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Development of a fast CE method for high throughput screening of ecto‐5′‐nucleotidase inhibitors

Published: Jun 14, 2018

Author(s): Rabia Raza, Yu Bai, Huwei Liu

Journal: ELECTROPHORESIS

Abstract Overexpression of ecto‐5′‐nucleotidase is found to be linked to cancer progression and other diseases which makes screening of its inhibitors on demand. Unfortunately, there is scarcity of reported ecto‐5′‐nucleotidase inhibitors because of unavailability of simple, fast and efficient methods to study its inhibition. In this study, we have developed a very fast, reverse polarity capillary electrophoresis based method for...

Read More thumbnail image: Development of a fast CE method for high throughput screening of ecto5nucleotidase inhibitors

Gold surface plasmon crystal structure based‐on polystyrene template for biosensor application

Published: Jun 13, 2018

Author(s): Min‐Zhuo Cheng, Jing Zhang, Dequan Bao, Xiwei Huang

Journal: ELECTROPHORESIS

Abstract In this communication, we assembled ordered polystyrene (PS) microsphere array as a template with the drop‐coating method, and the oxygen plasma was used to etch the template to adjust the spacing between the PS microspheres. Nano‐triangular gold array and silver nano‐pyramid array were obtained by ion beam sputtering to deposit precious metal gold and silver. We observed the surface morphology of Au and Au/Ag composite...

Read More thumbnail image: Gold surface plasmon crystal structure basedon polystyrene template for biosensor application

Pressurized hot water extraction of bioactive compounds from artichoke by‐products

Published: Jun 13, 2018

Author(s): Imma Pagano, Anna Lisa Piccinelli, Rita Celano, Luca Campone, Patrizia Gazzerro, Mariateresa Russo, Luca Rastrelli

Journal: ELECTROPHORESIS

Abstract Artichoke by‐products are a suitable source of health‐promoting ingredients for the production of dietary supplements and food additives. A pressurized hot water extraction (PHWE) was developed to recover caffeoylquinic acids (CQAs) and flavone glycosides (FLs) from agro‐industrial artichoke by‐products. The main factors influencing PHWE efficiency and CQA isomerization (temperature, numbers of cycles, modifier, and...

Read More thumbnail image: Pressurized hot water extraction of bioactive compounds from artichoke byproducts

Structural and technological characterization of pectin extracted with sodium citrate and nitric acid from sunflower heads

Published: Jun 13, 2018

Author(s): Nerea Muñoz‐Almagro, Fabián Rico‐Rodriguez, Peter J. Wilde, Antonia Montilla, Mar Villamiel

Journal: ELECTROPHORESIS

Abstract An optimization of temperature, time, and extracting agent concentration of pectin extraction from sunflower heads using sodium citrate and nitric acid (SP‐SC and SP‐NA) was carried out. At optimal conditions, the yield of extraction with nitric acid (SPO‐NA) was twofold greater than the corresponding with sodium citrate (SPO‐SC) (14.3 versus 7.7%, respectively). Regarding pectin structure, the galacturonic acid (GalA)...

Read More thumbnail image: Structural and technological characterization of pectin extracted with sodium citrate and nitric acid from sunflower heads

Hollow mesoporous structured molecularly imprinted polymer as adsorbent in pipette‐tip solid‐phase extraction for the determination of antiretrovirals from plasma of HIV‐infected patients

Published: Jun 13, 2018

Author(s): Nathália Soares Simões, Hanna Leijoto Oliveira, Ricky Cássio Santos da Silva, Leila Suleimara Teixeira, Thaís Lorenna Souza Sales, Whocely Victor Castro, Maria José Nunes Paiva, Cristina Sanches, Keyller Bastos Borges

Journal: ELECTROPHORESIS

Abstract In this work a hollow mesoporous structured molecularly imprinted polymer was synthetized and used as adsorbent in pipette‐tip solid‐phase extraction for the determination of lamivudine (3TC), zidovudine (AZT) and efavirenz (EFZ) from plasma of human immunodeficiency virus (HIV) infected patients by high‐performance liquid chromatography (HPLC). All parameters that influence the recovery of the pipette tip based on hollow...

