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Study of gliquidone degradation behavior by high‐performance thin‐layer chromatography and ultra‐performance liquid chromatography methods

Published: Aug 3, 2017

Author(s): Nada S. Abdelwahab, Mohammed T. Elsaady, Aml G. Korany, Maha A. Hegazy

Journal: Biomedical Chromatography

Abstract Gliquidone (GQ) is an oral hypoglycemic agent, belonging to second‐generation sulfonylurea derivatives. New high‐performance thin‐layer chromatography (HPTLC) and ultra‐performance liquid chromatography (UPLC) methods have been developed and validated and used for complete stability study of GQ following International Conference on Harmonization guidelines. GQ was subjected to stress and forced degradation under hydrolytic,...

Read More thumbnail image: Study of gliquidone degradation behavior by highperformance thinlayer chromatography and ultraperformance liquid chromatography methods

A fast and accurate method for the pharmacokinetic research of four coumarin analogs in Fructus cnidii using capillary electro‐chromatography with a methacrylate ester‐based monolithic column

Published: Aug 3, 2017

Author(s): Zhao Chen, Aili Xu, Xiaoli Bi, Wenhui Luo, Ji Li, Guorong Fan, Dongmei Sun

Journal: ELECTROPHORESIS

In the present study, a monolithic capillary column with higher permeability was developed for the in vivo discrimination of four coumarin analogs (bergapten, 2′‐acetylangelicin, imperatorin, and osthole) that typically require long separation times in HPLC. Instead of conventional methacrylate ester monolith (containing 19.5% porogen) with insufficient permeability (K = 1.52 – 1.66 × 10−14 M2) for plasma sample, the proposed...

Read More thumbnail image: A fast and accurate method for the pharmacokinetic research of four coumarin analogs in Fructus cnidii using capillary electrochromatography with a methacrylate esterbased monolithic column

Sensing carbon allotropes in protective coatings on optical fibers with far‐ and near‐field R aman spectroscopy and microscopy

Published: Aug 2, 2017

Author(s): Sergey S. Kharintsev, Svetlana V. Saparina, Andrei A. Stolov, Jie Li, Alexandr I. Fishman

Journal: Journal of Raman Spectroscopy

Hermetic carbon coatings of different thicknesses ranging from 1 to 100 nm on a series of optical fibers are characterized with confocal Raman spectroscopy and atomic force microscopy. Standard far‐field Raman spectra in the region of 1,000–2,000 cm−1 were fitted and well reproduced using 5 individual components assigned to different species of graphite‐like and disordered phases. Based on the fitting, a new spectroscopic indicator was...

Read More thumbnail image: Sensing carbon allotropes in protective coatings on optical fibers with far and nearfield R aman spectroscopy and microscopy

Purity and adulteration in cocaine seizures and drug market inspection in Galicia (Spain) across an eight‐year period

Published: Aug 1, 2017

Author(s): Mª. de los Ángeles Villar Núñez, José Sánchez Morcillo, María Adolfina Ruíz Martínez

Journal: Drug Testing and Analysis

Read More thumbnail image: Purity and adulteration in cocaine seizures and drug market inspection in Galicia Spain across an eightyear period

Raman scattering of graphene‐based systems in high magnetic fields

Published: Aug 1, 2017

Author(s): Clement Faugeras, Milan Orlita, Marek Potemski

Journal: Journal of Raman Spectroscopy

We review the different results obtained in the last decade in the field of Raman scattering of graphene‐based systems, with an applied magnetic field. Electronic properties of graphene‐based systems with an applied magnetic field are first described. The phonon response in magnetic field, the magneto‐phono resonance, is then introduced and described for graphene monolayer and multilayer, as well as for bulk graphite. Electronic Raman...

