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Oncogenic transformation of lung cells results in distinct exosome protein profile similar to the cell of origin

Published: Sep 15, 2017

Author(s): Richard J. Lobb, Marcus L. Hastie, Emma L. Norris, Rosa Amerongen, Jeffrey J. Gorman, Andreas Möller

Journal: PROTEOMICS

Abstract Lung cancer is responsible for the highest rate of cancer mortality worldwide. Lung cancer patients are often ineligible for tumor biopsies due to comorbidities. As a result, patients may not have the most effective treatment regimens administered. Patients with mutations in the epidermal growth factor receptor (EGFR) have improved survival in response to EGFR tyrosine kinase inhibitors. A noninvasive method of determining...

Read More thumbnail image: Oncogenic transformation of lung cells results in distinct exosome protein profile similar to the cell of origin

Employment of modified Fe 3 O 4 nanoparticles using thermo‐sensitive polymer for extraction and pre‐concentration of cefexime in biological samples

Published: Sep 14, 2017

Author(s): Saman Naghibi, Hamed Sahebi

Journal: Biomedical Chromatography

Abstract Cefexime is a useful antibiotic that can be prescribed to treat bacterial infections. Nanoparticles have been widely marketed as a universal solution among scientists. Many studies have been performed to modify nanoparticles to make them functional as extraction and pre‐concentration agents and drug carriers. Temperature‐sensitive polymers belong to a group of substances that undergo a major change in their physical...

Read More thumbnail image: Employment of modified Fe 3 O 4 nanoparticles using thermosensitive polymer for extraction and preconcentration of cefexime in biological samples

Application of HPLC‐LTQ Orbitrap MS for metabolic profiles of Polygonum multiflora extract in rats

Published: Sep 14, 2017

Author(s): Jing Zhang, Tenghua Wang, Zhiyao Ren, Lu Gong, Juan Huang, Junqi Bai, Xiaohui Qiu, Wen Xu

Journal: Biomedical Chromatography

Abstract The root of Polygonum multiflorum (PM) is an important Chinese herbal medicine for treatment of various diseases. Extensive pharmacological studies have been conducted and demonstrated that it shows a wide range of bioactivities. Meanwhile, a considerable number of hepatotoxicity cases owing to oral administration of PM have been reported and have attracted great attention. However, the limited knowledge regarding the...

Read More thumbnail image: Application of HPLCLTQ Orbitrap MS for metabolic profiles of Polygonum multiflora extract in rats

Qualitative analysis of Psoraleae Fructus by HPLC‐DAD/TOF‐MS fingerprint and quantitative analysis of multiple components by single marker

Published: Sep 14, 2017

Author(s): Lianjun Luan, Xiaoyu Shen, Xuesong Liu, Yongjiang Wu, Manliang Tan

Journal: Biomedical Chromatography

Abstract A variety of bioactive substances may account for the recognized efficacy and wide clinical application of Psoraleae Fructus in China. A high‐performance liquid chromatography–diode array detector (HPLC‐DAD) fingerprint method was developed to present the comprehensive phytochemical profile of the crude drug. Thirteen major compounds were separated and identified by HPLC coupled with time‐of‐flight mass spectrometry...

Read More thumbnail image: Qualitative analysis of Psoraleae Fructus by HPLCDADTOFMS fingerprint and quantitative analysis of multiple components by single marker

Anatomy and evolution of database search engines—a central component of mass spectrometry based proteomic workflows

Published: Sep 13, 2017

Author(s): Kenneth Verheggen, Helge Ræder, Frode S. Berven, Lennart Martens, Harald Barsnes, Marc Vaudel

Journal: Mass Spectrometry Reviews

Sequence database search engines are bioinformatics algorithms that identify peptides from tandem mass spectra using a reference protein sequence database. Two decades of development, notably driven by advances in mass spectrometry, have provided scientists with more than 30 published search engines, each with its own properties. In this review, we present the common paradigm behind the different implementations, and...

