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Optimization of recombinant β‐glucuronidase hydrolysis and quantification of eight urinary cannabinoids and metabolites by liquid chromatography tandem mass spectrometry

Published: Aug 16, 2017

Author(s): Cristina Sempio, Karl B. Scheidweiler, Allan J. Barnes, Marilyn A. Huestis

Journal: Drug Testing and Analysis

Prolonged urinary cannabinoid excretion in chronic frequent cannabis users confounds identification of recent cannabis intake that may be important in treatment, workplace, clinical, and forensic testing programs. In addition, differentiation of synthetic Δ9‐tetrahydrocannabinol (THC) intake from cannabis plant products might be an important interpretive issue. THC, 11‐hydroxy‐THC (11‐OH‐THC) and 11‐nor‐9‐carboxy‐THC (THCCOOH) urine...

Read More thumbnail image: Optimization of recombinant glucuronidase hydrolysis and quantification of eight urinary cannabinoids and metabolites by liquid chromatography tandem mass spectrometry

Investigation of drug products received for analysis in the Swedish STRIDA project on new psychoactive substances

Published: Aug 16, 2017

Author(s): Matilda Bäckberg, Karl‐Henrik Jönsson, Olof Beck, Anders Helander

Journal: Drug Testing and Analysis

The web‐based open sale of unregulated new psychoactive substances (NPS) has shown a steady increase in recent years. Analysis of drug products sold as NPS is useful to confirm the true chemical contents, for comparison with the substances detected in corresponding body fluids, but also to study drug trends. This work describes the examination of 251 drug products that were randomly submitted for analysis in 173 cases of suspected...

Read More thumbnail image: Investigation of drug products received for analysis in the Swedish STRIDA project on new psychoactive substances

Development and validation of a high‐performance liquid chromatography method for the quantification of talazoparib in rat plasma: Application to plasma protein binding studies

Published: Aug 15, 2017

Author(s): Mahendra Kumar Hidau, Srikanth Kolluru, Srinath Palakurthi

Journal: Biomedical Chromatography

Abstract A sensitive and selective RP‐HPLC method has been developed and validated for the quantification of a highly potent poly ADP ribose polymerase inhibitor talazoparib (TZP) in rat plasma. Chromatographic separation was performed with isocratic elution method. Absorbance for TZP was measured with a UV detector (SPD‐20A UV–vis) at a λmax of 227 nm. Protein precipitation was used to extract the drug from plasma samples using methanol–acetonitrile...

Read More thumbnail image: Development and validation of a highperformance liquid chromatography method for the quantification of talazoparib in rat plasma Application to plasma protein binding studies

Application of headspace solid‐phase microextraction followed by gas chromatography coupled with mass spectrometry to determine esters of carboxylic acids and other volatile compounds in Dermestes maculatus and Dermestes ater lipids

Published: Aug 15, 2017

Author(s): Magdalena Cerkowniak, Mieczysława I. Boguś, Emilia Włóka, Piotr Stepnowski, Marek Gołębiowski

Journal: Biomedical Chromatography

Abstract A constant problem in veterinary medicine, human healthcare, agriculture, forestry and horticulture is the large number of pests, and the lack of effective methods to combat them which cause no harm to the rest of the environment. It is recommended and desired to reduce the use of chemicals and increase the use of agents based on knowledge acquired in the fields of biology, chemistry and agrochemicals. To learn the defense...

Read More thumbnail image: Application of headspace solidphase microextraction followed by gas chromatography coupled with mass spectrometry to determine esters of carboxylic acids and other volatile compounds in Dermestes maculatus and Dermestes ater lipids

An LC–MS/MS method for quantitation of cyanidin‐3 ‐O‐ glucoside in rat plasma: Application to a comparative pharmacokinetic study in normal and streptozotocin‐induced diabetic rats

Published: Aug 13, 2017

Author(s): Chunxia Yang, Qiuhua Wang, Shenbao Yang, Qiong Yang, Ying Wei

Journal: Biomedical Chromatography

Abstract A sensitive and reliable liquid chromatography tandem mass spectrometry (LC–MS/MS) method was developed to determine cyanidin‐3‐O‐glucoside (Cy‐3G) in normal and streptozotocin‐induced diabetic rat plasma. Chromatographic separation was carried out on a Zorbax SB‐C18 (50 × 4.6 mm, 5 μm) column and mass spectrometric analysis was performed using a Thermo Finnigan TSQ Quantum Ultra triple‐quadrupole mass spectrometer coupled with an ESI...

Read More thumbnail image: An LCMSMS method for quantitation of cyanidin3 O glucoside in rat plasma Application to a comparative pharmacokinetic study in normal and streptozotocininduced diabetic rats

Quality control in mass spectrometry‐based proteomics

Published: Aug 12, 2017

Author(s): Wout Bittremieux, David L. Tabb, Francis Impens, An Staes, Evy Timmerman, Lennart Martens, Kris Laukens

Journal: Mass Spectrometry Reviews

Mass spectrometry is a highly complex analytical technique and mass spectrometry‐based proteomics experiments can be subject to a large variability, which forms an obstacle to obtaining accurate and reproducible results. Therefore, a comprehensive and systematic approach to quality control is an essential requirement to inspire confidence in the generated results. A typical mass spectrometry experiment consists of...