Read More thumbnail image: Raman scattering of graphenebased systems in high magnetic fields

The influence of small doses of ethanol on the urinary testosterone to epitestosterone ratio in men and women

Published: Aug 1, 2017

Author(s): Sami Albeiroti, Brian D. Ahrens, Timofei Sobolevskii, Anthony W. Butch

Journal: Drug Testing and Analysis

Endogenous steroid use can increase urinary testosterone/epitestosterone (T/E) values. In addition, ethanol in amounts >0.5 g per kg of body weight (g/kg) can also increase T/E values. However, the effect of smaller doses of ethanol on T/E values is unknown. The influence of 0.2 and 0.4 g/kg of ethanol on baseline T/E values in 20 men and 20 women with low and high baseline T/E values was investigated and correlated with...

Read More thumbnail image: The influence of small doses of ethanol on the urinary testosterone to epitestosterone ratio in men and women

Profiling ephedrine prepared from N ‐methylalanine via the Akabori‐Momotani reaction

Published: Aug 1, 2017

Author(s): Alexandra Doddridge, Michael Collins, Helen Salouros

Journal: Drug Testing and Analysis

Novel methods for synthesising methylamphetamine precursors are appearing in clandestine laboratories within Australia. One such laboratory involved the synthesis of ephedrine from N‐methylalanine and benzaldehyde via the Akabori‐Momotani reaction. This article presents chiral and stable isotope ratios of ephedrine synthesised via this method, along with a chemical profile of methylamphetamine produced from this ephedrine. Based on the...

Read More thumbnail image: Profiling ephedrine prepared from N methylalanine via the AkaboriMomotani reaction

Authentication of adulterated edible oil using coherent anti‐Stokes Raman scattering spectroscopy

Published: Aug 1, 2017

Author(s): Chang Woo Park, Ingu Lee, Seong‐Hoon Kwon, Kyu‐Sup Lee, Cheol Jo, Do‐Kyeong Ko

Journal: Journal of Raman Spectroscopy

A comparative analysis on five edible oils with the same chemical composition but different composition ratios was performed by using coherent anti‐Stokes Raman scattering spectroscopy in the wavenumber 2400–3200 cm−1 corresponding to C─H vibration band. Intensity ratio (I═C ─ H/IC ─ H) in C─H stretching region was obtained according to the mixing ratio of the two types of edible oil, and the fitting curves were obtained from the fact that the...

Read More thumbnail image: Authentication of adulterated edible oil using coherent antiStokes Raman scattering spectroscopy

The emergence of new psychoactive substance (NPS) benzodiazepines: A review

Published: Jul 31, 2017

Author(s): Kieran R. Manchester, Emma C. Lomas, Laura Waters, Fiona C. Dempsey, Peter D. Maskell

Journal: Drug Testing and Analysis

The market for new psychoactive substances has increased markedly in recent years and there is now a steady stream of compounds appearing every year. Benzodiazepines consist of only a fraction of the total number of these compounds but their use and misuse has rapidly increased. Some of these benzodiazepines have only been patented, some of them have not been previously synthesised, and the majority have never undergone clinical trials or...

Read More thumbnail image: The emergence of new psychoactive substance NPS benzodiazepines A review

Standardization approaches in absolute quantitative proteomics with mass spectrometry

Published: Jul 31, 2017

Author(s): Francisco Calderón‐Celis, Jorge Ruiz Encinar, Alfredo Sanz‐Medel

Journal: Mass Spectrometry Reviews

Mass spectrometry‐based approaches have enabled important breakthroughs in quantitative proteomics in the last decades. This development is reflected in the better quantitative assessment of protein levels as well as to understand post‐translational modifications and protein complexes and networks. Nowadays, the focus of quantitative proteomics shifted from the relative determination of proteins (ie, differential...

Read More thumbnail image: Standardization approaches in absolute quantitative proteomics with mass spectrometry

An investigation of a unique group of painted silk banners from a Polish collection

Published: Jul 28, 2017

Author(s): Anna Klisińska‐Kopacz

Journal: Journal of Raman Spectroscopy

Historic textiles represent a very important part of our cultural heritage. This research focused on the evaluation of a group of unique 16th century banners painted on silk. The banners were examined by Raman spectroscopy and X‐ray fluorescence spectrometry. The measurements were performed to characterize the pigments and materials used, in order to establish the most adequate display methods. Pigments typical of the Renaissance period...

