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Assessing the oxidation states and structural stability of the Ce analogue of brannerite

Published: Jul 4, 2017

Author(s): Esther Rani Aluri, Lisa M. Bachiu, Andrew P. Grosvenor, Scott H. Forbes, John E. Greedan

Journal: Surface and Interface Analysis

The Ce‐containing analogue of brannerite (ie, UTi2O6) was previously considered to be stoichiometric (ie, CeTi2O6); however, it has recently been determined that the material is O deficient. This oxygen‐deficient material has been suggested to be charged balanced by the presence of a minor concentration of Ce3+ or by the A‐site being cation deficient with the Ce oxidation state being 4+. A variety of Ti‐containing oxides (including brannerite) have...

Read More thumbnail image: Assessing the oxidation states and structural stability of the Ce analogue of brannerite

Development of a validated UPLC–MS/MS method for determination of humantenmine in rat plasma and its application in pharmacokinetics and bioavailability studies

Published: Jul 3, 2017

Author(s): Yanxian Hu, Minghao Chen, Zhaoyu Wang, Yao Lan, Lan Tang, Menghua Liu, Jie Zhao, Ming Hu, Lulu Zhang, Ling Ye

Journal: Biomedical Chromatography

Abstract Humantenmine (HMT), the most toxic compound isolated from Gelsemium elegans Benth, is a well‐known active herbal compound. A rapid and sensitive ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was developed and validated to estimate the absolute oral bioavailability of HMT in rats. Quantification was performed by multiple reaction monitoring using electrospray ionization operated in positive ion...

Read More thumbnail image: Development of a validated UPLCMSMS method for determination of humantenmine in rat plasma and its application in pharmacokinetics and bioavailability studies

Quantification of morusin using LC–MS in rat plasma: Application to a pharmacokinetic study

Published: Jun 29, 2017

Author(s): Zhipeng Deng, Xiaohui Sun, Shenbao Yang, Lei Zhang, Peilu Sun, Xuepeng Teng, Hao Zhong

Journal: Biomedical Chromatography

Abstract A sensitive LC–MS method was developed for the quantification of morusin in rat plasma using praeruptorin C as internal standard. After extraction with diethyl ether, post‐treatment samples were chromatographed on a Hypersil C18 column. An isocratic mobile phase consisting of methanol–water (70:30, v/v) was applied at a flow rate of 0.4 mL/min. Detection was performed via electrospray ionization source with positive ion mode using...

Read More thumbnail image: Quantification of morusin using LCMS in rat plasma Application to a pharmacokinetic study

Single‐step isolation of embelin using high‐performance countercurrent chromatography and determination of the fatty acid composition of seeds of Embelia schimperi

Published: Jun 29, 2017

Author(s): Minaleshewa Atlabachew, Bewketu Mehari, Sandra Combrinck, Robert McCrindle

Journal: Biomedical Chromatography

Abstract Embelin (2,5‐dihydroxy‐3‐undecyl‐p‐benzoquinone) is known for its potent anthelmintic activity, but also for wound‐healing, antidiabetic, anticonvulsant, antitumour, anti‐inflammatory, analgesic, hepatoprotective, antioxidant, antibacterial and antispermatogenic activities. A high‐performance countercurrent chromatography method was developed for the purification of embelin from an extract of the seeds of Embelia schimperi fruit. The...

Read More thumbnail image: Singlestep isolation of embelin using highperformance countercurrent chromatography and determination of the fatty acid composition of seeds of Embelia schimperi

Hydrophilic interaction and reversed‐phase ultra‐performance liquid chromatography TOF‐MS for metabolomic analysis of Veratrum nigrum ‐induced cardiotoxicity

Published: Jun 29, 2017

Author(s): Ziheng Wei, Xu Dong, Hanzhe Zhang, Songyan Gao, Wei Shi, Feng Yang, Xin Dong

Journal: Biomedical Chromatography

Abstract The acute cardiotoxicity induced by Veratrum nigrum (VN) is explored by analyzing heart tissue metabolic profiles in mouse models and applying reversed‐phase liquid chromatography mass spectrometry and hydrophilic interaction liquid chromatography mass spectrometry that are based on ultra‐high‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry. An animal model of acute heart injury was established in ...

