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Rapid automatic creation of monodisperse emulsion droplets by microfluidic device with degassed PDMS slab as a detachable suction actuator

Published: Sep 1, 2017

Author(s): Yuki Murata, Yuta Nakashoji, Masaki Kondo, Yugo Tanaka, Masahiko Hashimoto

Journal: ELECTROPHORESIS

We previously developed a technique that enabled automatic creation of monodisperse water‐in‐oil droplets with the use of an air‐evacuated PDMS microfluidic device. Although the device generated droplets over a long‐time period, the production rate was slow (∼10 droplets per second). In the current study, we aimed to improve this rate, using the same fluid pumping principle described in our previous work, by remodeling our device...

Read More thumbnail image: Rapid automatic creation of monodisperse emulsion droplets by microfluidic device with degassed PDMS slab as a detachable suction actuator

Advances in the analysis of “less‐conventional” human body fluids: An overview of the CE‐ and HPLC‐MS applications in the years 2015–2017

Published: Sep 1, 2017

Author(s): Monica Di Venere, Simona Viglio, Maddalena Cagnone, Anna Bardoni, Roberta Salvini, Paolo Iadarola

Journal: ELECTROPHORESIS

Aim of this article is to focus the attention of the reader on the application of CE/MS and LC/MS to the analysis of human body fluids not currently used for the diagnosis of disorders and, for this reason, catalogued as “less/nonconventional” fluids, that is, tears, nasal secretions, cerumen, bronchoalveolar lavage fluid, sputum, exhaled breath condensate, nipple aspirate, breast milk, amniotic fluid, bile, seminal plasma, liposuction...

Read More thumbnail image: Advances in the analysis of lessconventional human body fluids An overview of the CE and HPLCMS applications in the years 20152017

Decoding the microstructural correlate of diffusion MRI

Published: Aug 31, 2017

Author(s): Svenja Caspers, Markus Axer

Journal: NMR in Biomedicine

Diffusion imaging has evolved considerably over the past decade. While it provides valuable information about the structural connectivity at the macro‐ and mesoscopic scale, bridging the gap to the microstructure at the level of single nerve fibers poses an enormous challenge. This is particularly true for the human brain with its large size, its large white‐matter volume and availability of histological techniques for studying human...

Read More thumbnail image: Decoding the microstructural correlate of diffusion MRI

Post‐modified non‐negative matrix factorization for deconvoluting the gene expression profiles of specific cell types from heterogeneous clinical samples based on RNA‐sequencing data

Published: Aug 31, 2017

Author(s): Yuan Liu, Yu Liang, Qifan Kuang, Fanfan Xie, Yingyi Hao, Zhining Wen, Menglong Li

Journal: Journal of Chemometrics

Abstract The application of supervised algorithms in clinical practice has been limited by the lack of information on pure cell types. Several supervised algorithms have been proposed to estimate the gene expression patterns of specific cell types from heterogeneous samples. Post‐modified non‐negative matrix factorization (NMF), the unsupervised algorithm we proposed here, is capable of estimating the gene expression profiles and...

Read More thumbnail image: Postmodified nonnegative matrix factorization for deconvoluting the gene expression profiles of specific cell types from heterogeneous clinical samples based on RNAsequencing data

Raman spectroscopic determination of Sr/Ca ratios of calcite samples

Published: Aug 31, 2017

Author(s): Yusuke Shibano, Kohei Takahata, Jun Kawano, Tsuyoshi Watanabe, Daisuke Enomoto, Hiroyuki Kagi, Natsumi Kamiya, Junji Yamamoto

Journal: Journal of Raman Spectroscopy

Abstract We investigated the relation between Sr# [= 100 Sr/(Sr + Ca) in mol] of calcites and their Raman spectra for Sr‐doped calcite samples with Sr# of 0–13.2. We selected 3 major Raman peaks observed at 150–155 cm−1 (peak A), 274–282 cm−1 (peak B), and 710–712.5 cm−1 (peak C). With increasing Sr#, the peaks shifted monotonously to lower wavenumbers. We obtained a linear expression for peak B as...

