EarlyView Articles

Skip to Navigation

The very latest articles from the scientific literature
on Wiley Online Library...


You can keep up-to date on these EarlyView articles, which focus on spectroscopy
and separation science:

Earlyview RSS Feed

rss

Filter by Journal

Browse By Journal

Mapping of Activity through Dichotomic Scores (MADS): A new chemoinformatic approach to detect activity‐rich structural regions

Published: Jan 18, 2018

Author(s): Roberto Todeschini, Viviana Consonni, Davide Ballabio, Francesca Grisoni

Journal: Journal of Chemometrics

Abstract A new chemoinformatic approach, called Mapping of Activity through Dichotomic Scores, is introduced. Its goal is the supervised projection of molecules, represented with strings of binary digits expressing the presence or absence of selected structural features, onto a novel 2‐dimensional space, which highlights regions of active (inactive) molecules of interest. At the same time, variables are projected onto a second...

Read More thumbnail image: Mapping of Activity through Dichotomic Scores MADS A new chemoinformatic approach to detect activityrich structural regions

Raman spectroscopy and density functional theory study of energetically closely separated C 2 ′‐endo and C 3 ′‐endo pentose forms in purine nucleoside analogue drug‐gold conjugates

Published: Jan 18, 2018

Author(s): Erdene‐Ochir Ganbold, Thanh Danh Nguyen, Nguyen Hoang Ly, Sang‐Woo Joo, Linzi Li, B. Moon Kim

Journal: Journal of Raman Spectroscopy

Abstract We performed a vibrational analysis of a cyclin‐dependent kinase inhibitor as an anticancer drug using Raman spectroscopy and quantum mechanical calculations. BMK‐Y101, a purine nucleoside analogue cyclin‐dependent kinase inhibitor, was found to adsorb on gold nanoparticles as evidenced by ultraviolet–visible absorption spectroscopy. Density functional theory (DFT) calculations were introduced to examine the energetic...

Read More thumbnail image: Raman spectroscopy and density functional theory study of energetically closely separated C 2 endo and C 3 endo pentose forms in purine nucleoside analogue druggold conjugates

Basalt fibers functionalized with gold nanoparticles for in‐tube solid‐phase microextraction

Published: Jan 18, 2018

Author(s): Juanjuan Feng, Yu Tian, Xiuqin Wang, Chuannan Luo, Min Sun

Journal: Journal of Separation Science

Abstract Basalt fibers were functionalized with gold nanoparticles and characterized by scanning electron microscopy and energy‐dispersive X‐ray spectroscopy. An in‐tube solid‐phase microextraction device was developed by packing the functionalized basalt fibers in a polyether ether ketone tube. The device was connected into high performance liquid chromatography equipment with a diode array detector to build online enrichment and...

Read More thumbnail image: Basalt fibers functionalized with gold nanoparticles for intube solidphase microextraction

Analysis of bioactive components and multi‐component pharmacokinetics of saponins from the leaves of Panax notoginseng in rat plasma after oral administration by LC–MS/MS

Published: Jan 18, 2018

Author(s): Zhengcai Ju, Jia Li, Han Han, Li Yang, Zhengtao Wang

Journal: Journal of Separation Science

Abstract In this study, simple ultra‐high performance liquid chromatography coupled with quadrupole time‐of‐flight mass tandem mass spectrometry is used to characterize the absorbed components in rat plasma after the oral administration of saponins from the leaves of Panax notoginseng. Seventeen prototype compounds are structurally characterized. Furthermore, a simple and sensitive liquid chromatography with tandem mass spectrometry...

Read More thumbnail image: Analysis of bioactive components and multicomponent pharmacokinetics of saponins from the leaves of Panax notoginseng in rat plasma after oral administration by LCMSMS

Determination of the clean‐up efficiency of the solid‐phase extraction of rosemary extracts: Application of full‐factorial design in hyphenation with Gaussian peak fit function

Published: Jan 18, 2018

Author(s): Florian Meischl, Christian Günter Kirchler, Michael Andreas Jäger, Christian Wolfgang Huck, Matthias Rainer

Journal: Journal of Separation Science

Abstract We present a novel method for the quantitative determination of the clean‐up efficiency to provide a calculated parameter for peak purity through iterative fitting in conjunction with design of experiments. Rosemary extracts were used and analyzed before and after solid‐phase extraction using a self‐fabricated mixed‐mode sorbent based on poly(N‐vinylimidazole/ethylene glycol dimethacrylate). Optimization was performed by variation of...

