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Sevoflurane metabolite cross‐react in the ethyl glucuronide DRI® immunoassay

Published: Jul 28, 2017

Author(s): Michael Böttcher, David Kühne, Olof Beck

Journal: Drug Testing and Analysis

Read More thumbnail image: Sevoflurane metabolite crossreact in the ethyl glucuronide DRI immunoassay

Characterization and discrimination of raw and vinegar‐baked Bupleuri radix based on UHPLC‐Q‐TOF‐MS coupled with multivariate statistical analysis

Published: Jul 28, 2017

Author(s): Tianli Lei, Shifeng Chen, Kai Wang, Dandan Zhang, Lin Dong, Chongning Lv, Jing Wang, Jincai Lu

Journal: Biomedical Chromatography

Abstract Bupleuri Radix is a commonly used herb in clinic, and raw and vinegar‐baked Bupleuri Radix are both documented in the Pharmacopoeia of People's Republic of China. According to the theories of traditional Chinese medicine, Bupleuri Radix possesses different therapeutic effects before and after processing. However, the chemical mechanism of this processing is still unknown. In this study, ultra‐high‐performance liquid chromatography with...

Read More thumbnail image: Characterization and discrimination of raw and vinegarbaked Bupleuri radix based on UHPLCQTOFMS coupled with multivariate statistical analysis

Non‐targeted acquisition strategy for screening doping compounds based on GC‐EI‐hybrid quadrupole‐Orbitrap mass spectrometry: A focus on exogenous anabolic steroids

Published: Jul 27, 2017

Author(s): Gustavo Albuquerque Cavalcanti, Lucas Martins Rodrigues, Leonardo Santos, Xin Zheng, Amit Gujar, Jason Cole, Monica Costa Padilha, Francisco Radler Aquino Neto

Journal: Drug Testing and Analysis

This is a first look at a non‐targeted screening method based on Orbitrap gas chromatography–mass spectrometry (GC–MS) technology for a large number of banned compounds in sports found in urine, including exogenous anabolic steroids, β‐agonists, narcotics, stimulants, hormone modulators, and diuretics. A simple sample preparation was processed in four steps: an enzymatic hydrolysis, liquid–liquid extraction, evaporation, and...

Read More thumbnail image: Nontargeted acquisition strategy for screening doping compounds based on GCEIhybrid quadrupoleOrbitrap mass spectrometry A focus on exogenous anabolic steroids

A step towards removing plasma volume variance from the Athlete's Biological Passport: The use of biomarkers to describe vascular volumes from a simple blood test

Published: Jul 27, 2017

Author(s): Louisa M. Lobigs, Pierre‐Edouard Sottas, Pitre C. Bourdon, Zoran Nikolovski, Mohamed El‐Gingo, Evdokia Varamenti, Peter Peeling, Brian Dawson, Yorck O. Schumacher

Journal: Drug Testing and Analysis

The haematological module of the Athlete's Biological Passport (ABP) has significantly impacted the prevalence of blood manipulations in elite sports. However, the ABP relies on a number of concentration‐based markers of erythropoiesis, such as haemoglobin concentration ([Hb]), which are influenced by shifts in plasma volume (PV). Fluctuations in PV contribute to the majority of biological variance associated with volumetric ABP markers....

Read More thumbnail image: A step towards removing plasma volume variance from the Athletes Biological Passport The use of biomarkers to describe vascular volumes from a simple blood test

Prevalence of new psychoactive substances and prescription drugs in the Belgian driving under the influence of drugs population

Published: Jul 27, 2017

Author(s): S. M. R. Wille, C. Richeval, M. Nachon‐Phanithavong, J. M. Gaulier, V. Di Fazio, L. Humbert, N. Samyn, D. Allorge

Journal: Drug Testing and Analysis

Driving under the influence of drugs (DUID) is a worldwide problem. Several countries have adopted DUID legislations which prove their deterrent effect and impact on road safety. However, the use of new psychoactive substances (NPS) and prescription drugs is not known, as the applied roadside screening tests have not yet been adapted for these compounds. In this study, 558 blood samples obtained during roadside controls in Belgium...

