EarlyView Articles

Skip to Navigation

The very latest articles from the scientific literature
on Wiley Online Library...


You can keep up-to date on these EarlyView articles, which focus on spectroscopy
and separation science:

Earlyview RSS Feed

rss

Filter by Journal

Browse By Journal

Simultaneous determination of tryptophan, kynurenine, kynurenic acid, xanthurenic acid and 5‐hydroxytryptamine in human plasma by LC‐MS/MS and its application to acute myocardial infarction monitoring

Published: Dec 26, 2017

Author(s): Qing Tong, Jia Song, Guangjie Yang, Li Fan, Wei Xiong, Jianguo Fang

Journal: Biomedical Chromatography

Abstract Reliable methods for the determination of tryptophan and its metabolites are vital to the monitoring of biochemical states during the initiation and progression of cardiovascular disease. In the present study, a single‐run liquid chromatography–tandem mass spectrometry (LC‐MS/MS) method was developed for the simultaneous determination of tryptophan (Trp) and its metabolites, including kynurenine (Kyn), kynurenic acid (KA),...

Read More thumbnail image: Simultaneous determination of tryptophan kynurenine kynurenic acid xanthurenic acid and 5hydroxytryptamine in human plasma by LCMSMS and its application to acute myocardial infarction monitoring

Pharmacokinetics and tissue distribution of pefloxacin mesylate in chickens

Published: Dec 26, 2017

Author(s): Shuqian Lin, Guiming Li, Zengcheng Zhao, Jian Fu, Minyan Feng, Minxun Song, Zhongli Huang, Shifa Yang, Shuli Wang, Renzhong Wan

Journal: Biomedical Chromatography

Abstract A specific, sensitive and stable high‐performance liquid chromatography (HPLC)‐based analytical method was established to determine the level of pefloxacin mesylate (PM) in the plasma and various tissues of chickens. Chickens were randomly assigned to 12 equal experiment groups, including 11 treatment groups and one control group. The chickens in the treatment groups received oral administration of PM and were sacrificed at...

Read More thumbnail image: Pharmacokinetics and tissue distribution of pefloxacin mesylate in chickens

Pharmacokinetics and tissue distribution of pefloxacin mesylate in chickens

Published: Dec 26, 2017

Author(s): Shuqian Lin, Guiming Li, Zengcheng Zhao, Jian Fu, Minyan Feng, Minxun Song, Zhongli Huang, Shifa Yang, Shuli Wang, Renzhong Wan

Journal: Biomedical Chromatography

Abstract A specific, sensitive and stable high‐performance liquid chromatography (HPLC)‐based analytical method was established to determine the level of pefloxacin mesylate (PM) in the plasma and various tissues of chickens. Chickens were randomly assigned to 12 equal experiment groups, including 11 treatment groups and one control group. The chickens in the treatment groups received oral administration of PM and were sacrificed at...

Read More thumbnail image: Pharmacokinetics and tissue distribution of pefloxacin mesylate in chickens

Development and validation of an LC‐MS/MS method for the determination of a novel thienoquinolin urea transporter inhibitor PU‐48 in rat plasma and its application to a pharmacokinetic study

Published: Dec 22, 2017

Author(s): Zhi‐Yuan Zhang, Xin Wang, Dan Liu, Hua Zhang, Qiang Zhang, Ying‐Yuan Lu, Pu Li, Ya‐Qing Lou, Bao‐Xue Yang, Chuang Lu, Ya‐Xin Lou, Guo‐Liang Zhang

Journal: Biomedical Chromatography

Abstract A specific, sensitive and stable high‐performance liquid chromatographic–tandem mass spectrometry (LC‐MS/MS) method was developed and validated for the quantitative determination of methyl 3‐amino‐6‐methoxythieno [2,3‐b]quinoline‐2‐carboxylate (PU‐48), a novel diuretic thienoquinolin urea transporter inhibitor in rat plasma. In this method, the chromatographic separation of PU‐48 was achieved with a reversed‐phase C18...

