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Advances in organic–inorganic hybrid sorbents for the extraction of organic and inorganic pollutants in different types of food and environmental samples

Published: Sep 27, 2017

Author(s): Nyuk‐Ting Ng, Amirah Farhan Kamaruddin, Wan Aini Wan Ibrahim, Mohd Marsin Sanagi, Aemi S. Abdul Keyon

Journal: Journal of Separation Science

Abstract The efficiency of the extraction and removal of pollutants from food and the environment has been an important issue in analytical science. By incorporating inorganic species into an organic matrix, a new material known as an organic–inorganic hybrid material is formed. As it possesses high selectivity, permeability, and mechanical and chemical stabilities, organic–inorganic hybrid materials constitute an emerging research...

Read More thumbnail image: Advances in organicinorganic hybrid sorbents for the extraction of organic and inorganic pollutants in different types of food and environmental samples

Mass‐spectrometry‐based lipidomics

Published: Sep 27, 2017

Author(s): Ting Hu, Jin‐Lan Zhang

Journal: Journal of Separation Science

Abstract Lipids, which have a core function in energy storage, signalling and biofilm structures, play important roles in a variety of cellular processes because of the great diversity of their structural and physiochemical properties. Lipidomics is the large‐scale profiling and quantification of biogenic lipid molecules, the comprehensive study of their pathways and the interpretation of their physiological significance based on...

Read More thumbnail image: Massspectrometrybased lipidomics

Techniques for the analysis of pentacyclic triterpenoids in medicinal plants

Published: Sep 26, 2017

Author(s): Congcong Xu, Bing Wang, Yiqiong Pu, Jiansheng Tao, Tong Zhang

Journal: Journal of Separation Science

Abstract Triterpenes are a major class of chemical compounds found in natural plants and can be categorized into acyclic triterpenoids, monocyclic triterpenoids, tricyclic triterpenoids, tetracyclic triterpenoids, and pentacyclic triterpenoids. Among them, pentacyclic triterpenoids have gained more extensive attention due to their biological activities, including anti‐inflammation, antibacterial, antioxidation, antitumor, anti‐HIV,...

Read More thumbnail image: Techniques for the analysis of pentacyclic triterpenoids in medicinal plants

Open‐tubular capillary electrochromatography using carboxylatopillar[5]arene as stationary phase

Published: Sep 26, 2017

Author(s): Deying Kong, Zilin Chen

Journal: ELECTROPHORESIS

Abstract Pillar[n]arenes have achieved much interest in material chemistry and supramolecular chemistry due to unusual pillar shape structure and high selectivity toward guest. However, pillar[n]arenes have not yet been applied in capillary electrochromatography. This work at first time reports that carboxylatopillar[5]arene is used as a stationary phase in open‐tubular capillary electrochromatography. Carboxylatopillar[5]arene not only...

Read More thumbnail image: Opentubular capillary electrochromatography using carboxylatopillar5arene as stationary phase

Advanced immunocapture of milk‐borne Salmonella by microfluidic magnetically stabilized fluidized bed

Published: Sep 26, 2017

Author(s): Jana Srbova, Pavla Krulisova, Lucie Holubova, Iago Pereiro, Amel Bendali, Audrey Hamiot, Veronika Podzemna, Jan Macak, Bruno Dupuy, Stephanie Descroix, Jean‐Louis Viovy, Zuzana Bilkova

Journal: ELECTROPHORESIS

Abstract The success of microfluidic immunocapture based on magnetic beads depends primarily on a sophisticated microscale separation system and on the quality of the magnetic immunosorbent. A microfluidic chip containing a magnetically stabilized fluidized bed (μMSFB), developed for the capture and on‐chip amplification of bacteria, was recently described by Pereiro et al.. The present work shows the thorough development of...

