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Semi‐high‐throughput isolation and N ‐glycan analysis of human fibrinogen using monolithic supports bearing monoclonal anti‐human fibrinogen antibodies

Published: Jun 21, 2017

Author(s): Urška Vidic, Irena Trbojević‐Akmačić, Urh Černigoj, Malena Albers, Jernej Gašperšič, Maja Pučić‐Baković, Jana Vidič, Aleš Štrancar, Gordan Lauc

Journal: ELECTROPHORESIS

Fibrinogen (FIB) is a secretory glycoprotein synthesized by hepatocytes that has a key role in blood clotting. Its glycosylation has not been studied in detail and little is known about the biological variability of FIB N‐glycosylation, mainly due to the lack of fast, simple, and robust approaches to purify FIB from blood plasma samples. In recent years, customised chromatographic monoliths have been used for a variety of biological applications due...

Read More thumbnail image: Semihighthroughput isolation and N glycan analysis of human fibrinogen using monolithic supports bearing monoclonal antihuman fibrinogen antibodies

Relationship between the UPLC‐Q‐TOF‐MS fingerprinted constituents from Daphne genkwa and their anti‐inflammatory, anti‐oxidant activities

Published: Jun 20, 2017

Author(s): Wen‐Juan Du, Jun Ji, Ling Wang, Xin‐Yi Lan, Jia Li, Jun‐Qiu Lei, Xin He, Chun‐Feng Zhang, Wen‐Zhe Huang, Zhen‐Zhong Wang, Wei Xiao, Chong‐Zhi Wang, Chun‐Su Yuan

Journal: Biomedical Chromatography

Abstract Daphne genkwa Sieb.et Zucc. is a well‐known medicinal plant. This study was designed to apply the ultra‐high performance liquid chromatography system to establish a quality control method for D. genkwa. Data revealed that there were 15 common peaks in 10 batches of D. genkwa Sieb. Et Zucc. (Thymelaeaceae) from different provinces of China. On this basis, the fingerprint chromatogram was established to provide references for quality...

Read More thumbnail image: Relationship between the UPLCQTOFMS fingerprinted constituents from Daphne genkwa and their antiinflammatory antioxidant activities

Photochemistry of single particles using acoustic levitation coupled with Raman microspectrometry

Published: Jun 20, 2017

Author(s): Yeny A. Tobon, Samantha Seng, Lorena A. Picone, Yanina B. Bava, Luciana C. Juncal, Myriam Moreau, Rosana M. Romano, Jacques Barbillat, Sophie Sobanska

Journal: Journal of Raman Spectroscopy

The photoreactivity of single particles with atmospheric interest was studied by using an acoustic levitation system coupled to Raman microspectrometry. Both, inorganic and organic single particle phototransformation has been investigated without any surface contact. The Raman microspectrometry has suitably provided the identification, the chemical heterogeneity as well as the formation rates of products. Complex surface limited processes...

Read More thumbnail image: Photochemistry of single particles using acoustic levitation coupled with Raman microspectrometry

Raman hyperspectral imaging and analysis of fat spreads

Published: Jun 20, 2017

Author(s): G. Dalen, E. J. J. Velzen, P. C. M. Heussen, M. Sovago, K. F. Malssen, J. P. M. Duynhoven

Journal: Journal of Raman Spectroscopy

The microstructure of fat spreads is of fundamental importance to their sensorial properties such as texture, mouthfeel and spreadability. Fat spreads are water in oil emulsions, with a continuous phase supported by a fat crystal network. Confocal Raman microscopy offers the possibility for the spatial mapping of the microstructure of fat spreads: It can distinguish the solid and liquid phases of the lipids and the emulsifiers present at...

