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Quality control in mass spectrometry‐based proteomics

Published: Aug 12, 2017

Author(s): Wout Bittremieux, David L. Tabb, Francis Impens, An Staes, Evy Timmerman, Lennart Martens, Kris Laukens

Journal: Mass Spectrometry Reviews

Mass spectrometry is a highly complex analytical technique and mass spectrometry‐based proteomics experiments can be subject to a large variability, which forms an obstacle to obtaining accurate and reproducible results. Therefore, a comprehensive and systematic approach to quality control is an essential requirement to inspire confidence in the generated results. A typical mass spectrometry experiment consists of...

Read More thumbnail image: Quality control in mass spectrometrybased proteomics

Quality control in mass spectrometry‐based proteomics

Published: Aug 12, 2017

Author(s): Wout Bittremieux, David L. Tabb, Francis Impens, An Staes, Evy Timmerman, Lennart Martens, Kris Laukens

Journal: Mass Spectrometry Reviews

Mass spectrometry is a highly complex analytical technique and mass spectrometry‐based proteomics experiments can be subject to a large variability, which forms an obstacle to obtaining accurate and reproducible results. Therefore, a comprehensive and systematic approach to quality control is an essential requirement to inspire confidence in the generated results. A typical mass spectrometry experiment consists of...

Read More thumbnail image: Quality control in mass spectrometrybased proteomics

Structural characterization and pharmacological evaluation of the new synthetic cannabinoid CUMYL‐PEGACLONE

Published: Aug 9, 2017

Author(s): Verena Angerer, Lukas Mogler, Jan‐Patrick Steitz, Philippe Bisel, Cornelius Hess, Clara T. Schoeder, Christa E. Müller, Laura M. Huppertz, Folker Westphal, Jan Schäper, Volker Auwärter

Journal: Drug Testing and Analysis

The number of new psychoactive substances (NPS) that have emerged on the European market has been rapidly growing in recent years, with a particularly high number of new compounds from the group of synthetic cannabinoid receptor agonists. There have been various political efforts to control the trade and the use of NPS worldwide. In Germany, the Act to control the distribution of new psychoactive substances (NpSG) came into force in November 2016. In...

Read More thumbnail image: Structural characterization and pharmacological evaluation of the new synthetic cannabinoid CUMYLPEGACLONE

Transcriptomic biomarkers of altered erythropoiesis to detect autologous blood transfusion

Published: Aug 9, 2017

Author(s): Olivier Salamin, Jonathan Mignot, Tiia Kuuranne, Martial Saugy, Nicolas Leuenberger

Journal: Drug Testing and Analysis

Autologous blood transfusion is a powerful means of improving performance and remains one of the most challenging methods to detect. Recent investigations have identified 3 candidate reticulocytes genes whose expression was significantly influenced by blood transfusion. Using quantitative reverse transcription polymerase chain reaction as an alternative quantitative method, the present study supports that delta‐aminolevulinate synthase 2...

Read More thumbnail image: Transcriptomic biomarkers of altered erythropoiesis to detect autologous blood transfusion

Pharmacokinetics and tissue distribution study of clevidipine and its primary metabolite H152/81 in rats

Published: Aug 8, 2017

Author(s): Yan Wang, Lanting Zhao, Tengfei Li, Wen Yang, Qian Li, Luning Sun, Li Ding

Journal: Biomedical Chromatography

Abstract This present study was designed to investigate the pharmacokinetic profiles and tissue distribution characteristics of clevidipine and its primary metabolite H152/81 in rats following a single intravenous administration of clevidipine butyrate injectable emulsion. For this study, a sensitive and selective liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was established and validated for the simultaneous...

Read More thumbnail image: Pharmacokinetics and tissue distribution study of clevidipine and its primary metabolite H15281 in rats

In situ chemical and morphological characterization of copper under near ambient reduction and oxidation conditions

Published: Aug 8, 2017

Author(s): H. Sezen, M. Al‐Hada, M. Amati, L. Gregoratti

Journal: Surface and Interface Analysis

By using spatially resolved photoelectron spectromicroscopy, we have investigated the formation of Cu(I) oxide phases when a bulk Cu foil is exposed to a near ambient pressure of molecular oxygen. The experiment was performed by using a novel cell for in operando measurements capable to overcome the so called ‘pressure gap’. We have found that the oxidation of Cu proceeds through the formation of Cu(I) oxide domains in the micron and...

Read More thumbnail image: In situ chemical and morphological characterization of copper under near ambient reduction and oxidation conditions

A UPLC‐TOF/MS‐based metabolomics study of rattan stems of Schisandra chinensis effects on Alzheimer's disease rats model

Published: Aug 7, 2017

Author(s): Bing‐You Yang, Jin‐Yan Tan, Yan Liu, Bo Liu, Shuang Jin, Hong‐Wei Guo, Hai‐Xue Kuang

Journal: Biomedical Chromatography

Abstract A UPLC‐TOF/MS‐based metabolomics method was established to explore the therapeutic mechanisms of rattan stems of S. chinensis (SCS) in Alzheimer's disease (AD). Experimental AD model was induced by intra‐hippocampal Aβ1–42 injection in rats. Cognitive function and oxidative stress condition in brain of AD rats were assessed using Morris water maze tests and antioxidant assays [malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione...