Read More thumbnail image: An investigation of a unique group of painted silk banners from a Polish collection

Liquid magnetic competitive immunoassay of clenbuterol based on surface‐enhanced Raman spectroscopy

Published: Jul 28, 2017

Author(s): Chao Wei, Chenjie Zhang, Minmin Xu, Yaxian Yuan, Jianlin Yao

Journal: Journal of Raman Spectroscopy

The surface‐enhanced Raman spectroscopy (SERS)‐based immunoassay has attracted considerable interests due to its extremely high sensitivity. However, the involved solid substrate brought significant difficulties in its extensive application. Herein, based on the integration of magnetic nanoparticles and SERS, a facial liquid magnetic competitive immunoassay was developed to detect clenbuterol (CL) with high sensitivity and specificity....

Read More thumbnail image: Liquid magnetic competitive immunoassay of clenbuterol based on surfaceenhanced Raman spectroscopy

Raman spectroscopy characterization of 10‐cash productions from the late C hinese emperors to the R epublic

Published: Jul 28, 2017

Author(s): Noemí Montoya, Elena Montagna, Yu Lee, María Teresa Doménech‐Carbó, Antonio Doménech‐Carbó

Journal: Journal of Raman Spectroscopy

The use of Raman spectroscopy for discriminating monetary emissions, a recurrent problem in much archaeological studies, is described. The method involves the record of Raman signatures of tenorite and crystalline and defective cuprite in the patina based on the idea that subtle, mint‐characteristic variations in the composition and metallography of the base metal during the manufacturing process are reflected in the variation in depth of...

Read More thumbnail image: Raman spectroscopy characterization of 10cash productions from the late C hinese emperors to the R epublic

Sevoflurane metabolite cross‐react in the ethyl glucuronide DRI® immunoassay

Published: Jul 28, 2017

Author(s): Michael Böttcher, David Kühne, Olof Beck

Journal: Drug Testing and Analysis

Read More thumbnail image: Sevoflurane metabolite crossreact in the ethyl glucuronide DRI immunoassay

Quantitative structure‐selectivity relationship (QSSR)‐based molecular insight into the cross‐reactivity and specificity of chemotherapeutic inhibitors between PI3K α and PI3K β

Published: Jul 28, 2017

Author(s): Xi Ding, Xingcai Liu, Lixia Zhu

Journal: Journal of Chemometrics

Selective inhibition of phosphoinositide 3‐kinase (PI3K) isoforms α and β with small‐molecule inhibitors can result in distinct biological effects on anticancer chemotherapy. However, many existing PI3K inhibitors have moderate or high promiscuity and cross‐reactivity between the 2 kinase isoforms. Here, a quantitative structure‐selectivity relationship–based statistical modeling scheme was used to characterize the relative contribution of ...

Read More thumbnail image: Quantitative structureselectivity relationship QSSRbased molecular insight into the crossreactivity and specificity of chemotherapeutic inhibitors between PI3K  and PI3K

Characterization and discrimination of raw and vinegar‐baked Bupleuri radix based on UHPLC‐Q‐TOF‐MS coupled with multivariate statistical analysis

Published: Jul 28, 2017

Author(s): Tianli Lei, Shifeng Chen, Kai Wang, Dandan Zhang, Lin Dong, Chongning Lv, Jing Wang, Jincai Lu

Journal: Biomedical Chromatography

Abstract Bupleuri Radix is a commonly used herb in clinic, and raw and vinegar‐baked Bupleuri Radix are both documented in the Pharmacopoeia of People's Republic of China. According to the theories of traditional Chinese medicine, Bupleuri Radix possesses different therapeutic effects before and after processing. However, the chemical mechanism of this processing is still unknown. In this study, ultra‐high‐performance liquid chromatography with...

