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Bioconjugated graphene oxide‐based Raman probe for selective identification of SKBR3 breast cancer cells

Published: May 31, 2017

Author(s): Afua A. Antwi‐Boasiako, Derrick Dunn, Samuel S. R. Dasary, Yolanda K. Jones, Sandra L. Barnes, Anant K. Singh

Journal: Journal of Raman Spectroscopy

In this article, we demonstrate the use of bioconjugated 2D graphene oxide (bio‐GO) nanostructure to probe breast cancer cell (SKBR3) with excellent discrimination over other types of circulating tumor cell. We distinctly observed that bio‐GO nanostructure targets and binds SKBR3 cell selectively in the cell mixture. Longer incubation of SKBR3 cell with bio‐GO causes Raman signal ‘turn off’ when excited with 532‐nm laser. This is...

Read More thumbnail image: Bioconjugated graphene oxidebased Raman probe for selective identification of SKBR3 breast cancer cells

Fast and stable partial least squares modelling: A benchmark study with theoretical comments

Published: May 30, 2017

Author(s): Åke Björck, Ulf G. Indahl

Journal: Journal of Chemometrics

Algorithms for partial least squares (PLS) modelling are placed into a sound theoretical context focusing on numerical precision and computational efficiency. NIPALS and other PLS algorithms that perform deflation steps of the predictors (X) may be slow or even computationally infeasible for sparse and/or large‐scale data sets. As alternatives, we develop new versions of the Bidiag1 and Bidiag2 algorithms. These include full reorthogonalization of...

Read More thumbnail image: Fast and stable partial least squares modelling A benchmark study with theoretical comments

Centrifugal‐driven, reduced‐dimension, planar chromatography

Published: May 29, 2017

Author(s): Rachel B. Strickhouser, Nahla A. Hatab, Nickolay V. Lavrik, Michael J. Sepaniak

Journal: ELECTROPHORESIS

A fundamental problem with efficiency in capillary action driven planar chromatography results from diminishing flow rates as development proceeds, giving rise to molecular diffusion related band dispersion for most sample types. Overpressure and electrokinetic means to speed flow have been used successfully in TLC. We explore the use of centrifugal force (CF) to drive flow for reduced‐dimension planar platforms (ultra‐TLC, low micrometer...

Read More thumbnail image: Centrifugaldriven reduceddimension planar chromatography

Field identification of minerals at burning coal dumps using miniature Raman spectrometers

Published: May 26, 2017

Author(s): Košek F., Culka A., Jehlička J.

Journal: Journal of Raman Spectroscopy

Earthy, finely crystalline, weathering, and condensation products sometimes occur at the surface and subsurface of waste dumps or burning coal dumps which remain after coal mining. Surface crusts at the burning dumps of bituminous coal at Heřmanice (Silesia, Czech Republic) were investigated using a lightweight portable Raman spectrometer. The compact instrument, with 785‐nm diode excitation, allowed for the recording of good quality...

Read More thumbnail image: Field identification of minerals at burning coal dumps using miniature Raman spectrometers

Raman spectroscopy and theoretic study of hyperpolarizability effect in diiodobutenyl‐ bis ‐thioquinolinium triiodide at low temperature

Published: May 26, 2017

Author(s): I. D. Yushina, V. I. Batalov, E. V. Bartashevich, A. O. Davydov, P. S. Zelenovskiy, A. E. Masunov

Journal: Journal of Raman Spectroscopy

Various structural features, such as proton disorder or noncovalent interactions, determine the existence of switchable nonlinear optical properties under varying external conditions. Thus, for the single crystal of diiodobutenyl‐bis‐thioquinolinium triiodide with the bridge hydrogen atom, previously characterized under ambient conditions by C2/c symmetry, we have measured Raman spectra in the temperature range from 298 K down to 113 K....

