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Quantitative surface‐enhanced resonance Raman scattering analysis of methylene blue using silver colloid

Published: Aug 31, 2017

Author(s): J.A. Anastasopoulos, A. Soto Beobide, A.C. Manikas, G.A. Voyiatzis

Journal: Journal of Raman Spectroscopy

Abstract Quantitative analysis of methylene blue (MB) has been performed with Surface Enhanced Raman Scattering, SERS, using citrate reduced silver colloid activated with NaCl. In this study, the combination of SERS occurring at the proximity of the plasmon surface and of resonance Raman with excitation wavelength matched to the maximum absorbance of the molecule being analyzed, was successfully applied to maximize the Raman...

Read More thumbnail image: Quantitative surfaceenhanced resonance Raman scattering analysis of methylene blue using silver colloid

Quantification of cocaine in ternary mixtures using partial least squares regression applied to Raman and Fourier transform infrared spectroscopy

Published: Aug 31, 2017

Author(s): Ciro Augusto Fernandes Oliveira Penido, Marcos Tadeu Tavares Pacheco, Etelvino Henrique Novotny, Igor K. Lednev, Landulfo Silveira

Journal: Journal of Raman Spectroscopy

Abstract The use of chemicals is often related to suicide attempts and acute poisoning, which account for a significant number of hospital admissions. The differential diagnosis of patients exposed to poisoning is intricate and varies according to the substance used. The identification of drugs and drug abuse in cases of poisoning often requires time‐consuming and complex techniques, such as chromatography. The use of vibrational...

Read More thumbnail image: Quantification of cocaine in ternary mixtures using partial least squares regression applied to Raman and Fourier transform infrared spectroscopy

Identifying the stacking order of multilayer graphene grown by chemical vapor deposition via Raman spectroscopy

Published: Aug 31, 2017

Author(s): Miao‐Ling Lin, Tao Chen, Wei Lu, Qing‐Hai Tan, Pei Zhao, Hong‐Tao Wang, Yang Xu, Ping‐Heng Tan

Journal: Journal of Raman Spectroscopy

Large‐area monolayer (1LG) and multilayer graphene (MLG) grown by chemical vapor deposition (CVD) have been of great technological importance for the graphene electronics and photonics. Such CVD‐grown MLG (CVD‐MLG) flakes consist of multiple single crystal domains, whose stacking orders can be diverse due to the various choices of layer number, stacking sequence, and twist angle. Here, we demonstrated a way to identify the stacking order...

Read More thumbnail image: Identifying the stacking order of multilayer graphene grown by chemical vapor deposition via Raman spectroscopy

Alkaloid profiling of herbal drugs using high resolution mass spectrometry

Published: Aug 31, 2017

Author(s): Tiziana Nardin, Edi Piasentier, Chiara Barnaba, Roberto Larcher

Journal: Drug Testing and Analysis

Abstract Herbal infusions are consumed worldwide thanks to their “natural” beneficial effects, also due to the presence of alkaloids, although these compounds can have poisonous effects. A method combining online solid‐phase purification with high resolution mass spectrometry was used to define the alkaloid profiles of 117 herbs and 7 commercial blends. Forty‐one alkaloids were quantified in reference to analytical standards, while...

Read More thumbnail image: Alkaloid profiling of herbal drugs using high resolution mass spectrometry

Power of Orbitrap‐based LC‐high resolution‐MS/MS for comprehensive drug testing in urine with or without conjugate cleavage or using dried urine spots after on‐spot cleavage in comparison to established LC–MS n or GC–MS procedures

Published: Aug 31, 2017

Author(s): Julian A. Michely, Markus R. Meyer, Hans H. Maurer

Journal: Drug Testing and Analysis

Abstract Reliable, sensitive, and comprehensive urine screening procedures by gas chromatography–mass spectrometry (GC–MS) or liquid chromatography–mass spectrometry (LC–MS) with low or high resolution (HR) are of high importance for drug testing, adherence monitoring, or detection of toxic compounds. Besides conventional urine sampling, dried urine spots are of increasing interest. In the present study, the power of LC–HR–MS/MS was...

