophoresis

Published: Oct 4, 2017

Author(s): Huifen Ma, Yun Bai, Jin Li, Yan‐xu Chang

Journal: ELECTROPHORESIS

Abstract Bioactive ingredients of natural products can protect human body from harm, as well as prevent and treat disease. Screening bioactive compounds from natural products is attracting particular attention. It is a great challenge to separate and detect the active compounds from complex matrix natural products. CE plays a vital role in screening active compounds because of its unique features such as high‐efficiency separation,...

Read More thumbnail image: Screening bioactive compounds from natural product and its preparations using capillary electrophoresis

Cultivation and quantitative single‐cell analysis of Saccharomyces cerevisiae on a multifunctional microfluidic device

Published: Oct 4, 2017

Author(s): Simone Stratz, Pascal Emilio Verboket, Karina Hasler, Petra Stephanie Dittrich

Journal: ELECTROPHORESIS

Abstract Here, we present a multifunctional microfluidic device whose integrative design enables to combine cell culture studies and quantitative single cell biomolecule analysis. The platform consists of 32 analysis units providing two key features; first, a micrometer‐sized trap for hydrodynamic capture of a single Saccharomyces cerevisiae (S. cerevisiae) yeast cell; second, a convenient double‐valve configuration surrounding the trap....

Read More thumbnail image: Cultivation and quantitative singlecell analysis of Saccharomyces cerevisiae on a multifunctional microfluidic device

Electrokinetic motion of a spherical micro particle at an oil−water interface in microchannel

Published: Oct 4, 2017

Author(s): Chengfa Wang, Mengqi Li, Yongxin Song, Xinxiang Pan, Dongqing Li

Journal: ELECTROPHORESIS

Abstract The electrokinetic motion of a negatively charged spherical particle at an oil−water interface in a microchannel is numerically investigated and analyzed in this paper. A three−dimensional (3D) transient numerical model is developed to simulate the particle electrokinetic motion. The channel wall, the surface of the particle and the oil−water interface are all considered negatively charged. The effects of the direct current...

Read More thumbnail image: Electrokinetic motion of a spherical micro particle at an oilwater interface in microchannel

Organic polymer‐based monolithic stationary phases with incorporated nanostructured materials for HPLC and CEC

Published: Oct 4, 2017

Author(s): Nisansala Ganewatta, Ziad El Rassi

Journal: ELECTROPHORESIS

Abstract This review article is concerned with the recent advances made in the field of organic polymer‐based monoliths with incorporated nanostructured materials (NSMs) for use in liquid chromatography and capillary electrochromatography. It covers the pertinent literature published over the last 7–8 years with a total of 56 references. The present article has two distinct parts: one major part encompassing “traditional” organic...

Read More thumbnail image: Organic polymerbased monolithic stationary phases with incorporated nanostructured materials for HPLC and CEC

Anti‐inflammatory activities and glycerophospholipids metabolism in KLA‐stimulated RAW 264.7 macrophage cells by diarylheptanoids from the rhizomes of Alpinia officinarum

Published: Oct 2, 2017

Author(s): Guogai Zhang, Lifang Zhao, Jiancheng Zhu, Yifan Feng, Xia Wu

Journal: Biomedical Chromatography

Abstract Alpinia officinarum is used for its anti‐inflammatory activity historically in China. Diarylheptanoids isolated from A. officinarum play important biological roles in the prevention and treatment of inflammatory disorders. Seven diarylheptanoids (1–7) were isolated from A. officinarum. The cell viabilities and anti‐inflammatory activities of diarylheptanoids were evaluated by MTT assay and tumor necrosis factor‐α production in...