Read More thumbnail image: Raman spectroscopic determination of SrCa ratios of calcite samples

Quantitative surface‐enhanced resonance Raman scattering analysis of methylene blue using silver colloid

Published: Aug 31, 2017

Author(s): J.A. Anastasopoulos, A. Soto Beobide, A.C. Manikas, G.A. Voyiatzis

Journal: Journal of Raman Spectroscopy

Abstract Quantitative analysis of methylene blue (MB) has been performed with Surface Enhanced Raman Scattering, SERS, using citrate reduced silver colloid activated with NaCl. In this study, the combination of SERS occurring at the proximity of the plasmon surface and of resonance Raman with excitation wavelength matched to the maximum absorbance of the molecule being analyzed, was successfully applied to maximize the Raman...

Read More thumbnail image: Quantitative surfaceenhanced resonance Raman scattering analysis of methylene blue using silver colloid

Quantification of cocaine in ternary mixtures using partial least squares regression applied to Raman and Fourier transform infrared spectroscopy

Published: Aug 31, 2017

Author(s): Ciro Augusto Fernandes Oliveira Penido, Marcos Tadeu Tavares Pacheco, Etelvino Henrique Novotny, Igor K. Lednev, Landulfo Silveira

Journal: Journal of Raman Spectroscopy

Abstract The use of chemicals is often related to suicide attempts and acute poisoning, which account for a significant number of hospital admissions. The differential diagnosis of patients exposed to poisoning is intricate and varies according to the substance used. The identification of drugs and drug abuse in cases of poisoning often requires time‐consuming and complex techniques, such as chromatography. The use of vibrational...

Read More thumbnail image: Quantification of cocaine in ternary mixtures using partial least squares regression applied to Raman and Fourier transform infrared spectroscopy

Identifying the stacking order of multilayer graphene grown by chemical vapor deposition via Raman spectroscopy

Published: Aug 31, 2017

Author(s): Miao‐Ling Lin, Tao Chen, Wei Lu, Qing‐Hai Tan, Pei Zhao, Hong‐Tao Wang, Yang Xu, Ping‐Heng Tan

Journal: Journal of Raman Spectroscopy

Large‐area monolayer (1LG) and multilayer graphene (MLG) grown by chemical vapor deposition (CVD) have been of great technological importance for the graphene electronics and photonics. Such CVD‐grown MLG (CVD‐MLG) flakes consist of multiple single crystal domains, whose stacking orders can be diverse due to the various choices of layer number, stacking sequence, and twist angle. Here, we demonstrated a way to identify the stacking order...

Read More thumbnail image: Identifying the stacking order of multilayer graphene grown by chemical vapor deposition via Raman spectroscopy

Alkaloid profiling of herbal drugs using high resolution mass spectrometry

Published: Aug 31, 2017

Author(s): Tiziana Nardin, Edi Piasentier, Chiara Barnaba, Roberto Larcher

Journal: Drug Testing and Analysis

Abstract Herbal infusions are consumed worldwide thanks to their “natural” beneficial effects, also due to the presence of alkaloids, although these compounds can have poisonous effects. A method combining online solid‐phase purification with high resolution mass spectrometry was used to define the alkaloid profiles of 117 herbs and 7 commercial blends. Forty‐one alkaloids were quantified in reference to analytical standards, while...

Read More thumbnail image: Alkaloid profiling of herbal drugs using high resolution mass spectrometry

Power of Orbitrap‐based LC‐high resolution‐MS/MS for comprehensive drug testing in urine with or without conjugate cleavage or using dried urine spots after on‐spot cleavage in comparison to established LC–MS n or GC–MS procedures

Published: Aug 31, 2017

Author(s): Julian A. Michely, Markus R. Meyer, Hans H. Maurer

Journal: Drug Testing and Analysis

Abstract Reliable, sensitive, and comprehensive urine screening procedures by gas chromatography–mass spectrometry (GC–MS) or liquid chromatography–mass spectrometry (LC–MS) with low or high resolution (HR) are of high importance for drug testing, adherence monitoring, or detection of toxic compounds. Besides conventional urine sampling, dried urine spots are of increasing interest. In the present study, the power of LC–HR–MS/MS was...