Read More thumbnail image: Power of Orbitrapbased LChigh resolutionMSMS for comprehensive drug testing in urine with or without conjugate cleavage or using dried urine spots after onspot cleavage in comparison to established LCMS n or GCMS procedures

Study of the in vitro and in vivo metabolism of the tryptamine 5‐MeO‐MiPT using human liver microsomes and real case samples

Published: Aug 31, 2017

Author(s): Katharina Elisabeth Grafinger, Marianne Hädener, Stefan König, Wolfgang Weinmann

Journal: Drug Testing and Analysis

Abstract The synthetic tryptamine 5‐methoxy‐N‐methyl‐N‐isopropyltryptamine (5‐MeO‐MiPT) has recently been abused as a hallucinogenic drug in Germany and Switzerland. This study presents a case of 5‐MeO‐MiPT intoxication and the structural elucidation of metabolites in pooled human liver microsomes (pHLM), blood, and urine. Microsomal incubation experiments were performed using pHLM to detect and identify in vitro metabolites. In August 2016,...

Read More thumbnail image: Study of the in vitro and in vivo metabolism of the tryptamine 5MeOMiPT using human liver microsomes and real case samples

A multi‐analyte approach to help in assessing the severity of acute poisonings – Development and validation of a fast LC–MS/MS quantification approach for 45 drugs and their relevant metabolites with one‐point calibration

Published: Aug 31, 2017

Author(s): Julian A. Michely, Hans H. Maurer

Journal: Drug Testing and Analysis

Abstract Diagnosis, monitoring of the efficiency of detoxification, and estimating the prognosis of acute poisonings are important tasks in emergency toxicology. Comprehensive screening and quantification of relevant substances by gas chromatography–mass spectrometry (GC–MS) or liquid chromatography–mass spectrometry (LC–MS) help in assessing the severity of most acute poisonings. Turnaround time for such analyses must be short...

Read More thumbnail image: A multianalyte approach to help in assessing the severity of acute poisonings  Development and validation of a fast LCMSMS quantification approach for 45 drugs and their relevant metabolites with onepoint calibration

A proteomics method using immunoaffinity fluorogenic derivatization–liquid chromatography/tandem mass spectrometry (FD‐LC‐MS/MS) to identify a set of interacting proteins

Published: Aug 31, 2017

Author(s): Katsunori Nakata, Ryoichi Saitoh, Masaki Ishigai, Kazuhiro Imai

Journal: Biomedical Chromatography

Abstract Biological functions in organisms are usually controlled by a set of interacting proteins, and identifying the proteins that interact is useful for understanding the mechanism of the functions. Immunoprecipitation is a method that utilizes the affinity of an antibody to isolate and identify the proteins that have interacted in a biological sample. In this study, the FD‐LC–MS/MS method, which involves fluorogenic...

Read More thumbnail image: A proteomics method using immunoaffinity fluorogenic derivatizationliquid chromatographytandem mass spectrometry FDLCMSMS to identify a set of interacting proteins

Surface‐enhanced Raman spectra on graphene

Published: Aug 29, 2017

Author(s): Johan Ek Weis, Jana Vejpravova, Tim Verhagen, Zuzana Melnikova, Sara Costa, Martin Kalbac

Journal: Journal of Raman Spectroscopy

Surface‐enhanced Raman spectroscopy is a valuable tool for inspection of trace concentrations of various molecules; hence, this method has a great potential for characterization of functionalised graphene. However, to make this method a reliable analytical tool, the influence of the metal–graphene interactions on Raman spectra of the graphene must be understood. Here, the surface‐enhanced Raman spectra of exfoliated single‐layer graphene...

Read More thumbnail image: Surfaceenhanced Raman spectra on graphene

Detection of cancerous kidney tissue by means of SERS spectroscopy of extracellular fluid

Published: Aug 29, 2017

Author(s): M. Velicka, M. Pucetaite, V. Urboniene, J. Ceponkus, F. Jankevicius, V. Sablinskas

Journal: Journal of Raman Spectroscopy

Abstract We present a novel approach for detection of cancerous kidney tissue areas by measuring surface enhanced Raman scattering (SERS) spectra of extracellular fluid taken from kidney tissue. The method is based on spectral analysis of the cancerous and normal tissue areas in order to find the specific spectral markers. The samples were prepared by sliding the kidney tissue over a substrate—calcium fluoride optical window. For...