Read More thumbnail image: Hydrophilic interaction and reversedphase ultraperformance liquid chromatography TOFMS for metabolomic analysis of Veratrum nigrum induced cardiotoxicity

X‐ray photoelectron study of oxides formed on Ni metal and Ni‐Cr alloy surfaces under electrochemical control at 25 °C and 150 °C

Published: Jun 29, 2017

Author(s): B. P. Payne, P. G. Keech, N. S. McIntyre

Journal: Surface and Interface Analysis

Abstract The oxide chemical composition on metallic Ni and NiCr alloy electrodes has been studied for changes in simulated reactor coolant solution chemistry, through a range of oxidizing potentials and pH settings at 25 °C and 150 °C. Even under strongly reducing conditions, the Ni surface has a 2‐nm layer of oxide and hydroxide from which further oxides form, depending on the subsequent oxidative step. For basic (normal...

Read More thumbnail image: Xray photoelectron study of oxides formed on Ni metal and NiCr alloy surfaces under electrochemical control at 25C and 150C

Archeological ceramic artifacts characterization through computed microtomography and X ‐ray fluorescence

Published: Jun 29, 2017

Author(s): A.S. Machado, D.F. Oliveira, H.S. Gama Filho, R. Latini, A.V.B. Bellido, J.T. Assis, M.J. Anjos, R.T. Lopes

Journal: X-Ray Spectrometry

The analysis of ceramic materials has been proven to be an indispensable tool for indirectly approaching past people and societies through their cultural remnants, allowing inferences about their technology, and their interaction with their surrounding physical and social environments. Pottery products acquire their characteristic properties during the manufacture process. Compositional (mineralogical and chemical) and microstructural...

Read More thumbnail image: Archeological ceramic artifacts characterization through computed microtomography and X ray fluorescence

The comparative verification of calibration curve and background fundamental parameter methods for impurity analysis in drug materials

Published: Jun 29, 2017

Author(s): Hiroaki Furukawa, Naoto Ichimaru, Keijiro Suzuki, Makoto Nishino, Jennifer Broughton, Johan Leinders, Hirotomo Ochi

Journal: X-Ray Spectrometry

The United States Pharmacopeia (USP) has established general analysis guidelines of X‐Ray fluorescence (XRF) methodology in chapter , XRF spectrometry. Meanwhile, the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH Q3D) guideline, presenting a policy for limiting 24 elements such as Cd, Pb, and As in drug products and pharmaceutical ingredients, has now reached...

Read More thumbnail image: The comparative verification of calibration curve and background fundamental parameter methods for impurity analysis in drug materials

Data quantification procedures for a bench‐top elemental microimaging of brain specimens for the clinical studies on the obesity treatment by transcranial direct current brain stimulation

Published: Jun 28, 2017

Author(s): Agata Ziomber, Artur D. Surowka, Pawel Wrobel, Magdalena Szczerbowska‐Boruchowska

Journal: X-Ray Spectrometry

A decision on how to choose the appropriate data quantification procedure lies behind the most serious methodological challenges in microbeam X‐ray fluorescence imaging of tissue slices. This problem becomes particularly cumbersome whenever intermediate thickness samples must be utilized in order to increase the signal to noise ratio. Noteworthy, it is always the case when laboratory‐based X‐ray sources are used, which arises from their...

Read More thumbnail image: Data quantification procedures for a benchtop elemental microimaging of brain specimens for the clinical studies on the obesity treatment by transcranial direct current brain stimulation

Building connectomes using diffusion MRI: why, how and but

Published: Jun 27, 2017

Author(s): Stamatios N. Sotiropoulos, Andrew Zalesky

Journal: NMR in Biomedicine

Why has diffusion MRI become a principal modality for mapping connectomes in vivo? How do different image acquisition parameters, fiber tracking algorithms and other methodological choices affect connectome estimation? What are the main factors that dictate the success and failure of connectome reconstruction? These are some of the key questions that we aim to address in this review. We provide an overview of the key methods that can be used to...