Read More thumbnail image: Power of Orbitrapbased LChigh resolutionMSMS for comprehensive drug testing in urine with or without conjugate cleavage or using dried urine spots after onspot cleavage in comparison to established LCMS n or GCMS procedures

Study of the in vitro and in vivo metabolism of the tryptamine 5‐MeO‐MiPT using human liver microsomes and real case samples

Published: Aug 31, 2017

Author(s): Katharina Elisabeth Grafinger, Marianne Hädener, Stefan König, Wolfgang Weinmann

Journal: Drug Testing and Analysis

Abstract The synthetic tryptamine 5‐methoxy‐N‐methyl‐N‐isopropyltryptamine (5‐MeO‐MiPT) has recently been abused as a hallucinogenic drug in Germany and Switzerland. This study presents a case of 5‐MeO‐MiPT intoxication and the structural elucidation of metabolites in pooled human liver microsomes (pHLM), blood, and urine. Microsomal incubation experiments were performed using pHLM to detect and identify in vitro metabolites. In August 2016,...

Read More thumbnail image: Study of the in vitro and in vivo metabolism of the tryptamine 5MeOMiPT using human liver microsomes and real case samples

A multi‐analyte approach to help in assessing the severity of acute poisonings – Development and validation of a fast LC–MS/MS quantification approach for 45 drugs and their relevant metabolites with one‐point calibration

Published: Aug 31, 2017

Author(s): Julian A. Michely, Hans H. Maurer

Journal: Drug Testing and Analysis

Abstract Diagnosis, monitoring of the efficiency of detoxification, and estimating the prognosis of acute poisonings are important tasks in emergency toxicology. Comprehensive screening and quantification of relevant substances by gas chromatography–mass spectrometry (GC–MS) or liquid chromatography–mass spectrometry (LC–MS) help in assessing the severity of most acute poisonings. Turnaround time for such analyses must be short...

Read More thumbnail image: A multianalyte approach to help in assessing the severity of acute poisonings  Development and validation of a fast LCMSMS quantification approach for 45 drugs and their relevant metabolites with onepoint calibration

A proteomics method using immunoaffinity fluorogenic derivatization–liquid chromatography/tandem mass spectrometry (FD‐LC‐MS/MS) to identify a set of interacting proteins

Published: Aug 31, 2017

Author(s): Katsunori Nakata, Ryoichi Saitoh, Masaki Ishigai, Kazuhiro Imai

Journal: Biomedical Chromatography

Abstract Biological functions in organisms are usually controlled by a set of interacting proteins, and identifying the proteins that interact is useful for understanding the mechanism of the functions. Immunoprecipitation is a method that utilizes the affinity of an antibody to isolate and identify the proteins that have interacted in a biological sample. In this study, the FD‐LC–MS/MS method, which involves fluorogenic...

Read More thumbnail image: A proteomics method using immunoaffinity fluorogenic derivatizationliquid chromatographytandem mass spectrometry FDLCMSMS to identify a set of interacting proteins

Surface‐enhanced Raman spectra on graphene

Published: Aug 29, 2017

Author(s): Johan Ek Weis, Jana Vejpravova, Tim Verhagen, Zuzana Melnikova, Sara Costa, Martin Kalbac

Journal: Journal of Raman Spectroscopy

Surface‐enhanced Raman spectroscopy is a valuable tool for inspection of trace concentrations of various molecules; hence, this method has a great potential for characterization of functionalised graphene. However, to make this method a reliable analytical tool, the influence of the metal–graphene interactions on Raman spectra of the graphene must be understood. Here, the surface‐enhanced Raman spectra of exfoliated single‐layer graphene...

Read More thumbnail image: Surfaceenhanced Raman spectra on graphene

Detection of cancerous kidney tissue by means of SERS spectroscopy of extracellular fluid

Published: Aug 29, 2017

Author(s): M. Velicka, M. Pucetaite, V. Urboniene, J. Ceponkus, F. Jankevicius, V. Sablinskas

Journal: Journal of Raman Spectroscopy

Abstract We present a novel approach for detection of cancerous kidney tissue areas by measuring surface enhanced Raman scattering (SERS) spectra of extracellular fluid taken from kidney tissue. The method is based on spectral analysis of the cancerous and normal tissue areas in order to find the specific spectral markers. The samples were prepared by sliding the kidney tissue over a substrate—calcium fluoride optical window. For...