Read More thumbnail image: Antiinflammatory activities and glycerophospholipids metabolism in KLAstimulated RAW 264_7 macrophage cells by diarylheptanoids from the rhizomes of Alpinia officinarum

Simultaneous determination of baicalin, baicalein, wogonoside, wogonin, scutellarin, berberine, coptisine, ginsenoside Rb1 and ginsenoside Re of Banxia xiexin decoction in rat plasma by LC–MS/MS and its application to a pharmacokinetic study

Published: Oct 2, 2017

Author(s): Ying Wang, Yifan Zhang, Juan Xiao, Ranchi Xu, Qiangli Wang, Xinhong Wang

Journal: Biomedical Chromatography

Abstract A rapid and high‐sensitivity liquid chromatography/tandem mass spectrometry (LC/MS/MS) method was developed for simultaneous determination of nine active constituents (baicalin, baicalein, wogonoside, wogonin, scutellarin, berberine, coptisine, ginsenoside Rb1 and ginsenoside Re) in rat plasma after oral administration of Banxia xiexin decoction (BXD). Biological samples were processed wtih acetone–ethyl acetate (4:1, v/v)....

Read More thumbnail image: Simultaneous determination of baicalin baicalein wogonoside wogonin scutellarin berberine coptisine ginsenoside Rb1 and ginsenoside Re of Banxia xiexin decoction in rat plasma by LCMSMS and its application to a pharmacokinetic study

Simple determination of betaine, l ‐carnitine and choline in human urine using self‐packed column and column‐switching ion chromatography with nonsuppressed conductivity detection

Published: Oct 2, 2017

Author(s): Dan Wei, Yan Zhu, Ming Guo

Journal: Biomedical Chromatography

Abstract A sequential online extraction, clean‐up and separation system for the determination of betaine, l‐carnitine and choline in human urine using column‐switching ion chromatography with nonsuppressed conductivity detection was developed in this work. A self‐packed pretreatment column (50 × 4.6 mm, i.d.) was used for the extraction and clean‐up of betaine, l‐carnitine and choline. The separation was achieved using self‐packed cationic...

Read More thumbnail image: Simple determination of betaine l carnitine and choline in human urine using selfpacked column and columnswitching ion chromatography with nonsuppressed conductivity detection

Overcoming interference of plasma phospholipids using HybridSPE for the determination of trimetazidine by UPLC–MS/MS

Published: Oct 2, 2017

Author(s): Pravin G. Vanol, Manish Yadav, Mallika Sanyal, Priyanka A. Shah, Pranav S. Shrivastav

Journal: Biomedical Chromatography

Abstract An improved, precise and reliable ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method has been developed for the quantification of trimetazidine, using trimetazidine‐d8 as the internal standard (IS). Interference owing to plasma phospholipids during sample preparation was overcome using a hybrid solid‐phase extraction–phospholipid ultra cartridge. The mean extraction recovery of...

Read More thumbnail image: Overcoming interference of plasma phospholipids using HybridSPE for the determination of trimetazidine by UPLCMSMS

Intergrated metabonomic study of the effects of Guizhi Fuling capsule intervention on primary dysmenorrheal using RP‐UPLC–MS complementary with HILIC‐UPLC–MS technique

Published: Oct 2, 2017

Author(s): Lang Lang, Zhaorui Meng, Lan Sun, Wei Xiao, Longshan Zhao, Zhili Xiong

Journal: Biomedical Chromatography

Abstract Guizhi Fuling capsule (GFC), developed from the traditional Chinese prescription of Guizhi Fuling Wan, has been commonly used for the treatment of primary dysmenorrhea (PD). However, the intervention effective mechanism in vivo has not been well elucidated. In this study, an integrated plasma metabonomic strategy based on RP‐UPLC‐MS coupled with HILIC‐UPLC‐MS technique has been developed to investigate the global therapeutic effects and...

Read More thumbnail image: Intergrated metabonomic study of the effects of Guizhi Fuling capsule intervention on primary dysmenorrheal using RPUPLCMS complementary with HILICUPLCMS technique

Real‐time metabolite monitoring of glucose‐fed Clostridium acetobutylicum fermentations using Raman assisted metabolomics

Published: Oct 2, 2017

Author(s): Theresah N.K. Zu, Sanchao Liu, Elliot S. Gerlach, Katherine L. Germane, Matthew D. Servinsky, David M. Mackie, Christian J. Sund

Journal: Journal of Raman Spectroscopy

Abstract Data obtained from in situ Raman spectroscopy probes and high‐performance liquid chromatography (HPLC) analysis were applied together with chemometrics to build partial least squares models of metabolite concentrations for the industrially relevant organism Clostridium acetobutylicum. Models were built for predominant products (acetic acid, butyric acid, and butanol) of C. acetobutylicum cultures grown on glucose as a substrate....

