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Metabolomics revealed the toxicity of cationic liposomes in HepG2 cells using UHPLC‐Q‐TOF/MS and multivariate data analysis

Published: Jul 17, 2017

Author(s): Jing Yu, Hai Zhang, Ying Li, Sen Sun, Jie Gao, Yanqiang Zhong, Duxin Sun, Guoqing Zhang

Journal: Biomedical Chromatography

Abstract Cationic liposomes (CLs) are novel nonviral vectors widely used for delivering drugs or genes. However, applications of CLs are largely hampered by their cytotoxicity, partly because the potential mechanism underlying the cytotoxicity of CLs remains unclear. The aim of the present study was to explore the underlying mechanism of cytotoxicity induced by CLs on HepG2 cells. Differential metabolites were identified and...

Read More thumbnail image: Metabolomics revealed the toxicity of cationic liposomes in HepG2 cells using UHPLCQTOFMS and multivariate data analysis

Pharmacokinetic comparison of two phenolic acids after oral administration of Typhae pollen to normal rats and rats with acute cold blood stasis

Published: Jul 16, 2017

Author(s): Yingni Pan, Wenjie Zhang, Wei Zhang, Xuewei Bai, Shumeng Ren, Jiang Zheng, Dongmei Wang, Xiaoqiu Liu

Journal: Biomedical Chromatography

Abstract Typhae Pollen, dried pollen of Typha angustifolia L., Typha orientalis Presl or other plants of the same genus (Typhaeceae), has the effect of activating the circulation to cure blood stasis in traditional Chinese Medicine. The purpose of this study was to set up an ultra‐high performance liquid chromatography method that could determine p‐hydroxybenzoic acid and vanillic acid simultaneously in rat plasma, and to compare their...

Read More thumbnail image: Pharmacokinetic comparison of two phenolic acids after oral administration of Typhae pollen to normal rats and rats with acute cold blood stasis

Lansoprazole‐sulfide, pharmacokinetics of this promising anti‐tuberculous agent

Published: Jul 13, 2017

Author(s): Sipho Mdanda, Sooraj Baijnath, Adeola Shobo, Sanil D. Singh, Glenn E.M. Maguire, Hendrik G. Kruger, Per I. Arvidsson, Tricia Naicker, Thavendran Govender

Journal: Biomedical Chromatography

Abstract Lansoprazole (LPZ) is a commercially available proton‐pump inhibitor whose primary metabolite, lansoprazole sulfide (LPZS) was recently reported to have in vitro and in vivo activity against Mycobacterium tuberculosis. It was also reported that a 300 mg kg−1 oral administration of LPZS was necessary to reach therapeutic levels in the lung, with the equivalent human dose being unrealistic. A validated liquid chromatography–tandem mass...

Read More thumbnail image: Lansoprazolesulfide pharmacokinetics of this promising antituberculous agent

The influence of chromium and molybdenum on the repassivation of nickel‐chromium‐molybdenum alloys in saline solutions

Published: Jul 13, 2017

Author(s): N. Ebrahimi, M. C. Biesinger, D. W. Shoesmith, J. J. Noël

Journal: Surface and Interface Analysis

The electrochemical properties and compositions of passive, transpassive, and re‐formed passive oxides on the Ni‐Cr‐Mo alloys C22 (high Cr/low Mo) and HYBRID BC1 (low Cr/high Mo) have been studied in 5.0M NaCl solutions. At low potentials in the passive region, the oxide was less resistive on BC1 compared to C22, possibly due to the influence of Mo in increasing the number of defects in the oxide. At higher potentials in the passive...

Read More thumbnail image: The influence of chromium and molybdenum on the repassivation of nickelchromiummolybdenum alloys in saline solutions

The EIS‐based Kohonen neural network for high strength steel coating degradation assessment

Published: Jul 12, 2017

Author(s): Junshuang Ran, Yuanming Xu, Yan Tong

Journal: Journal of Chemometrics

Electrochemical impedance spectroscopy (EIS) method is used for a long‐term and in‐depth study on the failure analysis of polymer coatings. With the assistance of neural networks, a deeper insight into the changing states of corrosion during certain exposure circumstances has been investigated by applying specific Kohonen intelligent learning networks. The Kohonen artificial network has been trained by using 4 sets of samples from sample...