Read More thumbnail image: Raman spectroscopy and theoretic study of hyperpolarizability effect in diiodobutenyl bis thioquinolinium triiodide at low temperature

In situ Raman spectroscopy investigation of the solubility and dissolution mechanism of 1,2‐dichlorobenzene in hot compressed water in a fused silica capillary reactor

Published: May 26, 2017

Author(s): Ke Bei, Jie Chen, Junliang Wang, I‐Ming Chou, Minghai Yao, Zhiyan Pan

Journal: Journal of Raman Spectroscopy

Hot compressed water (HCW), with its unique properties, is regarded as a promising solvent for industrial applications. A number of methods to measure the solubility of hydrophobic organic compounds (HOCs) in HCW have been reported. However, these methods were conducted in large‐scale stainless‐steel reactors, and few included an in situ study regarding the dissolution mechanism of HOCs in HCW during the solubility determination process. In this...

Read More thumbnail image: In situ Raman spectroscopy investigation of the solubility and dissolution mechanism of 12dichlorobenzene in hot compressed water in a fused silica capillary reactor

Online monitoring of electrocatalytic reactions of alcohols at platinum and gold electrodes in acidic, neutral and alkaline media by capillary electrophoresis with contactless conductivity detection (EC‐CE‐C 4 D)

Published: May 26, 2017

Author(s): Mauro Sérgio Ferreira Santos, Fernando Silva Lopes, Ivano Gebhardt Rolf Gutz

Journal: ELECTROPHORESIS

An EC‐CE‐C4D flow system was applied to the investigation of electrocatalytic processes by monitoring carboxylic acids formed during the electro‐oxidation at various potentials of primary alcohols (mixture of 1 mmol/L of ethanol, n‐propanol, n‐butanol and n‐pentanol) in acidic, neutral and alkaline media. The electro‐oxidation was carried out on gold and platinum disk electrodes (3 mm of diameter) in a thin‐layer electrochemical...

Read More thumbnail image: Online monitoring of electrocatalytic reactions of alcohols at platinum and gold electrodes in acidic neutral and alkaline media by capillary electrophoresis with contactless conductivity detection ECCEC 4 D

Detection of the recently emerged synthetic cannabinoid 5F–MDMB‐PICA in ‘legal high’ products and human urine samples

Published: May 24, 2017

Author(s): Lukas Mogler, Florian Franz, Daniel Rentsch, Verena Angerer, Georg Weinfurtner, Mitchell Longworth, Samuel D. Banister, Michael Kassiou, Bjoern Moosmann, Volker Auwärter

Journal: Drug Testing and Analysis

Indole or indazole‐based synthetic cannabinoids (SCs) bearing substituents derived from valine or tert‐leucine are frequently abused new psychoactive substances (NPS). The emergence of 5F–MDMB‐PICA (methyl N‐{[1‐(5‐fluoropentyl)‐1H–indol‐3‐yl]carbonyl}‐3‐methylvalinate) on the German drug market is a further example of a substance synthesized in the context of scientific research being misused by clandestine laboratories by adding it to ‘legal high’ products. In...

Read More thumbnail image: Detection of the recently emerged synthetic cannabinoid 5FMDMBPICA in legal high products and human urine samples

Report on an anti‐doping operation in Guadeloupe: High number of positive cases and inferences about doping habits

Published: May 24, 2017

Author(s): A. Marchand, C. Buisson, L. Martin, J.‐A. Martin, A. Molina, D. Ressiot

Journal: Drug Testing and Analysis

Anti‐doping controls in non‐major events are relatively infrequent and athletes that compete only in these events are less likely to be controlled. The French Anti‐Doping Agency carried out an anti‐doping operation during a regional cycling competition in Guadeloupe. The urine and serum samples were analysed by the French anti‐doping laboratory. Out of 42 athletes, 7 were positive for one or more substances prohibited by the World...

Read More thumbnail image: Report on an antidoping operation in Guadeloupe High number of positive cases and inferences about doping habits

Affinity monolith chromatography: A review of general principles and applications

Published: May 22, 2017

Author(s): Zhao Li, Elliott Rodriguez, Shiden Azaria, Allegra Pekarek, David S. Hage

Journal: ELECTROPHORESIS

Affinity monolith chromatography, or AMC, is a liquid chromatographic method in which the support is a monolith and the stationary phase is a biological‐binding agent or related mimic. AMC has become popular for the isolation of biochemicals, for the measurement of various analytes, and for studying biological interactions. This review will examine the principles and applications of AMC. The materials that have been used to prepare AMC...