Read More thumbnail image: Anatomy and evolution of database search enginesa central component of mass spectrometry based proteomic workflows

Advances in Capillary Electrophoretically Mediated Microanalysis for On‐line Enzymatic and Derivatization Reactions

Published: Sep 13, 2017

Author(s): Shengyun Huang, Prasanta Paul, Pranov Ramana, Erwin Adams, Patrick Augustijns, Ann Schepdael

Journal: ELECTROPHORESIS

Abstract This review summarizes recent developments, applications, and innovations of capillary electrophoretically mediated microanalysis methods. As a follow up of an earlier review, it covers the literature from early 2015 to early 2017. This article is divided into three parts. In the first part, different types of mixing procedures and applications of enzyme mediated microanalysis are discussed; the second part summarizes...

Read More thumbnail image: Advances in Capillary Electrophoretically Mediated Microanalysis for Online Enzymatic and Derivatization Reactions

Recent advances in amino acid analysis by capillary electromigration methods: June 2015–May 2017

Published: Sep 13, 2017

Author(s): Véréna Poinsot, Varravaddheay Ong‐Meang, Audrey Ric, Pierre Gavard, Lucie Perquis, François Couderc

Journal: ELECTROPHORESIS

Abstract In the tenth edition of this article focused on recent advances in amino acid analysis using capillary electrophoresis, we describe the most important research articles published on this topic during the period from June 2015 to May 2017. This article follows the format of the previous articles published in Electrophoresis. The new developments in amino acid analysis with CE mainly describe improvements in CE associated...

Read More thumbnail image: Recent advances in amino acid analysis by capillary electromigration methods June 2015May 2017

Recent advances in microscale separation

Published: Sep 12, 2017

Author(s): Yuanyuan Liu, Weiwei Wang, Mengqi Jia, Rangdong Liu, Qing Liu, Han Xiao, Jing Li, Yun Xue, Yan Wang, Chao Yan

Journal: ELECTROPHORESIS

Abstract This review focuses on the recent advances on microscale separation technology, particularly on the new development on column and detection technologies in electrophoretic and chromatographic separation modes (i.e., CE, CEC, cLC, etc.). Representative examples illustrate also applications on the small molecules, peptides, proteins, polysaccharides, chiral and so on. 246 relevant articles are cited covering the literature...

Read More thumbnail image: Recent advances in microscale separation

Sensitive liquid chromatography/tandem mass spectrometry method for the determination of two novel highly lipophilic anticancer drug candidates in rat plasma and tissues

Published: Sep 12, 2017

Author(s): Shirin Hooshfar, Michael R. Linzey, Daqing Wu, Lajos Gera, Kenza Mamouni, Xin Li, Yanhua Chen, Yang Yang, Oluwasegun Olorunyolemi, Michael G. Bartlett

Journal: Biomedical Chromatography

Abstract A simple and sensitive liquid chromatography/electrospray ionization tandem mass spectrometry (LC‐ESI‐MS/MS) method was developed and validated for determination of two highly lipophilic anticancer drug candidates, LG1980 and GH501, in rat plasma and tissues (liver, kidney and femur bones). LG1980 and GH501 were extracted from rat plasma and tissue homogenates using liquid–liquid extraction. The method provided a linear...

Read More thumbnail image: Sensitive liquid chromatographytandem mass spectrometry method for the determination of two novel highly lipophilic anticancer drug candidates in rat plasma and tissues

Proteomic Analysis of Neuroblastoma‐Derived Exosomes: New Insights into a Metastatic Signature

Published: Sep 12, 2017

Author(s): Marta Colletti, Andrea Petretto, Angela Galardi, Virginia Di Paolo, Luigi Tomao, Chiara Lavarello, Elvira Inglese, Maurizio Bruschi, Ana Amor Lopez, Luisa Pascucci, Birgit Geoerger, Hector Peinado, Franco Locatelli, Angela Di Giannatale

Journal: PROTEOMICS

Abstract Neuroblastoma (NB) is the most common extracranial pediatric solid tumor. Around 70% of patients with metastatic disease at diagnosis present bone‐marrow infiltration, which is considered a marker of poor outcome; however, the mechanism underlying this specific tropism has to be elucidated. Tumor‐derived exosomes may support metastatic progression in several tumors by interacting with the microenvironment, and may serve as...