Read More thumbnail image: Hollow mesoporous structured molecularly imprinted polymer as adsorbent in pipettetip solidphase extraction for the determination of antiretrovirals from plasma of HIVinfected patients

Capillary zone electrophoresis for the determination of amodiaquine and three of its synthetic impurities in pharmaceutical formulations

Published: Jun 13, 2018

Author(s): Jean‐Pierre Mufusama, Ludwig Hoellein, Doris Feineis, Ulrike Holzgrabe, Gerhard Bringmann

Journal: ELECTROPHORESIS

Abstract A simple and robust CZE method was developed for the separation and quantification of the antimalarial compound amodiaquine as well as three of its synthetic impurities at a concentration equal to or lower than 0.5%. For capillary electrophoresis, a fused‐silica capillary, a background electrolyte of 100 mM sodium phosphate buffer at a pH value of 6.2, a voltage of +20 kV, and a detection wavelength of 220 nm...

Read More thumbnail image: Capillary zone electrophoresis for the determination of amodiaquine and three of its synthetic impurities in pharmaceutical formulations

An accurate bacterial DNA quantification assay for HTS library preparation of human biological samples

Published: Jun 13, 2018

Author(s): Sarah Seashols‐Williams, Raquel Green, Denise Wohlfahrt, Angela Brand, Antonio Limjuco Tan‐Torres, Francy Nogales, J Paul Brooks, Baneshwar Singh

Journal: ELECTROPHORESIS

Abstract Sequencing and classification of microbial taxa within forensically relevant biological fluids has the potential for applications in the forensic science and biomedical fields. The quantity of bacterial DNA from human samples is currently estimated based on quantity of total DNA isolated. This method can miscalculate bacterial DNA quantity due to the mixed nature of the sample, and consequently library preparation is often...

Read More thumbnail image: An accurate bacterial DNA quantification assay for HTS library preparation of human biological samples

Determining the effects of adulterants on drug detection via enzyme‐linked immunosorbent assay and adulterant tests strips

Published: Jun 11, 2018

Author(s): Bianca Olivieri, Mark Marić, Candice Bridge

Journal: Drug Testing and Analysis

Abstract The use of immunoassays for drug screening has increased due to their sensitivity towards target analytes, specifically the enzyme‐linked immunosorbent assay (ELISA) technique. Adulterant test strips are commonly used in conjunction with immunoassay tests to ensure the integrity of the specimen has not been altered prior to drug screening. This research focuses on determining which adulterants can produce a false negative...

Read More thumbnail image: Determining the effects of adulterants on drug detection via enzymelinked immunosorbent assay and adulterant tests strips

DNA adducts: Formation, biological effects, and new biospecimens for mass spectrometric measurements in humans

Published: Jun 11, 2018

Author(s): Byeong Hwa Yun, Jingshu Guo, Medjda Bellamri, Robert J. Turesky

Journal: Mass Spectrometry Reviews

Hazardous chemicals in the environment and diet or their electrophilic metabolites can form adducts with genomic DNA, which can lead to mutations and the initiation of cancer. In addition, reactive intermediates can be generated in the body through oxidative stress and damage the genome. The identification and measurement of DNA adducts are required for understanding exposure and the causal role of a genotoxic...

Read More thumbnail image: DNA adducts Formation biological effects and new biospecimens for mass spectrometric measurements in humans

Proteomics biomarkers for solid tumors: Current status and future prospects

Published: Jun 11, 2018

Author(s): Iwona Belczacka, Agnieszka Latosinska, Jochen Metzger, David Marx, Antonia Vlahou, Harald Mischak, Maria Frantzi

Journal: Mass Spectrometry Reviews

Cancer is a heterogeneous multifactorial disease, which continues to be one of the main causes of death worldwide. Despite the extensive efforts for establishing accurate diagnostic assays and efficient therapeutic schemes, disease prevalence is on the rise, in part, however, also due to improved early detection. For years, studies were focused on genomics and transcriptomics, aiming at the discovery of new tests...