Read More thumbnail image: Prevalence of new psychoactive substances and prescription drugs in the Belgian driving under the influence of drugs population

A study of the origin of chloramphenicol isomers in honey

Published: Jul 27, 2017

Author(s): Dmytro Yanovych, Bjorn Berendsen, Zvenyslava Zasadna, Mariana Rydchuk, Tobias Czymai

Journal: Drug Testing and Analysis

Due to the unexpected detection of chloramphenicol isomer residues in honey, we have studied the hypothesis of unauthorized or unintended use of unregistered veterinary drug preparations. First, we have investigated honey samples in which a discrepancy was observed between the results of the immunological screening methods and the confirmatory liquid chromatography–tandem mass spectrometry (LC–MS/MS) method. In all samples, previously...

Read More thumbnail image: A study of the origin of chloramphenicol isomers in honey

Return of the lysergamides. Part IV: Analytical and pharmacological characterization of lysergic acid morpholide (LSM‐775)

Published: Jul 27, 2017

Author(s): Simon D. Brandt, Pierce V. Kavanagh, Brendan Twamley, Folker Westphal, Simon P. Elliott, Jason Wallach, Alexander Stratford, Landon M. Klein, John D. McCorvy, David E. Nichols, Adam L. Halberstadt

Journal: Drug Testing and Analysis

Lysergic acid diethylamide (LSD) is perhaps one of the best‐known psychoactive substances and many structural modifications of this prototypical lysergamide have been investigated. Several lysergamides were recently encountered as ‘research chemicals’ or new psychoactive substances (NPS). Although lysergic acid morpholide (LSM‐775) appeared on the NPS market in 2013, there is disagreement in the literature regarding the potency and...

Read More thumbnail image: Return of the lysergamides_ Part IV Analytical and pharmacological characterization of lysergic acid morpholide LSM775

Development and applications of nonlinear optical spectroscopy: 15th ECONOS/35th ECW meeting in Gothenburg (Sweden)

Published: Jul 27, 2017

Author(s): Stina Hemdal, David Sedarsky, Johannes Kiefer, Julian Moger

Journal: Journal of Raman Spectroscopy

Read More thumbnail image: Development and applications of nonlinear optical spectroscopy 15th ECONOS35th ECW meeting in Gothenburg Sweden

Enhanced Raman and photoluminescence response in monolayer MoS 2 due to laser healing of defects

Published: Jul 27, 2017

Author(s): Achintya Bera, D. V. S. Muthu, A. K. Sood

Journal: Journal of Raman Spectroscopy

Bound quasiparticles, negatively charged trions and neutral excitons are associated with the direct optical transitions at the K‐points of the Brillouin zone for monolayer MoS2. The change in the carrier concentration, surrounding dielectric constant, and defect concentration can modulate the photoluminescence and Raman spectra. Here, we show that exposing the monolayer MoS2 in air to a modest laser intensity for a brief period of time enhances...

Read More thumbnail image: Enhanced Raman and photoluminescence response in monolayer MoS 2 due to laser healing of defects

Metabolism of novel opioid agonists U‐47700 and U‐49900 using human liver microsomes with confirmation in authentic urine specimens from drug users

Published: Jul 26, 2017

Author(s): Alex J. Krotulski, Amanda L. A. Mohr, Donna M. Papsun, Barry K. Logan

Journal: Drug Testing and Analysis

Recently, the number of adverse events, including death, involving novel opioids has continued to increase, providing additional and sustained challenges for forensic and medical communities. Identification of emerging novel opioids can be challenging, compounded by detection windows and unknown metabolic profiles. In this study, human liver microsomes were used for the generation of in vitro metabolic profiles of U‐47700 and U‐49900....

Read More thumbnail image: Metabolism of novel opioid agonists U47700 and U49900 using human liver microsomes with confirmation in authentic urine specimens from drug users

Elevated levels of liver methylglyoxal and d ‐lactate in early‐stage hepatitis in rats

Published: Jul 26, 2017

Author(s): Wen‐Chuang Wang, Chu‐Kuang Chou, Ming‐Cheng Chuang, Yi‐Chieh Li, Jen‐Ai Lee

Journal: Biomedical Chromatography

Abstract Methylglyoxal (MGO) is highly cytotoxic and its levels are elevated in diabetes, nephropathy and atherosclerosis. However, it has never been studied in liver disease. For this reason, we aimed to assess the levels of MGO and its metabolite d‐lactate in an early hepatitis model. Wistar rats were administered CCl4 (0.75 mL/kg, i.p.) to induce hepatitis. In either CCl4‐treated or untreated rats, alanine transaminase and aspartate transaminase levels...