Read More thumbnail image: Development and validation of an LCMSMS method for the determination of a novel thienoquinolin urea transporter inhibitor PU48 in rat plasma and its application to a pharmacokinetic study

Development and validation of an LC‐MS/MS method for the determination of a novel thienoquinolin urea transporter inhibitor PU‐48 in rat plasma and its application to a pharmacokinetic study

Published: Dec 22, 2017

Author(s): Zhi‐Yuan Zhang, Xin Wang, Dan Liu, Hua Zhang, Qiang Zhang, Ying‐Yuan Lu, Pu Li, Ya‐Qing Lou, Bao‐Xue Yang, Chuang Lu, Ya‐Xin Lou, Guo‐Liang Zhang

Journal: Biomedical Chromatography

Abstract A specific, sensitive and stable high‐performance liquid chromatographic–tandem mass spectrometry (LC‐MS/MS) method was developed and validated for the quantitative determination of methyl 3‐amino‐6‐methoxythieno [2,3‐b]quinoline‐2‐carboxylate (PU‐48), a novel diuretic thienoquinolin urea transporter inhibitor in rat plasma. In this method, the chromatographic separation of PU‐48 was achieved with a reversed‐phase C18...

Read More thumbnail image: Development and validation of an LCMSMS method for the determination of a novel thienoquinolin urea transporter inhibitor PU48 in rat plasma and its application to a pharmacokinetic study

Selective extraction of morphine from biological fluids by magnetic molecularly imprinted polymers and determination using UHPLC with diode array detection

Published: Dec 22, 2017

Author(s): Mahdiyeh Ebrahimi Rahmani, Mehdi Ansari, Maryam Kazemipour, Mohammadreza Nateghi

Journal: Journal of Separation Science

Abstract The determination of morphine concentration in the blood and urine is necessary for patients and recruitment purposes. Herein, a magnetic molecularly imprinted polymer for selective and efficient extraction of morphine from biological samples was synthesized by using a core–shell method. Fe3O4 nanoparticles were coated with SiO2‐NH2. The molecularly imprinted polymer was coated on the Fe3O4/SiO2‐NH2 surface by the copolymerization of...

Read More thumbnail image: Selective extraction of morphine from biological fluids by magnetic molecularly imprinted polymers and determination using UHPLC with diode array detection

Selective extraction of morphine from biological fluids by magnetic molecularly imprinted polymers and determination using UHPLC with diode array detection

Published: Dec 22, 2017

Author(s): Mahdiyeh Ebrahimi Rahmani, Mehdi Ansari, Maryam Kazemipour, Mohammadreza Nateghi

Journal: Journal of Separation Science

Abstract The determination of morphine concentration in the blood and urine is necessary for patients and recruitment purposes. Herein, a magnetic molecularly imprinted polymer for selective and efficient extraction of morphine from biological samples was synthesized by using a core–shell method. Fe3O4 nanoparticles were coated with SiO2‐NH2. The molecularly imprinted polymer was coated on the Fe3O4/SiO2‐NH2 surface by the copolymerization of...

Read More thumbnail image: Selective extraction of morphine from biological fluids by magnetic molecularly imprinted polymers and determination using UHPLC with diode array detection

Identification of Salvia species using high‐performance liquid chromatography combined with chemical pattern recognition analysis

Published: Dec 22, 2017

Author(s): Yang Wang, Kun Jiang, Lijun Wang, Dongqi Han, Guo Yin, Jue Wang, Bin Qin, Shaoping Li, Tiejie Wang

Journal: Journal of Separation Science

Abstract Salvia miltiorrhiza, also known as Danshen, is a widely used traditional Chinese medicine for the treatment of cardiovascular diseases and hematological abnormalities. The root and rhizome of Salvia przewalskii and Salvia yunnanensis have been found as substitutes for Salvia miltiorrhiza in the market. In this study, the chemical information of 14 major compounds in Salvia miltiorrhiza and its substitutes were determined using a high‐performance...

Read More thumbnail image: Identification of Salvia species using highperformance liquid chromatography combined with chemical pattern recognition analysis

Comparisons of glyphosate adsorption properties of different functional Cr‐based metal–organic frameworks

Published: Dec 22, 2017

Author(s): Dan Feng, Yan Xia

Journal: Journal of Separation Science

Abstract A Cr‐based metal–organic framework, namely, MIL‐101(Cr), was modified with amino (NH2–) and urea (UR2–) groups, and the materials were evaluated as adsorbents for glyphosate, and a comparison with commercial activated carbon was also discussed. The effects of the adsorption factors, such as adsorbent concentration, adsorption time, pH and ionic strength were mainly investigated. The results showed that a pseudo‐second‐order rate...