Read More thumbnail image: Detection of cancerous kidney tissue by means of SERS spectroscopy of extracellular fluid

SERS analysis of selectively captured exosomes using an integrin‐specific peptide ligand

Published: Aug 29, 2017

Author(s): Changwon Lee, Randy Carney, Kit Lam, James W. Chan

Journal: Journal of Raman Spectroscopy

Abstract We demonstrate selective capturing of exosomes for surface‐enhanced Raman spectroscopy (SERS) analysis using a thiolated peptide ligand that is bound to the surface of silver nanoparticles via thiol‐metallic bond formation. The ligand preferentially binds to α3ß1 integrin over‐expressed in exosomes secreted from SKOV‐3 cancer cells. Several Raman peaks at 894 cm−1, 1,080 cm−1, 1,252 cm−1, 1,340 cm−1, and...

Read More thumbnail image: SERS analysis of selectively captured exosomes using an integrinspecific peptide ligand

Validation of an LC–MS/MS method for analysis of anti‐diabetic drugs in botanical dietary supplements labeled for blood sugar management

Published: Aug 29, 2017

Author(s): Jun Ma, Rahul S. Pawar, Erich Grundel

Journal: Drug Testing and Analysis

Abstract We developed and validated a liquid chromatography–tandem mass spectrometry (LC–MS/MS) method to detect and quantitate 14 anti‐diabetic, 2 anti‐obesity, and 3 cholesterol‐lowering drugs in botanical dietary supplements marketed for blood sugar management. Many botanical dietary supplements which carry label statements related to blood sugar management are available over the Internet. Potential adulteration of such dietary...

Read More thumbnail image: Validation of an LCMSMS method for analysis of antidiabetic drugs in botanical dietary supplements labeled for blood sugar management

In‐source collision‐induced dissociation (IS‐CID): Applications, issues and structure elucidation with single‐stage mass analyzers

Published: Aug 29, 2017

Author(s): Jon F. Parcher, Mei Wang, Amar G. Chittiboyina, Ikhlas A. Khan

Journal: Drug Testing and Analysis

Abstract A discussion of the definition, advantages, and issues with the formation of ions in the transition region between an electrospray ionization (ESI) source and the ion optics of a mass analyzer is presented. The various types of ions formed in the so‐called in‐source collision‐induced dissociation (IS‐CID) process are illustrated. Applications of IS‐CID with single‐stage mass analyzers, such as structure elucidation and...

Read More thumbnail image: Insource collisioninduced dissociation ISCID Applications issues and structure elucidation with singlestage mass analyzers

Human urinary metabolic patterns of the designer benzodiazepines flubromazolam and pyrazolam studied by liquid chromatography–high resolution mass spectrometry

Published: Aug 29, 2017

Author(s): Madeleine Pettersson Bergstrand, Markus R. Meyer, Olof Beck, Anders Helander

Journal: Drug Testing and Analysis

Abstract Over the past ~8 years, hundreds of unregulated new psychoactive substances (NPS) of various chemical categories have been introduced as recreational drugs through mainly open online trade. This study was performed to further investigate the human metabolic pattern of the NPS, or designer benzodiazepines flubromazolam and pyrazolam, and to propose analytical targets for urine drug testing of these substances. The urine...

Read More thumbnail image: Human urinary metabolic patterns of the designer benzodiazepines flubromazolam and pyrazolam studied by liquid chromatographyhigh resolution mass spectrometry

Residual dynamic and risk assessment of dimethomorph in Swiss chard grown at two different sites

Published: Aug 28, 2017

Author(s): Md. Humayun Kabir, A. M. Abd El‐Aty, Md. Musfiqur Rahman, Hyung Suk Chung, Han Sol Lee, Mi‐Ra Kim, Byung‐Joon Chang, Jing Wang, Ho‐Chul Shin, Jae‐Han Shim

Journal: Biomedical Chromatography

Abstract Residue analysis of dimethomorph in Swiss chard cultivated at two different locations under greenhouse conditions was conducted using high‐performance liquid chromatography–ultraviolet detection and confirmed by tandem mass spectrometry. The randomly collected samples (over 14 days) were extracted with acetonitrile and purified using a Florisil solid‐phase extraction cartridge. Linearity over a concentration range of...