Read More thumbnail image: Quality control in mass spectrometrybased proteomics

Quality control in mass spectrometry‐based proteomics

Published: Aug 12, 2017

Author(s): Wout Bittremieux, David L. Tabb, Francis Impens, An Staes, Evy Timmerman, Lennart Martens, Kris Laukens

Journal: Mass Spectrometry Reviews

Mass spectrometry is a highly complex analytical technique and mass spectrometry‐based proteomics experiments can be subject to a large variability, which forms an obstacle to obtaining accurate and reproducible results. Therefore, a comprehensive and systematic approach to quality control is an essential requirement to inspire confidence in the generated results. A typical mass spectrometry experiment consists of...

Read More thumbnail image: Quality control in mass spectrometrybased proteomics

Structural characterization and pharmacological evaluation of the new synthetic cannabinoid CUMYL‐PEGACLONE

Published: Aug 9, 2017

Author(s): Verena Angerer, Lukas Mogler, Jan‐Patrick Steitz, Philippe Bisel, Cornelius Hess, Clara T. Schoeder, Christa E. Müller, Laura M. Huppertz, Folker Westphal, Jan Schäper, Volker Auwärter

Journal: Drug Testing and Analysis

The number of new psychoactive substances (NPS) that have emerged on the European market has been rapidly growing in recent years, with a particularly high number of new compounds from the group of synthetic cannabinoid receptor agonists. There have been various political efforts to control the trade and the use of NPS worldwide. In Germany, the Act to control the distribution of new psychoactive substances (NpSG) came into force in November 2016. In...

Read More thumbnail image: Structural characterization and pharmacological evaluation of the new synthetic cannabinoid CUMYLPEGACLONE

Transcriptomic biomarkers of altered erythropoiesis to detect autologous blood transfusion

Published: Aug 9, 2017

Author(s): Olivier Salamin, Jonathan Mignot, Tiia Kuuranne, Martial Saugy, Nicolas Leuenberger

Journal: Drug Testing and Analysis

Autologous blood transfusion is a powerful means of improving performance and remains one of the most challenging methods to detect. Recent investigations have identified 3 candidate reticulocytes genes whose expression was significantly influenced by blood transfusion. Using quantitative reverse transcription polymerase chain reaction as an alternative quantitative method, the present study supports that delta‐aminolevulinate synthase 2...

Read More thumbnail image: Transcriptomic biomarkers of altered erythropoiesis to detect autologous blood transfusion

Pharmacokinetics and tissue distribution study of clevidipine and its primary metabolite H152/81 in rats

Published: Aug 8, 2017

Author(s): Yan Wang, Lanting Zhao, Tengfei Li, Wen Yang, Qian Li, Luning Sun, Li Ding

Journal: Biomedical Chromatography

Abstract This present study was designed to investigate the pharmacokinetic profiles and tissue distribution characteristics of clevidipine and its primary metabolite H152/81 in rats following a single intravenous administration of clevidipine butyrate injectable emulsion. For this study, a sensitive and selective liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was established and validated for the simultaneous...

Read More thumbnail image: Pharmacokinetics and tissue distribution study of clevidipine and its primary metabolite H15281 in rats

In situ chemical and morphological characterization of copper under near ambient reduction and oxidation conditions

Published: Aug 8, 2017

Author(s): H. Sezen, M. Al‐Hada, M. Amati, L. Gregoratti

Journal: Surface and Interface Analysis

By using spatially resolved photoelectron spectromicroscopy, we have investigated the formation of Cu(I) oxide phases when a bulk Cu foil is exposed to a near ambient pressure of molecular oxygen. The experiment was performed by using a novel cell for in operando measurements capable to overcome the so called ‘pressure gap’. We have found that the oxidation of Cu proceeds through the formation of Cu(I) oxide domains in the micron and...

Read More thumbnail image: In situ chemical and morphological characterization of copper under near ambient reduction and oxidation conditions

A UPLC‐TOF/MS‐based metabolomics study of rattan stems of Schisandra chinensis effects on Alzheimer's disease rats model

Published: Aug 7, 2017

Author(s): Bing‐You Yang, Jin‐Yan Tan, Yan Liu, Bo Liu, Shuang Jin, Hong‐Wei Guo, Hai‐Xue Kuang

Journal: Biomedical Chromatography

Abstract A UPLC‐TOF/MS‐based metabolomics method was established to explore the therapeutic mechanisms of rattan stems of S. chinensis (SCS) in Alzheimer's disease (AD). Experimental AD model was induced by intra‐hippocampal Aβ1–42 injection in rats. Cognitive function and oxidative stress condition in brain of AD rats were assessed using Morris water maze tests and antioxidant assays [malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione...