Read More thumbnail image: Building connectomes using diffusion MRI why how and but

Trypsin inhibitor screening in traditional Chinese medicine by using an immobilized enzyme microreactor in capillary and molecular docking study

Published: Jun 23, 2017

Author(s): Mengxia Cheng, Zilin Chen

Journal: Journal of Separation Science

A trypsin immobilized enzyme microreactor was successfully prepared in capillary for studying enzyme kinetics of trypsin and online screening of trypsin inhibitors from traditional Chinese medicine through capillary electrophoresis. Trypsin was immobilized on the inner wall at the inlet of the capillary treated with polydopamine. The rest of the capillary was used as a separation channel. The parameters including the separation efficiency...

Read More thumbnail image: Trypsin inhibitor screening in traditional Chinese medicine by using an immobilized enzyme microreactor in capillary and molecular docking study

Uncorrelated component analysis on manifold for statistical process monitoring

Published: Jun 23, 2017

Author(s): Qilong Jia, Yingwei Zhang, Lirong Zhai, Lin Feng

Journal: Journal of Chemometrics

A novel process modeling approach referred to as locally invariant uncorrelated component analysis (LIUCA) is proposed for the purpose of statistical process monitoring. The contributions are as follows: (1) LIUCA intends to find a part‐based representation subspace in which two data points are close to each other, if they are close in the k‐nearest neighbor graph; (2) LIUCA can exploit the geometrical structure of the data space, which will improve...

Read More thumbnail image: Uncorrelated component analysis on manifold for statistical process monitoring

Ephedra alkaloid contents of Chinese herbal formulae sold in Taiwan

Published: Jun 23, 2017

Author(s): Chih‐Wei Chang, Szu‐Yun Hsu, Guan‐Qian Huang, Mei‐Chich Hsu

Journal: Drug Testing and Analysis

Consumption of Ephedra alkaloids is prohibited in‐competition by the World Anti‐Doping Agency (WADA). In Taiwan, colds are often treated with Chinese herbal formulae containing Herba Ephedrae. We screened products sold in Taiwan and preliminarily assessed their relationships with WADA threshold violations. Fifty‐six concentrated powder products, including 19 Chinese herbal formulae that contained Herba Ephedrae, were collected. The...

Read More thumbnail image: Ephedra alkaloid contents of Chinese herbal formulae sold in Taiwan

Influence of bleaching and coloring on ethyl glucuronide content in human hair

Published: Jun 22, 2017

Author(s): Silvana Petzel‐Witt, Werner Pogoda, Cora Wunder, Alexander Paulke, Manfred Schubert‐Zsilavecz, Stefan W. Toennes

Journal: Drug Testing and Analysis

Ethyl glucuronide (EtG) is increasingly used in forensic toxicology as a marker for alcohol use in analyses of hair samples, especially in abstinence control. Some cosmetic treatments are considered to markedly reduce the EtG content. In view of especially many women with coloured hair the present study was performed to further investigate the effect of a variety of colouring procedures (bleaching, tinting, permanent and semi‐permanent...

Read More thumbnail image: Influence of bleaching and coloring on ethyl glucuronide content in human hair

Semi‐high‐throughput isolation and N ‐glycan analysis of human fibrinogen using monolithic supports bearing monoclonal anti‐human fibrinogen antibodies

Published: Jun 21, 2017

Author(s): Urška Vidic, Irena Trbojević‐Akmačić, Urh Černigoj, Malena Albers, Jernej Gašperšič, Maja Pučić‐Baković, Jana Vidič, Aleš Štrancar, Gordan Lauc

Journal: ELECTROPHORESIS

Fibrinogen (FIB) is a secretory glycoprotein synthesized by hepatocytes that has a key role in blood clotting. Its glycosylation has not been studied in detail and little is known about the biological variability of FIB N‐glycosylation, mainly due to the lack of fast, simple, and robust approaches to purify FIB from blood plasma samples. In recent years, customised chromatographic monoliths have been used for a variety of biological applications due...

Read More thumbnail image: Semihighthroughput isolation and N glycan analysis of human fibrinogen using monolithic supports bearing monoclonal antihuman fibrinogen antibodies

Relationship between the UPLC‐Q‐TOF‐MS fingerprinted constituents from Daphne genkwa and their anti‐inflammatory, anti‐oxidant activities

Published: Jun 20, 2017

Author(s): Wen‐Juan Du, Jun Ji, Ling Wang, Xin‐Yi Lan, Jia Li, Jun‐Qiu Lei, Xin He, Chun‐Feng Zhang, Wen‐Zhe Huang, Zhen‐Zhong Wang, Wei Xiao, Chong‐Zhi Wang, Chun‐Su Yuan

Journal: Biomedical Chromatography

Abstract Daphne genkwa Sieb.et Zucc. is a well‐known medicinal plant. This study was designed to apply the ultra‐high performance liquid chromatography system to establish a quality control method for D. genkwa. Data revealed that there were 15 common peaks in 10 batches of D. genkwa Sieb. Et Zucc. (Thymelaeaceae) from different provinces of China. On this basis, the fingerprint chromatogram was established to provide references for quality...