Read More thumbnail image: Determination of the cleanup efficiency of the solidphase extraction of rosemary extracts Application of fullfactorial design in hyphenation with Gaussian peak fit function

A validated LC‐MS/MS method for the determination of senkyunolide I in dog plasma and its application to a pharmacokinetic and bioavailability studies

Published: Jan 16, 2018

Author(s): Jin‐Qi Li, Jia‐Feng Wang, Jie Li, Shu‐han Zhang, Dan He, Rong‐Sheng Tong, Shu‐Ya She

Journal: Biomedical Chromatography

Abstract Senkyunolide I is one of the major bioactive components in the herbal medicine Ligusticum chuanxiong. The aim of this study was to develop and validate a fast, simple and sensitive LC‐MS/MS method for the determination of senkyunolide I in dog plasma. The plasma samples were processed with acetonitrile and separated on a Waters Acquity UPLC BEH C18 column (50 × 2.1 mm, 1.7 μm). The mobile phase consisted of 0.1% formic acid aqueous and...

Read More thumbnail image: A validated LCMSMS method for the determination of senkyunolide I in dog plasma and its application to a pharmacokinetic and bioavailability studies

The determination of polycyclic aromatic hydrocarbons in human urine by high‐resolution gas chromatography–mass spectrometry

Published: Jan 16, 2018

Author(s): Sung‐Hee Cho, Sun‐Kyung Lee, Chong Hyeak Kim

Journal: Biomedical Chromatography

Abstract Polycyclic aromatic hydrocarbons (PAHs), organic compounds formed by at least two condensed aromatic rings, are ubiquitous environmental pollutants that are produced by incomplete combustion of organic materials. PAHs have been classified as carcinogenIC to humans by the International Agency for Research on Cancer, because they can bind to DNA, causing mutations. Therefore, the levels of PAHs in human urine can be used as...

Read More thumbnail image: The determination of polycyclic aromatic hydrocarbons in human urine by highresolution gas chromatographymass spectrometry

Synthesis and chromatographic evaluation of phenyl/tetrazole bonded stationary phase based on thiol‐epoxy ring opening reaction

Published: Jan 16, 2018

Author(s): Gaowa Jin, Yanming Liu, Fan Yang, Dongping Yu, Jingyu Yan, Weijia Zhou, Zhimou Guo, Jianhua Zhu, Xinmiao Liang

Journal: Journal of Separation Science

Abstract A silica‐based reversed‐phase stationary phase bonding with phenyl and tetrazole groups was synthesized by thiol‐epoxy ring opening reaction. The bonded groups could not only provide hydrophobic interaction, but also π–π, hydrogen bonding, electrostatic interactions, and so on. The results of characterization with elemental analysis and solid‐state 13C cross‐polarization magic‐angle‐spinning NMR spectroscopy indicated the successful...

Read More thumbnail image: Synthesis and chromatographic evaluation of phenyltetrazole bonded stationary phase based on thiolepoxy ring opening reaction

Determination of sugars and cyclitols isolated from various morphological parts of Medicago sativa L

Published: Jan 16, 2018

Author(s): Hossam Al‐Suod, Ileana‐Andreea Ratiu, Magdalena Ligor, Tomasz Ligor, Bogusław Buszewski

Journal: Journal of Separation Science

Abstract Plant research interest has increased all over the world, and a large body of evidence has been collected to show the huge potential of medicinal plants in various disease treatments. Medicago sativa L., known as alfalfa, is a rich source of biologically active components and secondary metabolites and was frequently used from the ancient times both as fodder crop and as a traditional medicine in the treatment of various diseases....

Read More thumbnail image: Determination of sugars and cyclitols isolated from various morphological parts of Medicago sativa L

Dynamic evaluation of a trilobal capillary‐channeled polymer fiber shape for reversed phase protein separations and comparison to the eight‐channeled form

Published: Jan 16, 2018

Author(s): Lei Wang, Kathryn A. Stevens, Paul Haupt‐Renaud, R. Kenneth Marcus

Journal: Journal of Separation Science

Abstract A new, trilobal‐shaped capillary‐channeled polymer fiber is under development to address the issues of poor A‐term performance of the previous eight‐channeled form. The trilobal geometry should provide better packing homogeneity due to the fewer potential orientations of the symmetric fiber geometry. Comparisons of separation efficiency and peak shape were made between the two fiber shapes through several dynamic...