Read More thumbnail image: Affinity monolith chromatography A review of general principles and applications

Flubromazolam – Basic pharmacokinetic evaluation of a highly potent designer benzodiazepine

Published: May 19, 2017

Author(s): Laura M. Huppertz, Bjoern Moosmann, Volker Auwärter

Journal: Drug Testing and Analysis

Since their first appearance on the Internet in 2012, designer benzodiazepines established as an additional, quickly growing compound class among new psychoactive substances. Data regarding pharmacokinetic parameters, metabolism, and detectability for new compounds are limited or often not available. One of these compounds, flubromazolam (8‐bromo‐6‐(2‐fluorophenyl)‐1‐methyl‐4H‐[1,2,4]triazolo[4,3‐a][1,4]benzodiazepine), the triazolo‐analogue of...

Read More thumbnail image: Flubromazolam  Basic pharmacokinetic evaluation of a highly potent designer benzodiazepine

Probing nanostructured materials using X‐ray fluorescence analysis

Published: May 18, 2017

Author(s): Gangadhar Das, Ajay Khooha, A.K. Singh, M.K. Tiwari

Journal: X-Ray Spectrometry

Dispersion of metal nanoparticles on flat surfaces has attracted considerable interest in many technological applications. Numerous advantages of functionalized patterned nanostructures especially in medical physics, chemistry, biology, and semiconductor quantum dot applications have rapidly driven the growth of this field in the last two decades. In particular, for applications involving biomedical imaging, the nanoparticles have...

Read More thumbnail image: Probing nanostructured materials using Xray fluorescence analysis

Characterization of microbial mixtures by mass spectrometry

Published: May 16, 2017

Author(s): Todd R. Sandrin, Plamen A. Demirev

Journal: Mass Spectrometry Reviews

MS applications in microbiology have increased significantly in the past 10 years, due in part to the proliferation of regulator‐approved commercial MALDI MS platforms for rapid identification of clinical infections. In parallel, with the expansion of MS technologies in the “omics” fields, novel MS‐based research efforts to characterize organismal as well as environmental microbiomes have emerged. Successful...

Read More thumbnail image: Characterization of microbial mixtures by mass spectrometry

A new quantitative X‐ray system for micro‐PIXE analysis

Published: May 16, 2017

Author(s): Jan Pallon, Nathaly De La Rosa, Mikael Elfman, Per Kristiansson, E.J. Charlotta Nilsson, Linus Ros

Journal: X-Ray Spectrometry

Particle Induced X‐ray Emission is a well‐established technique for quantitative elemental analysis down to trace levels. During microbeam analysis, where the beam is collimated and focused into a small spot, the beam current reduces to nA or less. The generation of characteristic X‐rays is reduced in the same proportion, leading to long data‐acquisition times. This can partly be compensated for by using detectors with a large solid...

Read More thumbnail image: A new quantitative Xray system for microPIXE analysis

Feature selection based on graph Laplacian by using compounds with known and unknown activities

Published: May 15, 2017

Author(s): Razieh Sheikhpour, Mehdi Agha Sarram, Sajjad Gharaghani, Mohammad Ali Zare Chahooki

Journal: Journal of Chemometrics

A semisupervised feature selection method based on graph Laplacian (S2FSGL) was proposed for quantitative structure‐activity relationship (QSAR) models, which uses an ℓ2,1‐norm and compounds with both known and unknown activities. In the proposed S2FSGL method, 2 graphs Gunsup and Gsup are constructed. It uses the label information of compounds with known activities and the local structure of compounds with known and unknown activities to select the most...