Read More thumbnail image: Advanced immunocapture of milkborne Salmonella by microfluidic magnetically stabilized fluidized bed

Simultaneous determination of glaucocalyxin A and glaucocalyxin B in rat plasma by LC‐MS/MS and its application to a pharmacokinetic study after oral administration of Rabdosia japonica extract

Published: Sep 26, 2017

Author(s): Weili Huang, Xiaohui Guan, Yongchen Lv

Journal: Biomedical Chromatography

Abstract A specific and sensitive liquid chromatography tandem mass spectrometry (LC‐MS/MS) method was developed and validated for the analysis of glaucocalyxin A and glaucocalyxin B in rat plasma using praeruptorin A as an internal standard. Separation was performed on a Hypurity C18 column (2.1 × 50 mm, 5 μm) with isocratic elution using 0.2% formic acid in water–acetonitrile (20:80, v/v). Mass spectrometric detection was...

Read More thumbnail image: Simultaneous determination of glaucocalyxin A and glaucocalyxin B in rat plasma by LCMSMS and its application to a pharmacokinetic study after oral administration of Rabdosia japonica extract

Simultaneous determination of boscalid and fludioxonil in grape and soil under field conditions by gas chromatography/tandem triple quadrupole mass spectrometry

Published: Sep 26, 2017

Author(s): Haizhen Zhang, A'wei Zhang, Min Huang, Weiwei Yu, Zhurui Li, Sizhuo Wu, Kunming Zheng, Kankan Zhang, Deyu Hu

Journal: Biomedical Chromatography

Abstract A gas chromatography–tandem mass spectrometry method was developed and validated to simultaneously determine boscalid and fludioxonil in grape and soil samples. These samples were extracted with 10 mL of acetonitrile and purified using a mixed primary secondary amine/octadecylsilane sorbent. The method showed good linearity (R2 > 0.99) in the calibration range 0.005–2 μg/mL for both pesticides. The limits of detection and...

Read More thumbnail image: Simultaneous determination of boscalid and fludioxonil in grape and soil under field conditions by gas chromatographytandem triple quadrupole mass spectrometry

LC‐ESI‐MS/MS determination of 4‐methylpyrazole in dog plasma and its application to a pharmacokinetic study in dogs

Published: Sep 25, 2017

Author(s): Devaraj V. Chandrasekhar, Ponnayyan Sulochana Suresh, Sreekanth Dittakavi, Rakesh A. Hiremath, Ravi Kanth Bhamidipati, Wolfgang Richter, Nuggehally R. Srinivas, Ramesh Mullangi

Journal: Biomedical Chromatography

Abstract A simple, specific, sensitive and rapid LC‐ESI‐MS/MS method has been developed and validated for the quantification of 4‐methylpyrazole in dog plasma using N‐methylnicotinamide‐d4 as an internal standard (IS) as per regulatory guidelines. Sample preparation was accomplished through a simple protein precipitation. Chromatographic separation of 4‐methylpyrazole and the IS was performed on a monolithic (Chromolith RP18e) column using an...

Read More thumbnail image: LCESIMSMS determination of 4methylpyrazole in dog plasma and its application to a pharmacokinetic study in dogs

Diffusion MRI fiber tractography of the brain

Published: Sep 25, 2017

Author(s): Ben Jeurissen, Maxime Descoteaux, Susumu Mori, Alexander Leemans

Journal: NMR in Biomedicine

The ability of fiber tractography to delineate non‐invasively the white matter fiber pathways of the brain raises possibilities for clinical applications and offers enormous potential for neuroscience. In the last decade, fiber tracking has become the method of choice to investigate quantitative MRI parameters in specific bundles of white matter. For neurosurgeons, it is quickly becoming an invaluable tool for the planning of surgery,...

Read More thumbnail image: Diffusion MRI fiber tractography of the brain

Recent developments in capillary and microchip electroseparations of peptides (2015–mid 2017)

Published: Sep 25, 2017

Author(s): Václav Kašička

Journal: ELECTROPHORESIS

Abstract The review brings a comprehensive overview of recent developments and applications of high performance capillary and microchip electroseparation methods (zone electrophoresis, isotachophoresis, isoelectric focusing, affinity electrophoresis, electrokinetic chromatography, and electrochromatography) to analysis, microscale isolation, purification, and physicochemical and biochemical characterization of peptides in the years...