Read More thumbnail image: Residual dynamic and risk assessment of dimethomorph in Swiss chard grown at two different sites

Derivatisation for separation and detection in capillary electrophoresis (2015–2017)

Published: Aug 25, 2017

Author(s): Alain Wuethrich, Joselito P. Quirino

Journal: ELECTROPHORESIS

Derivatisation is an integrated part of many analytical workflows to enable separation and detection of the analytes. In CE, derivatisation is adapted in the four modes of pre‐capillary, in‐line, in‐capillary, and post‐capillary derivatisation. In this review, we discuss the progress in derivatisation from February 2015 to May 2017 from multiple points of view including sections about the derivatisation modes, derivatisation to improve...

Read More thumbnail image: Derivatisation for separation and detection in capillary electrophoresis 20152017

Validated LC–MS/MS method for quantitation of demethylbellidifolin in rat plasma and its application to pharmacokinetic and bioavailability studies

Published: Aug 24, 2017

Author(s): Jie Zhang, Huiyu Yan, Xiaoyu Qu, Wei Zhou

Journal: Biomedical Chromatography

Abstract Demethylbellidifolin, a major xanthone compound of Swertia davidi Franch, shows many beneficial pharmacological effects including antioxidation, anti‐inflammation, anti‐fibrosis and cardiovascular protection effects. In this research, a rapid and sensitive LC–MS/MS method for the quantitative analysis of demethylbellidifolin in rat plasma was developed. The demethylbellidifolin and internal standard of aurantio‐obtusin were extracted...

Read More thumbnail image: Validated LCMSMS method for quantitation of demethylbellidifolin in rat plasma and its application to pharmacokinetic and bioavailability studies

Tip‐enhanced Raman scattering of graphene

Published: Aug 24, 2017

Author(s): Ryan Beams

Journal: Journal of Raman Spectroscopy

This article reviews the mechanism of tip‐enhanced Raman spectroscopy (TERS) and its importance for characterizing graphene. The theoretical foundation of TERS and experimental implementation are discussed. Conventionally, Raman scattering is treated as a spatially incoherent process where the total signal is proportional to the scattering volume. However, in the near‐field regime, the scattered fields can add coherently because the TERS...

Read More thumbnail image: Tipenhanced Raman scattering of graphene

Heroin in Malaysia and Singapore

Published: Aug 24, 2017

Author(s): Maimonah Sulaiman, Vanitha Kunalan, Angeline T. W. Yap, Wendy J. L. Lim, Joey Joo Yee Ng, Samuel Wei Xiong Loh, K. B. Chan

Journal: Drug Testing and Analysis

Abstract Clandestine heroin laboratories have been a feature of the Malaysian illicit drug scene since soon after the abuse of heroin emerged in 1972. The first few clandestine heroin laboratories which synthesised heroin via the acetylation of imported morphine were uncovered in 1973 and 1977. By the mid‐1980s, this type of laboratory was replaced by heroin‐cutting laboratories whereby imported high‐grade heroin was cut to street...

Read More thumbnail image: Heroin in Malaysia and Singapore

Development and validation of an LC–MS/MS method for the simultaneous quantification of seven constituents in rat plasma and application in a pharmacokinetic study of the Zaoren Anshen prescription

Published: Aug 24, 2017

Author(s): Ajing Zhao, Li Zhang, Rong Li, Jiao Shang, Huihui Yi, Yuan Wang, Dian Zhang, Shixiang Wang, Minfeng Fang

Journal: Biomedical Chromatography

Abstract A sensitive, specific and accurate liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed and validated for the simultaneous determination of seven constituents of the Zaoren Anshen prescription (ZAP) in rat plasma after oral administration of the ZAP: spinosin, salvianic acid A, 6′′′‐feruloylspinosin, protocatechualdehyde, salvianolic acid B, schisandrin and deoxyschisandrin. The plasma samples and...

Read More thumbnail image: Development and validation of an LCMSMS method for the simultaneous quantification of seven constituents in rat plasma and application in a pharmacokinetic study of the Zaoren Anshen prescription
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