Read More thumbnail image: Proteomic Analysis of NeuroblastomaDerived Exosomes New Insights into a Metastatic Signature

Determination of fat‐ and water‐soluble vitamins by supercritical fluid chromatography: A review

Published: Sep 11, 2017

Author(s): Katarzyna Tyśkiewicz, Agnieszka Dębczak, Roman Gieysztor, Tomasz Szymczak, Edward Rój

Journal: Journal of Separation Science

Abstract Vitamins are compounds that take part in all basic functions of an organism but also are subject of number of studies performed by different researchers. Two groups of vitamins are distinguished taking into consideration their solubility. Chromatography with supercritical CO2 has found application in the determination, separation, and quantitative analyses of both fat‐ and water‐soluble vitamins. The methods of vitamins...

Read More thumbnail image: Determination of fat and watersoluble vitamins by supercritical fluid chromatography A review

Pharmacokinetics and metabolism of olerciamide A from Portulaca oleracea L. in rats by UHPLC‐UV and UHPLC‐ESI‐Q‐TOF/MS

Published: Sep 10, 2017

Author(s): Zheming Ying, Cuiyu Li, Mingzhe Gao, Xixiang Ying, Guanlin Yang

Journal: Biomedical Chromatography

Abstract The aim of this study was to elucidate the pharmacokinetics of olerciamide A in rats after oral and intravenous administration of Portulaca oleracea L. extract by a simple and rapid ultra high‐performance liquid chromatography method with bergapten as internal standard. The pharmacokinetic results indicated that olerciamide A was rapidly distributed with a time to peak concentration of 30 min after oral administration and...

Read More thumbnail image: Pharmacokinetics and metabolism of olerciamide A from Portulaca oleracea L_ in rats by UHPLCUV and UHPLCESIQTOFMS

Versatile chromatographic method for catechin determination in development of topical formulations containing natural extracts

Published: Sep 10, 2017

Author(s): Ricardo Ferreira‐Nunes, Tamara Angelo, Sandra Márcia Mazutti Silva, Pérola Oliveira Magalhães, Tais Gratieri, Marcílio Sérgio Soares Cunha‐Filho, Guilherme Martins Gelfuso

Journal: Biomedical Chromatography

Abstract Catechin is found in several natural sources, as Eugenia dysenterica and Syzygium cumini extracts. Its antioxidant and UV‐protective properties suggest a potential use in cosmetic and dermatological formulations. A simple analytical method capable of giving support to experiments performed along the development of topical formulations containing this natural substance (i.e. drug assay, skin permeation and stability studies), however,...

Read More thumbnail image: Versatile chromatographic method for catechin determination in development of topical formulations containing natural extracts

A review of diffusion MRI of typical white matter development from early childhood to young adulthood

Published: Sep 8, 2017

Author(s): Catherine Lebel, Sarah Treit, Christian Beaulieu

Journal: NMR in Biomedicine

Abstract Understanding typical, healthy brain development provides a baseline from which to detect and characterize brain anomalies associated with various neurological or psychiatric disorders and diseases. Diffusion MRI is well suited to study white matter development, as it can virtually extract individual tracts and yield parameters that may reflect alterations in the underlying neural micro‐structure (e.g. myelination, axon...

Read More thumbnail image: A review of diffusion MRI of typical white matter development from early childhood to young adulthood

Quantitative determination of trigonelline in mouse serum by means of hydrophilic interaction liquid chromatography–MS/MS analysis: Application to a pharmacokinetic study

Published: Sep 7, 2017

Author(s): Damian Szczesny, Ewa Bartosińska, Julia Jacyna, Małgorzata Patejko, Danuta Siluk, Roman Kaliszan

Journal: Biomedical Chromatography

Abstract Trigonelline is a pyridine alkaloid found in fenugreek seeds and coffee beans. Most of the previous studies are concerned with the quantification of trigonelline along with other constituents in coffee herbs or beverages. Only a few have focused on its determination in animal or human tissues by applying different modes of HPLC with UV or MS detection. The aim of the study was to develop and validate a fast and simple...