Read More thumbnail image: Recent developments in capillary and microchip electroseparations of peptides 2015mid 2017

An aptamer‐based paper microfluidic device for the colorimetric determination of cocaine

Published: Sep 25, 2017

Author(s): Ling Wang, Giacomo Musile, Bruce R. McCord

Journal: ELECTROPHORESIS

Abstract A method utilizing paper microfluidics coupled with gold nanoparticles and two anticocaine aptamers has been developed to detect seized cocaine samples. The ready‐to‐use format involves the use of a paper strip that produces a color change resulting from the salt‐induced aggregation of gold nanoparticles producing a visible color change indicating the presence of the drug. This format is specific for the detection of...

Read More thumbnail image: An aptamerbased paper microfluidic device for the colorimetric determination of cocaine

Simulation analysis of rectifying microfluidic mixing with field‐effect‐tunable electrothermal induced flow

Published: Sep 25, 2017

Author(s): Weiyu Liu, Yukun Ren, Ye Tao, Bobin Yao, You Li

Journal: ELECTROPHORESIS

Abstract We report herein field‐effect control on in‐phase electrothermal streaming from a theoretical point of view, a phenomenon termed “alternating‐current electrothermal‐flow field effect transistor” (ACET‐FFET), in the context of a new technology for handing analytes in microfluidics. Field‐effect control through a gate terminal endows ACET‐FFET the ability to generate arbitrary symmetry breaking in the transverse vortex flow...

Read More thumbnail image: Simulation analysis of rectifying microfluidic mixing with fieldeffecttunable electrothermal induced flow

A continuous flow microfluidic device based on contactless dielectrophoresis for bioparticles enrichment

Published: Sep 25, 2017

Author(s): Ali Rahmani, Aliasghar Mohammadi, Hamid Reza Kalhor

Journal: ELECTROPHORESIS

Abstract In recent years, applications of dielectrophoresis‐based platforms have been recognized as effective and dependable approach to separate cells and bioparticles, suspended in different carrier fluids, based on particle size and electrical properties. In this study, a microfluidic device was fabricated by an unprecedented electrode pattern, and several experiments were performed to enrich samples including either of yeast,...

Read More thumbnail image: A continuous flow microfluidic device based on contactless dielectrophoresis for bioparticles enrichment

Investigation of pharmacokinetics, tissue distribution and excretion of schisandrin B in rats by HPLC–MS/MS

Published: Sep 24, 2017

Author(s): Zhuo Wang, Linjun You, Yan Cheng, Kaiyong Hu, Zhanbo Wang, Yanan Cheng, Jin Yang, Yong Yang, Guangji Wang

Journal: Biomedical Chromatography

Abstract Schisandrin B has received much attention owing to its various biological activities. The present study was aimed at the formulation development of schisandrin B and investigation of the pharmacokinetic profiles, distribution and excretion of schisandrin B in Sprague–Dawley rats. In this study, micronized schisandrin B particles with particle size of 10–20 μm were chosen as the research object. Chromatographic separation...

Read More thumbnail image: Investigation of pharmacokinetics tissue distribution and excretion of schisandrin B in rats by HPLCMSMS

Monitoring quality consistency of Liuwei Dihuang Pill by integrating the ultraviolet spectroscopic fingerprint, a multi‐wavelength fusion fingerprint method, and antioxidant activities

Published: Sep 21, 2017

Author(s): Bo Yan, Guoxiang Sun

Journal: Journal of Separation Science

Abstract Liuwei Dihuang Pill, a classical traditional Chinese medicine, has been widely used to treat kidney yin deficiency in China for hundreds of years. Little attention, however, has been paid to quality control methods for this formulation. In the present study, we aimed to establish a comprehensive and practical quality evaluation system for Liuwei Dihuang Pill. Thus, ultraviolet spectroscopic fingerprints and multi‐wavelength...

Read More thumbnail image: Monitoring quality consistency of Liuwei Dihuang Pill by integrating the ultraviolet spectroscopic fingerprint a multiwavelength fusion fingerprint method and antioxidant activities

Quantitative analysis of clofazimine (Lamprene®), an antileprosy agent, in human dried blood spots using liquid chromatography–tandem mass spectrometry

Published: Sep 20, 2017

Author(s): Wenkui Li, John Doherty, Yunlin Fu, Jimmy Flarakos

Journal: Biomedical Chromatography

Abstract An LC–MS/MS method was developed and validated for bioanalysis of clofazimine in human dried blood spot (DBS) samples in support of a clinical study on multidrug‐resistant tuberculosis in developing countries. The validated assay dynamic range was from 10.0 to 2000 ng/mL using a 1/8 inch DBS punch. The accuracy and precision of the assay were ±11.0% (bias) and ≤13.5% (CV) for the LLOQs (10.0 ng/mL) and ±15% (bias) and ≤15%...