Read More thumbnail image: Proteomics biomarkers for solid tumors Current status and future prospects

Raman spectroscopy as a powerful technique for the identification of polymers used in cast sculptures from museum collections

Published: Jun 8, 2018

Author(s): Anna Klisińska‐Kopacz, Barbara Łydżba‐Kopczyńska, Monika Czarnecka, Tomasz Koźlecki, Julio Hoyo Mélendez, Agata Mendys, Anna Kłosowska‐Klechowska, Michał Obarzanowski, Piotr Frączek

Journal: Journal of Raman Spectroscopy

Abstract The chemical identification of materials is the first step for developing and implementing recommendations for the care and display of resin cast and plastic objects in museum collections. This paper presents advantages as well as limitations of portable Raman. Therefore, a comparative analysis of portable and benchtop Raman instruments was performed in the study of materials found in the contemporary art collections of the...

Read More thumbnail image: Raman spectroscopy as a powerful technique for the identification of polymers used in cast sculptures from museum collections

Optimization of artemisinin extraction from Artemisia annua L. with supercritical carbon dioxide + ethanol using response surface methodology

Published: Jun 7, 2018

Author(s): Ozan Nazim Ciftci, Jessica Cahyadi, Selma E. Guigard, Marleny D. A. Saldaña

Journal: ELECTROPHORESIS

Abstract Malaria is a high priority life‐threatening public health concern in developing countries, and therefore there is a growing interest to obtain artemisinin for the production of artemisinin‐based combination therapy products. In this study, artemisinin was extracted from the Artemisia annua L. plant using supercritical carbon dioxide (SC‐CO2) modified with ethanol. Response surface methodology based on central composite rotatable design...

Read More thumbnail image: Optimization of artemisinin extraction from Artemisia annua L_ with supercritical carbon dioxide  ethanol using response surface methodology

Investigation of the pigment use in the Tomb of the Reliefs and other tombs in the Etruscan Banditaccia Necropolis

Published: Jun 7, 2018

Author(s): Matthias Alfeld, Cecilia Baraldi, Maria Cristina Gamberini, Philippe Walter

Journal: X-Ray Spectrometry

The pigment use in the Tomb of the Reliefs (fourth century BC) and four other tombs (seventh to fourth century BC) in the Etruscan Banditaccia Necropolis near Cerveteri, Italy, has been investigated. We made use of X‐ray fluorescence (XRF) and Raman spot analysis, XRF imaging, infrared luminescence and photography supported by Dstretch contrast enhancement. We identified the use of haematite, goethite, calcite, carbon black, manganese...

Read More thumbnail image: Investigation of the pigment use in the Tomb of the Reliefs and other tombs in the Etruscan Banditaccia Necropolis

Development of micellar electrokinetic chromatography method for the determination of three defined impurities in indomethacin

Published: Jun 5, 2018

Author(s): Petra Riasová, Dagmar Doubková, Lucie Pincová, Ondřej Jung, Miroslav Polášek, Pavel Jáč

Journal: ELECTROPHORESIS

Abstract A micellar electrokinetic chromatography method for the determination of indomethacin impurities (4‐chlorobenzoic acid, 5‐methoxy‐2‐methyl‐3‐indoleacetic acid, and 3,4‐dichloroindomethacin) has been developed. A 64.5/56‐cm fused silica 50 μm id capillary with extended light path (150 μm id) detection window was used. Internal standard was 1‐naphthylacetic acid. The analytes were separated at 30 kV with ...

Read More thumbnail image: Development of micellar electrokinetic chromatography method for the determination of three defined impurities in indomethacin

Current state‐of‐art of STR sequencing in forensic genetics

Published: Jun 5, 2018

Author(s): Antonio Alonso, Pedro Alberto Barrio, Petra Müller, Steffi Köcher, Burkhard Berger, Pablo Martin, Martin Bodner, Sascha Willuweit, Walther Parson, Lutz Roewer, Bruce Budowle

Journal: ELECTROPHORESIS

Abstract The current state of validation and implementation strategies of massively parallel sequencing (MPS) technology for the analysis of STR markers for forensic genetics use is described, covering the topics of the current catalog of commercial MPS‐STR panels, leading MPS‐platforms, and MPS‐STR data analysis tools. In addition, the developmental and internal validation studies carried out to date to evaluate reliability,...