Read More thumbnail image: Detection of cancerous kidney tissue by means of SERS spectroscopy of extracellular fluid

SERS analysis of selectively captured exosomes using an integrin‐specific peptide ligand

Published: Aug 29, 2017

Author(s): Changwon Lee, Randy Carney, Kit Lam, James W. Chan

Journal: Journal of Raman Spectroscopy

Abstract We demonstrate selective capturing of exosomes for surface‐enhanced Raman spectroscopy (SERS) analysis using a thiolated peptide ligand that is bound to the surface of silver nanoparticles via thiol‐metallic bond formation. The ligand preferentially binds to α3ß1 integrin over‐expressed in exosomes secreted from SKOV‐3 cancer cells. Several Raman peaks at 894 cm−1, 1,080 cm−1, 1,252 cm−1, 1,340 cm−1, and...

Read More thumbnail image: SERS analysis of selectively captured exosomes using an integrinspecific peptide ligand

Validation of an LC–MS/MS method for analysis of anti‐diabetic drugs in botanical dietary supplements labeled for blood sugar management

Published: Aug 29, 2017

Author(s): Jun Ma, Rahul S. Pawar, Erich Grundel

Journal: Drug Testing and Analysis

Abstract We developed and validated a liquid chromatography–tandem mass spectrometry (LC–MS/MS) method to detect and quantitate 14 anti‐diabetic, 2 anti‐obesity, and 3 cholesterol‐lowering drugs in botanical dietary supplements marketed for blood sugar management. Many botanical dietary supplements which carry label statements related to blood sugar management are available over the Internet. Potential adulteration of such dietary...

Read More thumbnail image: Validation of an LCMSMS method for analysis of antidiabetic drugs in botanical dietary supplements labeled for blood sugar management

In‐source collision‐induced dissociation (IS‐CID): Applications, issues and structure elucidation with single‐stage mass analyzers

Published: Aug 29, 2017

Author(s): Jon F. Parcher, Mei Wang, Amar G. Chittiboyina, Ikhlas A. Khan

Journal: Drug Testing and Analysis

Abstract A discussion of the definition, advantages, and issues with the formation of ions in the transition region between an electrospray ionization (ESI) source and the ion optics of a mass analyzer is presented. The various types of ions formed in the so‐called in‐source collision‐induced dissociation (IS‐CID) process are illustrated. Applications of IS‐CID with single‐stage mass analyzers, such as structure elucidation and...

Read More thumbnail image: Insource collisioninduced dissociation ISCID Applications issues and structure elucidation with singlestage mass analyzers

Human urinary metabolic patterns of the designer benzodiazepines flubromazolam and pyrazolam studied by liquid chromatography–high resolution mass spectrometry

Published: Aug 29, 2017

Author(s): Madeleine Pettersson Bergstrand, Markus R. Meyer, Olof Beck, Anders Helander

Journal: Drug Testing and Analysis

Abstract Over the past ~8 years, hundreds of unregulated new psychoactive substances (NPS) of various chemical categories have been introduced as recreational drugs through mainly open online trade. This study was performed to further investigate the human metabolic pattern of the NPS, or designer benzodiazepines flubromazolam and pyrazolam, and to propose analytical targets for urine drug testing of these substances. The urine...

Read More thumbnail image: Human urinary metabolic patterns of the designer benzodiazepines flubromazolam and pyrazolam studied by liquid chromatographyhigh resolution mass spectrometry

Residual dynamic and risk assessment of dimethomorph in Swiss chard grown at two different sites

Published: Aug 28, 2017

Author(s): Md. Humayun Kabir, A. M. Abd El‐Aty, Md. Musfiqur Rahman, Hyung Suk Chung, Han Sol Lee, Mi‐Ra Kim, Byung‐Joon Chang, Jing Wang, Ho‐Chul Shin, Jae‐Han Shim

Journal: Biomedical Chromatography

Abstract Residue analysis of dimethomorph in Swiss chard cultivated at two different locations under greenhouse conditions was conducted using high‐performance liquid chromatography–ultraviolet detection and confirmed by tandem mass spectrometry. The randomly collected samples (over 14 days) were extracted with acetonitrile and purified using a Florisil solid‐phase extraction cartridge. Linearity over a concentration range of...

Read More thumbnail image: Residual dynamic and risk assessment of dimethomorph in Swiss chard grown at two different sites
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