Read More thumbnail image: Raman hyperspectral imaging and analysis of fat spreads

Identification, isolation, and synthesis of seven novel impurities of anti‐diabetic drug Repaglinide

Published: Jun 20, 2017

Author(s): Prasad Kancherla, Srinivas Keesari, Pallavi Alegete, Mukkanti Khagga, Parthasarathi Das

Journal: Drug Testing and Analysis

Seven unknown impurities in Repaglinide bulk drug batches at below 0.1% (ranging from 0.05 to 0.10%) were detected by an ultra‐performance liquid chromatographic (UPLC) method. These impurities were isolated from the crude sample of Repaglinide using preparative high performance liquid chromatography (prep‐HPLC). Based on liquid chromatography‐electrospray ionization‐mass spectrometry (LC‐ESI/MS) study, the chemical structures of seven...

Read More thumbnail image: Identification isolation and synthesis of seven novel impurities of antidiabetic drug Repaglinide

Analysis of RBC‐microparticles in stored whole blood bags – a promising marker to detect blood doping in sports?

Published: Jun 20, 2017

Author(s): Sven Christian Voss, Morana Jaganjac, Amna Mohamed Al‐Thani, Jean‐Charles Grivel, Christophe Michel Raynaud, Hind Al‐Jaber, Afnan Saleh Al‐Menhali, Zeyed Ahmad Merenkov, Mohammed Alsayrafi, Aishah Latiff, Costas Georgakopoulos

Journal: Drug Testing and Analysis

Blood doping in sports is prohibited by the World Anti‐Doping Agency (WADA). To find a possible biomarker for the detection of blood doping, we investigated the changes in blood stored in CPDA‐1 blood bags of eight healthy subjects who donated one unit of blood. Aliquots were taken on days 0, 14, and 35. Platelet‐free plasma was prepared and stored at −80°C until analysis on a flow cytometer dedicated for the analysis of microparticles...

Read More thumbnail image: Analysis of RBCmicroparticles in stored whole blood bags  a promising marker to detect blood doping in sports

Raman bands of twisted bilayer graphene

Published: Jun 20, 2017

Author(s): Valentin N. Popov

Journal: Journal of Raman Spectroscopy

A theoretical approach to the modelling of the resonant Raman scattering by phonons in twisted bilayer graphene is developed and presented. The normally very large unit cells of twisted bilayer graphene hinder the large scale calculation of the electronic, vibrational, and optical properties by microscopic models. Here, a perturbative approach within a non‐orthogonal tight‐binding model is proposed that allows for a significant reduction...

Read More thumbnail image: Raman bands of twisted bilayer graphene

Analysis of the pigments for smoked mural by confocal micro‐Raman spectroscopy

Published: Jun 20, 2017

Author(s): Yan Li, Fengping Wang, Xinyi Fu, Zhijun Sun, Yingqing Xu

Journal: Journal of Raman Spectroscopy

Smudging is one of the most serious damages of Mogao Grottoes' murals. In this paper, confocal micro‐Raman spectroscopy is adopted to investigate the smoked murals in Mogao Grottoes. The exutive fragments from the smoked murals in 71 Grotto have been analyzed. The white pigment, which is covered by a layer of black, is identified as calcite, and the black is amorphous carbon. No any other chromatic pigments were found in all exutive...

Read More thumbnail image: Analysis of the pigments for smoked mural by confocal microRaman spectroscopy

Pressure‐induced Fermi resonance between fundamental modes in 7,7,8,8‐tetracyanoquinodimethane

Published: Jun 20, 2017

Author(s): Chenglin Sun, Hongliang Zhao, Chunyu Liu, Mi Zhou

Journal: Journal of Raman Spectroscopy

Herein, in‐situ high pressure Raman spectra of 7,7,8,8‐tetracyanoquinodimethane (TCNQ) have been measured up to 10 GPa, and a first‐order phase transition was detected at about 2.3 GPa. An anharmonic coupling (Fermi resonance) between fundamental modes was observed. The relationship of Fermi resonance parameters (intensity ratio, coupling coefficient, frequency separation and frequency separation of unperturbed transition) with...