Read More thumbnail image: Current stateofart of STR sequencing in forensic genetics

Development of a massively parallel sequencing assay for investigating sequence polymorphisms of 15 short tandem repeats in a Chinese Northern Han population

Published: Jun 5, 2018

Author(s): Qing‐Xia Zhang, Meng Yang, Ya‐Jiao Pan, Jing Zhao, Bao‐Wang Qu, Feng Cheng, Ya‐Ran Yang, Zhang‐Ping Jiao, Li Liu, Jiang‐Wei Yan

Journal: ELECTROPHORESIS

Abstract Massively parallel sequencing (MPS) has been used in forensic genetics in recent years owing to several advantages, e.g. MPS can provide precise descriptions of the repeat allele structure and variation in the repeat‐flanking regions, increasing the discriminating power among loci and individuals. However, it cannot be fully utilized unless sufficient population data are available for all loci. Thus, there is a pressing...

Read More thumbnail image: Development of a massively parallel sequencing assay for investigating sequence polymorphisms of 15 short tandem repeats in a Chinese Northern Han population

Evaluation of massively parallel sequencing for forensic DNA methylation profiling

Published: Jun 5, 2018

Author(s): Rebecca Richards, Jayshree Patel, Kate Stevenson, SallyAnn Harbison

Journal: ELECTROPHORESIS

Abstract Epigenetics is an emerging area of interest in forensic science. DNA methylation, a type of epigenetic modification, can be applied to chronological age estimation, identical twin differentiation and body fluid identification. However, there is not yet an agreed, established methodology for targeted detection and analysis of DNA methylation markers in forensic research. Recently, a massively parallel sequencing‐based...

Read More thumbnail image: Evaluation of massively parallel sequencing for forensic DNA methylation profiling

Cancer in the crosshairs: targeting cancer metabolism with hyperpolarized carbon‐13 MRI technology

Published: Jun 5, 2018

Author(s): Cornelius Morze, Matthew E. Merritt

Journal: NMR in Biomedicine

Magnetic resonance (MR)‐based hyperpolarized (HP) 13C metabolic imaging is under active pursuit as a new clinical diagnostic method for cancer detection, grading, and monitoring of therapeutic response. Following the tremendous success of metabolic imaging by positron emission tomography, which already plays major roles in clinical oncology, the added value of HP 13C MRI is emerging. Aberrant glycolysis and central carbon metabolism is a hallmark of...

Read More thumbnail image: Cancer in the crosshairs targeting cancer metabolism with hyperpolarized carbon13 MRI technology

Enhanced oil recovery assignment using a new strategy for clustering oil reservoirs: Application of fuzzy logics

Published: Jun 5, 2018

Author(s): Mohsen Khojastehmehr, Abbas Naderifar, Babak Aminshahidy

Journal: Journal of Chemometrics

Abstract Enhanced Oil Recovery (EOR) aims at producing more oil from low productive reservoirs. EOR is a costly process due to the time and expenses required to allocate a suitable EOR method to an oil reservoir. For this purpose, this work presents a systematic approach to incorporate past experiences into a compact system to assign the EOR process to oil reservoirs. Because the number of clusters within the reservoirs data is not...

Read More thumbnail image: Enhanced oil recovery assignment using a new strategy for clustering oil reservoirs Application of fuzzy logics

Multimode complex process monitoring using double‐level local information based local outlier factor method

Published: Jun 5, 2018

Author(s): Lei Wang, Xiaogang Deng, Yuping Cao

Journal: Journal of Chemometrics

Abstract Industrial processes typically have multiple operating modes with complex data distribution and locality faults, which challenges the traditional multivariate statistical process monitoring methods. To address this problem, a double‐level local information‐based local outlier factor (LOF) method is proposed in this work for multimode complex process monitoring. First, to handle the multimodality, the local neighborhood...

Read More thumbnail image: Multimode complex process monitoring using doublelevel local information based local outlier factor method
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