Read More thumbnail image: Quantitative analysis of clofazimine Lamprene an antileprosy agent in human dried blood spots using liquid chromatographytandem mass spectrometry

Recent advances in CE and microchip‐CE in clinical applications: 2014 to mid‐2017

Published: Sep 20, 2017

Author(s): Terry M. Phillips

Journal: ELECTROPHORESIS

Abstract CE and microchip CE (ME) are powerful tools for the analysis of a number of different analytes and have been applied to a variety of clinical fields and human samples. This review will present an overview of the most recent applications of these techniques to different areas of clinical medicine during the period of 2014 to mid‐2017. CE and ME have been applied to clinical chemistry, drug detection and monitoring,...

Read More thumbnail image: Recent advances in CE and microchipCE in clinical applications 2014 to mid2017

Pressurizing the mixtures of two ionic liquids: Crystallization versus vetrification

Published: Sep 20, 2017

Author(s): F. Capitani, F. Trequattrini, O. Palumbo, P. Roy, P. Postorino, A. Paolone

Journal: Journal of Raman Spectroscopy

Abstract A series of mixtures prepared with different content of the ionic liquids N‐trimethyl‐N‐propylammonium bis(trifluoromethylsulfonyl)imide (TMPA‐TFSI) and N‐trimethyl‐N‐hexylammonium bis(trifluoromethylsulfonyl)imide (TMHA‐TFSI), namely, (TMPA‐TFSI)100−x (TMHA‐TFSI)x, is investigated by means of Raman spectroscopy as a function of pressure at room temperature. Both pure TMPA‐TFSI and the x = 2 mixture crystallize under an...

Read More thumbnail image: Pressurizing the mixtures of two ionic liquids Crystallization versus vetrification

Ultra‐performance liquid chromatography–tandem mass spectrometry assay for determination of plasma nomegestrol acetate and estradiol in healthy postmenopausal women

Published: Sep 19, 2017

Author(s): Sneha G. Nair, Daxesh P. Patel, Mallika Sanyal, Puran Singhal, Pranav S. Shrivastav

Journal: Biomedical Chromatography

Abstract A highly sensitive and selective ultra‐performance liquid chromatography–tandem mass spectrometry method is described for the simultaneous determination of nomegestrol acetate (NOMAC), a highly selective progestogen, and estradiol (E2), a natural estrogen in human plasma. NOMAC was obtained from plasma by solid‐phase extraction, while E2 was first separated by liquid–liquid extraction with methyl tert‐butyl ether followed...

Read More thumbnail image: Ultraperformance liquid chromatographytandem mass spectrometry assay for determination of plasma nomegestrol acetate and estradiol in healthy postmenopausal women

Development and validation of a simple high‐performance liquid chromatography analytical method for simultaneous determination of phytosterols, cholesterol and squalene in parenteral lipid emulsions

Published: Sep 19, 2017

Author(s): Ana Novak, Mercè Gutiérrez‐Zamora, Lluís Domenech, Josep M. Suñé‐Negre, Montserrat Miñarro, Encarna García‐Montoya, Josep M. Llop, Josep R. Ticó, Pilar Pérez‐Lozano

Journal: Biomedical Chromatography

Abstract A simple analytical method for simultaneous determination of phytosterols, cholesterol and squalene in lipid emulsions was developed owing to increased interest in their clinical effects. Method development was based on commonly used stationary (C18, C8 and phenyl) and mobile phases (mixtures of acetonitrile, methanol and water) under isocratic conditions. Differences in stationary phases resulted in peak overlapping or...

Read More thumbnail image: Development and validation of a simple highperformance liquid chromatography analytical method for simultaneous determination of phytosterols cholesterol and squalene in parenteral lipid emulsions
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