Read More thumbnail image: A UPLCTOFMSbased metabolomics study of rattan stems of Schisandra chinensis effects on Alzheimers disease rats model

Purity and adulteration in cocaine seizures and drug market inspection in Galicia (Spain) across an eight‐year period

Published: Aug 1, 2017

Author(s): Mª. de los Ángeles Villar Núñez, José Sánchez Morcillo, María Adolfina Ruíz Martínez

Journal: Drug Testing and Analysis

Read More thumbnail image: Purity and adulteration in cocaine seizures and drug market inspection in Galicia Spain across an eightyear period

Raman scattering of graphene‐based systems in high magnetic fields

Published: Aug 1, 2017

Author(s): Clement Faugeras, Milan Orlita, Marek Potemski

Journal: Journal of Raman Spectroscopy

We review the different results obtained in the last decade in the field of Raman scattering of graphene‐based systems, with an applied magnetic field. Electronic properties of graphene‐based systems with an applied magnetic field are first described. The phonon response in magnetic field, the magneto‐phono resonance, is then introduced and described for graphene monolayer and multilayer, as well as for bulk graphite. Electronic Raman...

Read More thumbnail image: Raman scattering of graphenebased systems in high magnetic fields

The influence of small doses of ethanol on the urinary testosterone to epitestosterone ratio in men and women

Published: Aug 1, 2017

Author(s): Sami Albeiroti, Brian D. Ahrens, Timofei Sobolevskii, Anthony W. Butch

Journal: Drug Testing and Analysis

Endogenous steroid use can increase urinary testosterone/epitestosterone (T/E) values. In addition, ethanol in amounts >0.5 g per kg of body weight (g/kg) can also increase T/E values. However, the effect of smaller doses of ethanol on T/E values is unknown. The influence of 0.2 and 0.4 g/kg of ethanol on baseline T/E values in 20 men and 20 women with low and high baseline T/E values was investigated and correlated with...

Read More thumbnail image: The influence of small doses of ethanol on the urinary testosterone to epitestosterone ratio in men and women

Profiling ephedrine prepared from N ‐methylalanine via the Akabori‐Momotani reaction

Published: Aug 1, 2017

Author(s): Alexandra Doddridge, Michael Collins, Helen Salouros

Journal: Drug Testing and Analysis

Novel methods for synthesising methylamphetamine precursors are appearing in clandestine laboratories within Australia. One such laboratory involved the synthesis of ephedrine from N‐methylalanine and benzaldehyde via the Akabori‐Momotani reaction. This article presents chiral and stable isotope ratios of ephedrine synthesised via this method, along with a chemical profile of methylamphetamine produced from this ephedrine. Based on the...

Read More thumbnail image: Profiling ephedrine prepared from N methylalanine via the AkaboriMomotani reaction

The emergence of new psychoactive substance (NPS) benzodiazepines: A review

Published: Jul 31, 2017

Author(s): Kieran R. Manchester, Emma C. Lomas, Laura Waters, Fiona C. Dempsey, Peter D. Maskell

Journal: Drug Testing and Analysis

The market for new psychoactive substances has increased markedly in recent years and there is now a steady stream of compounds appearing every year. Benzodiazepines consist of only a fraction of the total number of these compounds but their use and misuse has rapidly increased. Some of these benzodiazepines have only been patented, some of them have not been previously synthesised, and the majority have never undergone clinical trials or...

Read More thumbnail image: The emergence of new psychoactive substance NPS benzodiazepines A review

Standardization approaches in absolute quantitative proteomics with mass spectrometry

Published: Jul 31, 2017

Author(s): Francisco Calderón‐Celis, Jorge Ruiz Encinar, Alfredo Sanz‐Medel

Journal: Mass Spectrometry Reviews

Mass spectrometry‐based approaches have enabled important breakthroughs in quantitative proteomics in the last decades. This development is reflected in the better quantitative assessment of protein levels as well as to understand post‐translational modifications and protein complexes and networks. Nowadays, the focus of quantitative proteomics shifted from the relative determination of proteins (ie, differential...

Read More thumbnail image: Standardization approaches in absolute quantitative proteomics with mass spectrometry

An investigation of a unique group of painted silk banners from a Polish collection

Published: Jul 28, 2017

Author(s): Anna Klisińska‐Kopacz

Journal: Journal of Raman Spectroscopy

Historic textiles represent a very important part of our cultural heritage. This research focused on the evaluation of a group of unique 16th century banners painted on silk. The banners were examined by Raman spectroscopy and X‐ray fluorescence spectrometry. The measurements were performed to characterize the pigments and materials used, in order to establish the most adequate display methods. Pigments typical of the Renaissance period...