Read More thumbnail image: Comparisons of glyphosate adsorption properties of different functional Crbased metalorganic frameworks

Quantitative analysis of Mo–Si–B alloy phases with wavelength dispersive spectroscopy (WDS–SEM)

Published: Dec 21, 2017

Author(s): P.M. Kellner, H. Dijkstra, U. Glatzel

Journal: X-Ray Spectrometry

Mo–Si–B alloys show great potential as high temperature materials. Due to peak overlapping of B‐Kα and Mo‐Mζ, analyzing these alloys with microanalysis presents a real challenge. This paper describes the analytical methodology used to qualify and quantify the boron content in these alloys without stoichiometric reference samples by the use of a single parallel‐beam wavelength dispersive spectrometer. Characterization of boron is performed by using a...

Read More thumbnail image: Quantitative analysis of MoSiB alloy phases with wavelength dispersive spectroscopy WDSSEM

Stress degradation of edaravone: Separation, isolation and characterization of major degradation products

Published: Dec 21, 2017

Author(s): Madhuri Baghel, Sadhana J. Rajput

Journal: Biomedical Chromatography

Abstract In the present study the International Conference on Harmonization‐prescribed stress degradation was carried out to study the degradation profile of edaravone. To establish a Quality by Design (QbD)‐assisted stability‐indicating assay, the reaction solutions in which different degradation products were formed were mixed. Plackett Burman and central composite design were used to screen and optimize experimental variables to...

Read More thumbnail image: Stress degradation of edaravone Separation isolation and characterization of major degradation products

Stress degradation of edaravone: Separation, isolation and characterization of major degradation products

Published: Dec 21, 2017

Author(s): Madhuri Baghel, Sadhana J. Rajput

Journal: Biomedical Chromatography

Abstract In the present study the International Conference on Harmonization‐prescribed stress degradation was carried out to study the degradation profile of edaravone. To establish a Quality by Design (QbD)‐assisted stability‐indicating assay, the reaction solutions in which different degradation products were formed were mixed. Plackett Burman and central composite design were used to screen and optimize experimental variables to...

Read More thumbnail image: Stress degradation of edaravone Separation isolation and characterization of major degradation products

Parallel probing of drug uptake of single cancer cells on a microfluidic device

Published: Dec 21, 2017

Author(s): Yoonsun Yang, Séverine Le Gac, Leon WMM Terstappen, Hoon Suk Rho

Journal: ELECTROPHORESIS

Abstract Drug resistance is frequently developing during treatment of cancer patients. Intracellular drug uptake is one of the important characteristics to understand mechanism of drug resistance. However, the heterogeneity of cancer cells requires the investigation of drug uptake at the single cell level. Here, we developed a microfluidic device for parallel probing of drug uptake. We combined a v‐type valve and peristaltic pumping...

Read More thumbnail image: Parallel probing of drug uptake of single cancer cells on a microfluidic device

Integrated microfluidic biosensing platform for simultaneous confocal microscopy and electrophysiological measurements on bilayer lipid membranes and ion channels

Published: Dec 21, 2017

Author(s): Verena C. Schulze Greiving, Hans L. Boer, Johan G. Bomer, Albert den Berg, Séverine Gac

Journal: ELECTROPHORESIS

Abstract Combining high‐resolution imaging and electrophysiological recordings is key for various types of experimentation on lipid bilayers and ion channels. Here, we propose an integrated biosensing platform consisting of a microfluidic cartridge and a dedicated chip‐holder to conduct such dual measurements on suspended lipid bilayers, in a user‐friendly manner. To illustrate the potential of the integrated platform, we...

Read More thumbnail image: Integrated microfluidic biosensing platform for simultaneous confocal microscopy and electrophysiological measurements on bilayer lipid membranes and ion channels

CE‐XRF–initial steps toward a non‐invasive elemental sensitive detector for liquid separations

Published: Dec 21, 2017

Author(s): Inger Marie Bergø Tyssebotn, Andreas Fittschen, Ursula Elisabeth Adriane Fittschen

Journal: ELECTROPHORESIS

Abstract The toxicity, bioavailability, and mobilization of elements within the biosphere is dependent on its species. CE has emerged as a strong separation technique for elemental speciation. Conventionally, CE has been coupled with UV‐vis, C4D, PIXE (proton‐induced X‐ray emission), and ICP‐MS. UV‐vis and C4D are not elemental sensitive detection methods, PIXE requires the etching of the detection window resulting in a very brittle capillary,...