Read More thumbnail image: Pressureinduced Fermi resonance between fundamental modes in 7788tetracyanoquinodimethane

Raman spectroscopy of weathered shungites

Published: Jun 20, 2017

Author(s): S. Y. Chazhengina, V. V. Kovalevski

Journal: Journal of Raman Spectroscopy

Raman spectroscopy has proven to be a useful tool for the study of carbonaceous material (CM). This method is used to distinguish various types of CM and to study the evolution of Raman spectra characteristics of CM during metamorphic transformations. In the present study, we applied the Raman spectroscopy and electron diffraction methods to investigate the evolution of structural ordering of CM of shungite rocks, Karelia (Russia), during...

Read More thumbnail image: Raman spectroscopy of weathered shungites

Sensing trace levels of molecular species in solution via zinc oxide nanoprobe Raman spectroscopy

Published: Jun 20, 2017

Author(s): Andrew L. Cook, Carcia S. Carson, Claire E. Marvinney, Todd D. Giorgio, Richard R. Mu

Journal: Journal of Raman Spectroscopy

Surface‐enhanced Raman spectroscopy (SERS) has potential for unique clinical, environmental, and military applications, among many others, but it is limited by a rapid decrease in signal with distance from the sensing surface. For this reason, much study of SERS‐based biosensing involves chemical or physical adsorption of analytes to an active surface. Adsorption, however, limits the types of analytes that can be detected and detection...

Read More thumbnail image: Sensing trace levels of molecular species in solution via zinc oxide nanoprobe Raman spectroscopy

On‐line reaction monitoring by mass spectrometry, modern approaches for the analysis of chemical reactions

Published: Jun 19, 2017

Author(s): Andrew Ray, Tony Bristow, Chris Whitmore, Jackie Mosely

Journal: Mass Spectrometry Reviews

The application of on‐line mass spectrometry for direct analysis of chemical and other types of process continues to grow in importance and impact. The ability of the technique to characterize many aspects of a chemical reaction such as product and impurity formation, along with reactant consumption in a single experiment is key to its adoption and development. Innovations in ionization techniques and mass...

Read More thumbnail image: Online reaction monitoring by mass spectrometry modern approaches for the analysis of chemical reactions

Gas phase basicities of polyfunctional molecules. Part 6: Cyanides and isocyanides

Published: Jun 16, 2017

Author(s): Guy Bouchoux

Journal: Mass Spectrometry Reviews

This paper gathers structural and thermochemical informations related to the gas‐phase basicity of molecules containing cyanides (nitriles) and isocyanides (isonitriles) functional groups. It constitutes the sixth part of a general review devoted to gas‐phase basicities of polyfunctional compounds. A large corpus of cyanides and isocyanides molecules is examined under seven major chapters. In the first one, a rapid...

Read More thumbnail image: Gas phase basicities of polyfunctional molecules_ Part 6 Cyanides and isocyanides

A new micro X‐ray fluorescence spectrometer for in vivo elemental analysis in plants

Published: Jun 16, 2017

Author(s): U.E.A. Fittschen, H.‐H. Kunz, R. Höhner, I.M.B. Tyssebotn, A. Fittschen

Journal: X-Ray Spectrometry

In vivo micro X‐ray fluorescence (micro‐XRF) on plants is aimed at mapping spatial ion accumulation, eg. in plant leaves to minimize artifacts arising from sample preparation and to be able to detect changes occurring under environmental stress. To obtain reliable results, a spectrometer and sample setup that maintain the plant in good physiological condition are necessary. We have built a micro‐XRF spectrometer, in which analyses are...

Read More thumbnail image: A new micro Xray fluorescence spectrometer for in vivo elemental analysis in plants

Comparative pharmacokinetics of acteoside from total glycoside extracted from leaves of Rehmannia and Dihuangye total glycoside capsule in normal and diabetic nephropathy rats

Published: Jun 14, 2017

Author(s): Xin‐Xin Dai, Shu‐Lan Su, Hong‐Die Cai, Dan‐Dan Wei, Tian‐Yao Zheng, Zhen‐Hua Zhu, Hui Yan, Er‐Xin Shang, Sheng Guo, Da‐Wei Qian, Jin‐Ao Duan

Journal: Biomedical Chromatography

Abstract Rehmannia glutinosa Libosch (RG), is officially listed in the Chinese Pharmacopoeia and is widely used in China. In this paper, a sensitive and rapid ultra‐performance liquid chromatography–mass spectrometry method including multiple‐reaction monitoring mode was developed and applied to study the pharmacokinetic effect of acteoside from total glycoside extracted from the leaves of Rehmannia (TLR) and Dihuangye total glycoside capsule...