Read More thumbnail image: Quantitative determination of trigonelline in mouse serum by means of hydrophilic interaction liquid chromatographyMSMS analysis Application to a pharmacokinetic study

Recent developments in open tubular capillary electrochromatography from 2016 to 2017

Published: Sep 6, 2017

Author(s): Faustino M. Tarongoy, Paul R. Haddad, Joselito P. Quirino

Journal: ELECTROPHORESIS

Abstract Interest in open‐tubular capillary electrochromatography (OT‐CEC) continues to thrive because of the inherent advantage of OT‐CEC combining the high efficiency of capillary electrophoresis and the high selectivity of high performance liquid chromatography. For the period 2016 to 2017, novel materials have been developed as first‐time stationary phases for OT‐CEC and are grouped in this review as polymer‐based materials,...

Read More thumbnail image: Recent developments in open tubular capillary electrochromatography from 2016 to 2017

Quantification of free fatty acids in human stratum corneum using tandem mass spectrometry and surrogate analyte approach

Published: Sep 5, 2017

Author(s): Irena Dapic, Renata Kobetic, Lidija Brkljacic, Sanja Kezic, Ivone Jakasa

Journal: Biomedical Chromatography

Abstract The free fatty acids (FFAs) are one of the major components of the lipids in the stratum corneum (SC), the uppermost layer of the skin. Relative composition of FFAs has been proposed as a biomarker of the skin barrier status in patients with atopic dermatitis (AD). Here, we developed an LC‐ESI‐MS/MS method for simultaneous quantification of a range of FFAs with long and very long chain length in the SC collected by adhesive...

Read More thumbnail image: Quantification of free fatty acids in human stratum corneum using tandem mass spectrometry and surrogate analyte approach

Potential impact of the sewer system on the applicability of alcohol and tobacco biomarkers in wastewater‐based epidemiology

Published: Sep 5, 2017

Author(s): Andrew P.W. Banks, Foon Yin Lai, Jochen F. Mueller, Guangming Jiang, Steve Carter, Phong K. Thai

Journal: Drug Testing and Analysis

Abstract Understanding the actual consumption of alcohol and tobacco in the population is important for forming public health policy. For this purpose, wastewater‐based epidemiology has been applied as a complementary method to estimate the overall alcohol and tobacco consumption in different communities. However, the stability of their consumption biomarkers – ethyl sulfate, ethyl glucuronide, cotinine, and trans‐3′‐hydroxycotinine...

Read More thumbnail image: Potential impact of the sewer system on the applicability of alcohol and tobacco biomarkers in wastewaterbased epidemiology

Confirmation of recent heroin abuse: Accepting the challenge

Published: Sep 5, 2017

Author(s): Alexandra Maas, Burkhard Madea, Cornelius Hess

Journal: Drug Testing and Analysis

Abstract Confirmation or exclusion of recent heroin consumption is still one of the major challenges for forensic and clinical toxicologists. A great variety of biomarkers is available for heroin abuse confirmation, including various opium alkaloids (eg, morphine, codeine), street heroin impurities (eg, 6‐acetylcodeine [6‐AC], noscapine, papaverine) as well as associated metabolites (eg, 6‐monoacetylmorphine [6‐MAM], morphine...

Read More thumbnail image: Confirmation of recent heroin abuse Accepting the challenge

Multicomponent determination of traditional Chinese medicine preparation yin‐zhi‐huang injection by LC–MS/MS for screening of its potential bioactive candidates using HepaRG cells

Published: Sep 4, 2017

Author(s): Zhi Rao, Fan Zhang, Xiao‐Yi Zhang, Guo‐Qiang Zhang, Yan‐Rong Ma, Yan Zhou, Hong‐Yan Qin, Xin‐An Wu, Yu‐Hui Wei

Journal: Biomedical Chromatography

Abstract Yin‐zhi‐huang (YZH) injection is an injectable multiherbal prescription derived from the ancient Chinese medicine formula of Yin‐chen‐hao‐tang, which is widely used in the clinic for the treatment of jaundice and chronic liver diseases. To date, the systematic study of the components in this multiherbal prescription still lacks suitable analytical methods that are able to simultaneously detect a broad array of components at...

Read More thumbnail image: Multicomponent determination of traditional Chinese medicine preparation yinzhihuang injection by LCMSMS for screening of its potential bioactive candidates using HepaRG cells
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