Read More thumbnail image: Dynamic evaluation of a trilobal capillarychanneled polymer fiber shape for reversed phase protein separations and comparison to the eightchanneled form

Polysaccharide‐based chiral stationary phases as halogen bond acceptors: A novel strategy for detection of stereoselective σ‐hole bonds in solution

Published: Jan 16, 2018

Author(s): Paola Peluso, Victor Mamane, Roberto Dallocchio, Alessandro Dessì, Rosaria Villano, Daniele Sanna, Emmanuel Aubert, Patrick Pale, Sergio Cossu

Journal: Journal of Separation Science

Abstract In the last few years, halogen bonds have been exploited in a variety of research areas both in the solid state and in solution. Nevertheless, several factors make formation and detection of halogen bonds in solution challenging. Moreover, to date, few chiral molecules containing electrophilic halogens as recognition sites have been reported. Recently, we described the first series of halogen‐bond‐driven...

Read More thumbnail image: Polysaccharidebased chiral stationary phases as halogen bond acceptors A novel strategy for detection of stereoselective hole bonds in solution

Intracellular potassium under osmotic stress determines the dielectrophoresis cross‐over frequency of murine myeloma cells in the MHz range

Published: Jan 15, 2018

Author(s): Colin Chung, Ronald Pethig, Stewart Smith, Martin Waterfall

Journal: ELECTROPHORESIS

Abstract Dielectrophoresis (DEP) has been widely studied for its potential as a biomarker‐free method of sorting and characterizing cells based upon their dielectric properties. Most studies have employed voltage signals from ∼1 kHz to no higher than ∼30 MHz. Within this range a transition from negative to positive DEP can be observed at the cross‐over frequency fx01. The value of fx01 is determined by the conductivity of the...

Read More thumbnail image: Intracellular potassium under osmotic stress determines the dielectrophoresis crossover frequency of murine myeloma cells in the MHz range

Development of manganese‐enhanced magnetic resonance imaging of the rostral ventrolateral medulla of conscious rats: Importance of normalization and comparison with other regions of interest

Published: Jan 12, 2018

Author(s): Daniel J. Huereca, Konstandinos A. Bakoulas, Farhad Ghoddoussi, Bruce A. Berkowitz, Avril Genene Holt, Patrick J. Mueller

Journal: NMR in Biomedicine

Spinally projecting neurons in the rostral ventrolateral medulla (RVLM) are believed to contribute to pathophysiological alterations in sympathetic nerve activity and the development of cardiovascular disease. The ability to identify changes in the activity of RVLM neurons in conscious animals and humans, especially longitudinally, would represent a clinically important advancement in our understanding of the contribution of the RVLM to...

Read More thumbnail image: Development of manganeseenhanced magnetic resonance imaging of the rostral ventrolateral medulla of conscious rats Importance of normalization and comparison with other regions of interest

Enhanced surface free energy of UHMWPE fibers and its interfacial adhesion behavior to PI resins

Published: Jan 12, 2018

Author(s): Runqin He, Qiuxiang Chang, Xinjun Huang, Jian Li

Journal: Surface and Interface Analysis

Mechanical properties of composites made up of ultra‐high‐molecular‐weight polyethylene (UHMWPE) fiber, polyimide (PI), and TiO2 particles were investigated. The hybrid composite of 20 vol% of UHMWPE fiber with TiO2 showed tensile strength greater than UHMWPE fiber/PI composite. A positive hybrid effect in tensile strength is obtained. It is observed that addition of small amount of TiO2 to UHMWPE fiber/PI increased the tensile strength of the...

Read More thumbnail image: Enhanced surface free energy of UHMWPE fibers and its interfacial adhesion behavior to PI resins

Investigation of molar concentration effect on structural, optical, electrical, and photovoltaic properties of spray‐coated Cu 2 O thin films

Published: Jan 12, 2018

Author(s): R. David Prabu, S. Valanarasu, V. Ganesh, Mohd Shkir, S. AlFaify, A. Kathalingam

Journal: Surface and Interface Analysis

High quality copper oxide thin films were prepared by nebulizer spray pyrolysis technique using different concentrations of copper precursor solution. Concentration‐dependent structural, morphological, optical, and electrical properties of the prepared films are discussed. X‐ray diffraction studies done for the samples confirmed that the deposited films are in Cu2O phase with polycrystalline cubic structure. Atomic force microscopy analysis revealed...