Read More thumbnail image: Comparative pharmacokinetics of acteoside from total glycoside extracted from leaves of Rehmannia and Dihuangye total glycoside capsule in normal and diabetic nephropathy rats

Quantitative analysis based on spectral shape deformation: A review of the theory and its applications

Published: Jun 14, 2017

Author(s): Zeng‐Ping Chen, Shun Xiong, Qi Zuo, Cai‐Xia Shi

Journal: Journal of Chemometrics

Most of the commonly used calibration methods in quantitative spectroscopic analysis are established or derived from the assumption of a linear relationship between the concentrations of the analytes of interest and corresponding absolute spectral intensities. They are not applicable for heterogeneous samples where the potential uncontrolled variations in optical path length due to the changes in samples' physical properties undermine the...

Read More thumbnail image: Quantitative analysis based on spectral shape deformation A review of the theory and its applications

Applying portable Raman spectrometers for field discrimination of sulfates: Training for successful extraterrestrial detection

Published: Jun 8, 2017

Author(s): Filip Košek, Adam Culka, Petr Drahota, Jan Jehlička

Journal: Journal of Raman Spectroscopy

The presence of sulfates containing Mg, Fe, and Ca (in several hydration states) has been confirmed on Mars from data acquired by both orbital and in‐situ measurements. It has been suggested that the sulfates on Mars originated deep the past from the evaporation of water at accumulation points on the Martian surface. Consequently, they can be seen as highly relevant to any search for the presence of extraterrestrial life. ...

Read More thumbnail image: Applying portable Raman spectrometers for field discrimination of sulfates Training for successful extraterrestrial detection

Application of monolithic chromatographic supports in virus research

Published: Jun 8, 2017

Author(s): Mladen Krajacic, Maja Ravnikar, Aleš Štrancar, Ion Gutiérrez‐Aguirre

Journal: ELECTROPHORESIS

Key properties of monolithic chromatographic supports, make them suitable for separation and/or concentration of large biomolecules, especially virus particles and viral genomes. One by one, the studies that have been completed so far, contributed to the knowledge that monolith chromatography has hardly any limitation to be applied in virus research. Viruses of different sizes, possessing icosahedral structure and symmetrical morphology,...

Read More thumbnail image: Application of monolithic chromatographic supports in virus research

Severe metabolic impairment with increasing age for CYP3A and CYP2D substrates in rats: Possible consequences for drug development

Published: Jun 7, 2017

Author(s): Nuggehally R. Srinivas

Journal: Biomedical Chromatography

Read More thumbnail image: Severe metabolic impairment with increasing age for CYP3A and CYP2D substrates in rats Possible consequences for drug development

Application of TXRF and XRPD techniques for analysis of elemental and chemical composition of human kidney stones

Published: Jun 7, 2017

Author(s): A. Kubala‐Kukuś, M. Arabski, I. Stabrawa, D. Banaś, W. Różański, M. Lipiński, U. Majewska, J. Wudarczyk‐Moćko, J. Braziewicz, M. Pajek, S. Góźdź

Journal: X-Ray Spectrometry

Total reflection X‐ray fluorescence analysis and X‐ray powder diffraction were used for elemental and chemical composition analysis of 83 samples of human kidney stones. Samples came from patients after surgical removal of stones. Elements such as P, K, Ca, Fe, Zn, Ni, Br, Sr, and Pb were determined in all samples. Other elements Mg, S, Cl, Ti, V, Cr, Mn, Cu, Se, Rb, I, and Bi were found in some of the analyzed kidney stones (censoring...

Read More thumbnail image: Application of TXRF and XRPD techniques for analysis of elemental and chemical composition of human kidney stones
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