Read More thumbnail image: Characterization and discrimination of raw and vinegarbaked Bupleuri radix based on UHPLCQTOFMS coupled with multivariate statistical analysis

Surface and buried interface layer studies on challenging structures as studied by ARXPS

Published: Jul 28, 2017

Author(s): Rana N. S. Sodhi, Peter Brodersen, Ludovico Cademartiri, Martin M. Thuo, Christian A. Nijhuis

Journal: Surface and Interface Analysis

Previous extensive studies were performed at Surface Science Western on the treatment of III‐V semiconductors to produce surfaces suitable for subsequent epitaxial growth. X‐ray photoelectron spectroscopy (XPS) was used to study oxide formation and capping techniques, and to monitor changes that would occur upon thermal desorption. The effects of a remote plasma on these surfaces were studied as well as to apply thin dielectric films of...

Read More thumbnail image: Surface and buried interface layer studies on challenging structures as studied by ARXPS

Non‐targeted acquisition strategy for screening doping compounds based on GC‐EI‐hybrid quadrupole‐Orbitrap mass spectrometry: A focus on exogenous anabolic steroids

Published: Jul 27, 2017

Author(s): Gustavo Albuquerque Cavalcanti, Lucas Martins Rodrigues, Leonardo Santos, Xin Zheng, Amit Gujar, Jason Cole, Monica Costa Padilha, Francisco Radler Aquino Neto

Journal: Drug Testing and Analysis

This is a first look at a non‐targeted screening method based on Orbitrap gas chromatography–mass spectrometry (GC–MS) technology for a large number of banned compounds in sports found in urine, including exogenous anabolic steroids, β‐agonists, narcotics, stimulants, hormone modulators, and diuretics. A simple sample preparation was processed in four steps: an enzymatic hydrolysis, liquid–liquid extraction, evaporation, and...

Read More thumbnail image: Nontargeted acquisition strategy for screening doping compounds based on GCEIhybrid quadrupoleOrbitrap mass spectrometry A focus on exogenous anabolic steroids

A step towards removing plasma volume variance from the Athlete's Biological Passport: The use of biomarkers to describe vascular volumes from a simple blood test

Published: Jul 27, 2017

Author(s): Louisa M. Lobigs, Pierre‐Edouard Sottas, Pitre C. Bourdon, Zoran Nikolovski, Mohamed El‐Gingo, Evdokia Varamenti, Peter Peeling, Brian Dawson, Yorck O. Schumacher

Journal: Drug Testing and Analysis

The haematological module of the Athlete's Biological Passport (ABP) has significantly impacted the prevalence of blood manipulations in elite sports. However, the ABP relies on a number of concentration‐based markers of erythropoiesis, such as haemoglobin concentration ([Hb]), which are influenced by shifts in plasma volume (PV). Fluctuations in PV contribute to the majority of biological variance associated with volumetric ABP markers....

Read More thumbnail image: A step towards removing plasma volume variance from the Athletes Biological Passport The use of biomarkers to describe vascular volumes from a simple blood test

Prevalence of new psychoactive substances and prescription drugs in the Belgian driving under the influence of drugs population

Published: Jul 27, 2017

Author(s): S. M. R. Wille, C. Richeval, M. Nachon‐Phanithavong, J. M. Gaulier, V. Di Fazio, L. Humbert, N. Samyn, D. Allorge

Journal: Drug Testing and Analysis

Driving under the influence of drugs (DUID) is a worldwide problem. Several countries have adopted DUID legislations which prove their deterrent effect and impact on road safety. However, the use of new psychoactive substances (NPS) and prescription drugs is not known, as the applied roadside screening tests have not yet been adapted for these compounds. In this study, 558 blood samples obtained during roadside controls in Belgium...

Read More thumbnail image: Prevalence of new psychoactive substances and prescription drugs in the Belgian driving under the influence of drugs population
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