Read More thumbnail image: Investigation of molar concentration effect on structural optical electrical and photovoltaic properties of spraycoated Cu 2 O thin films

Enantioseparation and determination of asenapine in biological fluid micromatrices by HPLC with diode array detection

Published: Jan 12, 2018

Author(s): Michele Protti, Alice Vignali, Teresa Sanchez Blanco, James Rudge, Francesca Bugamelli, Anna Ferranti, Roberto Mandrioli, Laura Mercolini

Journal: Journal of Separation Science

Abstract Asenapine is a recent drug approved in the European Union for the treatment of bipolar disorder. An original approach has been developed for asenapine analysis in patients treated with the drug, including miniaturized microsampling procedures, separation and quantitation of drug enantiomers. An original enantioselective method based on high‐performance liquid chromatography with diode array detection was developed and...

Read More thumbnail image: Enantioseparation and determination of asenapine in biological fluid micromatrices by HPLC with diode array detection

Isolation of sinapic acid from broccoli using molecularly imprinted polymers

Published: Jan 12, 2018

Author(s): Heba Hosny, Nesrine El Gohary, Engy Saad, Heba Handoussa, Rasha M. El Nashar

Journal: Journal of Separation Science

Abstract A molecularly imprinted polymer was synthesized for the purpose of sinapic acid isolation from Egyptian nutraceutical Botrytis italica, L. (broccoli) due to its prominent medicinal and wide pharmacological activities. A computational study was first developed to determine the optimal template to functional monomer molar ratio. Based on the computational results, five polymers were synthesized using a bulk polymerization method with...

Read More thumbnail image: Isolation of sinapic acid from broccoli using molecularly imprinted polymers

Coupling nanoliter high‐performance liquid chromatography to inductively coupled plasma mass spectrometry for arsenic speciation

Published: Jan 12, 2018

Author(s): Heyong Cheng, Lihuan Shen, Jinhua Liu, Zigang Xu, Yuanchao Wang

Journal: Journal of Separation Science

Abstract Nanoliter high‐performance liquid chromatography shows low consumption of solvents and samples, offering one of the best choices for arsenic speciation in precious samples in combination with inuctively coupled plasma mass spectrometry. A systematic investigation on coupling nanoliter high‐performance liquid chromatography to inductively coupled plasma mass spectrometry from instrument design to injected sample volume and...

Read More thumbnail image: Coupling nanoliter highperformance liquid chromatography to inductively coupled plasma mass spectrometry for arsenic speciation

Functionalization of zwitterionic polymer brushes, do they remain antifouling?

Published: Jan 12, 2018

Author(s): Shoghik Hakobyan, Olena Rzhepishevska, David R. Barbero, Madeleine Ramstedt

Journal: Surface and Interface Analysis

Polymer brushes are surface coatings that can be tailored in many ways to suit specific demands including reduction of protein and bacterial fouling of biomaterials. Previously, we reported that antifouling poly (2‐(methacryloxy)ethyl)dimethyl‐3‐sulphopropyl ammonium hydroxide) brushes dramatically reduced formation of bacterial biofilm. We hypothesized that: (1) this brush could be efficiently functionalized with a small molecule...

Read More thumbnail image: Functionalization of zwitterionic polymer brushes do they remain antifouling

Functionalization of zwitterionic polymer brushes, do they remain antifouling?

Published: Jan 12, 2018

Author(s): Shoghik Hakobyan, Olena Rzhepishevska, David R. Barbero, Madeleine Ramstedt

Journal: Surface and Interface Analysis

Polymer brushes are surface coatings that can be tailored in many ways to suit specific demands including reduction of protein and bacterial fouling of biomaterials. Previously, we reported that antifouling poly (2‐(methacryloxy)ethyl)dimethyl‐3‐sulphopropyl ammonium hydroxide) brushes dramatically reduced formation of bacterial biofilm. We hypothesized that: (1) this brush could be efficiently functionalized with a small molecule...

Read More thumbnail image: Functionalization of zwitterionic polymer brushes do they remain antifouling
Page:   Prev 19 20 21 22 23 24 25 26 27 28 29 Next

Social Links

Share This Links

Bookmark and Share

Microsites

Suppliers Selection
Societies Selection

Banner Ad

Click here to see
all job opportunities

Most Viewed

Copyright Information

Interested in separation science? Visit our sister site separationsNOW.com

Copyright © 2018 John Wiley & Sons, Inc. All Rights Reserved