Read More thumbnail image: An investigation of a unique group of painted silk banners from a Polish collection

Sevoflurane metabolite cross‐react in the ethyl glucuronide DRI® immunoassay

Published: Jul 28, 2017

Author(s): Michael Böttcher, David Kühne, Olof Beck

Journal: Drug Testing and Analysis

Read More thumbnail image: Sevoflurane metabolite crossreact in the ethyl glucuronide DRI immunoassay

Characterization and discrimination of raw and vinegar‐baked Bupleuri radix based on UHPLC‐Q‐TOF‐MS coupled with multivariate statistical analysis

Published: Jul 28, 2017

Author(s): Tianli Lei, Shifeng Chen, Kai Wang, Dandan Zhang, Lin Dong, Chongning Lv, Jing Wang, Jincai Lu

Journal: Biomedical Chromatography

Abstract Bupleuri Radix is a commonly used herb in clinic, and raw and vinegar‐baked Bupleuri Radix are both documented in the Pharmacopoeia of People's Republic of China. According to the theories of traditional Chinese medicine, Bupleuri Radix possesses different therapeutic effects before and after processing. However, the chemical mechanism of this processing is still unknown. In this study, ultra‐high‐performance liquid chromatography with...

Read More thumbnail image: Characterization and discrimination of raw and vinegarbaked Bupleuri radix based on UHPLCQTOFMS coupled with multivariate statistical analysis

Non‐targeted acquisition strategy for screening doping compounds based on GC‐EI‐hybrid quadrupole‐Orbitrap mass spectrometry: A focus on exogenous anabolic steroids

Published: Jul 27, 2017

Author(s): Gustavo Albuquerque Cavalcanti, Lucas Martins Rodrigues, Leonardo Santos, Xin Zheng, Amit Gujar, Jason Cole, Monica Costa Padilha, Francisco Radler Aquino Neto

Journal: Drug Testing and Analysis

This is a first look at a non‐targeted screening method based on Orbitrap gas chromatography–mass spectrometry (GC–MS) technology for a large number of banned compounds in sports found in urine, including exogenous anabolic steroids, β‐agonists, narcotics, stimulants, hormone modulators, and diuretics. A simple sample preparation was processed in four steps: an enzymatic hydrolysis, liquid–liquid extraction, evaporation, and...

Read More thumbnail image: Nontargeted acquisition strategy for screening doping compounds based on GCEIhybrid quadrupoleOrbitrap mass spectrometry A focus on exogenous anabolic steroids

A step towards removing plasma volume variance from the Athlete's Biological Passport: The use of biomarkers to describe vascular volumes from a simple blood test

Published: Jul 27, 2017

Author(s): Louisa M. Lobigs, Pierre‐Edouard Sottas, Pitre C. Bourdon, Zoran Nikolovski, Mohamed El‐Gingo, Evdokia Varamenti, Peter Peeling, Brian Dawson, Yorck O. Schumacher

Journal: Drug Testing and Analysis

The haematological module of the Athlete's Biological Passport (ABP) has significantly impacted the prevalence of blood manipulations in elite sports. However, the ABP relies on a number of concentration‐based markers of erythropoiesis, such as haemoglobin concentration ([Hb]), which are influenced by shifts in plasma volume (PV). Fluctuations in PV contribute to the majority of biological variance associated with volumetric ABP markers....

Read More thumbnail image: A step towards removing plasma volume variance from the Athletes Biological Passport The use of biomarkers to describe vascular volumes from a simple blood test

Prevalence of new psychoactive substances and prescription drugs in the Belgian driving under the influence of drugs population

Published: Jul 27, 2017

Author(s): S. M. R. Wille, C. Richeval, M. Nachon‐Phanithavong, J. M. Gaulier, V. Di Fazio, L. Humbert, N. Samyn, D. Allorge

Journal: Drug Testing and Analysis

Driving under the influence of drugs (DUID) is a worldwide problem. Several countries have adopted DUID legislations which prove their deterrent effect and impact on road safety. However, the use of new psychoactive substances (NPS) and prescription drugs is not known, as the applied roadside screening tests have not yet been adapted for these compounds. In this study, 558 blood samples obtained during roadside controls in Belgium...

Read More thumbnail image: Prevalence of new psychoactive substances and prescription drugs in the Belgian driving under the influence of drugs population

A study of the origin of chloramphenicol isomers in honey

Published: Jul 27, 2017

Author(s): Dmytro Yanovych, Bjorn Berendsen, Zvenyslava Zasadna, Mariana Rydchuk, Tobias Czymai

Journal: Drug Testing and Analysis

Due to the unexpected detection of chloramphenicol isomer residues in honey, we have studied the hypothesis of unauthorized or unintended use of unregistered veterinary drug preparations. First, we have investigated honey samples in which a discrepancy was observed between the results of the immunological screening methods and the confirmatory liquid chromatography–tandem mass spectrometry (LC–MS/MS) method. In all samples, previously...

Read More thumbnail image: A study of the origin of chloramphenicol isomers in honey
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