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10 years of Drug Testing and Analysis

Published: Dec 11, 2017

Author(s): Paul Trevorrow

Journal: Drug Testing and Analysis

Read More thumbnail image: 10 years of Drug Testing and Analysis

Elimination profile of triamcinolone in urine following oral administration

Published: Dec 11, 2017

Author(s): Ting‐Ting Chen, Yi‐Chun Tseng, Tai‐Yuan Huang, Guo‐Ping Chang‐Chien, Mei‐Chich Hsu

Journal: Drug Testing and Analysis

Abstract Triamcinolone (T) is a glucocorticoid commonly used to relieve inflammation and treat arthritis, severe allergies, and asthma; however, it is banned by the World Anti‐Doping Agency in competition for athletes when administered orally, intravenously, intramuscularly, or rectally. The minimum required performance limit (MRPL) for urinary T is 30 ng/mL. However, the data about the urinary excretion of T after oral...

Read More thumbnail image: Elimination profile of triamcinolone in urine following oral administration

Functional characterization of CYP2C19 variants in nebivolol 4‐hydroxlation in vitro

Published: Dec 11, 2017

Author(s): Xiao‐Yang Zhou, Xiao‐Xia Hu, Meng‐Fang Li, Hao Wang, Li‐Qun Zhang, Guo‐Xin Hu, Jian‐Ping Cai

Journal: Drug Testing and Analysis

Abstract Cytochrome P450 2C19 (CYP2C19) allelic variants are thought to play an important part in inter‐individual variability in drug metabolism. We evaluated the in vitro hydroxylation of nebivolol by 31 CYP2C19 alleles identified in a Chinese Han population recently. Wild‐type CYP2C19*1B and 30 isoforms were highly expressed in insect cells, and the enzymatic activities of CYP2C19 variants towards nebivolol hydroxylation were...

Read More thumbnail image: Functional characterization of CYP2C19 variants in nebivolol 4hydroxlation in vitro

Development and validation of a simple solid‐phase extraction method coupled with liquid chromatography–triple quadrupole tandem mass spectrometry for simultaneous determination of lincomycin, tylosin A and tylosin B in royal jelly

Published: Dec 11, 2017

Author(s): Weijia Zheng, Jin‐A Park, A. M. Abd El‐Aty, Seong‐Kwan Kim, Sang‐Hyun Cho, Jeong‐Min Choi, Mohamad Warda, Jing Wang, Jae‐Han Shim, Ho‐Chul Shin

Journal: Biomedical Chromatography

Abstract We have developed an analytical method for the determination of lincomycin, tylosin A and tylosin B residues in royal jelly using liquid chromatography–triple quadrupole tandem mass spectrometry analysis. For extraction and purification, we employed 1% trifluoroacetic acid and 0.1 m Na2EDTA solutions along with an Oasis HLB cartridge. The target antibiotics were well separated in a Kinetex EVO C18 reversed‐phase analytical column...

Read More thumbnail image: Development and validation of a simple solidphase extraction method coupled with liquid chromatographytriple quadrupole tandem mass spectrometry for simultaneous determination of lincomycin tylosin A and tylosin B in royal jelly

A target and nontarget strategy for identification or characterization of the chemical ingredients in Chinese herb preparation Shuang‐Huang‐Lian oral liquid by ultra‐performance liquid chromatography–quadrupole time‐of‐flight mass spectrometry

Published: Dec 11, 2017

Author(s): Feng‐Xiang Zhang, Min Li, Zhi‐Hong Yao, Chang Li, Li‐Rui Qiao, Xiu‐Yu Shen, Kate Yu, Yi Dai, Xin‐Sheng Yao

Journal: Biomedical Chromatography

Abstract A target and nontarget strategy based on in‐house chemical components library was developed for rapid and comprehensive analysis of complicated components from traditional Chinese medicine preparation Shuang‐Huang‐Lian oral liquid. The sample was analyzed by ultra‐performance liquid chromatography–quadrupole time‐of‐flight mass spectrometry using generic acquisition parameters. Automated detection and data filtering were...