Read More thumbnail image: Realtime metabolite monitoring of glucosefed Clostridium acetobutylicum fermentations using Raman assisted metabolomics

Raman mapping of the S 3 chromophore in degraded ultramarine blue paints

Published: Oct 2, 2017

Author(s): Eleanor Cato, Nadim Scherrer, Ester S.B. Ferreira

Journal: Journal of Raman Spectroscopy

Abstract A specific case of degradation was observed in synthetic ultramarine paint within 3 paintings from the early 20th century, manifesting as an intricate pattern of white lines criss‐crossing the blue paint surface. Raman spectroscopy can be performed directly on untreated sample surfaces and is sensitive to the colour components in ultramarine (S3− and S2− chromophores). This method was chosen to map the chromophore intensity...

Read More thumbnail image: Raman mapping of the S 3  chromophore in degraded ultramarine blue paints

The identification and analytical characterization of 2,2′‐difluorofentanyl

Published: Oct 2, 2017

Author(s): Cuimei Liu, Tao Li, Yu Han, Zhendong Hua, Wei Jia, Zhenhua Qian

Journal: Drug Testing and Analysis

Abstract New psychoactive substances (NPS) have expanded their distribution and become widely available in the global market in recent years. The illicit use of fentanyl and its analogs has become an important worldwide concern linked to their high potency and risk of fatal overdose. This study describes the analytical characterization of a new fentanyl derivative N‐(1‐(2‐fluorophenethyl)‐4‐piperidinyl)‐N‐(2‐fluorophenyl)propionamide...

Read More thumbnail image: The identification and analytical characterization of 22difluorofentanyl

Recent progress of task‐specific ionic liquids in chiral resolution and extraction of biological samples and metal ions

Published: Sep 28, 2017

Author(s): Datong Wu, Pengfei Cai, Xiaoyong Zhao, Yong Kong, Yuanjiang Pan

Journal: Journal of Separation Science

Abstract Ionic liquids have been functionalized for modern applications. The functional ionic liquids are also called task‐specific ionic liquids. Various task‐specific ionic liquids with certain groups have been constructed and exploited widely in the field of separation. To take advantage of their properties in separation science, task‐specific ionic liquids are generally used in techniques such as liquid–liquid extraction,...

Read More thumbnail image: Recent progress of taskspecific ionic liquids in chiral resolution and extraction of biological samples and metal ions

Raman spectroscopy of methane (CH 4 ) to 165 GPa: Effect of structural changes on Raman spectra

Published: Sep 28, 2017

Author(s): J.E. Proctor, H.E. Maynard‐Casely, M.A. Hakeem, D. Cantiah

Journal: Journal of Raman Spectroscopy

Abstract We have conducted a Raman study of methane (CH4), a major constituent of the outer planets, at pressures up to 165 GPa. We observe splitting of the principal Raman‐active vibrational mode above 45 GPa and a nonlinear dependence of Raman peak position on pressure. A discontinuous change in the pressure derivative of the ν3 peak position is observed at approximately 75 GPa, corresponding to the phase change previously...

Read More thumbnail image: Raman spectroscopy of methane CH 4  to 165GPa Effect of structural changes on Raman spectra

To correlate and predict the potential and new functions of traditional Chinese medicine formulas based on similarity indices

Published: Sep 28, 2017

Author(s): Lu Xu, Peng‐Fei Gao, Guo‐Chan Qin, Ying‐He An, Bang‐Cheng Tang, Huan Wang, Yuan‐Bin She

Journal: Journal of Chemometrics

Abstract A typical traditional Chinese medicine (TCM) formula (or a prescription) is composed of 1 or several single herbs. The number of possible TCM formulas is nearly as large as that of chemical structures, so the development of quantitative formula‐activity relationship models is as appealing as to build a quantitative structure‐activity relationship model. In this work, a formula descriptor system based on the TCM holistic...

Read More thumbnail image: To correlate and predict the potential and new functions of traditional Chinese medicine formulas based on similarity indices
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