Read More thumbnail image: CEXRFinitial steps toward a noninvasive elemental sensitive detector for liquid separations

CE‐XRF–initial steps toward a non‐invasive elemental sensitive detector for liquid separations

Published: Dec 21, 2017

Author(s): Inger Marie Bergø Tyssebotn, Andreas Fittschen, Ursula Elisabeth Adriane Fittschen

Journal: ELECTROPHORESIS

Abstract The toxicity, bioavailability, and mobilization of elements within the biosphere is dependent on its species. CE has emerged as a strong separation technique for elemental speciation. Conventionally, CE has been coupled with UV‐vis, C4D, PIXE (proton‐induced X‐ray emission), and ICP‐MS. UV‐vis and C4D are not elemental sensitive detection methods, PIXE requires the etching of the detection window resulting in a very brittle capillary,...

Read More thumbnail image: CEXRFinitial steps toward a noninvasive elemental sensitive detector for liquid separations

Evaluation of phenolic composition and antioxidant activity changes in olive flowers during development using HPLC/DAD and LC‐MS/MS

Published: Dec 21, 2017

Author(s): Ons Rekik, Amir Ben Mansour, Mohamed Bouaziz

Journal: ELECTROPHORESIS

Abstract Olive fruit and leaves have been extensively studied for their chemical compositions and biological activities. However, less attention has been given to its flowers. The present research was achieved on Tunisian olive flowers. It aimed at studying the effects of flower development on phenolic compounds and antioxidant activity. The extracts were analyzed using high performance liquid chromatography coupled to diode array...

Read More thumbnail image: Evaluation of phenolic composition and antioxidant activity changes in olive flowers during development using HPLCDAD and LCMSMS

Evaluation of phenolic composition and antioxidant activity changes in olive flowers during development using HPLC/DAD and LC‐MS/MS

Published: Dec 21, 2017

Author(s): Ons Rekik, Amir Ben Mansour, Mohamed Bouaziz

Journal: ELECTROPHORESIS

Abstract Olive fruit and leaves have been extensively studied for their chemical compositions and biological activities. However, less attention has been given to its flowers. The present research was achieved on Tunisian olive flowers. It aimed at studying the effects of flower development on phenolic compounds and antioxidant activity. The extracts were analyzed using high performance liquid chromatography coupled to diode array...

Read More thumbnail image: Evaluation of phenolic composition and antioxidant activity changes in olive flowers during development using HPLCDAD and LCMSMS

Separation and determination of polyurethane amine catalysts in polyether polyols by using UHPLC–Q‐TOF‐MS on a reversed‐phase/cation‐exchange mixed‐mode column

Published: Dec 21, 2017

Author(s): Jiaxiao Li, Marcel Zhu

Journal: Journal of Separation Science

Abstract A simple, selective, and accurate ultra‐high performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry method was established and validated for the efficient separation and quantification of polyurethane amine catalysts in polyether polyols. Amine catalysts were primarily separated in polyether polyol‐based sample by solid‐phase extraction, and further baseline separated on a...

Read More thumbnail image: Separation and determination of polyurethane amine catalysts in polyether polyols by using UHPLCQTOFMS on a reversedphasecationexchange mixedmode column

Separation and determination of polyurethane amine catalysts in polyether polyols by using UHPLC–Q‐TOF‐MS on a reversed‐phase/cation‐exchange mixed‐mode column

Published: Dec 21, 2017

Author(s): Jiaxiao Li, Marcel Zhu

Journal: Journal of Separation Science

Abstract A simple, selective, and accurate ultra‐high performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry method was established and validated for the efficient separation and quantification of polyurethane amine catalysts in polyether polyols. Amine catalysts were primarily separated in polyether polyol‐based sample by solid‐phase extraction, and further baseline separated on a...

Read More thumbnail image: Separation and determination of polyurethane amine catalysts in polyether polyols by using UHPLCQTOFMS on a reversedphasecationexchange mixedmode column
Page:   Prev 18 19 20 21 22 23 24 25 26 27 28 Next

Social Links

Share This Links

Bookmark and Share

Microsites

Suppliers Selection
Societies Selection

Banner Ad

Click here to see
all job opportunities

Most Viewed

Copyright Information

Interested in separation science? Visit our sister site separationsNOW.com

Copyright © 2018 John Wiley & Sons, Inc. All Rights Reserved