Read More thumbnail image: Feature selection based on graph Laplacian by using compounds with known and unknown activities

Oral absorption, distribution, metabolism, and excretion of icaritin in rats by Q‐TOF and UHPLC–MS/MS

Published: May 15, 2017

Author(s): Shuang‐Qing Zhang, Shi‐Zhong Zhang

Journal: Drug Testing and Analysis

Icaritin (ICT) displays numerous pharmacological activities for the treatment of various cancers, osteoporosis, inflammation, and angiocardiopathy. The absorption, distribution, metabolism, and excretion of ICT still remain unknown. ICT was administered to rats at 2 mg/kg for intravenous injection or 40 mg/kg for oral route. Major metabolite of ICT was identified using quadrupole time‐of‐flight (Q‐TOF), and ICT and its major...

Read More thumbnail image: Oral absorption distribution metabolism and excretion of icaritin in rats by QTOF and UHPLCMSMS

Background conductivity independent counter flow preconcentration method for capillary electrophoresis

Published: May 15, 2017

Author(s): Israel Joel Koenka, Peter C. Hauser

Journal: ELECTROPHORESIS

A preconcentration method for anions is presented, which relies on a trap created by applying an electric field against a hydrodynamic flow of the sample. The trapping zone is created in front of a cation exchange membrane that allows the isolation of the electrode and thus prevents any interference by electrolysis products. Preconcentration factors of up to 20 were demonstrated for nitrate and formate as model analyte ions and were...

Read More thumbnail image: Background conductivity independent counter flow preconcentration method for capillary electrophoresis

Determination of cannabinoid and synthetic cannabinoid metabolites in wastewater by liquid–liquid extraction and ultra‐high performance supercritical fluid chromatography‐tandem mass spectrometry

Published: May 12, 2017

Author(s): Iria González‐Mariño, Kevin V. Thomas, Malcolm J. Reid

Journal: Drug Testing and Analysis

For the first time, ultra‐high performance supercritical fluid chromatography (UHPSFC) coupled to tandem mass spectrometry has been used to determine cannabinoid and synthetic cannabinoid residues in wastewater. Combined with a downscaled version of the classic liquid‐liquid extraction, the proposed method allows for the quantification of Δ9‐tetrahydrocannabinol, three of its major metabolites (the monohydroxylated, the dehydroxylated,...

Read More thumbnail image: Determination of cannabinoid and synthetic cannabinoid metabolites in wastewater by liquidliquid extraction and ultrahigh performance supercritical fluid chromatographytandem mass spectrometry

Identification and characterization of novel long‐term metabolites of oxymesterone and mesterolone in human urine by application of selected reaction monitoring GC‐CI‐MS/MS

Published: May 12, 2017

Author(s): Michael Polet, Wim Van Gansbeke, Lore Geldof, Koen Deventer, Peter Van Eenoo

Journal: Drug Testing and Analysis

The search for metabolites with longer detection times remains an important task in, for example, toxicology and doping control. The impact of these long‐term metabolites is highlighted by the high number of positive cases after reanalysis of samples that were stored for several years, e.g. samples of previous Olympic Games. A substantial number of previously alleged negative samples have now been declared positive due to the detection of...

Read More thumbnail image: Identification and characterization of novel longterm metabolites of oxymesterone and mesterolone in human urine by application of selected reaction monitoring GCCIMSMS

Development of a dried blood spot HPLC‐PDA method for the analysis of linezolid and ciprofloxacin in hospital‐acquired pneumonia patients

Published: May 12, 2017

Author(s): Vincenzo Ferrone, Maura Carlucci, Roberto Cotellese, Paolo Raimondi, Annadomenica Cichella, Lorenzo Di Marco, Salvatore Genovese, Giuseppe Carlucci

Journal: Drug Testing and Analysis

This study developed a high performance liquid chromatography (HPLC) method involving dried blood spotting (DBS) as a sampling method for the therapeutic drug monitoring of antimicrobial combination therapy with linezolid and ciprofloxacin. DBS for standards, quality control samples, and patient samples was excised and then extracted using a mixture of methanol/water/formic acid 80:20:0.1 (v/v/v), respectively. Linezolid (LZD) and...

Read More thumbnail image: Development of a dried blood spot HPLCPDA method for the analysis of linezolid and ciprofloxacin in hospitalacquired pneumonia patients
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