Read More thumbnail image: Elevated levels of liver methylglyoxal and d lactate in earlystage hepatitis in rats

Syntheses, analytical and pharmacological characterizations of the ‘legal high’ 4‐[1‐(3‐methoxyphenyl)cyclohexyl]morpholine (3‐MeO‐PCMo) and analogues

Published: Jul 26, 2017

Author(s): Tristan Colestock, Jason Wallach, Matt Mansi, Nadine Filemban, Hamilton Morris, Simon P. Elliott, Folker Westphal, Simon D. Brandt, Adeboye Adejare

Journal: Drug Testing and Analysis

New psychoactive substances (NPS) are commonly referred to as ‘research chemicals’, ‘designer drugs’ or ‘legal highs’. One NPS class is represented by dissociative anesthetics, which include analogues of the arylcyclohexylamine phencyclidine (PCP), ketamine and diphenidine. A recent addition to the NPS market was 4‐[1‐(3‐methoxyphenyl)cyclohexyl]morpholine (3‐MeO‐PCMo), a morpholine analogue of 3‐MeO‐PCP. Although suspected to have...

Read More thumbnail image: Syntheses analytical and pharmacological characterizations of the legal high 413methoxyphenylcyclohexylmorpholine 3MeOPCMo and analogues

Assessing the toxicological significance of new psychoactive substances in fatalities

Published: Jul 26, 2017

Author(s): Simon Elliott, Roumen Sedefov, Michael Evans‐Brown

Journal: Drug Testing and Analysis

Read More thumbnail image: Assessing the toxicological significance of new psychoactive substances in fatalities

An LC–MS/MS method for determination of bioactive components of liquorice and Semen Strychni in rat plasma: Application to a pharmacokinetics study

Published: Jul 26, 2017

Author(s): Min Zhang, Yang Deng, Chao Wang, Hua‐Lin Cai, Jing Wen, Ping‐Fei Fang, Bi‐Kui Zhang, Huan‐De Li, Miao Yan

Journal: Drug Testing and Analysis

Semen Strychni is known for its treatment of rheumatic arthritis with a low therapeutic index. Liquorice contributes a lot in herb detoxification according to the traditional Chinese medicine theory. A simple, rapid, and sensitive liquid chromatography–mass spectrometric method (LC–MS) was developed and validated for simultaneous determination of main bioactive ingredients in liquorice and Semen Strychni in rat plasma. Using moclobemide...

Read More thumbnail image: An LCMSMS method for determination of bioactive components of liquorice and Semen Strychni in rat plasma Application to a pharmacokinetics study

Determination of silodosin and its active glucuronide metabolite KMD‐3213G in human plasma by LC–MS/MS for a bioequivalence study

Published: Jul 25, 2017

Author(s): Priyanka A. Shah, Pranav S. Shrivastav

Journal: Biomedical Chromatography

Abstract A sensitive and selective liquid chromatography–tandem mass spectrometry (LC–MS/MS) method is described for the simultaneous determination of silodosin (SLD) and its active metabolite silodosin β‐d‐glucuronide (KMD‐3213G) in human plasma. Liquid–liquid extraction of plasma samples was carried out with ethyl acetate and methyl tert‐butyl ether solvent mixture using deuterated analogs as internal standards. The extraction recoveries of...

Read More thumbnail image: Determination of silodosin and its active glucuronide metabolite KMD3213G in human plasma by LCMSMS for a bioequivalence study

Recent applications of metal–organic frameworks in sample pretreatment

Published: Jul 20, 2017

Author(s): Yonghua Wang, Min Rui, Guanghua Lu

Journal: Journal of Separation Science

Metal–organic frameworks are promising materials in diverse analytical applications especially in sample pretreatment by virtue of their diverse structure topology, tunable pore size, permanent nanoscale porosity, high surface area, and good thermostability. According to hydrostability, metal–organic frameworks are divided into moisture‐sensitive and water‐stable types. In the actual applications, both kinds of metal–organic frameworks...