Read More thumbnail image: A UPLCTOFMSbased metabolomics study of rattan stems of Schisandra chinensis effects on Alzheimers disease rats model

Purity and adulteration in cocaine seizures and drug market inspection in Galicia (Spain) across an eight‐year period

Published: Aug 1, 2017

Author(s): Mª. de los Ángeles Villar Núñez, José Sánchez Morcillo, María Adolfina Ruíz Martínez

Journal: Drug Testing and Analysis

Read More thumbnail image: Purity and adulteration in cocaine seizures and drug market inspection in Galicia Spain across an eightyear period

Raman scattering of graphene‐based systems in high magnetic fields

Published: Aug 1, 2017

Author(s): Clement Faugeras, Milan Orlita, Marek Potemski

Journal: Journal of Raman Spectroscopy

We review the different results obtained in the last decade in the field of Raman scattering of graphene‐based systems, with an applied magnetic field. Electronic properties of graphene‐based systems with an applied magnetic field are first described. The phonon response in magnetic field, the magneto‐phono resonance, is then introduced and described for graphene monolayer and multilayer, as well as for bulk graphite. Electronic Raman...

Read More thumbnail image: Raman scattering of graphenebased systems in high magnetic fields

The influence of small doses of ethanol on the urinary testosterone to epitestosterone ratio in men and women

Published: Aug 1, 2017

Author(s): Sami Albeiroti, Brian D. Ahrens, Timofei Sobolevskii, Anthony W. Butch

Journal: Drug Testing and Analysis

Endogenous steroid use can increase urinary testosterone/epitestosterone (T/E) values. In addition, ethanol in amounts >0.5 g per kg of body weight (g/kg) can also increase T/E values. However, the effect of smaller doses of ethanol on T/E values is unknown. The influence of 0.2 and 0.4 g/kg of ethanol on baseline T/E values in 20 men and 20 women with low and high baseline T/E values was investigated and correlated with...

Read More thumbnail image: The influence of small doses of ethanol on the urinary testosterone to epitestosterone ratio in men and women

Profiling ephedrine prepared from N ‐methylalanine via the Akabori‐Momotani reaction

Published: Aug 1, 2017

Author(s): Alexandra Doddridge, Michael Collins, Helen Salouros

Journal: Drug Testing and Analysis

Novel methods for synthesising methylamphetamine precursors are appearing in clandestine laboratories within Australia. One such laboratory involved the synthesis of ephedrine from N‐methylalanine and benzaldehyde via the Akabori‐Momotani reaction. This article presents chiral and stable isotope ratios of ephedrine synthesised via this method, along with a chemical profile of methylamphetamine produced from this ephedrine. Based on the...

Read More thumbnail image: Profiling ephedrine prepared from N methylalanine via the AkaboriMomotani reaction

The emergence of new psychoactive substance (NPS) benzodiazepines: A review

Published: Jul 31, 2017

Author(s): Kieran R. Manchester, Emma C. Lomas, Laura Waters, Fiona C. Dempsey, Peter D. Maskell

Journal: Drug Testing and Analysis

The market for new psychoactive substances has increased markedly in recent years and there is now a steady stream of compounds appearing every year. Benzodiazepines consist of only a fraction of the total number of these compounds but their use and misuse has rapidly increased. Some of these benzodiazepines have only been patented, some of them have not been previously synthesised, and the majority have never undergone clinical trials or...

Read More thumbnail image: The emergence of new psychoactive substance NPS benzodiazepines A review

Standardization approaches in absolute quantitative proteomics with mass spectrometry

Published: Jul 31, 2017

Author(s): Francisco Calderón‐Celis, Jorge Ruiz Encinar, Alfredo Sanz‐Medel

Journal: Mass Spectrometry Reviews

Mass spectrometry‐based approaches have enabled important breakthroughs in quantitative proteomics in the last decades. This development is reflected in the better quantitative assessment of protein levels as well as to understand post‐translational modifications and protein complexes and networks. Nowadays, the focus of quantitative proteomics shifted from the relative determination of proteins (ie, differential...

Read More thumbnail image: Standardization approaches in absolute quantitative proteomics with mass spectrometry

An investigation of a unique group of painted silk banners from a Polish collection

Published: Jul 28, 2017

Author(s): Anna Klisińska‐Kopacz

Journal: Journal of Raman Spectroscopy

Historic textiles represent a very important part of our cultural heritage. This research focused on the evaluation of a group of unique 16th century banners painted on silk. The banners were examined by Raman spectroscopy and X‐ray fluorescence spectrometry. The measurements were performed to characterize the pigments and materials used, in order to establish the most adequate display methods. Pigments typical of the Renaissance period...

Read More thumbnail image: An investigation of a unique group of painted silk banners from a Polish collection

Sevoflurane metabolite cross‐react in the ethyl glucuronide DRI® immunoassay

Published: Jul 28, 2017

Author(s): Michael Böttcher, David Kühne, Olof Beck

Journal: Drug Testing and Analysis

Read More thumbnail image: Sevoflurane metabolite crossreact in the ethyl glucuronide DRI immunoassay
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