Read More thumbnail image: The EISbased Kohonen neural network for high strength steel coating degradation assessment

Determining the number of pure chemical components in the mixed spectral data based on eigenvalue sequences transform

Published: Jul 12, 2017

Author(s): Qingbo Li, Kejiang Wu

Journal: Journal of Chemometrics

Determining the number of pure chemical components is an important step for various chemical data analysis methods like cluster analysis, principal component analysis, and spectral unmixing. In this paper, a method of eigenvalue sequences transform is proposed to improve the performance in determining the number of chemical components in spectral matrix. The proposed method converts the spectral data cube to eigenvalue sequences by...

Read More thumbnail image: Determining the number of pure chemical components in the mixed spectral data based on eigenvalue sequences transform

A review of chromatographic methods for ketamine and its metabolites norketamine and dehydronorketamine

Published: Jul 11, 2017

Author(s): Eylem Funda Göktaş, Filiz Arıöz

Journal: Biomedical Chromatography

Abstract Ketamine has a synthetic, sedative, nonbarbiturate and fast‐acting anaesthetic properties and it is commonly used in both humans and veterinary surgery. There are many analytical methods available for the qualitative and quantitative determination of ketamine and its metabolites. We have focused on sample pre‐treatment and chromatographic techniques used since the year 2000 for the determination of ketamine and its...

Read More thumbnail image: A review of chromatographic methods for ketamine and its metabolites norketamine and dehydronorketamine

LC–MS/MS characterization, anti‐inflammatory effects and antioxidant activities of polyphenols from different tissues of Korean Petasites japonicus (Meowi)

Published: Jul 11, 2017

Author(s): Jin Young Choi, Kebede Taye Desta, Venu Venkatarame Gowda Saralamma, Sung Joong Lee, Soo Jung Lee, Seong Min Kim, Anjugam Paramanantham, Ho Jeong Lee, Yun‐Hi Kim, Ho‐Chul Shin, Jae‐Han Shim, Mohamad Warda, Ahmet Hacımüftüoğlu, Ji Hoon Jeong, Sung Chul Shin, Gon‐Sup Kim, A. M. Abd El‐Aty

Journal: Biomedical Chromatography

Abstract The Korean Petasites japonicus is a perennial plant used in folk medicine as a remedy for many diseases and popularly consumed as spring greens. Ten polyphenols were characterized from the leaves, stems and roots of this plant via high‐performance liquid chromatography–tandem mass spectrometry. Individual polyphenols were quantified for the first time using calibration curves of six structurally related external standards. ...

Read More thumbnail image: LCMSMS characterization antiinflammatory effects and antioxidant activities of polyphenols from different tissues of Korean Petasites japonicus Meowi

Review of HPLC and LC–MS/MS assays for the determination of various nonsteroidal anti‐androgens used in the treatment of prostate cancer

Published: Jul 11, 2017

Author(s): P.S. Suresh, Nuggehally R. Srinivas, Ramesh Mullangi

Journal: Biomedical Chromatography

Abstract Prostate cancer is the most common cancer and one of the leading causes of cancer deaths in men. One of the commonly used approaches to treat metastatic prostate cancer was via first‐generation nonsteroidal anti‐androgens (NSAAs), namely flutamide, nilutamide, bicalutamide and topilutamide. Most prostate cancer patients who are initially responsive develop the most aggressive form of disease called castration‐resistant...

Read More thumbnail image: Review of HPLC and LCMSMS assays for the determination of various nonsteroidal antiandrogens used in the treatment of prostate cancer

The role of diffusion MRI in neuroscience

Published: Jul 11, 2017

Author(s): Yaniv Assaf, Heidi Johansen‐Berg, Michel Thiebaut de Schotten

Journal: NMR in Biomedicine

Diffusion‐weighted imaging has pushed the boundaries of neuroscience by allowing us to examine the white matter microstructure of the living human brain. By doing so, it has provided answers to fundamental neuroscientific questions, launching a new field of research that had been largely inaccessible. We briefly summarize key questions that have historically been raised in neuroscience concerning the brain's white matter. We then expand...