Read More thumbnail image: Recent applications of metalorganic frameworks in sample pretreatment

Polychromatic simultaneous WDXRF for chemical state analysis using laboratory X‐ray source

Published: Jul 20, 2017

Author(s): Kenji Sato, Akihiro Nishimura, Masatomo Kaino, Susumu Adachi

Journal: X-Ray Spectrometry

The authors have started the development of a new scanning‐free, wavelength‐dispersive X‐ray fluorescence spectrometer, which uses a silicon strip detector instead of a goniometer, a slit, flat analyzing crystal, and laboratory X‐ray source. The X‐rays dispersed by the slit and flat analyzing crystal are detected simultaneously by different silicon strip detector channels, and a high energy resolution is achieved by limiting the...

Read More thumbnail image: Polychromatic simultaneous WDXRF for chemical state analysis using laboratory Xray source

Fatal intoxication by 5F–ADB and diphenidine: Detection, quantification, and investigation of their main metabolic pathways in humans by LC/MS/MS and LC/Q‐TOFMS

Published: Jul 19, 2017

Author(s): Maiko Kusano, Kei Zaitsu, Kentaro Taki, Kazuaki Hisatsune, Jun'ichi Nakajima, Takako Moriyasu, Tomomi Asano, Yumi Hayashi, Hitoshi Tsuchihashi, Akira Ishii

Journal: Drug Testing and Analysis

Despite the implementation of a new blanket scheduling system in 2013, new psychoactive substance (NPS) abuse remains a serious social concern in Japan. We present a fatal intoxication case involving 5F–ADB (methyl 2‐[1‐(5‐fluoropentyl)‐1H–indazole‐3‐carboxamido]‐3,3‐dimethylbutanoate) and diphenidine. Postmortem blood screening by liquid chromatography/quadrupole time‐of‐flight mass spectrometry (LC/Q‐TOFMS) in the information‐dependent acquisition...

Read More thumbnail image: Fatal intoxication by 5FADB and diphenidine Detection quantification and investigation of their main metabolic pathways in humans by LCMSMS and LCQTOFMS

Identification and quantification of predominant metabolites of synthetic cannabinoid MAB‐CHMINACA in an authentic human urine specimen

Published: Jul 19, 2017

Author(s): Koutaro Hasegawa, Kayoko Minakata, Kunio Gonmori, Hideki Nozawa, Itaru Yamagishi, Kanako Watanabe, Osamu Suzuki

Journal: Drug Testing and Analysis

An autopsy case in which the cause of death was judged as drug poisoning by two synthetic cannabinoids, including MAB‐CHMINACA, was investigated. Although unchanged MAB‐CHMINACA could be detected from solid tissues, blood and stomach contents in the case, the compound could not be detected from a urine specimen. We obtained six kinds of reference standards of MAB‐CHMINACA metabolites from a commercial source. The MAB‐CHMINACA metabolites...

Read More thumbnail image: Identification and quantification of predominant metabolites of synthetic cannabinoid MABCHMINACA in an authentic human urine specimen

Ultra‐fast LC–MS/MS in therapeutic drug monitoring: Quantification of clozapine and norclozapine in human plasma

Published: Jul 19, 2017

Author(s): Lewis Couchman, Danielle S. Fisher, Krithika Subramaniam, Simon A. Handley, Robert J. Boughtflower, Christopher M. Benton, Robert J. Flanagan

Journal: Drug Testing and Analysis

A novel approach to high‐throughput, targeted liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis has been developed. A single chromatographic system can be used for the analysis of a range of 20 drugs and metabolites with a total analysis time of 36 s (one 96‐well plate of prepared samples per hour). To demonstrate the applicability of this approach to quantitative analysis, a method has been validated for the...

Read More thumbnail image: Ultrafast LCMSMS in therapeutic drug monitoring Quantification of clozapine and norclozapine in human plasma
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