Read More thumbnail image: Relationship between the UPLCQTOFMS fingerprinted constituents from Daphne genkwa and their antiinflammatory antioxidant activities

Photochemistry of single particles using acoustic levitation coupled with Raman microspectrometry

Published: Jun 20, 2017

Author(s): Yeny A. Tobon, Samantha Seng, Lorena A. Picone, Yanina B. Bava, Luciana C. Juncal, Myriam Moreau, Rosana M. Romano, Jacques Barbillat, Sophie Sobanska

Journal: Journal of Raman Spectroscopy

The photoreactivity of single particles with atmospheric interest was studied by using an acoustic levitation system coupled to Raman microspectrometry. Both, inorganic and organic single particle phototransformation has been investigated without any surface contact. The Raman microspectrometry has suitably provided the identification, the chemical heterogeneity as well as the formation rates of products. Complex surface limited processes...

Read More thumbnail image: Photochemistry of single particles using acoustic levitation coupled with Raman microspectrometry

Raman hyperspectral imaging and analysis of fat spreads

Published: Jun 20, 2017

Author(s): G. Dalen, E. J. J. Velzen, P. C. M. Heussen, M. Sovago, K. F. Malssen, J. P. M. Duynhoven

Journal: Journal of Raman Spectroscopy

The microstructure of fat spreads is of fundamental importance to their sensorial properties such as texture, mouthfeel and spreadability. Fat spreads are water in oil emulsions, with a continuous phase supported by a fat crystal network. Confocal Raman microscopy offers the possibility for the spatial mapping of the microstructure of fat spreads: It can distinguish the solid and liquid phases of the lipids and the emulsifiers present at...

Read More thumbnail image: Raman hyperspectral imaging and analysis of fat spreads

Identification, isolation, and synthesis of seven novel impurities of anti‐diabetic drug Repaglinide

Published: Jun 20, 2017

Author(s): Prasad Kancherla, Srinivas Keesari, Pallavi Alegete, Mukkanti Khagga, Parthasarathi Das

Journal: Drug Testing and Analysis

Seven unknown impurities in Repaglinide bulk drug batches at below 0.1% (ranging from 0.05 to 0.10%) were detected by an ultra‐performance liquid chromatographic (UPLC) method. These impurities were isolated from the crude sample of Repaglinide using preparative high performance liquid chromatography (prep‐HPLC). Based on liquid chromatography‐electrospray ionization‐mass spectrometry (LC‐ESI/MS) study, the chemical structures of seven...

Read More thumbnail image: Identification isolation and synthesis of seven novel impurities of antidiabetic drug Repaglinide

Analysis of RBC‐microparticles in stored whole blood bags – a promising marker to detect blood doping in sports?

Published: Jun 20, 2017

Author(s): Sven Christian Voss, Morana Jaganjac, Amna Mohamed Al‐Thani, Jean‐Charles Grivel, Christophe Michel Raynaud, Hind Al‐Jaber, Afnan Saleh Al‐Menhali, Zeyed Ahmad Merenkov, Mohammed Alsayrafi, Aishah Latiff, Costas Georgakopoulos

Journal: Drug Testing and Analysis

Blood doping in sports is prohibited by the World Anti‐Doping Agency (WADA). To find a possible biomarker for the detection of blood doping, we investigated the changes in blood stored in CPDA‐1 blood bags of eight healthy subjects who donated one unit of blood. Aliquots were taken on days 0, 14, and 35. Platelet‐free plasma was prepared and stored at −80°C until analysis on a flow cytometer dedicated for the analysis of microparticles...

Read More thumbnail image: Analysis of RBCmicroparticles in stored whole blood bags  a promising marker to detect blood doping in sports
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