Read More thumbnail image: The role of diffusion MRI in neuroscience

Fast ultra‐high‐performance liquid chromatography with diode array and mass spectrometry method for determination of tadalafil drug substance and its impurities

Published: Jul 11, 2017

Author(s): Ludovit Schreiber, Radoslav Halko, Milan Hutta

Journal: Biomedical Chromatography

Abstract Tadalafil is used for the treatment of erectile dysfunction. Its related patents expired in 2016, and so related generic drug production is predicted to be increased. This work is focused on developing a fast ultra‐high‐performance liquid chromatography with diode array detection and/or mass spectrometry detection for the separation and determination of tadalafil and its impurities in pharmaceutical samples. A modern...

Read More thumbnail image: Fast ultrahighperformance liquid chromatography with diode array and mass spectrometry method for determination of tadalafil drug substance and its impurities

Development of a HPLC method for determination of four UV filters in sunscreen and its application to skin penetration studies

Published: Jul 10, 2017

Author(s): Carla Souza, Patrícia M.B.G. Maia Campos

Journal: Biomedical Chromatography

Abstract This study describes the development, validation and application of a high‐performance liquid chromatography (HPLC) method for the simultaneous determination of the in vitro skin penetration profile of four UV filters on porcine skin. Experiments were carried out on a gel‐cream formulation containing the following UV filters: diethylamino hydroxybenzoyl hexyl benzoate (DHHB), bis‐ethylhexyloxyphenol methoxyphenyl triazine (BEMT),...

Read More thumbnail image: Development of a HPLC method for determination of four UV filters in sunscreen and its application to skin penetration studies

A validated UHPLC–MS/MS method for the measurement of riluzole in plasma and myocardial tissue samples

Published: Jul 10, 2017

Author(s): Suzanne L. Parker, Yarmarly C. Guerra Valero, Jeffrey Lipman, Steven Weiss, Camilla Smith, Lyndal Russell, Paul Smith, Jason A. Roberts, Steven C. Wallis

Journal: Biomedical Chromatography

Abstract Through blocking the cardiac persistent sodium current, riluzole has the potential to prevent myocardial damage post cardiac bypass surgery. A sensitive UHPLC–MS/MS method was developed and validated for quantitation of riluzole and 5‐methoxypsoralen in human plasma and myocardial tissue homogenate using a liquid–liquid extraction with dichloromethane. The chromatographic separation was achieved using Shimadzu Shim‐pack...

Read More thumbnail image: A validated UHPLCMSMS method for the measurement of riluzole in plasma and myocardial tissue samples

Determination of the serine palmitoyl transferase inhibitor myriocin by electrospray and Q‐trap mass spectrometry

Published: Jul 10, 2017

Author(s): Giuseppe Matteo Campisi, Paola Signorelli, Jessica Rizzo, Claudio Ghilardi, Jacopo Antognetti, Anna Caretti, Jelena S. Lazarević, Enrica Strettoi, Elena Novelli, Riccardo Ghidoni, Federico Maria Rubino, Rita Paroni

Journal: Biomedical Chromatography

Abstract Myriocin is a potent inhibitor of serine‐palmitoyl‐transferase, the first and rate‐determining enzyme in the sphingolipids biosynthetic pathway. This study developed, validated and applied a LC–MS/MS method to measure myriocin in minute specimens of animal tissue. The chemical analog 14‐OH–myriocin was used as the internal standard. The two molecules were extracted from the tissue homogenate by solid‐phase extraction,...

Read More thumbnail image: Determination of the serine palmitoyl transferase inhibitor myriocin by electrospray and Qtrap mass spectrometry

Immobilized monolithic enzymatic reactor and its application for analysis of in‐vitro fertilization media samples

Published: Jul 10, 2017

Author(s): Wei‐Qiang Chen, Philipp Obermayr, Urh Černigoj, Jana Vidič, Tanta Panić‐Janković, Goran Mitulović

Journal: ELECTROPHORESIS

Classical proteomics approaches involve enzymatic hydrolysis of proteins (either separated by polyacrylamide gels or in solution) followed by peptide identification using LC‐MS/MS analysis. This method requires normally more than 16 h to complete. In the case of clinical analysis, it is of the utmost importance to provide fast and reproducible analysis with minimal manual sample handling. Herein we report the method development for online...