Read More thumbnail image: A target and nontarget strategy for identification or characterization of the chemical ingredients in Chinese herb preparation ShuangHuangLian oral liquid by ultraperformance liquid chromatographyquadrupole timeofflight mass spectrometry

Mass spectrometry for protein sialoglycosylation

Published: Dec 11, 2017

Author(s): Qiwei Zhang, Zack Li, Yawei Wang, Qi Zheng, Jianjun Li

Journal: Mass Spectrometry Reviews

Sialic acids are a family of structurally unique and negatively charged nine‐carbon sugars, normally found at the terminal positions of glycan chains on glycoproteins and glycolipids. The glycosylation of proteins is a universal post‐translational modification in eukaryotic species and regulates essential biological functions, in which the most common sialic acid is N‐acetyl‐neuraminic acid...

Read More thumbnail image: Mass spectrometry for protein sialoglycosylation

Joule heating induced stream broadening in free‐flow zone electrophoresis

Published: Dec 11, 2017

Author(s): Debashis Dutta

Journal: ELECTROPHORESIS

Abstract The use of an electric field in free‐flow zone electrophoresis (FFZE) automatically leads to Joule heating yielding a higher temperature at the center of the separation chamber relative to that around the channel walls. For small amounts of heat generated, this thermal effect introduces a variation in the equilibrium position of the analyte molecules due to the dependence of liquid viscosity and analyte diffusivity on...

Read More thumbnail image: Joule heating induced stream broadening in freeflow zone electrophoresis

Combination of HPLC with organic and inorganic mass spectrometry to study the metabolic response of the clam Scrobicularia plana to arsenic exposure

Published: Dec 11, 2017

Author(s): Gema Rodríguez‐Moro, Tamara García‐Barrera, Chiara Trombini, Julián Blasco, José Luis Gómez‐Ariza

Journal: ELECTROPHORESIS

Abstract Arsenic is a toxic element extensively studied in the marine environment due to differential toxicological effects of inorganic and organic species. In the present work, the bivalve Scrobicularia plana was exposed to AsV (10 and 100 μg/L) for 14 days to evaluate the metabolic perturbations caused by this element. Arsenic speciation and metabolomic analysis were performed in the digestive gland of the bivalve using two...

Read More thumbnail image: Combination of HPLC with organic and inorganic mass spectrometry to study the metabolic response of the clam Scrobicularia plana to arsenic exposure

A mechanically strengthened polyacrylamide gel matrix fully compatible with electrophoresis of proteins and nucleic acids

Published: Dec 11, 2017

Author(s): Charlotte Pushparajan, Shailesh K. Goswami, C. John McAdam, Lyall R. Hanton, Peter K. Dearden, Stephen C. Moratti, Andrew G. Cridge

Journal: ELECTROPHORESIS

Abstract Polyacrylamide gel electrophoresis is a universal tool in a biochemist's toolkit for protein and nucleic acid separation and subsequent visualisation and analysis. The standard formulation of polyacrylamide gels consists of acrylamide (ACM) monomer crosslinked with bisacrylamide (MBA) which creates a gel with excellent sieving properties but which is mechanically fragile and prone to tearing during post‐electrophoresis...

Read More thumbnail image: A mechanically strengthened polyacrylamide gel matrix fully compatible with electrophoresis of proteins and nucleic acids

Interaction of albumins and heparinoids investigated by affinity capillary electrophoresis and free flow electrophoresis

Published: Dec 11, 2017

Author(s): Mona Mozafari, Sami El Deeb, Friederike Krull, Robert Wildgruber, Gerhard Weber, Christian G. Reiter, Hermann Wätzig

Journal: ELECTROPHORESIS

Abstract A fast and precise affinity capillary electrophoresis (ACE) method has been applied to investigate the interactions between two serum albumins (HSA and BSA) and heparinoids. Furthermore, different free flow electrophoresis methods were developed to separate the species which appears owing to interaction of albumins with pentosan polysulfate sodium (PPS) under different experimental conditions. For ACE experiments, the...