Read More thumbnail image: Immobilized monolithic enzymatic reactor and its application for analysis of invitro fertilization media samples

Zinc distribution in human prostate carcinoma cell line using synchrotron X‐ray microfluorescence

Published: Jul 9, 2017

Author(s): K.M.J. Rocha, R.G. Leitão, E.G. Oliveira‐Barros, M.A. Oliveira, C.G.L. Canellas, M.J. Anjos, L.E. Nasciutti, R.T. Lopes

Journal: X-Ray Spectrometry

Cancer is a worldwide public health problem, and its incidence in the world grew by 20% in the last decade. Zinc, an essential trace element, is involved in many cellular processes. Concerning prostate cancer, Zn could inhibit the growth of tumor cells, by inducing cell cycle arrest or apoptosis. X‐ray microfluorescence (μXRF) is an elemental analysis technique that allows mapping biologically important elements at a submillimeter scale,...

Read More thumbnail image: Zinc distribution in human prostate carcinoma cell line using synchrotron Xray microfluorescence

The Skyline ecosystem: Informatics for quantitative mass spectrometry proteomics

Published: Jul 9, 2017

Author(s): Lindsay K. Pino, Brian C. Searle, James G. Bollinger, Brook Nunn, Brendan MacLean, Michael J. MacCoss

Journal: Mass Spectrometry Reviews

Skyline is a freely available, open‐source Windows client application for accelerating targeted proteomics experimentation, with an emphasis on the proteomics and mass spectrometry community as users and as contributors. This review covers the informatics encompassed by the Skyline ecosystem, from computationally assisted targeted mass spectrometry method development, to raw acquisition file data processing, and...

Read More thumbnail image: The Skyline ecosystem Informatics for quantitative mass spectrometry proteomics

The Skyline ecosystem: Informatics for quantitative mass spectrometry proteomics

Published: Jul 9, 2017

Author(s): Lindsay K. Pino, Brian C. Searle, James G. Bollinger, Brook Nunn, Brendan MacLean, Michael J. MacCoss

Journal: Mass Spectrometry Reviews

Skyline is a freely available, open‐source Windows client application for accelerating targeted proteomics experimentation, with an emphasis on the proteomics and mass spectrometry community as users and as contributors. This review covers the informatics encompassed by the Skyline ecosystem, from computationally assisted targeted mass spectrometry method development, to raw acquisition file data processing, and...

Read More thumbnail image: The Skyline ecosystem Informatics for quantitative mass spectrometry proteomics

The human mast cell line‐1 cell membrane chromatography coupled with HPLC‐ESI‐MS/MS method for screening potentical anaphylactic components from chuanxinlian injection

Published: Jul 6, 2017

Author(s): Yuanyuan Lin, Cheng Wang, Yajing Hou, Huaizhen He, Limin Huang, Liu Yang, Meng Sun

Journal: Biomedical Chromatography

Abstract Chuanxinlian injection is a traditional Chinese medicine injection widely used in China to treat sore throat, cough and dysentery, although a high occurrence of severe adverse reactions has been reported in clinical practice in recent years. In the present study, a human mast cell line‐1 cell membrane chromatography coupled with HPLC‐ESI‐MS/MS method was established to screen and identify potentical anaphylactic components...

Read More thumbnail image: The human mast cell line1 cell membrane chromatography coupled with HPLCESIMSMS method for screening potentical anaphylactic components from chuanxinlian injection

Improved approach for the determination of low‐ Z elements in uranium samples using a vacuum chamber TXRF spectrometer

Published: Jul 6, 2017

Author(s): Kaushik Sanyal, Sangita Dhara, N.L. Misra

Journal: X-Ray Spectrometry

Total reflection X‐ray fluorescence (TXRF) method for the determination of low atomic number (Z) elements Na (Z = 11) to Ca (Z = 20) using Cr Kα excitation, vacuum atmosphere sample chamber, and ultrathin window detector of a low Z–high Z TXRF spectrometer has been developed. The earlier reported problem in determination of Al, due to interference of U Mα escape peak with Al Kα, was taken care by more intense solvent...

Read More thumbnail image: Improved approach for the determination of low Z elements in uranium samples using a vacuum chamber TXRF spectrometer
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