Read More thumbnail image: Interaction of albumins and heparinoids investigated by affinity capillary electrophoresis and free flow electrophoresis

Enzyme‐linked immunosorbent assays (ELISA) based on thread, paper, and fabric

Published: Dec 11, 2017

Author(s): Ariana Gonzalez, Michelle Gaines, Laura Y. Gallegos, Ricardo Guevara, Frank A. Gomez

Journal: ELECTROPHORESIS

Abstract This paper describes enzyme‐linked immunosorbent assays (ELISAs) utilizing microfluidic thread/paper‐based analytical devices (μTPAD), microfluidic fabric‐based analytical devices (μFAD), and microfluidic thread‐based analytical devices (μTAD). Here, the quantitative detection of biotinylated goat anti‐mouse IgG (system one) and rabbit IgG (system two) antibodies via colorimetric analysis is detailed. In both systems,...

Read More thumbnail image: Enzymelinked immunosorbent assays ELISA based on thread paper and fabric

Capillary‐HPLC with tandem mass spectrometry in analysis of alkaloid dyestuffs – a new approach

Published: Dec 11, 2017

Author(s): Damian Dąbrowski, Katarzyna Lech, Maciej Jarosz

Journal: ELECTROPHORESIS

Abstract Development of the identification method of alkaloid compounds in Amur cork tree as well as not examined so far Oregon grape and European Barberry shrubs are presented. The novel approach to separation of alkaloids was applied and the capillary‐high‐performance liquid chromatography (capillary‐HPLC) system was used, which has never previously been reported for alkaloid‐based dyestuffs analysis. Its optimization was...

Read More thumbnail image: CapillaryHPLC with tandem mass spectrometry in analysis of alkaloid dyestuffs  a new approach

Metabonomics study of the effects of traditional Chinese medicine formula Ermiaowan on hyperuricemic rats

Published: Dec 11, 2017

Author(s): Zhongbao Wei, Chen Xu, Shu Liu, Fengrui Song, Zhiqiang Liu, Xiaobo Qu

Journal: Journal of Separation Science

Abstract To explore the global mechanism of Ermiaowan on hyperuricemia regulation, the holistic function of Ermiaowan for hyperuricemia in rats was firstly assessed by the urinary metabonomics method which was based on ultra‐high performance liquid chromatography with electrospray ionization quadrupole time‐of‐flight mass spectrometry. The urinary targeted metabonomics approach combined with the serum biochemical analysis and...

Read More thumbnail image: Metabonomics study of the effects of traditional Chinese medicine formula Ermiaowan on hyperuricemic rats

Determination of multiple antibiotics in leafy vegetables using QuEChERS–UHPLC–MS/MS

Published: Dec 11, 2017

Author(s): Xiaolu Yu, Hang Liu, Chengjun Pu, Junhao Chen, Ying Sun, Lin Hu

Journal: Journal of Separation Science

Abstract A modified quick, easy, cheap, effective, rugged, and safe method was established for simultaneous extraction and cleanup of multiple antibiotics in leafy vegetables, and ultra‐high performance liquid chromatography with tandem mass spectrometry was used for analysis. Antibiotics in leafy vegetables were extracted with citric acid/sodium citrate in mixed solvents consisting of acetonitrile/methanol (85:15, v/v) from...

Read More thumbnail image: Determination of multiple antibiotics in leafy vegetables using QuEChERSUHPLCMSMS

Molecular dynamics simulations of aggregation behavior of sodium dodecyl sulfate on SiO 2 and CaCO 3 surfaces

Published: Dec 11, 2017

Author(s): Xiumin Wang, Gang Wu, Congtai Yuan, Qianqian Zhu, Chunling Li, Shuangqing Sun, Songqing Hu

Journal: Surface and Interface Analysis

Molecular dynamics simulations were carried out to investigate the aggregation behavior of anionic surfactant sodium dodecyl sulfate (SDS) on the surfaces of SiO2 and CaCO3. The results indicate that SDS molecules formed a spherical micelle structure near the SiO2 surface; moreover, there were more head groups near the SiO2 surface. However, they could form a self‐assemble film on the CaCO3 surface. The self‐assemble film of SDS on the CaCO3 surface was more...

Read More thumbnail image: Molecular dynamics simulations of aggregation behavior of sodium dodecyl sulfate on SiO 2 and CaCO 3 surfaces

High‐throughput LC–MS/MS method with 96‐well plate precipitation for the determination of arotinolol and amlodipine in a small volume of rat plasma: Application to a pharmacokinetic interaction study

Published: Dec 11, 2017

Author(s): Zheyuan Qian, Jian Le, Xiujuan Chen, Shengni Li, Hongjie Song, Zhanying Hong

Journal: Journal of Separation Science

Abstract A rapid, sensitive, and selective liquid chromatography with tandem mass spectrometry method was developed and fully validated for the simultaneous quantification of arotinolol and amlodipine in rat plasma. Two internal standards were introduced with metoprolol as the internal standard of arotinolol and (S)‐amlodipine‐d4 as the internal standard of amlodipine. The analytes were isolated from 50.0 μL plasma samples by a simple ...

Read More thumbnail image: Highthroughput LCMSMS method with 96well plate precipitation for the determination of arotinolol and amlodipine in a small volume of rat plasma Application to a pharmacokinetic interaction study

Highly selective and efficient imprinted polymers based on carboxyl‐functionalized magnetic nanoparticles for the extraction of gallic acid from pomegranate rind

Published: Dec 11, 2017

Author(s): Junjie Zhang, Benqiang Li, Huijuan Yue, Jing Wang, Yuansuo Zheng

Journal: Journal of Separation Science

Abstract With the combined surface imprinting technique and immobilized template strategy, molecularly imprinted magnetic nanoparticles were successfully prepared and coupled with high‐performance liquid chromatography to selectively separate and determine gallic acid from the pomegranate rind. On the surface of carboxyl‐functionalized magnetic nanospheres, thin imprinting shells were formed using dopamine as monomer and...

Read More thumbnail image: Highly selective and efficient imprinted polymers based on carboxylfunctionalized magnetic nanoparticles for the extraction of gallic acid from pomegranate rind

Flow injection gas chromatography with sulfur chemiluminescence detection for the analysis of total sulfur in complex hydrocarbon matrixes

Published: Dec 11, 2017

Author(s): Yujuan Hua, Myron Hawryluk, Ronda Gras, Randall Shearer, Jim Luong

Journal: Journal of Separation Science

Abstract A fast and reliable analytical technique for the determination of total sulfur levels in complex hydrocarbon matrices is introduced. The method employed flow injection technique using a gas chromatograph as a sample introduction device and a gas phase dual‐plasma sulfur chemiluminescence detector for sulfur quantification. Using the technique described, total sulfur measurement in challenging hydrocarbon matrices can be...

Read More thumbnail image: Flow injection gas chromatography with sulfur chemiluminescence detection for the analysis of total sulfur in complex hydrocarbon matrixes

Liquid chromatography coupled with hybrid ion trap time‐of‐flight mass spectrometry method for the determination of caulophine in rat bio‐samples and its pharmacokinetic study after intragastric and intraperitoneal administration

Published: Dec 11, 2017

Author(s): Dan Lu, Xiao Xu, Chunlei Li, Sicen Wang

Journal: Journal of Separation Science

Abstract A rapid and precise liquid chromatography coupled with hybrid ion trap/time‐of‐flight mass spectrometry method to detect and quantify caulophine and its possible active metabolites in rat plasma and urine was developed. Samples were prepared by plasma protein precipitation combined with a liquid‐liquid extraction method. The separation was carried out on an InertSustain® C18 column with a mobile phase comprising methanol...

Read More thumbnail image: Liquid chromatography coupled with hybrid ion trap timeofflight mass spectrometry method for the determination of caulophine in rat biosamples and its pharmacokinetic study after intragastric and intraperitoneal administration

Detection of 13 mycotoxins in feed using modified QuEChERS with dispersive magnetic materials and UHPLC–MS/MS

Published: Dec 11, 2017

Author(s): Mingrong Qian, Hua Yang, Zuguang Li, Yanping Liu, Jianmei Wang, Huizhen Wu, Xiaofeng Ji, Jie Xu

Journal: Journal of Separation Science

Abstract An analytical method for the simultaneous determination of 13 mycotoxins in feed by magnetic dispersive solid‐phase extraction combined with ultra‐high performance liquid chromatography and tandem mass spectrometry was developed. The samples were extracted with acetonitrile/water (80:20, v/v, containing 3% acetic acid), and separated by centrifugation after salting‐out, and then treated with magnetic adsorbents to remove...

Read More thumbnail image: Detection of 13 mycotoxins in feed using modified QuEChERS with dispersive magnetic materials and UHPLCMSMS
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